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Article

Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition

  • Authors:
    • Liya Ma
    • Ying Yu
    • Xiaohui Qu
  • View Affiliations / Copyright

    Affiliations: Clinical Skills Training Center, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, P.R. China, Perinatal Care Division, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, P.R. China, Obstetrics and Gynecology, Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000, P.R. China
  • Pages: 614-620
    |
    Published online on: October 24, 2018
       https://doi.org/10.3892/ijmm.2018.3954
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Abstract

Serum response factor (SRF) is a transcription factor that has important roles in tumor progression. However, its role in cervical cancer cell proliferation and invasion remains unclear. The present study revealed that SRF silencing constrained cervical cancer cell proliferation and invasion via controlling early growth response‑1 (Egr‑1). The results demonstrated that SRF was significantly increased in cervical cancer tissues and cell lines, compared with normal. Suppressing SRF, by using a loss‑of‑function experiment, constrained cervical cancer cell proliferation, invasion, and epithelial‑mesenchymal transition. Furthermore, SRF knockdown significantly downregulated Egr‑1 expression in cervical cancer cell lines, and overexpression of Egr‑1 reversed the effect of SRF on cell proliferation, invasion, and epithelial‑mesenchymal transition. Therefore, SRF may control cell proliferation and invasion by regulating Egr‑1 in cervical cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Ma L, Yu Y and Qu X: Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition. Int J Mol Med 43: 614-620, 2019.
APA
Ma, L., Yu, Y., & Qu, X. (2019). Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition. International Journal of Molecular Medicine, 43, 614-620. https://doi.org/10.3892/ijmm.2018.3954
MLA
Ma, L., Yu, Y., Qu, X."Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition". International Journal of Molecular Medicine 43.1 (2019): 614-620.
Chicago
Ma, L., Yu, Y., Qu, X."Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition". International Journal of Molecular Medicine 43, no. 1 (2019): 614-620. https://doi.org/10.3892/ijmm.2018.3954
Copy and paste a formatted citation
x
Spandidos Publications style
Ma L, Yu Y and Qu X: Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition. Int J Mol Med 43: 614-620, 2019.
APA
Ma, L., Yu, Y., & Qu, X. (2019). Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition. International Journal of Molecular Medicine, 43, 614-620. https://doi.org/10.3892/ijmm.2018.3954
MLA
Ma, L., Yu, Y., Qu, X."Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition". International Journal of Molecular Medicine 43.1 (2019): 614-620.
Chicago
Ma, L., Yu, Y., Qu, X."Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition". International Journal of Molecular Medicine 43, no. 1 (2019): 614-620. https://doi.org/10.3892/ijmm.2018.3954
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