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Article

Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation‑induced corneal neovascularization

  • Authors:
    • Min He
    • Tao Han
    • Yan Wang
    • Yao‑Hong Wu
    • Wei‑Shan Qin
    • Ling‑Zhen Du
    • Chang‑Qing Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The Second Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China, Clinical Medical College, Second Military Medical University, Shanghai 200433, P.R. China, Bayi Children's Hospital Affiliated to PLA Army General Hospital, Beijing 100700, P.R. China, Department of Otolaryngology, The Second Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China
  • Pages: 1888-1899
    |
    Published online on: February 27, 2019
       https://doi.org/10.3892/ijmm.2019.4114
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Abstract

Hepatocyte growth factor (HGF) and keratinocyte growth factor (KGF), two paracrine growth factors, modulate corneal epithelial cell metabolism, apoptosis and survival. Vascular endothelial growth factor (VEGF) serves as a proangiogenic factor in corneal neovascularization (CNV), which is a major cause of vision impairment and corneal blindness. The aim of the present study was to evaluate the ability of HGF and KGF to influence VEGF and its receptor, kinase insert domain receptor (Flk‑1) in corneal injury and CNV in rats induced by ultraviolet radiation (UVR). An UVR‑induced corneal injury rat model was successfully established to characterize the expression patterns of KGF, HGF, VEGF and Flk‑1 in corneal tissues. Corneal epithelial cells were extracted and treated with small interfering RNAs (siRNAs) targeting KGF, HGF or both (si‑KGF, si‑HGF or si‑HGF/KGF). The effects of HGF and KGF were examined through detection of the expression of KGF, HGF, VEGF and Flk‑1, and the evaluation of cell proliferation, cell cycle and cell apoptosis. The expression levels of KGF, HGF, VEGF and Flk‑1 in corneal tissues were increased in the rat model. In the cell experiments, the transfection of si‑HGF/KGF resulted in reductions in VEGF, Flk‑1, KGF and HGF. In addition, decreased cell proliferation and elevated cell apoptosis were found in the corneal epithelial cells from the rat model following KGF and HGF gene silencing. Taken together, these findings suggest that HGF and KGF gene silencing inhibits UVR‑induced corneal epithelial proliferation and CNV and may function as novel targets for corneal wound healing.
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View References

1 

Tsai CF, Lu FJ and Hsu YW: Protective effects of Dunaliella salina - a carotenoids-rich alga-against ultraviolet B-induced corneal oxidative damage in mice. Mol Vis. 18:1540–1547. 2012.

2 

Green PG, Alvarez P and Levine JD: Topical tetrodotoxin attenuates photophobia induced by corneal injury in the rat. J Pain. 16:881–886. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Couture C, Zaniolo K, Carrier P, Lake J, Patenaude J, Germain L and Guérin SL: The tissue-engineered human cornea as a model to study expression of matrix metalloproteinases during corneal wound healing. Biomaterials. 78:86–101. 2016. View Article : Google Scholar

4 

Lu Y, Feng J, Yang L, Tang H, Jin J and Xu X: Anti-inflammatory effects of a synthetic peptide derived from pigment epithelium-derived factor on H2O2-induced corneal injury in vitro. Chin Med J (Engl). 127:1438–1444. 2014.

5 

Lennikov A, Kitaichi N, Fukase R, Murata M, Noda K, Ando R, Ohguchi T, Kawakita T, Ohno S and Ishida S: Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops. Mol Vis. 18:455–464. 2012.PubMed/NCBI

6 

Lennikov A, Kitaichi N, Kase S, Noda K, Horie Y, Nakai A, Ohno S and Ishida S: Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice. Int J Mol Sci. 14:2175–2189. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Shi H, Yu HJ, Wang HY, Wang WT, Jin SH, Zhu P, Li SJ, Rong CT and Li JY: Topical administration of peroxiredoxin-6 on the cornea suppresses inflammation and neovascularization induced by ultraviolet radiation. Invest Ophthalmol Vis Sci. 53:8016–8028. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Gu XJ, Liu X, Chen YY, Zhao Y, Xu M, Han XJ, Liu QP, Yi JL and Li JM: Involvement of NADPH oxidases in alkali burn-induced corneal injury. Int J Mol Med. 38:75–82. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Chen MH, Tsai CF, Hsu YW and Lu FJ: Epigallocatechin gallate eye drops protect against ultraviolet B-induced corneal oxidative damage in mice. Mol Vis. 20:153–162. 2014.PubMed/NCBI

10 

Zuclich JA: Ultraviolet-induced photochemical damage in ocular tissues. Health Phys. 56:671–682. 1989. View Article : Google Scholar : PubMed/NCBI

11 

Golu A, Gheorghişor I, Bălăşoiu AT, Baltă F, Osiac E, Mogoantă L and Bold A: The effect of ultraviolet radiation on the cornea-experimental study. Rom J Morphol Embryol. 54:1115–1120. 2013.

12 

Seo M, Choi JS, Rho CR, Joo CK and Lee SK: MicroRNA miR-466 inhibits Lymphangiogenesis by targeting prospero-related homeobox 1 in the alkali burn corneal injury model. J Biomed Sci. 22:32015. View Article : Google Scholar : PubMed/NCBI

13 

Chu PH, Yeh LK, Lin HC, Jung SM, Ma DH, Wang IJ, Wu HH, Shiu TF and Chen J: Deletion of the FHL2 gene attenuating neovascularization after corneal injury. Invest Ophthalmol Vis Sci. 49:5314–5318. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Wilson SE, Chen L, Mohan RR, Liang Q and Liu J: Expression of HGF, KGF, EGF and receptor messenger RNAs following corneal epithelial wounding. Exp Eye Res. 68:377–397. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Matsumoto K, Funakoshi H, Takahashi H and Sakai K: HGF-Met pathway in regeneration and drug discovery. Biomedicines. 2:275–300. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Boccaccio C, Andò M, Tamagnone L, Bardelli A, Michieli P, Battistini C and Comoglio PM: Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature. 391:285–288. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Finch PW, Rubin JS, Miki T, Ron D and Aaronson SA: Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science. 245:752–755. 1989. View Article : Google Scholar : PubMed/NCBI

18 

Cheng CC, Wang DY, Kao MH and Chen JK: The growth-promoting effect of KGF on limbal epithelial cells is mediated by upregulation of DeltaNp63alpha through the p38 pathway. J Cell Sci. 122:4473–4480. 2009. View Article : Google Scholar : PubMed/NCBI

19 

McBain VA, Forrester JV and McCaig CD: HGF, MAPK, and a small physiological electric field interact during corneal epithelial cell migration. Invest Ophthalmol Vis Sci. 44:540–547. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Chandrasekher G, Pothula S, Maharaj G and Bazan HE: Differential effects of hepatocyte growth factor and keratinocyte growth factor on corneal epithelial cell cycle protein expression, cell survival, and growth. Mol Vis. 20:24–37. 2014.PubMed/NCBI

21 

Li X, Zhou Q, Hanus J, Anderson C, Zhang H, Dellinger M, Brekken R and Wang S: Inhibition of multiple pathogenic pathways by histone deacetylase inhibitor SAHA in a corneal alkali-burn injury model. Mol Pharm. 10:307–318. 2013. View Article : Google Scholar :

22 

Dvorak HF, Nagy JA, Feng D, Brown LF and Dvorak AM: Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr Top Microbiol Immunol. 237:97–132. 1999.PubMed/NCBI

23 

Das P, Pereira JA, Chaklader M, Law A, Bagchi K, Bhaduri G, Chaudhuri S and Law S: Phenotypic alteration of limbal niche-associated limbal epithelial stem cell deficiency by ultraviolet-B exposure-induced phototoxicity in mice. Biochem Cell Biol. 91:165–175. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Fujihara T, Nagano T, Endo K, Nakamura M and Nakata K: Lactoferrin protects against UV-B irradiation-induced corneal epithelial damage in rats. Cornea. 19:207–211. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Dickey JB, Cassidy EM and Bouchard CS: Periocular FK-506 delays allograft rejection in rat penetrating keratoplasty. Cornea. 12:204–207. 1993. View Article : Google Scholar : PubMed/NCBI

26 

Du S, Han B, Li K, Zhang X, Sha X and Gao L: Lycium barbarum polysaccharides protect rat corneal epithelial cells against ultraviolet B-induced apoptosis by attenuating the mitochondrial pathway and inhibiting JNK phosphorylation. Biomed Res Int. 2017:58068322017. View Article : Google Scholar :

27 

Schefe JH, Lehmann KE, Buschmann IR, Unger T and Funke-Kaiser H: Quantitative real-time RT-PCR data analysis: Current concepts and the novel ‘gene expression’s CT difference’ formula. J Mol Med (Berl). 84:901–910. 2006. View Article : Google Scholar

28 

Wood JC: Principles of gating. Curr Protoc Cytom Chapter. 1(Unit 1): 82001.

29 

Jose JG and Pitts DG: Wavelength dependency of cataracts in albino mice following chronic exposure. Exp Eye Res. 41:545–563. 1985. View Article : Google Scholar : PubMed/NCBI

30 

Podskochy A and Fagerholm P: Repeated UVR exposures cause keratocyte resistance to apoptosis and hyaluronan accumulation in the rabbit cornea. Acta Ophthalmol Scand. 79:603–608. 2001. View Article : Google Scholar

31 

Ibrahim OM, Kojima T, Wakamatsu TH, Dogru M, Matsumoto Y, Ogawa Y, Ogawa J, Negishi K, Shimazaki J, Sakamoto Y, et al: Corneal and retinal effects of ultraviolet-B exposure in a soft contact lens mouse model. Invest Ophthalmol Vis Sci. 53:2403–2413. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Pauloin T, Dutot M, Joly F, Warnet JM and Rat P: High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells. Mol Vis. 15:577–583. 2009.PubMed/NCBI

33 

Cejka C, Ardan T, Sirc J, Michálek J, Beneš J, Brůnová B and Rosina J: Hydration and transparency of the rabbit cornea irradiated with UVB-doses of 0.25 J/cm(2) and 0.5 J/cm(2) compared with equivalent UVB radiation exposure reaching the human cornea from sunlight. Curr Eye Res. 36:607–613. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Marchese C, Rubin J, Ron D, Faggioni A, Torrisi MR, Messina A, Frati L and Aaronson SA: Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: Differentiation response distinguishes KGF from EGF family. J Cell Physiol. 144:326–332. 1990. View Article : Google Scholar : PubMed/NCBI

35 

Weidner KM, Behrens J, Vandekerckhove J and Birchmeier W: Scatter factor: Molecular characteristics and effect on the invasiveness of epithelial cells. J Cell Biol. 111:2097–2108. 1990. View Article : Google Scholar : PubMed/NCBI

36 

Azfar MF, Khan MF and Alzeer AH: Protocolized eye care prevents corneal complications in ventilated patients in a medical intensive care unit. Saudi J Anaesth. 7:33–36. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Sharma GD, He J and Bazan HE: p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: Evidence of cross-talk activation between MAP kinase cascades. J Biol Chem. 278:21989–21997. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Chen TC and Chang SW: Effect of mitomycin C on IL-1R expression, IL-1-related hepatocyte growth factor secretion and corneal epithelial cell migration. Invest Ophthalmol Vis Sci. 51:1389–1396. 2010. View Article : Google Scholar

39 

Cullen AP, Chou BR, Hall MG and Jany SE: Ultraviolet-B damages corneal endothelium. Am J Optom Physiol Opt. 61:473–478. 1984. View Article : Google Scholar : PubMed/NCBI

40 

Schein OD: Phototoxicity and the cornea. J Natl Med Assoc. 84:579–583. 1992.PubMed/NCBI

41 

Mangan MS, Arici C, Atalay E, Tanyildiz B and Orucoglu F: Four cases of pediatric photokeratitis present to the emergency department after watching the same theater show. Turk J Ophthalmol. 45:226–228. 2015. View Article : Google Scholar

42 

Liou JC, Teng MC, Tsai YS, Lin EC and Chen BY: UV-blocking spectacle lens protects against UV-induced decline of visual performance. Mol Vis. 21:846–856. 2015.PubMed/NCBI

43 

Ambati BK, Nozaki M, Singh N, Takeda A, Jani PD, Suthar T, Albuquerque RJ, Richter E, Sakurai E, Newcomb MT, et al: Corneal avascularity is due to soluble VEGF receptor-1. Nature. 443:993–997. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Azar DT: Corneal angiogenic privilege: Angiogenic and anti-angiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc. 104:264–302. 2006.

45 

Zhang SX and Ma JX: Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy. Prog Retin Eye Res. 26:1–37. 2007. View Article : Google Scholar

46 

Dvorak HF, Brown LF, Detmar M and Dvorak AM: Vascular permeability factor/vascular endothelial growth factor, micro-vascular hyperpermeability, and angiogenesis. Am J Pathol. 146:1029–1039. 1995.PubMed/NCBI

47 

Philipp W, Speicher L and Humpel C: Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas. Invest Ophthalmol vis Sci. 41:2514–2522. 2000.PubMed/NCBI

48 

Matsumura A, Kubota T, Taiyoh H, Fujiwara H, Okamoto K, Ichikawa D, Shiozaki A, Komatsu S, Nakanishi M, Kuriu Y, et al: HGF regulates VEGF expression via the c-Met receptor downstream pathways, PI3K/Akt, MAPK and STAT3, in CT26 murine cells. Int J Oncol. 42:535–542. 2013. View Article : Google Scholar

49 

Narita K, Fujii T, Ishiwata T, Yamamoto T, Kawamoto Y, Kawahara K, Nakazawa N and Naito Z: Keratinocyte growth factor induces vascular endothelial growth factor-A expression in colorectal cancer cells. Int J Oncol. 34:355–360. 2009.PubMed/NCBI

50 

Pal-Ghosh S, Tadvalkar G and Stepp MA: Alterations in corneal sensory nerves during homeostasis, aging, and after injury in mice lacking the heparan sulfate proteoglycan syndecan-1. Invest Ophthalmol Vis Sci. 58:4959–4975. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Pan Z, Fukuoka S, Karagianni N, Guaiquil VH and Rosenblatt MI: Vascular endothelial growth factor promotes anatomical and functional recovery of injured peripheral nerves in the avascular cornea. FASEB J. 27:2756–2767. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Chandrasekher G, Kakazu AH and Bazan HE: HGF- and KGF-induced activation of PI-3K/p70 s6 kinase pathway in corneal epithelial cells: Its relevance in wound healing. Exp Eye Res. 73:191–202. 2001. View Article : Google Scholar : PubMed/NCBI

53 

Weng J, Mohan RR, Li Q and Wilson SE: IL-1 upregulates keratinocyte growth factor and hepatocyte growth factor mRNA and protein production by cultured stromal fibroblast cells: Interleukin-1 beta expression in the cornea. Cornea. 16:465–471. 1997. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
He M, Han T, Wang Y, Wu YH, Qin WS, Du LZ and Zhao CQ: Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation‑induced corneal neovascularization. Int J Mol Med 43: 1888-1899, 2019.
APA
He, M., Han, T., Wang, Y., Wu, Y., Qin, W., Du, L., & Zhao, C. (2019). Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation‑induced corneal neovascularization. International Journal of Molecular Medicine, 43, 1888-1899. https://doi.org/10.3892/ijmm.2019.4114
MLA
He, M., Han, T., Wang, Y., Wu, Y., Qin, W., Du, L., Zhao, C."Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation‑induced corneal neovascularization". International Journal of Molecular Medicine 43.4 (2019): 1888-1899.
Chicago
He, M., Han, T., Wang, Y., Wu, Y., Qin, W., Du, L., Zhao, C."Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation‑induced corneal neovascularization". International Journal of Molecular Medicine 43, no. 4 (2019): 1888-1899. https://doi.org/10.3892/ijmm.2019.4114
Copy and paste a formatted citation
x
Spandidos Publications style
He M, Han T, Wang Y, Wu YH, Qin WS, Du LZ and Zhao CQ: Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation‑induced corneal neovascularization. Int J Mol Med 43: 1888-1899, 2019.
APA
He, M., Han, T., Wang, Y., Wu, Y., Qin, W., Du, L., & Zhao, C. (2019). Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation‑induced corneal neovascularization. International Journal of Molecular Medicine, 43, 1888-1899. https://doi.org/10.3892/ijmm.2019.4114
MLA
He, M., Han, T., Wang, Y., Wu, Y., Qin, W., Du, L., Zhao, C."Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation‑induced corneal neovascularization". International Journal of Molecular Medicine 43.4 (2019): 1888-1899.
Chicago
He, M., Han, T., Wang, Y., Wu, Y., Qin, W., Du, L., Zhao, C."Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation‑induced corneal neovascularization". International Journal of Molecular Medicine 43, no. 4 (2019): 1888-1899. https://doi.org/10.3892/ijmm.2019.4114
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