Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
January-2019 Volume 43 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2019 Volume 43 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice

  • Authors:
    • Hiroaki Suzuki
    • Ryohei Tsuji
    • Miho Sugamata
    • Naoki Yamamoto
    • Norio Yamamoto
    • Osamu Kanauchi
  • View Affiliations / Copyright

    Affiliations: Research Laboratories for Health Science and Food Technologies, Kirin Company, Ltd., Yokohama‑shi, Kanagawa 236‑0004, Japan, National Institute of Infectious Diseases, Tokyo 162‑8640, Japan, Department of Infection Control Science, Graduate School of Medicine, Juntendo University, Tokyo 113‑8421, Japan
  • Pages: 426-434
    |
    Published online on: October 24, 2018
       https://doi.org/10.3892/ijmm.2018.3955
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Dengue virus (DENV), a mosquito‑borne flavivirus, causes an acute febrile illness that is a major public health problem in the tropics and subtropics globally. However, methods to prevent or treat DENV infection have not been well established. It was previously demonstrated that Lactococcus lactis strain plasma (LC‑plasma) has the ability to stimulate plasmacytoid dendritic cells (pDCs). As pDCs are key immune cells that control viral infection by producing large amounts of type I interferons (IFN), the present study evaluated the effect of LC‑plasma on DENV infection using a mouse infectious DENV strain. Mice were divided into two groups and the test group was orally administered LC‑plasma for two weeks. Two weeks following administration, the mice were infected with DENV and the relative viral titers and the expression of the inflammatory genes in DENV‑infected tissue were measured using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). The relative viral titers were notably lower in the DENV‑infected tissues compared with the control group when LC‑plasma was orally administered prior to DENV infection. Furthermore, the expression of the inflammatory genes associated with DENV infection was also reduced by LC‑plasma administration. To investigate how LC‑plasma administration controls DENV infection, the present study examined anti‑viral gene expression, which is critical for the viral clearance induced by type I IFN. Two weeks subsequent to the administration of LC‑plasma, the expression of anti‑viral gene was measured using RT‑qPCR. Oral intake of LC‑plasma enhanced anti‑viral gene expression in DENV‑infected spleen tissue. To clarify the detailed mechanism, in vitro co‑culture studies using bone‑marrow derived DC (BMDC) were performed. BMDC were stimulated with LC‑plasma in combination with anti‑IFN‑α/β antibody and the expression of anti‑viral genes was measured. In vitro studies revealed that the effect of LC‑plasma on anti‑viral genes was dependent on type I IFN. Based on these results, LC‑plasma may be effective against DENV infection by stimulating pDCs, which results in the increased production of anti‑viral factors.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Diamond MS and Pierson TC: Molecular Insight into dengue virus pathogenesis and its implications for disease control. Cell. 162:488–492. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Holmes EC and Burch SS: The causes and consequences of genetic variation in dengue virus. Trends Microbiol. 8:74–77. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Halstead SB: Dengue. Lancet. 370:1644–1652. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Gubler DJ: Dengue/dengue haemorrhagic fever: History and current status. Novartis Found Symp. 277:3–16. 16–22. 71–73. 251–253. 2006.

5 

Srikiatkhachorn A, Mathew A and Rothman AL: Immune- mediated cytokine storm and its role in severe dengue. Semin Immunopath. 39:563–574. 2017. View Article : Google Scholar

6 

Guzman MG and Kouri G: Dengue: An update. Lancet Infect Dis. 2:33–42. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, Viramitrachai W, Ratanachu-eke S, Kiatpolpoj S, Innis BL, et al: Early clinical and laboratory indicators of acute dengue illness. J Infect Dis. 176:313–321. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Fagundes CT, Costa VV, Cisalpino D, Souza DG and Teixeira MM: Therapeutic opportunities in dengue infection. Drug Devel Res. 72:480–500. 2011. View Article : Google Scholar

9 

Perry AK, Chen G, Zheng D, Tang H and Cheng G: The host type I interferon response to viral and bacterial infections. Cell Res. 15:407–422. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Stetson DB and Medzhitov R: Type I interferons in host defense. Immunity. 25:373–381. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Fleming SB: Viral inhibition of the IFN-induced JAK/STAT signalling pathway: Development of live attenuated vaccines by mutation of viral-encoded IFN-antagonists. Vaccines. 4:pii: E232016. View Article : Google Scholar

12 

Schoggins JW, Dorner M, Feulner M, Imanaka N, Murphy MY, Ploss A and Rice CM: Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro. Proc Natl Acad Sci USA. 109:14610–14615. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Zellweger RM, Prestwood TR and Shresta S: Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease. Cell Host Microbe. 7:128–139. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Zust R, Toh YX, Valdes I, Cerny D, Heinrich J, Hermida L, Marcos E, Guillén G, Kalinke U, Shi PY, et al: Type I interferon signals in macrophages and dendritic cells control dengue virus infection: Implications for a new mouse model to test dengue vaccines. J Virol. 88:7276–7285. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Sarathy VV, White M, Li L, Gorder SR, Pyles RB, Campbell GA, Milligan GN, Bourne N and Barrett AD: A lethal murine infection model for dengue virus 3 in AG129 mice deficient in type I and II interferon receptors leads to systemic disease. J Virol. 89:1254–1266. 2015. View Article : Google Scholar :

16 

Diamond MS and Harris E: Interferon inhibits dengue virus infection by preventing translation of viral RNA through a PKR-independent mechanism. Virology. 289:297–311. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Helbig KJ, Carr JM, Calvert JK, Wati S, Clarke JN, Eyre NS, Narayana SK, Fiches GN, McCartney EM and Beard MR: Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin. PLoS Negl Trop Dis. 7:e21782013. View Article : Google Scholar : PubMed/NCBI

18 

Hishiki T, Han Q, Arimoto K, Shimotohno K, Igarashi T, Vasudevan SG, Suzuki Y and Yamamoto N: Interferon-mediated ISG15 conjugation restricts dengue virus 2 replication. Biochem Biophys Res Commun. 448:95–100. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Siegal FP, Kadowaki N, Shodell M, Fitzgerald-Bocarsly PA, Shah K, Ho S, Antonenko S and Liu YJ: The nature of the principal type 1 interferon-producing cells in human blood. Science. 284:1835–1837. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Cella M, Jarrossay D, Facchetti F, Alebardi O, Nakajima H, Lanzavecchia A and Colonna M: Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med. 5:919–923. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, Iwasaki A and Flavell RA: Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci USA. 101:5598–5603. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, et al: A Toll-like receptor recognizes bacterial DNA. Nature. 408:740–745. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Bauer S, Kirschning CJ, Häcker H, Redecke V, Hausmann S, Akira S, Wagner H and Lipford GB: Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA. 98:9237–9242. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Gilliet M, Cao W and Liu YJ: Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol. 8:594–606. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Perdigon G, Fuller R and Raya R: Lactic acid bacteria and their effect on the immune system. Current Issues Intest Microbiol. 2:27–42. 2001.

26 

Parcina M, Wendt C, Goetz F, Zawatzky R, Zähringer U, Heeg K and Bekeredjian-Ding I: Staphylococcus aureus-induced plasmacytoid dendritic cell activation is based on an IgG-mediated memory response. J Immunol. 181:3823–3833. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Piccioli D, Sammicheli C, Tavarini S, Nuti S, Frigimelica E, Manetti AG, Nuccitelli A, Aprea S, Valentini S, Borgogni E, et al: Human plasmacytoid dendritic cells are unresponsive to bacterial stimulation and require a novel type of cooperation with myeloid dendritic cells for maturation. Blood. 113:4232–4239. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Jounai K, Ikado K, Sugimura T, Ano Y, Braun J and Fujiwara D: Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via TLR9-dependent crosstalk with myeloid dendritic cells. PLoS One. 7:e325882012. View Article : Google Scholar : PubMed/NCBI

29 

Jounai K, Sugimura T, Ohshio K and Fujiwara D: Oral administration of Lactococcus lactis subsp lactis JCM5805 enhances lung immune response resulting in protection from murine para-influenza virus infection. PLoS One. 10:e01190552015. View Article : Google Scholar

30 

Jounai K, Sugimura T, Morita Y, Ohshio K and Fujiwara D: Administration of Lactococcus lactis strain Plasma induces maturation of plasmacytoid dendritic cells and protection from rotavirus infection in suckling mice. Int Immunopharmacol. 56:205–211. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Castillo Ramirez JA and Urcuqui-Inchima S: Dengue virus control of type I IFN responses: A history of manipulation and control. J Interferon Cytokine Res. 35:421–430. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar

33 

St John AL, Rathore AP, Raghavan B, Ng ML and Abraham SN: Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage. Elife. 2:e004812013. View Article : Google Scholar : PubMed/NCBI

34 

da Costa VG, Marques-Silva AC and Moreli ML: A meta-analysis of the diagnostic accuracy of two commercial NS1 antigen ELISA tests for early dengue virus detection. PLoS One. 9:e946552014. View Article : Google Scholar : PubMed/NCBI

35 

Brawand P, Fitzpatrick DR, Greenfield BW, Brasel K, Maliszewski CR and De Smedt T: Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs. J Immunol. 169:6711–6719. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Raut CG, Deolankar RP, Kolhapure RM and Goverdhan MK: Susceptibility of laboratory-bred rodents to the experimental infection with dengue virus type 2. Acta Virol. 40:143–146. 1996.PubMed/NCBI

37 

Johnson AJ and Roehrig JT: New mouse model for dengue virus vaccine testing. J Virol. 73:783–786. 1999.

38 

Orozco S, Schmid MA, Parameswaran P, Lachica R, Henn MR, Beatty R and Harris E: Characterization of a model of lethal dengue virus 2 infection in C57BL/6 mice deficient in the alpha/beta interferon receptor. J Gen Virol. 93:2152–2157. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Zellweger RM and Shresta S: Mouse models to study dengue virus immunology and pathogenesis. Front Immunol. 5:1512014. View Article : Google Scholar : PubMed/NCBI

40 

Syenina A, Jagaraj CJ, Aman SA, Sridharan A and St John AL: Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors. Elife. 4: View Article : Google Scholar : 2015.

41 

Gubler DJ: Dengue and dengue hemorrhagic fever. Clin Microbiol Rev. 11:480–496. 1998. View Article : Google Scholar : PubMed/NCBI

42 

Green S and Rothman A: Immunopathological mechanisms in dengue and dengue hemorrhagic fever. Curr Opin Infect Dis. 19:429–436. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Srikiatkhachorn A: Plasma leakage in dengue haemorrhagic fever. Thromb Haemost. 102:1042–1049. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Chaturvedi UC, Agarwal R, Elbishbishi EA and Mustafa AS: Cytokine cascade in dengue hemorrhagic fever: Implications for pathogenesis. FEMS Immunol Med Microbiol. 28:183–188. 2000. View Article : Google Scholar : PubMed/NCBI

45 

Verhelst J, Hulpiau P and Saelens X: Mx proteins: Antiviral gatekeepers that restrain the uninvited. Microbiol Mol Biol Rev. 77:551–566. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Fitzgerald KA: The interferon inducible gene: Viperin. J Interferon Cytokine Res. 31:131–135. 2011. View Article : Google Scholar :

47 

Zhao C, Collins MN, Hsiang TY and Krug RM: Interferon- induced ISG15 pathway: An ongoing virus-host battle. Trends Microbiol. 21:181–186. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Elkhateeb E, Tag-El-Din-Hassan HT, Sasaki N, Torigoe D, Morimatsu M and Agui T: The role of mouse 2′,5′-oligoadenylate synthetase 1 paralogs. Infect Genet Evol. 45:393–401. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Takeda S, Takeshita M, Kikuchi Y, Dashnyam B, Kawahara S, Yoshida H, Watanabe W, Muguruma M and Kurokawa M: Efficacy of oral administration of heat-killed probiotics from Mongolian dairy products against influenza infection in mice: Alleviation of influenza infection by its immunomodulatory activity through intestinal immunity. Int Immunopharmacol. 11:1976–1983. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Fujiwara D, Inoue S, Wakabayashi H and Fujii T: The anti-allergic effects of lactic acid bacteria are strain dependent and mediated by effects on both Th1/Th2 cytokine expression and balance. Int Arch Allergy Immunol. 135:205–215. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Wakabayashi H, Nariai C, Takemura F, Nakao W and Fujiwara D: Dietary supplementation with lactic acid bacteria attenuates the development of atopic-dermatitis-like skin lesions in NC/Nga mice in a strain-dependent manner. Int Arch Allergy Immunol. 145:141–151. 2008. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Suzuki H, Tsuji R, Sugamata M, Yamamoto N, Yamamoto N and Kanauchi O: Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice. Int J Mol Med 43: 426-434, 2019.
APA
Suzuki, H., Tsuji, R., Sugamata, M., Yamamoto, N., Yamamoto, N., & Kanauchi, O. (2019). Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice. International Journal of Molecular Medicine, 43, 426-434. https://doi.org/10.3892/ijmm.2018.3955
MLA
Suzuki, H., Tsuji, R., Sugamata, M., Yamamoto, N., Yamamoto, N., Kanauchi, O."Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice". International Journal of Molecular Medicine 43.1 (2019): 426-434.
Chicago
Suzuki, H., Tsuji, R., Sugamata, M., Yamamoto, N., Yamamoto, N., Kanauchi, O."Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice". International Journal of Molecular Medicine 43, no. 1 (2019): 426-434. https://doi.org/10.3892/ijmm.2018.3955
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki H, Tsuji R, Sugamata M, Yamamoto N, Yamamoto N and Kanauchi O: Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice. Int J Mol Med 43: 426-434, 2019.
APA
Suzuki, H., Tsuji, R., Sugamata, M., Yamamoto, N., Yamamoto, N., & Kanauchi, O. (2019). Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice. International Journal of Molecular Medicine, 43, 426-434. https://doi.org/10.3892/ijmm.2018.3955
MLA
Suzuki, H., Tsuji, R., Sugamata, M., Yamamoto, N., Yamamoto, N., Kanauchi, O."Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice". International Journal of Molecular Medicine 43.1 (2019): 426-434.
Chicago
Suzuki, H., Tsuji, R., Sugamata, M., Yamamoto, N., Yamamoto, N., Kanauchi, O."Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice". International Journal of Molecular Medicine 43, no. 1 (2019): 426-434. https://doi.org/10.3892/ijmm.2018.3955
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team