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Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

  • Authors:
    • Zhongjun Du
    • Shangya Chen
    • Guanqun Cui
    • Ye Yang
    • Enguo Zhang
    • Qiang Wang
    • Martin F. Lavin
    • Abrey J. Yeo
    • Cunxiang Bo
    • Yu Zhang
    • Chao Li
    • Xiaoshan Liu
    • Xu Yang
    • Cheng Peng
    • Hua Shao
  • View Affiliations / Copyright

    Affiliations: Department of Toxicology, Shandong Academy of Occupational Health and Occupational Medicine, Shandong Academy of Medical Sciences, Ji'nan, Shandong 250062, P.R. China, Department of Respiratory Medicine, Qilu Children's Hospital of Shandong University, Ji'nan, Shandong 250012, P.R. China, Department of Preventive Medicine and Public Health Laboratory Science, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China, Department of Radiology, Shandong Tumor Hospital, Shandong Academy of Medical Sciences, Ji'nan, Shandong 250117, P.R. China
    Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1229-1240
    |
    Published online on: December 31, 2018
       https://doi.org/10.3892/ijmm.2018.4045
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Abstract

Diseases of the cardiac system caused by silicon dioxide exposure have captured wide public attention. Upon entering the blood circulation, ultrafine particles have the potential to influence cardiomyocytes, leading to myocardial ischemia or even cardiac failure, and the molecular mechanisms remain to be completely elucidated. In this study, the toxicity of ultrafine particles on cardiomyocytes from rats exposed to silica nanoparticles was observed. Rats were randomly divided into a normal saline control group and three exposure groups (2, 5 and 10 mg/kg·body weight) that were intratracheally treated with 60‑nm silica nanoparticles. Alterations in body weight, routine blood factors and myocardial enzymes, histopathological and microstructural alterations, apoptosis and the expression of apoptosis‑associated proteins were assessed at the end of the exposure period. The silicon levels in the heart and serum, and myocardial enzymes in exposed rats were significantly increased in a dose‑dependent manner. In addition, exposure to the silica nanoparticles caused notable histological and ultrastructural alterations in the hearts of these animals. Furthermore, a significant apoptotic effect was observed in the exposure groups. The present data suggest that silica nanoparticles may enter the circulatory system through the lungs, and are distributed to the heart causing cardiovascular injury. Silica nanoparticle‑induced apoptosis via the mitochondrial pathway may serve an important role in observed cardiac damage.
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Copy and paste a formatted citation
Spandidos Publications style
Du Z, Chen S, Cui G, Yang Y, Zhang E, Wang Q, Lavin MF, Yeo AJ, Bo C, Zhang Y, Zhang Y, et al: Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation. Int J Mol Med 43: 1229-1240, 2019.
APA
Du, Z., Chen, S., Cui, G., Yang, Y., Zhang, E., Wang, Q. ... Shao, H. (2019). Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation. International Journal of Molecular Medicine, 43, 1229-1240. https://doi.org/10.3892/ijmm.2018.4045
MLA
Du, Z., Chen, S., Cui, G., Yang, Y., Zhang, E., Wang, Q., Lavin, M. F., Yeo, A. J., Bo, C., Zhang, Y., Li, C., Liu, X., Yang, X., Peng, C., Shao, H."Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation". International Journal of Molecular Medicine 43.3 (2019): 1229-1240.
Chicago
Du, Z., Chen, S., Cui, G., Yang, Y., Zhang, E., Wang, Q., Lavin, M. F., Yeo, A. J., Bo, C., Zhang, Y., Li, C., Liu, X., Yang, X., Peng, C., Shao, H."Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation". International Journal of Molecular Medicine 43, no. 3 (2019): 1229-1240. https://doi.org/10.3892/ijmm.2018.4045
Copy and paste a formatted citation
x
Spandidos Publications style
Du Z, Chen S, Cui G, Yang Y, Zhang E, Wang Q, Lavin MF, Yeo AJ, Bo C, Zhang Y, Zhang Y, et al: Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation. Int J Mol Med 43: 1229-1240, 2019.
APA
Du, Z., Chen, S., Cui, G., Yang, Y., Zhang, E., Wang, Q. ... Shao, H. (2019). Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation. International Journal of Molecular Medicine, 43, 1229-1240. https://doi.org/10.3892/ijmm.2018.4045
MLA
Du, Z., Chen, S., Cui, G., Yang, Y., Zhang, E., Wang, Q., Lavin, M. F., Yeo, A. J., Bo, C., Zhang, Y., Li, C., Liu, X., Yang, X., Peng, C., Shao, H."Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation". International Journal of Molecular Medicine 43.3 (2019): 1229-1240.
Chicago
Du, Z., Chen, S., Cui, G., Yang, Y., Zhang, E., Wang, Q., Lavin, M. F., Yeo, A. J., Bo, C., Zhang, Y., Li, C., Liu, X., Yang, X., Peng, C., Shao, H."Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation". International Journal of Molecular Medicine 43, no. 3 (2019): 1229-1240. https://doi.org/10.3892/ijmm.2018.4045
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