|
1
|
Masoli M, Fabian D, Holt S, Beasley R and
Global Initiative; for Asthma (GINA) Program: The global burden of
asthma: Executive summary of the GINA dissemination committee
report. Allergy. 59:469–478. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
D'Amato G, Holgate ST, Pawankar R, Ledford
DK, Cecchi L, Al-Ahmad M, Al-Enezi F, Al-Muhsen S, Ansotegui I,
Baena-Cagnani CE, et al: Meteorological conditions, climate change,
new emerging factors, and asthma and related allergic disorders. A
statement of the world allergy organization. World Allergy Organ J.
8:252015.PubMed/NCBI
|
|
3
|
Kuyper LM, Paré PD, Hogg JC, Lambert RK,
Ionescu D, Woods R and Bai TR: Characterization of airway plugging
in fatal asthma. Am J Med. 115:6–11. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Evans CM, Kim K, Tuvim MJ and Dickey BF:
Mucus hypersecretion in asthma: Causes and effects. Curr Opin Pulm
Med. 15:4–11. 2009. View Article : Google Scholar :
|
|
5
|
Bateman JR, Pavia D, Sheahan NF, Agnew JE
and Clarke SW: Impaired tracheobronchial clearance in patients with
mild stable asthma. Thorax. 38:463–467. 1983. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Agnew JE, Bateman JR, Pavia D and Clarke
SW: Radionuclide demonstration of ventilatory abnormalities in mild
asthma. Clin Sci (Lond). 66:525–531. 1984. View Article : Google Scholar
|
|
7
|
O'Riordan TG, Zwang J and Smaldone GC:
Mucociliary clearance in adult asthma. Am Rev Respir Dis.
146:598–603. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Messina MS, O'riordan TG and Smaldone GC:
Changes in mucociliary clearance during acute exacerbations of
asthma. Am Rev Respir Dis. 143:993–997. 1991. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Thornton DJ, Rousseau K and McGuckin MA:
Structure and function of the polymeric mucins in airways mucus.
Annu Rev Physiol. 70:459–486. 2008. View Article : Google Scholar
|
|
10
|
Rose MC and Voynow JA: Respiratory tract
mucin genes and mucin glycoproteins in health and disease. Physiol
Rev. 86:245–278. 2006. View Article : Google Scholar
|
|
11
|
Bonser LR and Erle DJ: Airway mucus and
asthma: The role of MUC5AC and MUC5B. J Clin Med. 6:E1122017.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Jeffery PK and Li D: Airway mucosa:
Secretory cells, mucus and mucin genes. Eur Respir J. 10:1655–1662.
1997. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Woodruff PG, Modrek B, Choy DF, Jia G,
Abbas AR, Ellwanger A, Koth LL, Arron JR and Fahy JV: T-helper type
2-driven inflammation defines major subphenotypes of asthma. Am J
Respir Crit Care Med. 180:388–395. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Bonser LR, Zlock L, Finkbeiner W and Erle
DJ: Epithelial tethering of MUC5AC-rich mucus impairs mucociliary
transport in asthma. J Clin Invest. 126:2367–2371. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Kuperman DA, Lewis CC, Woodruff PG,
Rodriguez MW, Yang YH, Dolganov GM, Fahy JV and Erle DJ: Dissecting
asthma using focused transgenic modeling and functional genomics. J
Allergy Clin Immunol. 116:305–311. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Zhen G, Park SW, Nguyenvu LT, Rodriguez
MW, Barbeau R, Paquet AC and Erle DJ: IL-13 and epidermal growth
factor receptor have critical but distinct roles in epithelial cell
mucin production. Am J Respir Cell Mol Biol. 36:244–253. 2007.
View Article : Google Scholar
|
|
17
|
Takeyama K, Dabbagh K, Lee HM, Agustí C,
Lausier JA, Ueki IF, Grattan KM and Nadel JA: Epidermal growth
factor system regulates mucin production in airways. Proc Natl Acad
Sci USA. 96:3081–3086. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Kraft M, Adler KB, Ingram JL, Crews AL,
Atkinson TP, Cairns CB, Krause DC and Chu HW: Mycoplasma pneumoniae
induces airway epithelial cell expression of MUC5AC in asthma. Eur
Respir J. 31:43–46. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Chen Y, Nickola TJ, DiFronzo NL,
Colberg-Poley AM and Rose MC: Dexamethasone-mediated repression of
MUC5AC gene expression in human lung epithelial cells. Am J Respir
Cell Mol Biol. 34:338–347. 2006. View Article : Google Scholar
|
|
20
|
Bannister AJ and Kouzarides T: The CBP
co-activator is a histone acetyltransferase. Nature. 384:641–643.
1996. View
Article : Google Scholar : PubMed/NCBI
|
|
21
|
Ogryzko VV, Schiltz RL, Russanova V,
Howard BH and Nakatani Y: The transcriptional coactivators P300 and
CBP are histone acetyltransferases. Cell. 87:953–959. 1996.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Ito K, Caramori G, Lim S, Oates T, Chung
KF, Barnes PJ and Adcock IM: Expression and activity of histone
deacetylases (HDAC) in human asthmatic airways. Am J Respir Crit
Care Med. 166:392–396. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Dancy BM and Cole PA: Protein lysine
acetylation by P300/CBP. Chem Rev. 115:2419–2452. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Boyes J, Byfield P, Nakatani Y and Ogryzko
V: Regulation of activity of the transcription factor GATA-1 by
acetylation. Nature. 396:594–598. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
26
|
Martin C, Frija-Masson J and Burgel PR:
Targeting mucus hyper-secretion: New therapeutic opportunities for
COPD? Drugs. 74:1073–1089. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Button BM and Button B: Structure and
function of the mucus clearance system of the lung. Cold Spring
Harb Perspect Med. 3:a0097202013. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Dunnill MS: The pathology of asthma, with
special reference to changes in the bronchial mucosa. J Clin
Pathol. 13:27–33. 1960. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Rogers DF and Barnes PJ: Treatment of
airway mucus hypersecretion. Ann Med. 38:116–125. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Di Valentin E, Crahay C, Garbacki N,
Hennuy B, Guéders M, Noël A, Foidart JM, Grooten J, Colige A,
Piette J and Cataldo D: New asthma biomarkers: Lessons from murine
models of acute and chronic asthma. Am J Physiol Lung Cell Mol
Physiol. 296:L185–L197. 2009. View Article : Google Scholar
|
|
31
|
Yu H, Li Q, Kolosov VP, Perelman JM and
Zhou X: Interlenkin-13 induces mucin 5AC production involving
STAT6/SPDEF in human airway epithelial cells. Cell Commun Adhes.
17:83–92. 2010. View Article : Google Scholar
|
|
32
|
Hattrup CL and Gendler SJ: Structure and
function of the cell surface (tethered) mucins. Annu Rev Physiol.
70:431–457. 2008. View Article : Google Scholar
|
|
33
|
Lee JW, Kim YI, Im CN, Kim SW, Kim SJ, Min
S, Joo YH, Yim SV and Chung N: Grape seed proanthocyanidin inhibits
mucin synthesis and viral replication by suppression of AP-1 and
NF-κB via p38 MAPKs/JNK signaling pathways in respiratory syncytial
virus-infected A549 cells. J Agric Food Chem. 65:4472–4483. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Al-Sawalha N, Pokkunuri I, Omoluabi O, Kim
H, Thanawala VJ, Hernandez A, Bond RA and Knoll BJ: Epinephrine
activation of the β2-adrenoceptor is required for IL-13-induced
mucin production in human bronchial epithelial cells. PLoS One.
10:e01325592015. View Article : Google Scholar
|
|
35
|
Song WY, Song YS, Ryu HW, Oh SR, Hong J
and Yoon DY: Tilianin inhibits MUC5AC expression mediated via
down-regulation of EGFR-MEK-ERK-Sp1 signaling pathway in NCI-H292
human airway cells. J Microbiol Biotechnol. 27:49–56. 2017.
View Article : Google Scholar
|
|
36
|
Berger JT, Horger T and Voynow JA:
Respiratory carcinoma cell lines express MUC5/5AC mRNA and secrete
MUC5/5AC mucins(C). In: 5th International Workshop on Carcinoma
Associated Mucins; Cambridge, UK. 1998;
|
|
37
|
Cui ZL, Gu W, Ding T, Peng XH, Chen X,
Luan CY, Han RC, Xu WG and Guo XJ: Histone modifications of Notch1
promoter affect lung CD4+T cell differentiation in
asthmatic rats. Int J Immunopathol Pharmacol. 26:371–381. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Hewson CA, Edbrooke MR and Johnston SL:
PMA induces the MUC5AC respiratory mucin in human bronchial
epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and
Sp1-dependent mechanisms. J Mol Biol. 344:683–695. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Perrais M, Pigny P, Copin MC, Aubert JP
and Van Seuningen I: Induction of MUC2 and MUC5AC mucins by factors
of the epidermal growth factor (EGF) family is mediated by EGF
receptor/Ras/Raf/extracellular signal-regulated kinase cascade and
Sp1. J Biol Chem. 277:32258–32267. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Chen Y, Garvin LM, Nickola TJ, Watson AM,
Colberg-Poley AM and Rose MC: IL-1β induction of MUC5AC gene
expression is mediated by CREB and NF-κB and repressed by
dexamethasone. Am J Physiol Lung Cell Mol Physiol. 306:L797–L807.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Janknecht R: The versatile functions of
the transcriptional coactivators P300 and CBP and their roles in
disease. Histol Histopathol. 17:657–668. 2002.PubMed/NCBI
|
