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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January-2019 Volume 43 Issue 1

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Epigenetic mechanisms and implications in tendon inflammation (Review)

Finosh G. Thankam, Chandra S. Boosani, Matthew F. Dilisio, Devendra K. Agrawal
Pages: 3-14
Published online on: 29 October 2018

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Review Open Access

Proteolysis is the most fundamental property of malignancy and its inhibition may be used therapeutically (Review)

Marzena Wyganowska‑Świątkowska, Mateusz Tarnowski, Daniel Murtagh, Ewa Skrzypczak‑Jankun, Jerzy Jankun
Pages: 15-25
Published online on: 07 November 2018

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Article Open Access

Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages

Ji Hye Hwang, Jun Nan Ma, Jong Hun Park, Hyo Won Jung, Yong‑Ki Park
Pages: 26-36
Published online on: 16 October 2018

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Article Open Access

Bone morphogenetic protein 7 enhances the osteogenic differentiation of human dermal-derived CD105+ fibroblast cells through the Smad and MAPK pathways

Fuguo Chen, Dan Bi, Chen Cheng, Sunxiang Ma, Yang Liu, Kaixiang Cheng
Pages: 37-46
Published online on: 17 October 2018

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Article Open Access

Differential expression of mTOR components in endometriosis and ovarian cancer: Effects of rapalogues and dual kinase inhibitors on mTORC1 and mTORC2 stoichiometry

Karly‑Rai Rogers‑Broadway, Juhi Kumar, Cristina Sisu, Gurleen Wander, Emily Mazey, Jeyarooban Jeyaneethi, George Pados, Dimitris Tsolakidis, Eleftherios Klonos, Thomas Grunt, Marcia Hall, Jayanta Chatterjee, Emmanouil Karteris
Pages: 47-56
Published online on: 31 October 2018

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Article Open Access

Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia

Yoshiji Yamada, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Tetsuo Fujimaki, Yoshiki Yasukochi, Ichiro Takeuchi, Jun Sakuma
Pages: 57-82
Published online on: 19 October 2018

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Article Open Access

A highly efficient method for isolating urinary exosomes

Liuqing He, Ding Zhu, Junpu Wang, Xiaoying Wu
Pages: 83-90
Published online on: 19 October 2018

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Article Open Access

MicroRNA-98 reduces amyloid β-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice

Fang‑Zhou Chen, Ying Zhao, Hui‑Zhao Chen
Pages: 91-102
Published online on: 24 October 2018

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Article Open Access

Galectin-1 gene silencing inhibits the activation and proliferation but induces the apoptosis of hepatic stellate cells from mice with liver fibrosis

Zhi‑Jun Jiang, Qing‑Hua Shen, Hai‑Yong Chen, Zhe Yang, Ming‑Qi Shuai, Shu‑Sen Zheng
Pages: 103-116
Published online on: 23 October 2018

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Article Open Access

Isorhamnetin protects against bleomycin-induced pulmonary fibrosis by inhibiting endoplasmic reticulum stress and epithelial-mesenchymal transition

Qing Zheng, Ming Tong, Baiqing Ou, Cuizhong Liu, Changping Hu, Yu Yang
Pages: 117-126
Published online on: 30 October 2018

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Article Open Access

CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer

Chun Feng, Yuxiao Li, Yan Lin, Xianbao Cao, Dongdong Li, Honglei Zhang, Xiaoguang He
Pages: 127-142
Published online on: 19 October 2018

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Article Open Access

miR-181b-5p suppresses starvation-induced cardiomyocyte autophagy by targeting Hspa5

Liuhui Chang, Xiaoming Chai, Peiming Chen, Jianfang Cao, Hong Xie, Jiang Zhu
Pages: 143-154
Published online on: 12 November 2018

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Article Open Access

Genome-wide methylation study of whole blood cells DNA in men with congenital hypopituitarism disease

Xuqian Fang, Changqiang Chen, Jialin Cai, Enfei Xiang, Jingquan Li, Peizhan Chen
Pages: 155-166
Published online on: 22 October 2018

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Article Open Access

Effect of 1α, 25-dihydroxyvitamin D3 on the osteogenic differentiation of human periodontal ligament stem cells and the underlying regulatory mechanism

Yawen Ji, Panpan Zhang, Yixiao Xing, Linglu Jia, Yunpeng Zhang, Tingting Jia, Xuan Wu, Bin Zhao, Xin Xu
Pages: 167-176
Published online on: 22 October 2018

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Article Open Access

Suppressive effect mediated by human adipose-derived stem cells on T cells involves the activation of JNK

Yinmin Wang, Xiuxia Wang, Xianyu Zhou, Zhu Zhu, Jun Yang, Fei Liu
Pages: 177-184
Published online on: 24 October 2018

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Spicatoside A in red Liriope platyphylla displays a laxative effect in a constipation rat model via regulating mAChRs and ER stress signaling Corrigendum in /10.3892/ijmm.2024.5462

Ji Eun Kim, Jun Go, Hee Seob Lee, Jin Tae Hong, Dae Youn Hwang
Pages: 185-198
Published online on: 29 October 2018

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Article Open Access

N-acetylcysteine alleviates H2O2-induced damage via regulating the redox status of intracellular antioxidants in H9c2 cells

Xiehong Liu, Li Wang, Jiaodi Cai, Ke Liu, Meidong Liu, Hao Wang, Huali Zhang
Pages: 199-208
Published online on: 29 October 2018

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Article Open Access

Overexpression of microRNA-183 promotes apoptosis of substantia nigra neurons via the inhibition of OSMR in a mouse model of Parkinson's disease

Jin-Xia Gao, Yu Li, Sai-Nan Wang, Xing-Chi Chen, Lu-Lu Lin, Hui Zhang
Pages: 209-220
Published online on: 07 November 2018

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Article Open Access

‘Governor vessel-unblocking and mind-regulating’ acupuncture therapy ameliorates cognitive dysfunction in a rat model of middle cerebral artery occlusion

Xuan Su, Zuqiang Wu, Fangyong Mai, Zhiyong Fan, Shujia Du, Hong Qian, Jingwen Zhu
Pages: 221-232
Published online on: 06 November 2018

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Article Open Access

Application of metabolomics part II: Focus on fatty acids and their metabolites in healthy adults

Dimitrios Tsoukalas, Athanasios K. Alegakis, Persefoni Fragkiadaki, Evangelos Papakonstantinou, Gerasimos Tsilimidos, Franco Geraci, Evangelia Sarandi, Dragana Nikitovic, Demetrios A. Spandidos, Aristides Tsatsakis
Pages: 233-242
Published online on: 14 November 2018

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Next generation sequencing reveals novel alterations in B-cell heavy chain receptor repertoires associated with acute-on-chronic liver failure

Qiang Yan, Lei Wang, Liusheng Lai, Song Liu, Huaizhou Chen, Jiaxing Zhang, Yong Dai, Weiguo Sui
Pages: 243-255
Published online on: 22 October 2018

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Article Open Access

Downregulation of miR-145-5p in cancer cells and their derived exosomes may contribute to the development of ovarian cancer by targeting CT

Wenzhao Hang, Yiwen Feng, Zhenyu Sang, Ye Yang, Yaping Zhu, Qian Huang, Xiaowei Xi
Pages: 256-266
Published online on: 25 October 2018

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Article Open Access

MicroRNA-421-targeted PDCD4 regulates breast cancer cell proliferation

Yiwei Wang, Zipeng Liu, Jian Shen
Pages: 267-275
Published online on: 15 October 2018

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Article Open Access

Bioinformatics-based study to detect chemical compounds that show potential as treatments for pulmonary thromboembolism

Keyu Sun, Zichen Xie, Jiqin Wang, Meirong Ling, Yanyan Li, Chao Qiu
Pages: 276-284
Published online on: 12 November 2018

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Article Open Access

The short-term effect of histone deacetylase inhibitors, chidamide and valproic acid, on the NF‑κB pathway in multiple myeloma cells

Zhaoyun Liu, Qian Jing, Yangyang Wang, Yanqi Li, Fu Mi, Chenhuan Xiang, Rong Fu
Pages: 285-293
Published online on: 29 October 2018

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Article Open Access

Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway

Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Miao
Pages: 294-304
Published online on: 15 October 2018

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Article Open Access

High-pressure carbon dioxide pneumoperitoneum induces oxidative stress and mitochondria-associated apoptotic pathway in rabbit kidneys with severe hydronephrosis

Sheng Zhao, Wei Li, Fan Cheng, Ting Rao, Weimin Yu, Yuan Ruan, Run Yuan, Xiaobing Yao, Jinzhuo Ning
Pages: 305-315
Published online on: 08 November 2018

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Article Open Access

Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR

Yu Ding, Zhaochang Jiang, Bohou Xia, Lizong Zhang, Caijuan Zhang, Jianhang Leng
Pages: 316-324
Published online on: 05 November 2018

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Article Open Access

Crosstalk between mitogen-activated protein kinase inhibitors and transforming growth factor-β signaling results in variable activation of human dermal fibroblasts

David M. Dolivo, Sara A. Larson, Tanja Dominko
Pages: 325-335
Published online on: 23 October 2018

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Article Open Access

Alterations of autophagy in knee cartilage by treatment with treadmill exercise in a rat osteoarthritis model

Xiaoning Zhang, Yue Yang, Xin Li, He Zhang, Yi Gang, Lunhao Bai
Pages: 336-344
Published online on: 23 October 2018

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Article Open Access

lncRNA MEG3 promotes hepatic insulin resistance by serving as a competing endogenous RNA of miR-214 to regulate ATF4 expression

Xiang Zhu, Hongqi Li, Yuanbo Wu, Jian Zhou, Guangwei Yang, Weidong Wang
Pages: 345-357
Published online on: 05 November 2018

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Article Open Access

Exosome-mediated microRNA-138 and vascular endothelial growth factor in endometriosis through inflammation and apoptosis via the nuclear factor-κB signaling pathway

Aifeng Zhang, Guoyun Wang, Lihua Jia, Tao Su, Lili Zhang
Pages: 358-370
Published online on: 06 November 2018

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Article Open Access

SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells

Xue‑Qing Wan, Jia‑Yu Cai, Yue Zhu, Qiu‑Xia Wang, Hai‑Tao Zhu, Hui‑Min Ju, Hong‑Yan Lu
Pages: 371-381
Published online on: 29 October 2018

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Article Open Access

Guanine and nucleotide binding protein 3 promotes odonto/osteogenic differentiation of apical papilla stem cells via JNK and ERK signaling pathways

Yang Zhang, Lichan Yuan, Li Meng, Mengru Fang, Shuyu Guo, Dongyue Wang, Junqing Ma, Lin Wang
Pages: 382-392
Published online on: 07 November 2018

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Article Open Access

Essential oil from Korean Chamaecyparis obtusa leaf ameliorates respiratory activity in Sprague‑Dawley rats and exhibits protection from NF-κB-induced inflammation in WI38 fibroblast cells

Suchismita Raha, Seong Min Kim, Ho Jeong Lee, Sang Joon Lee, Jeong Doo Heo, Venu Venkatarame Gowda Saralamma, Sang Eun Ha, Eun Hee Kim, Sung Phil Mun, Gon Sup Kim
Pages: 393-403
Published online on: 31 October 2018

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Article Open Access

Overexpression of CDCA8 promotes the malignant progression of cutaneous melanoma and leads to poor prognosis

Chao Ci, Biao Tang, Dalun Lyu, Wenbei Liu, Di Qiang, Xiang Ji, Xiamin Qiu, Lei Chen, Wei Ding
Pages: 404-412
Published online on: 07 November 2018

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Article Open Access

Hyperforin improves post-stroke social isolation‑induced exaggeration of PSD and PSA via TGF-β

Yujing Zhang, Peiyun Yu, Hong Liu, Hua Yao, Shanglong Yao, Shi‑Ying Yuan, Jian‑Cheng Zhang
Pages: 413-425
Published online on: 02 November 2018

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Article

Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice

Hiroaki Suzuki, Ryohei Tsuji, Miho Sugamata, Naoki Yamamoto, Norio Yamamoto, Osamu Kanauchi
Pages: 426-434
Published online on: 24 October 2018

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Article

Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor

Zhenhua Liu, Fumin Wang, Minglu Tang, Yongjun Zhao, Xiaoting Wang
Pages: 435-442
Published online on: 16 October 2018

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Article

Neuroprotective effects of midazolam on focal cerebral ischemia in rats through anti‑apoptotic mechanisms

Hang Yu, Xiaozhi Wang, Fuxin Kang, Zhile Chen, Yunxia Meng, Mingming Dai
Pages: 443-451
Published online on: 05 November 2018

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Article

Propofol attenuates inflammatory damage on neurons following cerebral infarction by inhibiting excessive activation of microglia

Hang Yu, Xiaozhi Wang, Fuxin Kang, Zhile Chen, Yunxia Meng, Mingming Dai
Pages: 452-460
Published online on: 05 November 2018

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Article

Quercetin‑3‑O‑α‑L‑rhamnopyranoside derived from the leaves of Lindera aggregata (Sims) Kosterm. evokes the autophagy‑induced nuclear factor erythroid 2‑related factor 2 antioxidant pathway in human umbilical vein endothelial cells

Haote Han, Bo Xu, Awais Amin, Hongliang Li, Xiuying Yu, Minghua Gong, Lin Zhang
Pages: 461-474
Published online on: 05 November 2018

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Article

COX-2 induces apoptosis-resistance in hepatocellular carcinoma cells via the HIF-1α/PKM2 pathway

Qin Wang, Donghui Lu, Lulu Fan, Yuhuan Li, Yu Liu, Hanqing Yu, Hua Wang, Jiatao Liu, Guoping Sun
Pages: 475-488
Published online on: 16 October 2018

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Article

Muscat Bailey A grape stalk extract ameliorates high-fat diet‑induced obesity by downregulating PPARγ and C/EPBα in mice

Bo‑Mi Kim, Byoung Ok Cho, Seon Il Jang
Pages: 489-500
Published online on: 24 October 2018

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Article

Effect of tetramethylpyrazine and hyperlipidemia on hepcidin homeostasis in mice

Miao Zhang, Ming‑Yue Sun, Chun‑Yu Guo, Jing‑Shang Wang, Feng‑Qin Xu, Hui‑Jun Yin
Pages: 501-506
Published online on: 01 November 2018

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Article

Suppression of cyclooxygenase 2 increases chemosensitivity to sesamin through the Akt‑PI3K signaling pathway in lung cancer cells

Qing Fang, Yuyin Zhu, Qilai Wang, Meijun Song, Guosheng Gao, Zhiming Zhou
Pages: 507-516
Published online on: 18 October 2018

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Article

miR-186 reverses cisplatin resistance and inhibits the formation of the glioblastoma-initiating cell phenotype by degrading Yin Yang 1 in glioblastoma

Jian Li, Jie Song, Feng Guo
Pages: 517-524
Published online on: 18 October 2018

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Article

MicroRNA‑222‑3p promotes tumor cell migration and invasion and inhibits apoptosis, and is correlated with an unfavorable prognosis of patients with renal cell carcinoma Corrigendum in /10.3892/ijmm.2024.5377

Liwen Zhao, Jing Quan, Zuwei Li, Xiang Pan, Jingyao Wang, Jinling Xu, Weijie Xu, Xin Guan, Hang Li, Shangqi Yang, Yaoting Gui, Yun Chen, Yongqing Lai
Pages: 525-534
Published online on: 15 October 2018

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Article

Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression

Si Yan Liu, Dong Dong Zhang, Yang Fang Wu, Huang Huang Luo, Guang Mei Jiang, Yao Xu, Yue Wu, Xun Xia, Wei Wei, Bo Hu, Peng Hu
Pages: 535-546
Published online on: 15 October 2018

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Article

Knockdown of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 inhibits the proliferation and migration of bladder cancer cells by modulating the microRNA-34a/cyclin D1 axis

Ye Liu, Saiyue Gao, Qingyan Du, Qingsong Zhao
Pages: 547-556
Published online on: 29 October 2018

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Article

CZ2HF mitigates β-amyloid 25-35 fragment-induced learning and memory impairment through inhibition of neuroinflammation and apoptosis in rats

Lingrong Zeng, Jianmei Gao, Yuanyuan Deng, Jingshan Shi, Qihai Gong
Pages: 557-566
Published online on: 24 October 2018

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Article

Deletion of FOXL2 by CRISPR promotes cell cycle G0/G1 restriction in KGN cells

Bin Tang, Yujie Zhang, Wei Zhang, Yuqing Zhu, Shaopeng Yuan
Pages: 567-574
Published online on: 24 October 2018

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Article

Ligustrazine inhibits platelet activation via suppression of the Akt pathway

Li Li, Hongwei Chen, Aling Shen, Qiongyu Li, Youqin Chen, Jianfeng Chu, Liya Liu, Jun Peng, Keji Chen
Pages: 575-582
Published online on: 01 November 2018

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Article

Bone morphogenetic protein 2 alleviated intervertebral disc degeneration through mediating the degradation of ECM and apoptosis of nucleus pulposus cells via the PI3K/Akt pathway

Yanlin Tan, Xingwang Yao, Zhehao Dai, Yunhua Wang, Guohua Lv
Pages: 583-592
Published online on: 02 November 2018

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Article

In vitro enhancement and functional characterization of neurite outgrowth by undifferentiated adipose-derived stem cells

Vesna Bucan, Malte Fliess, Reinhild Schnabel, Claas‑Tido Peck, Desiree Vaslaitis, Angela Fülbier, Kerstin Reimers, Sarah Strauss, Peter M. Vogt, Christine Radtke
Pages: 593-602
Published online on: 06 November 2018

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Article

Anti-obesity effects of Diospyros lotus leaf extract in mice with high-fat diet-induced obesity

Bo‑Mi Kim, Byoung Ok Cho, Seon Il Jang
Pages: 603-613
Published online on: 18 October 2018

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Article

Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition

Liya Ma, Ying Yu, Xiaohui Qu
Pages: 614-620
Published online on: 24 October 2018

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Article

C1QTNF6 is overexpressed in gastric carcinoma and contributes to the proliferation and migration of gastric carcinoma cells

Hai‑Xia Qu, Lin Cui, Xin‑Ying Meng, Zhi‑Jie Wang, Yan‑Xin Cui, Yun‑Peng Yu, Dong Wang, Xiang‑Jun Jiang
Pages: 621-629
Published online on: 06 November 2018

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Article

Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway

Dan Li, Gangcheng Wang, Guoguo Jin, Ke Yao, Zhenjiang Zhao, Liangyu Bie, Yongjun Guo, Ning Li, Wenying Deng, Xiaobin Chen, Beibei Chen, Yuanyuan Liu, Suxia Luo, Zhiping Guo
Pages: 630-640
Published online on: 01 November 2018

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Journal Cover
August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 231
Published online on: 24 June 2026

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Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

Kebing Lv, Zijie Ma, Qiuni Chen, Yang Su, Jingjing Ma, Chunling Wang, Liang Yu
Article Number: 230
Published online on: 23 June 2026

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Article Open Access

Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang
Article Number: 229
Published online on: 23 June 2026

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MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review)

Hao Xie, Ling Chen, Jing Gou, Xuehong Long, Ya Yang, Hai Hu, Ping Wu, Qibing Yan, Yongkang Wu
Article Number: 228
Published online on: 22 June 2026

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Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng, Huimin Li
Article Number: 227
Published online on: 22 June 2026

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Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review)

Ruipu Zhang, Liang Zhang, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 226
Published online on: 22 June 2026

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Retraction Open Access

[Retracted] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer

Kiyomu Fujii, Tomonori Sasahira, Yukiko Moriwaka, Naohide Oue, Wataru Yasui, Hiroki Kuniyasu
Article Number: 225
Published online on: 22 June 2026

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Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury

Jing Yao, Zeqing Huang, Songze Li, Minghui Lun, Jianing Fan
Article Number: 224
Published online on: 18 June 2026

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Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang
Article Number: 223
Published online on: 18 June 2026

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Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

Dimitrios A. Andreikos, Michael Aschner, Dimitrios C. Ziogas, Aristidis Tsatsakis, Demetrios A. Spandidos
Article Number: 222
Published online on: 18 June 2026

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Targeting glutathione metabolism for tumor radiosensitization (Review)

Haonan Xu, Meng Du, Xiaowen Liang, Xilin Xiao, Zhiyi Chen
Article Number: 221
Published online on: 16 June 2026

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Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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Correction Open Access

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

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Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

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Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

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Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

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Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

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GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

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FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

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Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

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Article Open Access

Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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Article Open Access

FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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