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Article

Muscat Bailey A grape stalk extract ameliorates high-fat diet‑induced obesity by downregulating PPARγ and C/EPBα in mice

  • Authors:
    • Bo‑Mi Kim
    • Byoung Ok Cho
    • Seon Il Jang
  • View Affiliations / Copyright

    Affiliations: Department of Chemical Engineering, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea, Research Institute, Ato Q&A Co., Ltd., Jeonju, Jeonbuk 54840, Republic of Korea
  • Pages: 489-500
    |
    Published online on: October 24, 2018
       https://doi.org/10.3892/ijmm.2018.3951
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Abstract

Muscat Bailey A grape stalk is an organic waste produced in marked amounts during the vinification of grapes. Previous studies have indicated that grape stalk is rich in bioactive phenolic compounds, and exhibits antioxidant and UV‑protective activities. However, its effects on obesity and obesity‑associated disorders have not yet been investigated. The effects of grape stalk extract on improving metabolic features were examined using a high‑fat diet (HFD)‑induced obesity mouse model. Oral administration of 200 mg/kg/day grape stalk extract over 16 weeks markedly prevented HFD‑induced obesity, hepatic steatosis, diabetic symptoms and the risk of developing cardiovascular disease. Furthermore, grape stalk extract prevented oxidative stress and inflammation caused by HFD in mice. The beneficial effect may be associated with CCAAT/enhancer‑binding protein α and peroxisome‑proliferator‑activated receptor γ down­regulation in liver tissue. Collectively, the results of the present study indicated that grape stalk extract may be a potent functional food ingredient for preventing obesity, hepatic steatosis and type 2 diabetes.
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1 

Amugsi DA, Dimbuene ZT, Mberu B, Muthuri S and Ezeh AC: Prevalence and time trends in overweight and obesity among urban women: An analysis of demographic and health surveys data from 24 African countries. BMJ Open. 7:e0173442017. View Article : Google Scholar

2 

Ogden CL, Carroll MD, Fryar CD and Flegal KM: Prevalence of Obesity Among Adults and Youth: United States, 2011-2014. NCHS Data Brief. 219:1–8. 2015.

3 

World Health Organization, Obesity Situation and trends: Global health observatory (GHO) data. http://www.who.int/gho/ncd/risk_factors/obesity_text/en/2016 accessed Feb 1, 2017.

4 

Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS and Marks JS: Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 289:76–79. 2003. View Article : Google Scholar

5 

Clain DJ and Lefkowitch JH: Fatty liver disease in morbid obesity. Gastroenterol Clin North Am. 16:239–252. 1987.PubMed/NCBI

6 

Fabbrini E, Sullivan S and Klein S: Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications. Hepatology. 51:679–689. 2010. View Article : Google Scholar

7 

Manna P and Jain SK: Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: Causes and therapeutic strategies. Metab Syndr Relat Disord. 13:423–444. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Bryan S, Baregzay B, Spicer D, Singal PK and Khaper N: Redox-inflammatory synergy in the metabolic syndrome. Can J Physiol Pharmacol. 91:22–30. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Savini I, Catani MV, Evangelista D, Gasperi V and Avigliano L: Obesity-associated oxidative stress: Strategies finalized to improve redox state. Int J Mol Sci. 14:10497–10538. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Loe YC, Bergeron N, Rodriguez N and Schwarz JM: Gas chromatography/mass spectrometry method to quantify blood hydroxycitrate concentration. Anal Biochem. 292:148–154. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Shara M, Ohia SE, Schmidt RE, Yasmin T, Zardetto-Smith A, Kincaid A, Bagchi M, Chatterjee A, Bagchi D and Stohs SJ: Physico-chemical properties of a novel (−)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Mol Cell Biochem. 260:171–186. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Shara M, Ohia SE, Yasmin T, Zardetto-Smith A, Kincaid A, Bagchi M, Chatterjee A, Bagchi D and Stohs SJ: Dose- and time-dependent effects of a novel (−)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem. 254:339–346. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Mattes RD and Bormann L: Effects of (−)-hydroxycitric acid on appetitive variables. Physiol Behav. 71:87–94. 2000. View Article : Google Scholar

14 

Preuss HG, Bagchi D, Bagchi M, Rao CV, Dey DK and Satyanarayana S: Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab. 6:171–180. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Fujioka K: Current and emerging medications for overweight or obesity in people with comorbidities. Diabetes Obes Metab. 17:1021–1032. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Eo H, Jeon YJ, Lee M and Lim Y: Brown alga Ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress, and inflammation by activation of AMPK and SIRT1 in high-fat diet-induced obese mice. J Agric Food Chem. 63:349–359. 2015. View Article : Google Scholar

17 

González-Castejón M and Rodriguez-Casado A: Dietary phytochemicals and their potential effects on obesity: A review. Pharmacol Res. 64:438–455. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Cárcel JA, García-Pérez JV, Mulet A, Rodríguez L and Riera E: Ultrasonically assisted antioxidant extraction from grape stalks and olive leaves. Phys Procedia. 3:147–152. 2010. View Article : Google Scholar

19 

Mattos GN, Tonon RV, Furtado AA and Cabral LM: Grape by-product extracts against microbial proliferation and lipid oxidation: A review. J Sci Food Agric. 97:1055–1064. 2017. View Article : Google Scholar

20 

Arora P, Ansari S and Nazish I: Study of antiobesity effects of ethanolic and water extracts of grapes seeds. J Complement Integr Med. 8:1553–3840.1510. 2011.

21 

Fujioka K, Greenway F, Sheard J and Ying Y: The effects of grapefruit on weight and insulin resistance: Relationship to the metabolic syndrome. J Med Food. 9:49–54. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Cho BO, Nchang Che D, Yin HH and Jang SI: Enhanced biological activities of gamma-irradiated persimmon leaf extract. J Radiat Res. 58:647–653. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Azab A, Nassar A and Azab AN: Anti-inflammatory activity of natural products. Molecules. 21:E13212016. View Article : Google Scholar : PubMed/NCBI

24 

Zhu L, Liu X, Tan J and Wang B: Influence of harvest season on antioxidant activity and constituents of rabbiteye blueberry (Vaccinium ashei) leaves. J Agric Food Chem. 61:11477–11483. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Gregoire FM, Smas CM and Sul HS: Understanding adipocyte differentiation. Physiol Rev. 78:783–809. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Pinent M, Bladé MC, Salvadó MJ, Arola L, Hackl H, Quackenbush J, Trajanoski Z and Ardévol A: Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation. Int J Obes (Lond). 29:934–941. 2005. View Article : Google Scholar

27 

Jeong YS, Hong JH, Cho KH and Jung HK: Grape skin extract reduces adipogenesis- and lipogenesis-related gene expression in 3T3-L1 adipocytes through the peroxisome proliferator-activated receptor-γ signaling pathway. Nutr Res. 32:514–521. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Zwiauer K, Widhalm K and Kerbl B: Relationship between body fat distribution and blood lipids in obese adolescents. Int J Obes. 14:271–277. 1990.PubMed/NCBI

29 

Kwon OJ, Kim MY and Roh SS: Improving effect of extract of Ganoderma lucidum in atherosclerosis from LDL receptor knockout mouse. Korea J Herbol. 31:17–23. 2016. View Article : Google Scholar

30 

Sacks FM, Tonkin AM, Craven T, Pfeffer MA, Shepherd J, Keech A, Furberg CD and Braunwald E: Coronary heart disease in patients with low LDL-cholesterol: Benefit of pravastatin in diabetics and enhanced role for HDL-cholesterol and triglycerides as risk factors. Circulation. 105:1424–1428. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Reaven GM: Banting lecture 1988 Role of insulin resistance in human disease. Diabetes. 37:1595–1607. 1988. View Article : Google Scholar : PubMed/NCBI

32 

Modan M, Halkin H, Almog S, Lusky A, Eshkol A, Shefi M, Shitrit A and Fuchs Z: Hyperinsulinemia A link between hypertension obesity and glucose intolerance. J Clin Invest. 75:809–817. 1985. View Article : Google Scholar : PubMed/NCBI

33 

Rabe K, Lehrke M, Parhofer KG and Broedl UC: Adipokines and insulin resistance. Mol Med. 14:741–751. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Combs TP and Marliss EB: Adiponectin signaling in the liver. Rev Endocr Metab Disord. 15:137–147. 2014. View Article : Google Scholar :

35 

Dowman JK, Tomlinson JW and Newsome PN: Pathogenesis of non-alcoholic fatty liver disease. QJM. 103:71–83. 2010. View Article : Google Scholar :

36 

Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ and Spiegelman BM: C/EBPalpha induces adipogenesis through PPARgamma: A unified pathway. Genes Dev. 16:22–26. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Imai T, Takakuwa R, Marchand S, Dentz E, Bornert JM, Messaddeq N, Wendling O, Mark M, Desvergne B, Wahli W, et al: Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci USA. 101:4543–4547. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Jo YH, Choi KM, Liu Q, Kim SB, Ji HJ, Kim M, Shin SK, Do SG, Shin E, Jung G, et al: Anti-obesity effect of 6,8-diprenylge-nistein, an isoflavonoid of Cudrania tricuspidata fruits in high-fat diet-induced obese mice. Nutrients. 7:10480–10490. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Kim Y, Kwon MJ, Choi JW, Lee MK, Kim C, Jung J, Aprianita H, Nam H and Nam TJ: Anti-obesity effects of boiled tuna extract in mice with obesity induced by a high-fat diet. Int J Mol Med. 38:1281–1288. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Sung YY, Kim DS, Kim SH and Kim HK: Anti-obesity activity, acute toxicity, and chemical constituents of aqueous and ethanol Viola mandshurica extracts. BMC Complement Altern Med. 17:2972017. View Article : Google Scholar : PubMed/NCBI

41 

Seo S, Lee MS, Chang E, Shin Y, Oh S, Kim IH and Kim Y: Rutin increases muscle mitochondrial biogenesis with AMPK activation in high-fat diet-induced obese rats. Nutrients. 7:8152–8169. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Zhao L, Zhang Q, Ma W, Tian F, Shen H and Zhou M: A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota. Food Funct. 8:4644–4656. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Milton-Laskibar I, Gómez-Zorita S, Aguirre L, Fernández- Quintela A, González M and Portillo MP: Resveratrol-induced effects on body fat differ depending on feeding conditions. Molecules. 22:E20912017. View Article : Google Scholar : PubMed/NCBI

44 

Ohyama K, Furuta C, Nogusa Y, Nomura K, Miwa T and Suzuki K: Catechin-rich grape seed extract supplementation attenuates diet-induced obesity in C57BL/6J mice. Ann Nutr Metab. 58:250–258. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Rahman HA, Sahib NG, Saari N, Abas F, Ismail A, Mumtaz MW and Hamid AA: Anti-obesity effect of ethanolic extract from Cosmos caudatus Kunth leaf in lean rats fed a high fat diet. BMC Complement Altern Med. 17:1222017. View Article : Google Scholar : PubMed/NCBI

46 

Rodriguez Lanzi C, Perdicaro DJ, Landa MS, Fontana A, Antoniolli A, Miatello RM, Oteiza PI and Vazquez Prieto MA: Grape pomace extract induced beige cells in white adipose tissue from rats and in 3T3-L1 adipocytes. J Nutr Biochem. 56:224–233. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Chen S, Li Z, Li W, Shan Z and Zhu W: Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK. Can J Physiol Pharmacol. 89:793–799. 2011.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim BM, Cho BO and Jang SI: Muscat Bailey A grape stalk extract ameliorates high-fat diet‑induced obesity by downregulating PPARγ and C/EPBα in mice. Int J Mol Med 43: 489-500, 2019.
APA
Kim, B., Cho, B.O., & Jang, S.I. (2019). Muscat Bailey A grape stalk extract ameliorates high-fat diet‑induced obesity by downregulating PPARγ and C/EPBα in mice. International Journal of Molecular Medicine, 43, 489-500. https://doi.org/10.3892/ijmm.2018.3951
MLA
Kim, B., Cho, B. O., Jang, S. I."Muscat Bailey A grape stalk extract ameliorates high-fat diet‑induced obesity by downregulating PPARγ and C/EPBα in mice". International Journal of Molecular Medicine 43.1 (2019): 489-500.
Chicago
Kim, B., Cho, B. O., Jang, S. I."Muscat Bailey A grape stalk extract ameliorates high-fat diet‑induced obesity by downregulating PPARγ and C/EPBα in mice". International Journal of Molecular Medicine 43, no. 1 (2019): 489-500. https://doi.org/10.3892/ijmm.2018.3951
Copy and paste a formatted citation
x
Spandidos Publications style
Kim BM, Cho BO and Jang SI: Muscat Bailey A grape stalk extract ameliorates high-fat diet‑induced obesity by downregulating PPARγ and C/EPBα in mice. Int J Mol Med 43: 489-500, 2019.
APA
Kim, B., Cho, B.O., & Jang, S.I. (2019). Muscat Bailey A grape stalk extract ameliorates high-fat diet‑induced obesity by downregulating PPARγ and C/EPBα in mice. International Journal of Molecular Medicine, 43, 489-500. https://doi.org/10.3892/ijmm.2018.3951
MLA
Kim, B., Cho, B. O., Jang, S. I."Muscat Bailey A grape stalk extract ameliorates high-fat diet‑induced obesity by downregulating PPARγ and C/EPBα in mice". International Journal of Molecular Medicine 43.1 (2019): 489-500.
Chicago
Kim, B., Cho, B. O., Jang, S. I."Muscat Bailey A grape stalk extract ameliorates high-fat diet‑induced obesity by downregulating PPARγ and C/EPBα in mice". International Journal of Molecular Medicine 43, no. 1 (2019): 489-500. https://doi.org/10.3892/ijmm.2018.3951
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