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Article

Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression

  • Authors:
    • Si Yan Liu
    • Dong Dong Zhang
    • Yang Fang Wu
    • Huang Huang Luo
    • Guang Mei Jiang
    • Yao Xu
    • Yue Wu
    • Xun Xia
    • Wei Wei
    • Bo Hu
    • Peng Hu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China
  • Pages: 535-546
    |
    Published online on: October 15, 2018
       https://doi.org/10.3892/ijmm.2018.3934
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Abstract

The purpose of the present study was to determine whether fibroblast growth factor (FGF)‑23 could serve as a novel biomarker for renal osteodystrophy (ROD) progression. A rat model of ROD was induced by left nephrectomy plus intravenous injection of Adriamycin. Serum FGF‑23 was determined using an enzyme‑linked immunosorbent assay. Serum level and bone expression of FGF‑23 were both significantly elevated in the ROD group at 24 h post‑surgery. Serum FGF‑23 was negatively correlated with calcium, phosphate, 25‑hydroxyvitamin D, conventional bone biomarkers and bone collagen X. More importantly, serum FGF‑23 was significantly associated with abnormalities in bone formation rate, osteoblasts, osteoclasts, trabecular volume thickness and osteoid volume. Therefore, FGF‑23 may serve as a novel biomarker for ROD.
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Copy and paste a formatted citation
Spandidos Publications style
Liu SY, Zhang DD, Wu YF, Luo HH, Jiang GM, Xu Y, Wu Y, Xia X, Wei W, Hu B, Hu B, et al: Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression. Int J Mol Med 43: 535-546, 2019.
APA
Liu, S.Y., Zhang, D.D., Wu, Y.F., Luo, H.H., Jiang, G.M., Xu, Y. ... Hu, P. (2019). Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression. International Journal of Molecular Medicine, 43, 535-546. https://doi.org/10.3892/ijmm.2018.3934
MLA
Liu, S. Y., Zhang, D. D., Wu, Y. F., Luo, H. H., Jiang, G. M., Xu, Y., Wu, Y., Xia, X., Wei, W., Hu, B., Hu, P."Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression". International Journal of Molecular Medicine 43.1 (2019): 535-546.
Chicago
Liu, S. Y., Zhang, D. D., Wu, Y. F., Luo, H. H., Jiang, G. M., Xu, Y., Wu, Y., Xia, X., Wei, W., Hu, B., Hu, P."Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression". International Journal of Molecular Medicine 43, no. 1 (2019): 535-546. https://doi.org/10.3892/ijmm.2018.3934
Copy and paste a formatted citation
x
Spandidos Publications style
Liu SY, Zhang DD, Wu YF, Luo HH, Jiang GM, Xu Y, Wu Y, Xia X, Wei W, Hu B, Hu B, et al: Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression. Int J Mol Med 43: 535-546, 2019.
APA
Liu, S.Y., Zhang, D.D., Wu, Y.F., Luo, H.H., Jiang, G.M., Xu, Y. ... Hu, P. (2019). Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression. International Journal of Molecular Medicine, 43, 535-546. https://doi.org/10.3892/ijmm.2018.3934
MLA
Liu, S. Y., Zhang, D. D., Wu, Y. F., Luo, H. H., Jiang, G. M., Xu, Y., Wu, Y., Xia, X., Wei, W., Hu, B., Hu, P."Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression". International Journal of Molecular Medicine 43.1 (2019): 535-546.
Chicago
Liu, S. Y., Zhang, D. D., Wu, Y. F., Luo, H. H., Jiang, G. M., Xu, Y., Wu, Y., Xia, X., Wei, W., Hu, B., Hu, P."Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression". International Journal of Molecular Medicine 43, no. 1 (2019): 535-546. https://doi.org/10.3892/ijmm.2018.3934
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