Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
March-2019 Volume 43 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2019 Volume 43 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

miR‑16‑2‑3p inhibits cell proliferation and migration and induces apoptosis by targeting PDPK1 in maxillary primordium mesenchymal cells

  • Authors:
    • Tao Han
    • Ni Wu
    • Youjing Wang
    • Weimin Shen
    • Jijun Zou
  • View Affiliations / Copyright

    Affiliations: Department of Burns and Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1441-1451
    |
    Published online on: January 21, 2019
       https://doi.org/10.3892/ijmm.2019.4070
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

MicroRNAs (miRNAs) post‑transcriptionally regulate gene expression by targeting the 3' untranslated region (UTR) of target genes, and serve diverse roles in cell proliferation, differentiation and apoptosis. However, the association between miR‑16‑2‑3p and 3‑phosphoinositide‑dependent protein kinase‑1 (PDPK1) in nonsyndromic cleft lip (NSCL) remains unclear. In the present study, a luciferase activity assay indicated that miR‑16‑2‑3p negatively regulated PDPK1 in maxillary primordium mesenchymal cells (MPMCs). In addition, it was confirmed that the expression levels of miR‑16‑2‑3p was markedly increased in cleft lip tissues compared with those in adjacent normal lip tissues. A negative correlation between miR‑16‑2‑3p and PDPK1 in cleft lip tissues was observed. Furthermore, miR‑16‑2‑3p inhibited cell proliferation and migration, and induced apoptosis of MPMCs via repressing PDPK1. Finally, miR‑16‑2‑3p exerted its suppressive role in MPMCs by inhibiting the PDPK1/protein kinase B signaling pathway. These results indicate that miR‑16‑2‑3p may inhibit cell proliferation and migration, and promote apoptosis in MPMCs through repression of PDPK1 and may be a potential target for future clinical prevention and treatment of NSCL.
View Figures
View References

1 

Rahimov F, Jugessur A and Murray JC: Genetics of nonsyndromic orofacial clefts. Cleft Palate Craniofac J. 49:73–91. 2012. View Article : Google Scholar :

2 

Vieira AR: Unraveling human cleft lip and palate research. J Dent Res. 87:119–125. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Sitzman TJ and Marcus JR: Cleft lip and palate: Current surgical management. Clin Plast Surg. 41:xi–xii. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Noorollahian M, Nematy M, Dolatian A, Ghesmati H, Akhlaghi S and Khademi GR: Cleft lip and palate and related factors: A 10 years study in university hospitalised patients at Mashhad-Iran. Afr J Paediatr Surg. 12:286–290. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Kuchler EC, Silva LAD, Nelson-Filho P, Sabóia TM, Rentschler AM, Granjeiro JM, Oliveira D, Tannure PN, Silva RAD, Antunes LS, et al: Assessing the association between hypoxia during craniofacial development and oral clefts. J Appl Oral Sci. 26. pp. e201702342018, View Article : Google Scholar

6 

Mulliken JB and Kim DC: Repair of bilateral incomplete cleft lip: Techniques and outcomes. Plast Reconstr Surg. 132:923–932. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Chen J, Shen W and Cui J: Modification of the rotation-advancement principle in cleft lip repair. J Craniofac Surg. 20:2215–2216. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Chen J, Shen W and Cui J: A marking for moderate bilateral cleft lip. J Craniofac Surg. 26:2022–2023. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Chen J, Shen W and Jie C: Mild incomplete cleft lip repair. J Craniofac Surg. 23:1131–1132. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Jianbing C, Shen W and Cui J: A marking for repair of complete cleft lip. J Craniofac Surg. 25:1122–1124. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Brennecke J, Hipfner DR, Stark A, Russell RB and Cohen SM: Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell. 113:25–36. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Kumari P, Singh SK and Raman R: A novel non-coding RNA within an intron of CDH2 and association of its SNP with non-syndromic cleft lip and palate. Gene. 658:123–128. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Li J, Zou J, Li Q, Chen L, Gao Y, Yan H, Zhou B and Li J: Assessment of differentially expressed plasma microRNAs in nonsyndromic cleft palate and nonsyndromic cleft lip with cleft palate. Oncotarget. 7:86266–86279. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Mehrotra D: Genomic expression in non syndromic cleft lip and palate patients: A review. J Oral Biol Craniofac Res. 5:86–91. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Zou J, Li J, Li J, Ji C, Li Q and Guo X: Expression profile of plasma microRNAs in nonsyndromic cleft lip and their clinical significance as biomarkers. Biomed Pharmacother. 82:459–466. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Zheng N, Ding X, Sun A and Jahan R: PDK1 activity regulates proliferation, invasion and growth of hemangiomas. Cell Physiol Biochem. 36:1903–1910. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Li Y, Yang C, Zhang L and Yang P: MicroRNA-210 induces endothelial cell apoptosis by directly targeting PDK1 in the setting of atherosclerosis. Cell Mol Biol Lett. 22:32017. View Article : Google Scholar : PubMed/NCBI

20 

Jiang R, Bush JO and Lidral AC: Development of the upper lip: Morphogenetic and molecular mechanisms. Dev Dyn. 235:1152–1166. 2006. View Article : Google Scholar

21 

Johnston MC and Bronsky PT: Prenatal craniofacial development: New insights on normal and abnormal mechanisms. Crit Rev Oral Biol Med. 6:25–79. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Ray HJ and Niswander L: Mechanisms of tissue fusion during development. Development. 139:1701–1711. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Ashique AM, Fu K and Richman JM: Endogenous bone morphogenetic proteins regulate outgrowth and epithelial survival during avian lip fusion. Development. 129:4647–4660. 2002.PubMed/NCBI

24 

Cox TC: Taking it to the max: The genetic and developmental mechanisms coordinating midfacial morphogenesis and dysmorphology. Clin Genet. 65:163–176. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Sun D, Baur S and Hay ED: Epithelial-mesenchymal transformation is the mechanism for fusion of the craniofacial primordia involved in morphogenesis of the chicken lip. Dev Biol. 228:337–349. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

27 

Zhao J and Wang R: Biologic characteristics and osteogenic differentiation of maxillary primordium mesenchymal cells. J Craniofac Surg. 26:340–342. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Yu HG, Ai YW, Yu LL, Zhou XD, Liu J, Li JH, Xu XM, Liu S, Chen J, Liu F, et al: Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. Int J Cancer. 122:433–443. 2008. View Article : Google Scholar

29 

Tsukamoto Y, Nakada C, Noguchi T, Tanigawa M, Nguyen LT, Uchida T, Hijiya N, Matsuura K, Fujioka T, Seto M and Moriyama M: MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res. 70:2339–2349. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Bush JO and Jiang R: Palatogenesis: Morphogenetic and molecular mechanisms of secondary palate development. Development. 139:231–243. 2012. View Article : Google Scholar :

31 

Yu H, Ye X, Guo N and Nathans J: Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: Evidence for a network of interacting genes. Development. 139:4383–4394. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Lidral AC, Murray JC, Buetow KH, Basart AM, Schearer H, Shiang R, Naval A, Layda E, Magee K and Magee W: Studies of the candidate genes TGFB2, MSX1, TGFA, and TGFB3 in the etiology of cleft lip and palate in the Philippines. Cleft Palate Craniofac J. 34:1–6. 1997.PubMed/NCBI

33 

Zhang Y, Li T, Qiu Y, Zhang T, Guo P, Ma X, Wei Q and Han L: Serum microRNA panel for early diagnosis of the onset of hepa-tocellular carcinoma. Medicine (Baltimore). 96:e56422017. View Article : Google Scholar

34 

Keller A, Leidinger P, Steinmeyer F, Stähler C, Franke A, Hemmrich-Stanisak G, Kappel A, Wright I, Dörr J, Paul F, et al: Comprehensive analysis of microRNA profiles in multiple sclerosis including next-generation sequencing. Mult Scler. 20:295–303. 2014. View Article : Google Scholar

35 

Gu Y, Zhang Y, Zhao C, Pan Y, Smales RJ, Wang H, Ni Y, Zhang H, Ni J, Ma J and Wang L: Serum microRNAs as potential biomarkers of mandibular prognathism. Oral Dis. 20:55–61. 2014. View Article : Google Scholar

36 

Foda HD and Zucker S: Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis. Drug Discov Today. 6:478–482. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Webb AH, Gao BT, Goldsmith ZK, Irvine AS, Saleh N, Lee RP, Lendermon JB, Bheemreddy R, Zhang Q, Brennan RC, et al: Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma. BMC Cancer. 17:4342017. View Article : Google Scholar : PubMed/NCBI

38 

Westmoreland JJ, Wang Q, Bouzaffour M, Baker SJ and Sosa-Pineda B: Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells. Dev Biol. 334:285–298. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Wada M, Horinaka M, Yasuda S, Masuzawa M, Sakai T and Katoh N: PDK1 is a potential therapeutic target against angiosarcoma cells. J Dermatol Sci. 78:44–50. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Gagliardi PA, di Blasio L and Primo L: PDK1: A signaling hub for cell migration and tumor invasion. Biochim Biophys Acta. 1856:178–188. 2015.PubMed/NCBI

41 

Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, Prescott AR, Lucocq JM and Alessi DR: Essential role of PDK1 in regulating cell size and development in mice. EMBO J. 21:3728–3738. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Xie F, Huang Q, Liu CH, Lin XS, Liu Z, Liu LL, Huang DW and Zhou HC: miR-1271 negatively regulates AKT/MTOR signaling and promotes apoptosis via targeting PDK1 in pancreatic cancer. Eur Rev Med Pharmacol Sci. 22:678–686. 2018.PubMed/NCBI

43 

Wang Z, Yao YJ, Zheng F, Guan Z, Zhang L, Dong N and Qin WJ: Mir-138-5p acts as a tumor suppressor by targeting pyruvate dehydrogenase kinase 1 in human retinoblastoma. Eur Rev Med Pharmacol Sci. 21:5624–5629. 2017.PubMed/NCBI

44 

Wang J, Yang S, Ge W, Wang Y, Han C and Li M: miR-613 suppressed the laryngeal squamous cell carcinoma progression through regulating PDK1. J Cell Biochem. 119:5118–5125. 2018. View Article : Google Scholar

45 

Wang J and Sun X: MicroRNA-375 inhibits the proliferation, migration and invasion of kidney cancer cells by triggering apoptosis and modulation of PDK1 expression. Environ Toxicol Pharmacol. 62:227–233. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Wang Y, Fu L, Cui M, Wang Y, Xu Y, Li M and Mi J: Amino acid transporter SLC38A3 promotes metastasis of non-small cell lung cancer cells by activating PDK1. Cancer Lett. 393:8–15. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Sargeant AM, Klein RD, Rengel RC, Clinton SK, Kulp SK, Kashida Y, Yamaguchi M, Wang X and Chen CS: Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer. Toxicol Pathol. 35:549–561. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Mo Y, Lu Y, Wang P, Huang S, He L, Li D, Li F, Huang J, Lin X, Li X, et al: Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p /PDK1/AKT axis in hepatocellular carcinoma. Tumour Biol. 39:10104283176909992017. View Article : Google Scholar

49 

Manning BD and Cantley LC: AKT/PKB signaling: Navigating downstream. Cell. 129:1261–1274. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Jia S, Agarwal M, Yang J, Horowitz JC, White ES and Kim KK: Discoidin domain receptor 2 signaling regulates fibroblast apop-tosis through PDK1/Akt. Am J Respir Cell Mol Biol. 59:295–305. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Maga G and Hubscher U: Proliferating cell nuclear antigen (PCNA): A dancer with many partners. J Cell Sci. 116:3051–3060. 2003. View Article : Google Scholar : PubMed/NCBI

52 

Wang LF, Chai CY, Kuo WR, Tai CF, Lee KW and Ho KY: The prognostic value of proliferating cell nuclear antigen (PCNA) and p53 protein expression in patients with advanced nasopharyngeal carcinoma. Acta Otolaryngol. 126:769–774. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Dai B, Wu Q, Zeng C, Zhang J, Cao L, Xiao Z and Yang M: The effect of Liuwei Dihuang decoction on PI3K/Akt signaling pathway in liver of type 2 diabetes mellitus (T2DM) rats with insulin resistance. J Ethnopharmacol. 192:382–389. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Nitulescu GM, Van De Venter M, Nitulescu G, Ungurianu A, Juzenas P, Peng Q, Olaru OT, Grădinaru D, Tsatsakis A, Tsoukalas D, et al: The Akt pathway in oncology therapy and beyond (Review). Int J Oncol. 53:2319–2331. 2018.PubMed/NCBI

55 

Xue M, Chen X, Guo Z, Liu X, Bi Y, Yin J, Hu H, Zhu P, Zhuang J, Cates C, et al: L-Carnitine attenuates cardiac dysfunction by ischemic insults through Akt signaling pathway. Toxicol Sci. 160:4292017. View Article : Google Scholar : PubMed/NCBI

56 

Steelman LS, Martelli AM, Cocco L, Libra M, Nicoletti F, Abrams SL and McCubrey JA: The therapeutic potential of mTOR inhibitors in breast cancer. Br J Clin Pharmacol. 82:1189–1212. 2016. View Article : Google Scholar : PubMed/NCBI

57 

Donia M, Mangano K, Amoroso A, Mazzarino MC, Imbesi R, Castrogiovanni P, Coco M, Meroni P and Nicoletti F: Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells. J Autoimmun. 33:135–140. 2009. View Article : Google Scholar : PubMed/NCBI

58 

Nicoletti F, Lapenta C, Donati S, Spada M, Ranazzi A, Cacopardo B, Mangano K, Belardelli F, Perno C and Aquaro S: Inhibition of human immunodeficiency virus (HIV-1) infection in human peripheral blood leucocytes-SCID reconstituted mice by rapamycin. Clin Exp Immunol. 155:28–34. 2009. View Article : Google Scholar :

59 

Nicoletti F, Fagone P, Meroni P, McCubrey J and Bendtzen K: mTOR as a multifunctional therapeutic target in HIV infection. Drug Discov Today. 16:715–721. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Kinoshita S, Ri M, Kanamori T, Aoki S, Yoshida T, Narita T, Totani H, Ito A, Kusumoto S, Ishida T, et al: Potent antitumor effect of combination therapy with sub-optimal doses of Akt inhibitors and pomalidomide plus dexamethasone in multiple myeloma. Oncol Lett. 15:9450–9456. 2018.PubMed/NCBI

61 

Chang Z, Shi G, Jin J, Guo H, Guo X, Luo F, Song Y and Jia X: Dual PI3K/mTOR inhibitor NVP-BEZ235-induced apoptosis of hepatocellular carcinoma cell lines is enhanced by inhibitors of autophagy. Int J Mol Med. 31:1449–1456. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Han T, Wu N, Wang Y, Shen W and Zou J: miR‑16‑2‑3p inhibits cell proliferation and migration and induces apoptosis by targeting PDPK1 in maxillary primordium mesenchymal cells . Int J Mol Med 43: 1441-1451, 2019.
APA
Han, T., Wu, N., Wang, Y., Shen, W., & Zou, J. (2019). miR‑16‑2‑3p inhibits cell proliferation and migration and induces apoptosis by targeting PDPK1 in maxillary primordium mesenchymal cells . International Journal of Molecular Medicine, 43, 1441-1451. https://doi.org/10.3892/ijmm.2019.4070
MLA
Han, T., Wu, N., Wang, Y., Shen, W., Zou, J."miR‑16‑2‑3p inhibits cell proliferation and migration and induces apoptosis by targeting PDPK1 in maxillary primordium mesenchymal cells ". International Journal of Molecular Medicine 43.3 (2019): 1441-1451.
Chicago
Han, T., Wu, N., Wang, Y., Shen, W., Zou, J."miR‑16‑2‑3p inhibits cell proliferation and migration and induces apoptosis by targeting PDPK1 in maxillary primordium mesenchymal cells ". International Journal of Molecular Medicine 43, no. 3 (2019): 1441-1451. https://doi.org/10.3892/ijmm.2019.4070
Copy and paste a formatted citation
x
Spandidos Publications style
Han T, Wu N, Wang Y, Shen W and Zou J: miR‑16‑2‑3p inhibits cell proliferation and migration and induces apoptosis by targeting PDPK1 in maxillary primordium mesenchymal cells . Int J Mol Med 43: 1441-1451, 2019.
APA
Han, T., Wu, N., Wang, Y., Shen, W., & Zou, J. (2019). miR‑16‑2‑3p inhibits cell proliferation and migration and induces apoptosis by targeting PDPK1 in maxillary primordium mesenchymal cells . International Journal of Molecular Medicine, 43, 1441-1451. https://doi.org/10.3892/ijmm.2019.4070
MLA
Han, T., Wu, N., Wang, Y., Shen, W., Zou, J."miR‑16‑2‑3p inhibits cell proliferation and migration and induces apoptosis by targeting PDPK1 in maxillary primordium mesenchymal cells ". International Journal of Molecular Medicine 43.3 (2019): 1441-1451.
Chicago
Han, T., Wu, N., Wang, Y., Shen, W., Zou, J."miR‑16‑2‑3p inhibits cell proliferation and migration and induces apoptosis by targeting PDPK1 in maxillary primordium mesenchymal cells ". International Journal of Molecular Medicine 43, no. 3 (2019): 1441-1451. https://doi.org/10.3892/ijmm.2019.4070
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team