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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January-2019 Volume 43 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Epigenetic mechanisms and implications in tendon inflammation (Review)

Finosh G. Thankam, Chandra S. Boosani, Matthew F. Dilisio, Devendra K. Agrawal
Pages: 3-14
Published online on: 29 October 2018

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Review Open Access

Proteolysis is the most fundamental property of malignancy and its inhibition may be used therapeutically (Review)

Marzena Wyganowska‑Świątkowska, Mateusz Tarnowski, Daniel Murtagh, Ewa Skrzypczak‑Jankun, Jerzy Jankun
Pages: 15-25
Published online on: 07 November 2018

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Article Open Access

Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages

Ji Hye Hwang, Jun Nan Ma, Jong Hun Park, Hyo Won Jung, Yong‑Ki Park
Pages: 26-36
Published online on: 16 October 2018

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Article Open Access

Bone morphogenetic protein 7 enhances the osteogenic differentiation of human dermal-derived CD105+ fibroblast cells through the Smad and MAPK pathways

Fuguo Chen, Dan Bi, Chen Cheng, Sunxiang Ma, Yang Liu, Kaixiang Cheng
Pages: 37-46
Published online on: 17 October 2018

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Article Open Access

Differential expression of mTOR components in endometriosis and ovarian cancer: Effects of rapalogues and dual kinase inhibitors on mTORC1 and mTORC2 stoichiometry

Karly‑Rai Rogers‑Broadway, Juhi Kumar, Cristina Sisu, Gurleen Wander, Emily Mazey, Jeyarooban Jeyaneethi, George Pados, Dimitris Tsolakidis, Eleftherios Klonos, Thomas Grunt, Marcia Hall, Jayanta Chatterjee, Emmanouil Karteris
Pages: 47-56
Published online on: 31 October 2018

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Article Open Access

Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia

Yoshiji Yamada, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Tetsuo Fujimaki, Yoshiki Yasukochi, Ichiro Takeuchi, Jun Sakuma
Pages: 57-82
Published online on: 19 October 2018

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Article Open Access

A highly efficient method for isolating urinary exosomes

Liuqing He, Ding Zhu, Junpu Wang, Xiaoying Wu
Pages: 83-90
Published online on: 19 October 2018

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Article Open Access

MicroRNA-98 reduces amyloid β-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice

Fang‑Zhou Chen, Ying Zhao, Hui‑Zhao Chen
Pages: 91-102
Published online on: 24 October 2018

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Article Open Access

Galectin-1 gene silencing inhibits the activation and proliferation but induces the apoptosis of hepatic stellate cells from mice with liver fibrosis

Zhi‑Jun Jiang, Qing‑Hua Shen, Hai‑Yong Chen, Zhe Yang, Ming‑Qi Shuai, Shu‑Sen Zheng
Pages: 103-116
Published online on: 23 October 2018

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Article Open Access

Isorhamnetin protects against bleomycin-induced pulmonary fibrosis by inhibiting endoplasmic reticulum stress and epithelial-mesenchymal transition

Qing Zheng, Ming Tong, Baiqing Ou, Cuizhong Liu, Changping Hu, Yu Yang
Pages: 117-126
Published online on: 30 October 2018

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Article Open Access

CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer

Chun Feng, Yuxiao Li, Yan Lin, Xianbao Cao, Dongdong Li, Honglei Zhang, Xiaoguang He
Pages: 127-142
Published online on: 19 October 2018

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Article Open Access

miR-181b-5p suppresses starvation-induced cardiomyocyte autophagy by targeting Hspa5

Liuhui Chang, Xiaoming Chai, Peiming Chen, Jianfang Cao, Hong Xie, Jiang Zhu
Pages: 143-154
Published online on: 12 November 2018

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Article Open Access

Genome-wide methylation study of whole blood cells DNA in men with congenital hypopituitarism disease

Xuqian Fang, Changqiang Chen, Jialin Cai, Enfei Xiang, Jingquan Li, Peizhan Chen
Pages: 155-166
Published online on: 22 October 2018

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Article Open Access

Effect of 1α, 25-dihydroxyvitamin D3 on the osteogenic differentiation of human periodontal ligament stem cells and the underlying regulatory mechanism

Yawen Ji, Panpan Zhang, Yixiao Xing, Linglu Jia, Yunpeng Zhang, Tingting Jia, Xuan Wu, Bin Zhao, Xin Xu
Pages: 167-176
Published online on: 22 October 2018

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Article Open Access

Suppressive effect mediated by human adipose-derived stem cells on T cells involves the activation of JNK

Yinmin Wang, Xiuxia Wang, Xianyu Zhou, Zhu Zhu, Jun Yang, Fei Liu
Pages: 177-184
Published online on: 24 October 2018

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Article Open Access

Spicatoside A in red Liriope platyphylla displays a laxative effect in a constipation rat model via regulating mAChRs and ER stress signaling Corrigendum in /10.3892/ijmm.2024.5462

Ji Eun Kim, Jun Go, Hee Seob Lee, Jin Tae Hong, Dae Youn Hwang
Pages: 185-198
Published online on: 29 October 2018

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Article Open Access

N-acetylcysteine alleviates H2O2-induced damage via regulating the redox status of intracellular antioxidants in H9c2 cells

Xiehong Liu, Li Wang, Jiaodi Cai, Ke Liu, Meidong Liu, Hao Wang, Huali Zhang
Pages: 199-208
Published online on: 29 October 2018

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Article Open Access

Overexpression of microRNA-183 promotes apoptosis of substantia nigra neurons via the inhibition of OSMR in a mouse model of Parkinson's disease

Jin-Xia Gao, Yu Li, Sai-Nan Wang, Xing-Chi Chen, Lu-Lu Lin, Hui Zhang
Pages: 209-220
Published online on: 07 November 2018

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Article Open Access

‘Governor vessel-unblocking and mind-regulating’ acupuncture therapy ameliorates cognitive dysfunction in a rat model of middle cerebral artery occlusion

Xuan Su, Zuqiang Wu, Fangyong Mai, Zhiyong Fan, Shujia Du, Hong Qian, Jingwen Zhu
Pages: 221-232
Published online on: 06 November 2018

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Article Open Access

Application of metabolomics part II: Focus on fatty acids and their metabolites in healthy adults

Dimitrios Tsoukalas, Athanasios K. Alegakis, Persefoni Fragkiadaki, Evangelos Papakonstantinou, Gerasimos Tsilimidos, Franco Geraci, Evangelia Sarandi, Dragana Nikitovic, Demetrios A. Spandidos, Aristides Tsatsakis
Pages: 233-242
Published online on: 14 November 2018

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Article Open Access

Next generation sequencing reveals novel alterations in B-cell heavy chain receptor repertoires associated with acute-on-chronic liver failure

Qiang Yan, Lei Wang, Liusheng Lai, Song Liu, Huaizhou Chen, Jiaxing Zhang, Yong Dai, Weiguo Sui
Pages: 243-255
Published online on: 22 October 2018

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Article Open Access

Downregulation of miR-145-5p in cancer cells and their derived exosomes may contribute to the development of ovarian cancer by targeting CT

Wenzhao Hang, Yiwen Feng, Zhenyu Sang, Ye Yang, Yaping Zhu, Qian Huang, Xiaowei Xi
Pages: 256-266
Published online on: 25 October 2018

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Article Open Access

MicroRNA-421-targeted PDCD4 regulates breast cancer cell proliferation

Yiwei Wang, Zipeng Liu, Jian Shen
Pages: 267-275
Published online on: 15 October 2018

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Article Open Access

Bioinformatics-based study to detect chemical compounds that show potential as treatments for pulmonary thromboembolism

Keyu Sun, Zichen Xie, Jiqin Wang, Meirong Ling, Yanyan Li, Chao Qiu
Pages: 276-284
Published online on: 12 November 2018

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Article Open Access

The short-term effect of histone deacetylase inhibitors, chidamide and valproic acid, on the NF‑κB pathway in multiple myeloma cells

Zhaoyun Liu, Qian Jing, Yangyang Wang, Yanqi Li, Fu Mi, Chenhuan Xiang, Rong Fu
Pages: 285-293
Published online on: 29 October 2018

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Article Open Access

Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway

Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Miao
Pages: 294-304
Published online on: 15 October 2018

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Article Open Access

High-pressure carbon dioxide pneumoperitoneum induces oxidative stress and mitochondria-associated apoptotic pathway in rabbit kidneys with severe hydronephrosis

Sheng Zhao, Wei Li, Fan Cheng, Ting Rao, Weimin Yu, Yuan Ruan, Run Yuan, Xiaobing Yao, Jinzhuo Ning
Pages: 305-315
Published online on: 08 November 2018

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Article Open Access

Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR

Yu Ding, Zhaochang Jiang, Bohou Xia, Lizong Zhang, Caijuan Zhang, Jianhang Leng
Pages: 316-324
Published online on: 05 November 2018

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Article Open Access

Crosstalk between mitogen-activated protein kinase inhibitors and transforming growth factor-β signaling results in variable activation of human dermal fibroblasts

David M. Dolivo, Sara A. Larson, Tanja Dominko
Pages: 325-335
Published online on: 23 October 2018

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Article Open Access

Alterations of autophagy in knee cartilage by treatment with treadmill exercise in a rat osteoarthritis model

Xiaoning Zhang, Yue Yang, Xin Li, He Zhang, Yi Gang, Lunhao Bai
Pages: 336-344
Published online on: 23 October 2018

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Article Open Access

lncRNA MEG3 promotes hepatic insulin resistance by serving as a competing endogenous RNA of miR-214 to regulate ATF4 expression

Xiang Zhu, Hongqi Li, Yuanbo Wu, Jian Zhou, Guangwei Yang, Weidong Wang
Pages: 345-357
Published online on: 05 November 2018

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Article Open Access

Exosome-mediated microRNA-138 and vascular endothelial growth factor in endometriosis through inflammation and apoptosis via the nuclear factor-κB signaling pathway

Aifeng Zhang, Guoyun Wang, Lihua Jia, Tao Su, Lili Zhang
Pages: 358-370
Published online on: 06 November 2018

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Article Open Access

SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells

Xue‑Qing Wan, Jia‑Yu Cai, Yue Zhu, Qiu‑Xia Wang, Hai‑Tao Zhu, Hui‑Min Ju, Hong‑Yan Lu
Pages: 371-381
Published online on: 29 October 2018

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Article Open Access

Guanine and nucleotide binding protein 3 promotes odonto/osteogenic differentiation of apical papilla stem cells via JNK and ERK signaling pathways

Yang Zhang, Lichan Yuan, Li Meng, Mengru Fang, Shuyu Guo, Dongyue Wang, Junqing Ma, Lin Wang
Pages: 382-392
Published online on: 07 November 2018

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Article Open Access

Essential oil from Korean Chamaecyparis obtusa leaf ameliorates respiratory activity in Sprague‑Dawley rats and exhibits protection from NF-κB-induced inflammation in WI38 fibroblast cells

Suchismita Raha, Seong Min Kim, Ho Jeong Lee, Sang Joon Lee, Jeong Doo Heo, Venu Venkatarame Gowda Saralamma, Sang Eun Ha, Eun Hee Kim, Sung Phil Mun, Gon Sup Kim
Pages: 393-403
Published online on: 31 October 2018

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Article Open Access

Overexpression of CDCA8 promotes the malignant progression of cutaneous melanoma and leads to poor prognosis

Chao Ci, Biao Tang, Dalun Lyu, Wenbei Liu, Di Qiang, Xiang Ji, Xiamin Qiu, Lei Chen, Wei Ding
Pages: 404-412
Published online on: 07 November 2018

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Article Open Access

Hyperforin improves post-stroke social isolation‑induced exaggeration of PSD and PSA via TGF-β

Yujing Zhang, Peiyun Yu, Hong Liu, Hua Yao, Shanglong Yao, Shi‑Ying Yuan, Jian‑Cheng Zhang
Pages: 413-425
Published online on: 02 November 2018

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Article

Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice

Hiroaki Suzuki, Ryohei Tsuji, Miho Sugamata, Naoki Yamamoto, Norio Yamamoto, Osamu Kanauchi
Pages: 426-434
Published online on: 24 October 2018

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Article

Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor

Zhenhua Liu, Fumin Wang, Minglu Tang, Yongjun Zhao, Xiaoting Wang
Pages: 435-442
Published online on: 16 October 2018

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Article

Neuroprotective effects of midazolam on focal cerebral ischemia in rats through anti‑apoptotic mechanisms

Hang Yu, Xiaozhi Wang, Fuxin Kang, Zhile Chen, Yunxia Meng, Mingming Dai
Pages: 443-451
Published online on: 05 November 2018

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Article

Propofol attenuates inflammatory damage on neurons following cerebral infarction by inhibiting excessive activation of microglia

Hang Yu, Xiaozhi Wang, Fuxin Kang, Zhile Chen, Yunxia Meng, Mingming Dai
Pages: 452-460
Published online on: 05 November 2018

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Article

Quercetin‑3‑O‑α‑L‑rhamnopyranoside derived from the leaves of Lindera aggregata (Sims) Kosterm. evokes the autophagy‑induced nuclear factor erythroid 2‑related factor 2 antioxidant pathway in human umbilical vein endothelial cells

Haote Han, Bo Xu, Awais Amin, Hongliang Li, Xiuying Yu, Minghua Gong, Lin Zhang
Pages: 461-474
Published online on: 05 November 2018

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Article

COX-2 induces apoptosis-resistance in hepatocellular carcinoma cells via the HIF-1α/PKM2 pathway

Qin Wang, Donghui Lu, Lulu Fan, Yuhuan Li, Yu Liu, Hanqing Yu, Hua Wang, Jiatao Liu, Guoping Sun
Pages: 475-488
Published online on: 16 October 2018

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Article

Muscat Bailey A grape stalk extract ameliorates high-fat diet‑induced obesity by downregulating PPARγ and C/EPBα in mice

Bo‑Mi Kim, Byoung Ok Cho, Seon Il Jang
Pages: 489-500
Published online on: 24 October 2018

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Article

Effect of tetramethylpyrazine and hyperlipidemia on hepcidin homeostasis in mice

Miao Zhang, Ming‑Yue Sun, Chun‑Yu Guo, Jing‑Shang Wang, Feng‑Qin Xu, Hui‑Jun Yin
Pages: 501-506
Published online on: 01 November 2018

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Article

Suppression of cyclooxygenase 2 increases chemosensitivity to sesamin through the Akt‑PI3K signaling pathway in lung cancer cells

Qing Fang, Yuyin Zhu, Qilai Wang, Meijun Song, Guosheng Gao, Zhiming Zhou
Pages: 507-516
Published online on: 18 October 2018

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Article

miR-186 reverses cisplatin resistance and inhibits the formation of the glioblastoma-initiating cell phenotype by degrading Yin Yang 1 in glioblastoma

Jian Li, Jie Song, Feng Guo
Pages: 517-524
Published online on: 18 October 2018

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Article

MicroRNA‑222‑3p promotes tumor cell migration and invasion and inhibits apoptosis, and is correlated with an unfavorable prognosis of patients with renal cell carcinoma Corrigendum in /10.3892/ijmm.2024.5377

Liwen Zhao, Jing Quan, Zuwei Li, Xiang Pan, Jingyao Wang, Jinling Xu, Weijie Xu, Xin Guan, Hang Li, Shangqi Yang, Yaoting Gui, Yun Chen, Yongqing Lai
Pages: 525-534
Published online on: 15 October 2018

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Article

Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression

Si Yan Liu, Dong Dong Zhang, Yang Fang Wu, Huang Huang Luo, Guang Mei Jiang, Yao Xu, Yue Wu, Xun Xia, Wei Wei, Bo Hu, Peng Hu
Pages: 535-546
Published online on: 15 October 2018

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Article

Knockdown of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 inhibits the proliferation and migration of bladder cancer cells by modulating the microRNA-34a/cyclin D1 axis

Ye Liu, Saiyue Gao, Qingyan Du, Qingsong Zhao
Pages: 547-556
Published online on: 29 October 2018

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Article

CZ2HF mitigates β-amyloid 25-35 fragment-induced learning and memory impairment through inhibition of neuroinflammation and apoptosis in rats

Lingrong Zeng, Jianmei Gao, Yuanyuan Deng, Jingshan Shi, Qihai Gong
Pages: 557-566
Published online on: 24 October 2018

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Article

Deletion of FOXL2 by CRISPR promotes cell cycle G0/G1 restriction in KGN cells

Bin Tang, Yujie Zhang, Wei Zhang, Yuqing Zhu, Shaopeng Yuan
Pages: 567-574
Published online on: 24 October 2018

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Article

Ligustrazine inhibits platelet activation via suppression of the Akt pathway

Li Li, Hongwei Chen, Aling Shen, Qiongyu Li, Youqin Chen, Jianfeng Chu, Liya Liu, Jun Peng, Keji Chen
Pages: 575-582
Published online on: 01 November 2018

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Article

Bone morphogenetic protein 2 alleviated intervertebral disc degeneration through mediating the degradation of ECM and apoptosis of nucleus pulposus cells via the PI3K/Akt pathway

Yanlin Tan, Xingwang Yao, Zhehao Dai, Yunhua Wang, Guohua Lv
Pages: 583-592
Published online on: 02 November 2018

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Article

In vitro enhancement and functional characterization of neurite outgrowth by undifferentiated adipose-derived stem cells

Vesna Bucan, Malte Fliess, Reinhild Schnabel, Claas‑Tido Peck, Desiree Vaslaitis, Angela Fülbier, Kerstin Reimers, Sarah Strauss, Peter M. Vogt, Christine Radtke
Pages: 593-602
Published online on: 06 November 2018

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Article

Anti-obesity effects of Diospyros lotus leaf extract in mice with high-fat diet-induced obesity

Bo‑Mi Kim, Byoung Ok Cho, Seon Il Jang
Pages: 603-613
Published online on: 18 October 2018

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Article

Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition

Liya Ma, Ying Yu, Xiaohui Qu
Pages: 614-620
Published online on: 24 October 2018

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Article

C1QTNF6 is overexpressed in gastric carcinoma and contributes to the proliferation and migration of gastric carcinoma cells

Hai‑Xia Qu, Lin Cui, Xin‑Ying Meng, Zhi‑Jie Wang, Yan‑Xin Cui, Yun‑Peng Yu, Dong Wang, Xiang‑Jun Jiang
Pages: 621-629
Published online on: 06 November 2018

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Article

Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway

Dan Li, Gangcheng Wang, Guoguo Jin, Ke Yao, Zhenjiang Zhao, Liangyu Bie, Yongjun Guo, Ning Li, Wenying Deng, Xiaobin Chen, Beibei Chen, Yuanyuan Liu, Suxia Luo, Zhiping Guo
Pages: 630-640
Published online on: 01 November 2018

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Journal Cover
January-2026 Volume 57 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

FK506‑binding proteins as emerging bridges linking proteostasis to multi‑system pathogenesis and therapeutic strategies (Review)

Zhi Li, Xiaolei Liu, Hesong Zeng
Article Number: 30
Published online on: 24 November 2025

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[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Article Number: 29
Published online on: 24 November 2025

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METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner

Yang Wang, Yihao Tian, Gang Yao
Article Number: 28
Published online on: 20 November 2025

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Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review)

Ruihao Xu, Haoming Ren, Zhengwei Yuan, Wanqi Huang, Hui Gu
Article Number: 27
Published online on: 20 November 2025

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MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang
Article Number: 26
Published online on: 18 November 2025

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Synergistic effects of Akebia saponin D and Semaglutide on diabetic nephropathy and osteoporosis via the Klotho‑p53 signaling axis

Qian Zhang, Dan Wang, Hongxia Jia, Zongji Zheng, Liyan Lin, Linna Li, Ling Wang, Yaoming Xue
Article Number: 25
Published online on: 18 November 2025

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[Retracted] MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Ke Li, Conghu Yuan
Article Number: 24
Published online on: 17 November 2025

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Article

Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein

Zhikui Li, Weijie Ding, Yubo Sun, Chenfeng Tian, Shuaishuai Fu, Fei Shi, Zhenchi Fang, Yuanzhe Li, Jianchang Li, Sirui Cai, Haobo Kang, Baozeng Sun, Junqi Zhang, Yuanjie Sun, Shuya Yang, Yusi Zhang, Chunmei Zhang, Yun Zhang, Xiyang Zhang, Kun Yang, Dongbo Jiang
Article Number: 23
Published online on: 14 November 2025

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Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy

Boya Zhang, Defeng Kong, Siji Chen, Xuewu Sun, Hao Cheng
Article Number: 22
Published online on: 14 November 2025

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Targeting p38 MAPK signaling pathway: 
Quercetin as a novel therapy for TMJ synovitis

Mosha Cheng, Yuhe Guan, Xiaotao Xin, Xin Yi, Yi Liu
Article Number: 21
Published online on: 13 November 2025

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Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review)

Yuchen Wang, Boxuan Wang, Jinchao Hou, Xiaodong Huo, Chenlin Liu, Ruili Guan, Honggang Chen, Yang Zhou, Jianbin Zhang, Congcong Zhuang, Yuankang Zou
Article Number: 20
Published online on: 13 November 2025

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Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review)

Peiyu Li, Yinghui Li, Qian Meng, Jie Wang, Kun Wang, Sumin Yang
Article Number: 19
Published online on: 13 November 2025

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Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes

Xiaona Chen, Ziqi Sun, Jiabo Chen, Jinquan Zhang, Zeyu Liu, Zhengzheng Yan, Quan Li, Zhixia Chen
Article Number: 18
Published online on: 12 November 2025

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Correction Open Access

[Corrigendum]  Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

Bo Meng, Yisong Wang, Bin Li
Article Number: 17
Published online on: 10 November 2025

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Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)

Jing Wang, Qin Zhao, Shuwan Zhang, Jia Liu, Xingyue Fan, Bin Han, Yaqin Hou, Xiaopeng Ai
Article Number: 16
Published online on: 05 November 2025

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High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review)

Min You, Fan Wu, Feng Xiong, Xue-Fei Hu, Huan Wu, Li Zhou, Hong-Xing Zhang
Article Number: 15
Published online on: 05 November 2025

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ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model

Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang
Article Number: 14
Published online on: 05 November 2025

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Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review)

Chaowei Zhang, Yuxuan Han, Weiyi Yao, Qing Hong, Na Chen
Article Number: 13
Published online on: 04 November 2025

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β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Xianyi Ding, Jiabin Wu, Lian Wang, Ke Li, Haoyang Gao, Mingyu Wu, Qiuyu Zhang, Ruonan Han, Wenhong Wang, Weihua Xiao
Article Number: 12
Published online on: 03 November 2025

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Review

Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

Xunjie Jian, Chang Cheng, Wenjie Lu, Hui Peng, Diqi Yang
Article Number: 11
Published online on: 03 November 2025

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Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)

Xitong Zhao, Pengqin Wang
Article Number: 10
Published online on: 03 November 2025

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Expression of Concern Open Access

[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 9
Published online on: 29 October 2025

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TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway

Linlin Xiao, Man Qu, Lulu Chen, Mingli Xiang, Qian Long, Jianguo Liu, Xiaoyan Guan, Chengcheng Liao
Article Number: 8
Published online on: 27 October 2025

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Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review)

Tao Duan, Hanhai Mao, Xingyue Jiang, Ying Tian, Jidong Zhang, Jun Tan
Article Number: 7
Published online on: 27 October 2025

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Retraction Open Access

[Retracted] Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma

Guanen Qiao, Chenguang Dai, Yang He, Junjie Shi, Chunfang Xu
Article Number: 6
Published online on: 27 October 2025

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Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review)

Yiming Shao, Ke Song, Ruixin Yu, He Xiao, Chengjun Li, Yuling Deng, Yuan Zhang, Yixing Ren
Article Number: 5
Published online on: 24 October 2025

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Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer

Chuanxi Lai, Xiya Jia, Yiyi Chen, Kangke Chen, Fei Wang, Qiqi Zhang, Xiaonan Xiang, Zhe-Sheng Chen, Lingna Xu, Sheng Dai
Article Number: 4
Published online on: 23 October 2025

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Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis

Weichao Sun, Yi Liao, Jianguo Feng, Jianhui Liang, Qifei He, Yinxing Cui, Dixi Huang, Houyin Shi, Wei You, Wei Sun, Qian Yi
Article Number: 3
Published online on: 23 October 2025

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Review

Importance of B cells (Review)

Zhiyuan Liu, Haoran Dai, Xiaoyu Cui, Yeping Liu, Zhaocheng Dong
Article Number: 2
Published online on: 22 October 2025

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Retraction Open Access

[Retracted] Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Article Number: 1
Published online on: 22 October 2025

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February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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