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Article Open Access

MicroRNA-101 inhibits autophagy to alleviate liver ischemia/reperfusion injury via regulating the mTOR signaling pathway

Erratum in: /10.3892/ijmm.2019.4160
  • Authors:
    • Hu Song
    • Chenyang Du
    • Xingxing Wang
    • Jianjun Zhang
    • Zhongyang Shen
  • View Affiliations / Copyright

    Affiliations: First Central Clinical College, Tianjin Medical University, Tianjin 300070, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1331-1342
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    Published online on: January 24, 2019
       https://doi.org/10.3892/ijmm.2019.4077
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Abstract

Liver ischemia/reperfusion injury (LIRI) is a common complication of liver surgery, and affects liver function post‑transplantation. However, the precise mechanism underlying LIRI has not yet been completely elucidated. Previous studies have demonstrated the involvement of a number of microRNAs (miRNAs/miRs) in liver pathophysiology. The objective of the present study was to determine the potential function and mechanism of miR‑101‑mediated regulation of autophagy in LIRI. Compared with the sham‑treated group, a significant decrease in miR‑101 and mechanistic target of rapamycin (mTOR) expression levels following ischemia/reperfusion (IR) were observed, along with an increased number of autophagosomes (P<0.001). The exogenous overexpression of miR‑101 has been demonstrated to inhibit autophagy during the LIRI response and the levels of mTOR and phosphorylated (p)‑mTOR expression are correspondingly elevated. However, compared with the miR‑NC group, miR‑101 silencing was associated with reduced mTOR and p‑mTOR levels and increased autophagy, as indicated by the gradual increase in the levels of the microtubule‑associated protein 1 light II (LC3II). The peak levels of LC3II were observed 12 h subsequent to reperfusion, which coincided with the lowest levels of miR‑101. In addition, inhibition of autophagy by 3‑methyladenine significant enhanced the protective effect of miR‑101 against LIRI, compared with the IR group (P<0.001). Altogether, miR‑101 attenuates LIRI by inhibiting autophagy via activating the mTOR pathway.
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1 

Cursio R, Colosetti P and Gugenheim J: Autophagy and liver ischemia-reperfusion injury. Biomed Res Int. 2015:4175902015. View Article : Google Scholar : PubMed/NCBI

2 

Rautou PE, Mansouri A, Lebrec D, Durand F, Valla D and Moreau R: Autophagy in liver diseases. J Hepatol. 53:1123–1134. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Sun P, Zhang P, Wang PX, Zhu LH, Du Y, Tian S, Zhu X and Li H: Mindin deficiency protects the liver against ischemia/reperfusion injury. J Hepatol. 63:1198–1211. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Clavien PA: How far can we go with marginal donors? J Hepatol. 45:483–484. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Halazun KJ, Quillin RC, Rosenblatt R, Bongu A, Griesemer AD, Kato T, Smith C, Michelassi F, Guarrera JV, Samstein B, et al: Expanding the margins: High volume utilization of marginal liver grafts among ≥2000 liver transplants at a single institution. Ann Surg. 266:441–449. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Lentsch AB, Kato A, Yoshidome H, McMasters KM and Edwards MJ: Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology. 32:169–173. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Qu Y, Zhang Q, Cai X, Li F, Ma Z, Xu M and Lu L: Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation. J Cell Mol Med. 21:2491–2502. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Tang B, Bao N, He G and Wang J: Long noncoding RNA HOTAIR regulates autophagy via the miR-20b-5p/ATG7 axis in hepatic ischemia/reperfusion injury. Gene. 686:56–62. 2019. View Article : Google Scholar

9 

Chen J, Yu Y, Li S, Liu Y, Zhou S, Cao S, Yin J and Li G: MicroRNA-30a ameliorates hepatic fibrosis by inhibiting beclin1-mediated autophagy. J Cell Mol Med. 21:3679–3692. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Lim LP, Glasner ME, Yekta S, Burge CB and Bartel DP: Vertebrate microRNA genes. Science. 299:15402003. View Article : Google Scholar : PubMed/NCBI

11 

Weiss JB, Eisenhardt SU, Stark GB, Bode C, Moser M and Grundmann S: MicroRNAs in ischemia-reperfusion injury. Am J Cardiovasc Dis. 2:237–247. 2012.PubMed/NCBI

12 

Valinezhad Orang A, Safaralizadeh R and Kazemzadeh-Bavili M: Mechanisms of miRNA-mediated gene regulation from common downregulation to mRNA-specific upregulation. Int J Genomics. 2014:9706072014. View Article : Google Scholar : PubMed/NCBI

13 

Yang Y and Liang C: MicroRNAs: An emerging player in autophagy. ScienceOpen Res. 2015:14293/S2199–1006. 2015.

14 

Bartel DP: Metazoan MicroRNAs. Cell. 173:20–51. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Frankel LB, Wen J, Lees M, Høyer-Hansen M, Farkas T, Krogh A, Jäättelä M and Lund AH: microRNA-101 is a potent inhibitor of autophagy. EMBO J. 30. pp. 4628–4641. 2011, View Article : Google Scholar

16 

Valera E, Spencer B, Mott J, Trejo M, Adame A, Mante M, Rockenstein E, Troncoso JC, Beach TG, Masliah E and Desplats P: MicroRNA-101 modulates autophagy and oligodendroglial alpha-synuclein accumulation in multiple system atrophy. Front Mol Neurosci. 10:3292017. View Article : Google Scholar : PubMed/NCBI

17 

Xu Y, An Y, Wang Y, Zhang C, Zhang H, Huang C, Jiang H, Wang X and Li X: miR-101 inhibits autophagy and enhances cisplatin-induced apoptosis in hepatocellular carcinoma cells. Oncol Rep. 29:2019–2024. 2013. View Article : Google Scholar : PubMed/NCBI

18 

National Research Council (US) Institute for Laboratory Animal Research: Guide for the Care and Use of Laboratory Animals. National Academies Press (US); Washington, DC: 1996

19 

National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals. National Academies Press (US); Washington, DC: 2011

20 

Ji H, Shen X, Gao F, Ke B, Freitas MC, Uchida Y, Busuttil RW, Zhai Y and Kupiec-Weglinski JW: Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury. Hepatology. 52:1380–1389. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Coleman MC, Olivier AK, Jacobus JA, Mapuskar KA, Mao G, Martin SM, Riley DP, Gius D and Spitz DR: Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3. Antioxid Redox Signal. 20:1423–1435. 2014. View Article : Google Scholar :

22 

Suzuki S, Toledo-Pereyra LH, Rodriguez FJ and Cejalvo D: Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. modulating effects of FK506 and cyclosporine. Transplantation. 55:1265–1272. 1993. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

24 

Vergne I, Roberts E, Elmaoued RA, Tosch V, Delgado MA, Proikas-Cezanne T, Laporte J and Deretic V: Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy. EMBO J. 28:2244–2258. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Zhou C, Zhong W, Zhou J, Sheng F, Fang Z, Wei Y, Chen Y, Deng X, Xia B and Lin J: Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells. Autophagy. 8:1215–1226. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Xu C, Yu C and Li Y: Current studies on therapeutic approaches for ischemia/reperfusion injury in steatotic livers. Hepatol Res. 38:851–859. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Li CX, Ng KT, Shao Y, Liu XB, Ling CC, Ma YY, Geng W, Qi X, Cheng Q, Chung SK, et al: The inhibition of aldose reductase attenuates hepatic ischemia-reperfusion injury through reducing inflammatory response. Ann Surg. 260:317–328. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Ohsumi Y: Historical landmarks of autophagy research. Cell Res. 24:9–23. 2014. View Article : Google Scholar :

29 

Ohsumi Y: Molecular dissection of autophagy: Two ubiquitin-like systems. Nat Rev Mol Cell Biol. 2:211–216. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Weidberg H, Shpilka T, Shvets E, Abada A, Shimron F and Elazar Z: LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis. Dev Cell. 20:444–454. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Li S, Zhang J, Wang Z, Wang T, Yu Y, He J, Zhang H, Yang T and Shen Z: MicroRNA-17 regulates autophagy to promote hepatic ischemia/reperfusion injury via suppression of signal transductions and activation of transcription-3 expression. Liver Transpl. 22:1697–1709. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Schneider JL and Cuervo AM: Liver autophagy: Much more than just taking out the trash. Nat Rev Gastroenterol Hepatol. 11:187–200. 2014. View Article : Google Scholar :

33 

Shin CS and Huh WK: Bidirectional regulation between TORC1 and autophagy in saccharomyces cerevisiae. Autophagy. 7:854–862. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Liu A, Huang L, Guo E, Li R, Yang J, Li A, Yang Y, Liu S, Hu J, Jiang X, et al: Baicalein pretreatment reduces liver ischemia/reperfusion injury via induction of autophagy in rats. Sci Rep. 6:250422016. View Article : Google Scholar : PubMed/NCBI

35 

Tan L, Jiang W, Lu A, Cai H and Kong L: miR-155 aggravates liver ischemia/reperfusion injury by suppressing SOCS1 in mice. Transplant Proc. 50:3831–3839. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Xiao Q, Ye QF, Wang W, Fu BQ, Xia ZP, Liu ZZ, Zhang XJ and Wang YF: Mild hypothermia pretreatment protects hepatocytes against ischemia reperfusion injury via down-regulating miR-122 and IGF-1R/AKT pathway. Cryobiology. 75:100–105. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Yang W, Chen J, Meng Y, Chen Z and Yang J: Novel targets for treating ischemia-reperfusion injury in the liver. Int J Mol Sci. 19:E13022018. View Article : Google Scholar : PubMed/NCBI

38 

Li SP, He JD, Wang Z, Yu Y, Fu SY, Zhang HM, Zhang JJ and Shen ZY: miR-30b inhibits autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate. World J Gastroenterol. 22:4501–4514. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Kim HJ, Joe Y, Yu JK, Chen Y, Jeong SO, Mani N, Cho GJ, Pae HO, Ryter SW and Chung HT: Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway. Biochim Biophys Acta. 1852:1550–1559. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Wang G, Yao J, Li Z, Zu G, Feng D, Shan W, Li Y, Hu Y, Zhao Y and Tian X: miR-34a-5p inhibition alleviates intestinal ischemia/reperfusion-induced reactive oxygen species accumulation and apoptosis via activation of SIRT1 signaling. Antioxid Redox Signal. 24:961–973. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Vasudevan S, Tong Y and Steitz JA: Switching from repression to activation: microRNAs can up-regulate translation. Science. 318:1931–1934. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Carthew RW and Sontheimer EJ: Origins and Mechanisms of miRNAs and siRNAs. Cell. 136:642–655. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Siomi H and Siomi MC: On the road to reading the RNA-interference code. Nature. 457:396–404. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Lin CC, Liu LZ, Addison JB, Wonderlin WF, Ivanov AV and Ruppert JM: A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context. Mol Cell Biol. 31:2513–2527. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Vasudevan S and Steitz JA: AU-rich-element-mediated upregulation of translation by FXR1 and argonaute 2. Cell. 128:1105–1118. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Moshiri F, Salvi A, Gramantieri L, Sangiovanni A, Guerriero P, De Petro G, Bassi C, Lupini L, Sattari A, Cheung D, et al: Circulating miR-106b-3p miR-101-3p and miR-1246 as diagnostic biomarkers of hepatocellular carcinoma. Oncotarget. 9:15350–15364. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Xu L, Beckebaum S, Iacob S, Wu G, Kaiser GM, Radtke A, Liu C, Kabar I, Schmidt HH, Zhang X, et al: MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity. J Hepatol. 60:590–598. 2014. View Article : Google Scholar

48 

Zhang S, Wang M, Li Q and Zhu P: MiR-101 reduces cell proliferation and invasion and enhances apoptosis in endometrial cancer via regulating PI3K/Akt/mTOR. Cancer Biomark. 21:179–186. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Saxton RA and Sabatini DM: mTOR signaling in growth, metabolism, and disease. Cell. 168:960–976. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Li Y, Wang S, Gao X, Zhao Y, Li Y, Yang B, Zhang N and Ma L: Octreotide alleviates autophagy by up-regulation of MicroRNA-101 in intestinal epithelial cell line caco-2. Cell Physiol Biochem. 49:1352–1363. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Cox LS: PCNA tightens its hold on the nucleus. Cell Cycle. 14:2727–2728. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Melo RM, Martins YS, Luz RK, Rizzo E and Bazzoli N: PCNA and apoptosis during post-spawning ovarian remodeling in the teleost oreochromis niloticus. Tissue Cell. 47:541–549. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Ghavami S, Hashemi M, Ande SR, Yeganeh B, Xiao W, Eshraghi M, Bus CJ, Kadkhoda K, Wiechec E, Halayko AJ and Los M: Apoptosis and cancer: Mutations within caspase genes. J Med Genet. 46:497–510. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Nikoonahad Lotfabadi N, Mohseni Kouchesfahani H, Sheikhha MH and Kalantar SM: In vitro transfection of anti-tumor miR-101 induces BIM, a pro-apoptotic protein, expression in acute myeloid leukemia (AML). EXCLI J. 16:1257–1267. 2017.

55 

Guertin DA and Sabatini DM: An expanding role for mTOR in cancer. Trends Mol Med. 11:353–361. 2005. View Article : Google Scholar : PubMed/NCBI

56 

Kim J, Kim YC, Fang C, Russell RC, Kim JH, Fan W, Liu R, Zhong Q and Guan KL: Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell. 152:290–303. 2013. View Article : Google Scholar : PubMed/NCBI

57 

Kim J, Kundu M, Viollet B and Guan KL: AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 13:132–141. 2011. View Article : Google Scholar : PubMed/NCBI

58 

Liu D, Tang H, Li XY, Deng MF, Wei N, Wang X, Zhou YF, Wang DQ, Fu P, Wang JZ, et al: Targeting the HDAC2/HNF-4A/miR-101b/AMPK pathway rescues tauopathy and dendritic abnormalities in alzheimer's disease. Mol Ther. 25:752–764. 2017. View Article : Google Scholar : PubMed/NCBI

59 

Liu P, Ye F and Xie X, Li X, Tang H, Li S, Huang X, Song C, Wei W and Xie X: mir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK. Oncotarget. 7:35188–35198. 2016.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Song H, Du C, Wang X, Zhang J and Shen Z: MicroRNA-101 inhibits autophagy to alleviate liver ischemia/reperfusion injury via regulating the mTOR signaling pathway Erratum in /10.3892/ijmm.2019.4160 . Int J Mol Med 43: 1331-1342, 2019.
APA
Song, H., Du, C., Wang, X., Zhang, J., & Shen, Z. (2019). MicroRNA-101 inhibits autophagy to alleviate liver ischemia/reperfusion injury via regulating the mTOR signaling pathway Erratum in /10.3892/ijmm.2019.4160 . International Journal of Molecular Medicine, 43, 1331-1342. https://doi.org/10.3892/ijmm.2019.4077
MLA
Song, H., Du, C., Wang, X., Zhang, J., Shen, Z."MicroRNA-101 inhibits autophagy to alleviate liver ischemia/reperfusion injury via regulating the mTOR signaling pathway Erratum in /10.3892/ijmm.2019.4160 ". International Journal of Molecular Medicine 43.3 (2019): 1331-1342.
Chicago
Song, H., Du, C., Wang, X., Zhang, J., Shen, Z."MicroRNA-101 inhibits autophagy to alleviate liver ischemia/reperfusion injury via regulating the mTOR signaling pathway Erratum in /10.3892/ijmm.2019.4160 ". International Journal of Molecular Medicine 43, no. 3 (2019): 1331-1342. https://doi.org/10.3892/ijmm.2019.4077
Copy and paste a formatted citation
x
Spandidos Publications style
Song H, Du C, Wang X, Zhang J and Shen Z: MicroRNA-101 inhibits autophagy to alleviate liver ischemia/reperfusion injury via regulating the mTOR signaling pathway Erratum in /10.3892/ijmm.2019.4160 . Int J Mol Med 43: 1331-1342, 2019.
APA
Song, H., Du, C., Wang, X., Zhang, J., & Shen, Z. (2019). MicroRNA-101 inhibits autophagy to alleviate liver ischemia/reperfusion injury via regulating the mTOR signaling pathway Erratum in /10.3892/ijmm.2019.4160 . International Journal of Molecular Medicine, 43, 1331-1342. https://doi.org/10.3892/ijmm.2019.4077
MLA
Song, H., Du, C., Wang, X., Zhang, J., Shen, Z."MicroRNA-101 inhibits autophagy to alleviate liver ischemia/reperfusion injury via regulating the mTOR signaling pathway Erratum in /10.3892/ijmm.2019.4160 ". International Journal of Molecular Medicine 43.3 (2019): 1331-1342.
Chicago
Song, H., Du, C., Wang, X., Zhang, J., Shen, Z."MicroRNA-101 inhibits autophagy to alleviate liver ischemia/reperfusion injury via regulating the mTOR signaling pathway Erratum in /10.3892/ijmm.2019.4160 ". International Journal of Molecular Medicine 43, no. 3 (2019): 1331-1342. https://doi.org/10.3892/ijmm.2019.4077
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