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Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression

  • Authors:
    • Yue‑Feng Xia
    • Jing Chang
    • Jin‑Feng Yang
    • Wen Ouyang
    • Bruce Pitt
    • Timothy Billiar
    • Li‑Ming Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Anesthesiology, Shanghai Children's Medical Center, Shanghai Jiao‑Tong University School of Medicine, Shanghai 200127, P.R. China, Department of Anesthesiology, Hunan Cancer Hospital, Changsha, Hunan 410013, P.R. China, Department of Environmental and Occupational Health, University of Pittsburgh Graduate School Public Health, Pittsburgh, PA 15261, USA, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA, Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Copyright: © Xia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1217-1228
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    Published online on: January 17, 2019
       https://doi.org/10.3892/ijmm.2019.4067
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Abstract

Mechanical ventilation may cause ventilator‑induced lung injury (VILI). Canonical Wnt signaling has been reported to serve an important role in the pathogenesis of VILI. Bioinformatics analysis revealed that canonical and non‑canonical Wnt signaling pathways were activated in VILI. However, the role of non‑canonical Wnt signaling in the pathogenesis of VILI remains unclear. The present study aimed to analyze the potential role of non‑canonical Wnt signaling in VILI pathogenesis. Lung injury was assessed via Evans blue albumin permeability and histological scoring, as well as by inflammatory cytokine expression and total protein concentration in bronchoalveolar lavage fluid. The relative protein expression of canonical and non‑canonical Wnt signaling pathway components were examined via western blotting and immunohistochemistry. The results demonstrated that 6 h of mechanical ventilation at low tidal volume (LTV; 6 ml/kg) or moderate tidal volume (MTV; 12 ml/kg) induced lung injury in sensitive A/J mice. Ventilation with MTV increased the protein levels of Wnt‑induced secreted protein 1 (WISP1), Rho‑associated protein kinase 1 (ROCK1), phosphorylated (p)‑Ras homolog gene family, member A and p‑C‑Jun N‑terminal kinase (JNK). Inhibition of ROCK1 by Y27632 and JNK by SP600125 attenuated MTV‑induced lung injury and decreased the expression of proteins involved in non‑canonical Wnt signaling, including WISP1. In conclusion, non‑canonical Wnt signaling participates in VILI by modulating WISP1 expression, which has been previously noted as critical for VILI development. Therefore, the non‑canonical Wnt signaling pathway may provide a preventive and therapeutic target in VILI.
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View References

1 

Hashemian SM, Mohajerani SA and Jamaati HR: Ventilator-induced lung injury. N Engl J Med. 370:979–980. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Rahaman U: Mathematics of ventilator-induced lung injury. Indian J Crit Care Med. 21:521–524. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Beitler JR, Malhotra A and Thompson BT: Ventilator-induced lung injury. Clin Chest Med. 37:633–646. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Plötz FB: Ventilator-induced lung injury. Intensive Care Med. 27:4522001. View Article : Google Scholar : PubMed/NCBI

5 

Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, Kairalla RA, Deheinzelin D, Munoz C, Oliveira R, et al: Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med. 338:347–354. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Zhu H, He J, Liu J, Zhang X, Yang F, Liu P and Wang S: Alpha 1-antitrypsin ameliorates ventilator-induced lung injury in rats by inhibiting inflammatory responses and apoptosis. Exp Biol Med (Maywood). 243:87–95. 2018. View Article : Google Scholar

7 

Park BH, Shin MH, Douglas IS, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Chang J, et al: Erythropoietin-producing hepatoma receptor tyrosine kinase A2 modulation associates with protective effect of prone position in ventilator-induced lung injury. Am J Respir Cell Mol Biol. 58:519–529. 2018. View Article : Google Scholar

8 

Suryadevara V, Fu P, Ebenezer DL, Berdyshev E, Bronova IA, Huang LS, Harijith A and Natarajan V: Sphingolipids in ventilator induced lung injury: Role of sphingosine-1-phosphate. lyase Int J Mol Sci. 19:E1142018. View Article : Google Scholar

9 

Huang X, Zhou W and Ding S: Downregulated Smad4 affects extracellular matrix remodeling in ventilator-induced lung injury. Ann Clin Lab Sci. 46:451–456. 2016.PubMed/NCBI

10 

Zhao T, Zhao H, Li G, Zheng S, Liu M, Gu C and Wang Y: Role of the PKCα-c-Src tyrosine kinase pathway in the mediation of p120-catenin degradation in ventilator-induced lung injury. Respirology. 21:1404–1410. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Chian CF, Chiang CH, Chuang CH, Liu SL and Tsai CL: SN50, a cell-permeable-inhibitor of nuclear factor-κB, attenuates ventilator-induced lung injury in an isolated and perfused rat lung model. Shock. 46:194–201. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Jun JI and Lau LF: Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov. 10:945–963. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Li HH, Li Q, Liu P, Liu Y, Li J, Wasserloos K, Chao W, You M, Oury TD, Chhinder S, et al: WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury. Am J Respir Cell Mol Biol. 47:528–535. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Chen Z, Ding X, Jin S, Pitt B, Zhang L, Billiar T and Li Q: WISP1-αvβ3 integrin signaling positively regulates TLR-triggered inflammation response in sepsis induced lung injury. Sci Rep. 6:288412016. View Article : Google Scholar

15 

Ding X, Wang X, Zhao X, Jin S, Tong Y, Ren H, Chen Z and Li Q: RGD peptides protects against acute lung injury in septic mice through Wisp1-integrin β6 pathway inhibition. Shock. 43:352–360. 2015. View Article : Google Scholar

16 

Jin S, Chen Z, Ding X, Zhao X, Jiang X, Tong Y, Billiar TR and Li Q: Mechanical ventilation augments poly(I:C)induced lung injury via a WISP1-integrin β3 dependent pathway in mice. Mol Med. 22:54–63. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Borcherding N, Kusner D, Kolb R, Xie Q, Li W, Yuan F, Velez G, Askeland R, Weigel RJ and Zhang W: Paracrine WNT5A signaling inhibits expansion of tumor-initiating cells. Cancer Res. 75:1972–1982. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J and Matsumoto K: The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 23:131–139. 2003. View Article : Google Scholar :

19 

Li C, Xiao J, Hormi K, Borok Z and Minoo P: Wnt5a participates in distal lung morphogenesis. Dev Biol. 248:68–81. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Li C, Hu L, Xiao J, Chen H, Li JT, Bellusci S, Delanghe S and Minoo P: Wnt5a regulates Shh and Fgf10 signaling during lung development. Dev Biol. 287:86–97. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Vuga LJ, Ben-Yehudah A, Kovkarova-Naumovski E, Oriss T, Gibson KF, Feghali-Bostwick C and Kaminski N: WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis. Am J Respir Cell Mol Biol. 41:583–589. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Spassov S, Pfeifer D, Strosing K, Ryter S, Hummel M, Faller S and Hoetzel A: Genetic targets of hydrogen sulfide in ventilator-induced lung injury-a microarray study. PLoS One. 9:e1024012014. View Article : Google Scholar

23 

Dolinay T, Wu W, Kaminski N, Ifedigbo E, Kaynar AM, Szilasi M, Watkins SC, Ryter SW, Hoetzel A and Choi AM: Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. PLoS One. 3:e16012008. View Article : Google Scholar : PubMed/NCBI

24 

Wray C, Mao Y, Pan J, Chandrasena A, Piasta F and Frank JA: Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 297:L219–L227. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Xie C, Mao X, Huang J, Ding Y, Wu J, Dong S, Kong L, Gao G, Li CY and Wei L: KOBAS 2.0: A web server for annotation and identification of enriched pathways and diseases. Nucleic Acids Res. 39(Web Server issue): W316–W322. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Kanehisa M, Sato Y, Kawashima M, Furumichi M and Tanabe M: KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 44:D457–D462. 2016. View Article : Google Scholar :

27 

Kilkenny C, Browne WJ, Cuthill IC, Emerson M and Altman DG: Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. PLoS Biol. 8:e10004122010. View Article : Google Scholar : PubMed/NCBI

28 

Chen T, Chen C, Zhang Z, Zou Y, Peng M and Wang Y: Toll-like receptor 4 knockout ameliorates neuroinflammation due to lung-brain interaction in mechanically ventilated mice. Brain Behav Immun. 56:42–55. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Li H, Su X, Yan X, Wasserloos K, Chao W, Kaynar AM, Liu ZQ, Leikauf GD, Pitt BR and Zhang LM: Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice. Anesthesiology. 113:619–629. 2010.PubMed/NCBI

30 

Achouiti A, van der Meer AJ, Florquin S, Yang H, Tracey KJ, van't Veer C, de Vos AF and van der Poll T: High-mobility group box 1 and the receptor for advanced glycation end products contribute to lung injury during Staphylococcus aureus pneumonia. Crit Care. 17:R2962013. View Article : Google Scholar : PubMed/NCBI

31 

Villar J, Cabrera NE, Valladares F, Casula M, Flores C, Blanch L, Quilez ME, Santana-Rodríguez N, Kacmarek RM and Slutsky AS: Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs. PLoS One. 6:e239142011. View Article : Google Scholar

32 

Tao G, Pan L, Jing R, Lin F, Dai H and Ge W: Study on Rac1/MAPK/ERK pathway mediated mechanism and role in rats with ventilator induced lung injury. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 29:249–254. 2017.In Chinese. PubMed/NCBI

33 

Villar J, Cabrera NE, Casula M, Valladares F, Flores C, López-Aguilar J, Blanch L, Zhang H, Kacmarek RM and Slutsky AS: WNT/β-catenin signaling is modulated by mechanical ventilation in an experimental model of acute lung injury. Intensive Care Med. 37:1201–1209. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Xiao J, Zhou H, Wu N and Wu L: The non-canonical Wnt pathway negatively regulates dendritic cell differentiation by inhibiting the expansion of Flt3+ lymphocyte-primed multipotent precursors. Cell Mol Immunol. 13:593–604. 2015. View Article : Google Scholar

35 

Ouyang W, Zhou H, Liu C, Wang S, Han Y, Xia J and Xu F: 25-Hydroxycholesterol protects against acute lung injury via targeting MD-2. J Cell Mol Med. 22:5494–5503. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Xu F, Diao R, Liu J, Kang Y, Wang X and Shi L: Curcumin attenuates staphylococcus aureus-induced acute lung injury. Clin Respir J. 9:87–97. 2015. View Article : Google Scholar

37 

Cheng L, Zhao Y, Qi D, Li W and Wang D: Wnt/β-catenin pathway promotes acute lung injury induced by LPS through driving the Th17 response in mice. Biochem Biophys Res Commun. 495:1890–1895. 2018. View Article : Google Scholar

38 

Chen X, Shi C, Meng X, Zhang K, Li X, Wang C, Xiang Z, Hu K and Han X: Inhibition of Wnt/β-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-β1 and FGF-2. Exp Mol Pathol. 101:22–30. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Ying H, Kang Y, Zhang H, Zhao D, Xia J, Lu Z, Wang H, Xu F and Shi L: MiR-127 modulates macrophage polarization and promotes lung inflammation and injury by activating the JNK pathway. J Immunol. 194:1239–1251. 2015. View Article : Google Scholar

40 

Kim J, Chang W, Jung Y, Song K and Lee I: Wnt5a activates THP-1 monocytic cells via a β-catenin-independent pathway involving JNK and NF-κB activation. Cytokine. 60:242–248. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Koval A, Purvanov V, Egger-Adam D and Katanaev VL: Yellow submarine of the Wnt/Frizzled signaling: Submerging from the G protein harbor to the targets. Biochem Pharmacol. 82:1311–1319. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB and Nathans J: A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 398:431–436. 1999. View Article : Google Scholar : PubMed/NCBI

43 

Saito S, Tampe B, Müller GA and Zeisberg M: Primary cilia modulate balance of canonical and non-canonical Wnt signaling responses in the injured kidney. Fibrogenesis Tissue Repair. 8:62015. View Article : Google Scholar : PubMed/NCBI

44 

Nakamura K, Sano S, Fuster JJ, Kikuchi R, Shimizu I, Ohshima K, Katanasaka Y, Ouchi N and Walsh K: Secreted Frizzled-related protein 5 diminishes cardiac inflammation and protects the heart from ischemia/reperfusion injury. J Biol Chem. 291:2566–2575. 2016. View Article : Google Scholar :

45 

Meyer IS, Jungmann A, Dieterich C, Zhang M, Lasitschka F, Werkmeister S, Haas J, Müller OJ, Boutros M, Nahrendorf M, et al: The cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction. EMBO Mol Med. 9:1279–1293. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Guan S and Zhou J: Frizzled-7 mediates TGF-β-induced pulmonary fibrosis by transmitting non-canonical Wnt signaling. Exp Cell Res. 359:226–234. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xia YF, Chang J, Yang JF, Ouyang W, Pitt B, Billiar T and Zhang LM: Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression. Int J Mol Med 43: 1217-1228, 2019.
APA
Xia, Y., Chang, J., Yang, J., Ouyang, W., Pitt, B., Billiar, T., & Zhang, L. (2019). Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression. International Journal of Molecular Medicine, 43, 1217-1228. https://doi.org/10.3892/ijmm.2019.4067
MLA
Xia, Y., Chang, J., Yang, J., Ouyang, W., Pitt, B., Billiar, T., Zhang, L."Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression". International Journal of Molecular Medicine 43.3 (2019): 1217-1228.
Chicago
Xia, Y., Chang, J., Yang, J., Ouyang, W., Pitt, B., Billiar, T., Zhang, L."Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression". International Journal of Molecular Medicine 43, no. 3 (2019): 1217-1228. https://doi.org/10.3892/ijmm.2019.4067
Copy and paste a formatted citation
x
Spandidos Publications style
Xia YF, Chang J, Yang JF, Ouyang W, Pitt B, Billiar T and Zhang LM: Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression. Int J Mol Med 43: 1217-1228, 2019.
APA
Xia, Y., Chang, J., Yang, J., Ouyang, W., Pitt, B., Billiar, T., & Zhang, L. (2019). Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression. International Journal of Molecular Medicine, 43, 1217-1228. https://doi.org/10.3892/ijmm.2019.4067
MLA
Xia, Y., Chang, J., Yang, J., Ouyang, W., Pitt, B., Billiar, T., Zhang, L."Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression". International Journal of Molecular Medicine 43.3 (2019): 1217-1228.
Chicago
Xia, Y., Chang, J., Yang, J., Ouyang, W., Pitt, B., Billiar, T., Zhang, L."Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression". International Journal of Molecular Medicine 43, no. 3 (2019): 1217-1228. https://doi.org/10.3892/ijmm.2019.4067
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