Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
May-2019 Volume 43 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2019 Volume 43 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplemenary_Data.pdf
Article Open Access

Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription

  • Authors:
    • Susumu Tanaka
    • Yoshiko Honda
    • Shizuka Takaku
    • Taro Koike
    • Souichi Oe
    • Yukie Hirahara
    • Takashi Yoshida
    • Nae Takizawa
    • Yasuharu Takamori
    • Kiyoshi Kurokawa
    • Tohru Kodama
    • Hisao Yamada
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan, SLEEP Disorders Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156‑8506, Japan, Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka 573‑1191, Japan
    Copyright: © Tanaka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2164-2176
    |
    Published online on: March 20, 2019
       https://doi.org/10.3892/ijmm.2019.4143
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The hypocretin/orexin neuropeptide system coordinates the regulation of various physiological processes. Our previous study reported that a reduction in the expression of pleomorphic adenoma gene‑like 1 (Plagl1), which encodes a C2H2 zinc‑finger transcription factor, occurs in hypocretin neuron‑ablated transgenic mice, suggesting that PLAGL1 is co‑expressed in hypocretin neurons and regulates hypocretin transcription. The present study examined whether canonical prepro‑hypocretin transcription is functionally modulated by PLAGL1. Double immunostaining indicated that the majority of hypocretin neurons were positive for PLAGL1 immunoreactivity in the nucleus. Notably, PLAGL1 immunoreactivity in hypocretin neurons was altered in response to several conditions affecting hypocretin function. An uneven localization of PLAGL1 was detected in the nuclei of hypocretin neurons following sleep deprivation. Chromatin immunoprecipitation revealed that endogenous PLAGL1 may bind to a putative PLAGL1‑binding site in the proximal region of the hypocretin gene, in the murine hypothalamus. In addition, electroporation of the PLAGL1 expression vector into the fetal hypothalamus promoted hypothalamic hypocretin transcription. These results suggested that PLAGL1 may regulate hypothalamic hypocretin transcription.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Sakurai T: The role of orexin in motivated behaviours. Nat Rev Neurosci. 15:719–731. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Sakurai T, Moriguchi T, Furuya K, Kajiwara N, Nakamura T, Yanagisawa M and Goto K: Structure and function of human prepro-orexin gene. J Biol Chem. 274:17771–17776. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Moriguchi T, Sakurai T, Takahashi S, Goto K and Yamamoto M: The human prepro-orexin gene regulatory region that activates gene expression in the lateral region and represses it in the medial regions of the hypothalamus. J Biol Chem. 277:16985–16992. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Amiot C, Brischoux F, Colard C, La Roche A, Fellmann D and Risold PY: Hypocretin/orexin-containing neurons are produced in one sharp peak in the developing ventral diencephalon. Eur J Neurosci. 22:531–534. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Tanaka S: Transcriptional regulation of the hypocretin/orexin gene. Vitam Horm. 89:75–90. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Ogawa Y, Kanda T, Vogt K and Yanagisawa M: Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates. J Comp Neurol. 525:3809–3820. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Zahr SK, Yang G, Kazan H, Borrett MJ, Yuzwa SA, Voronova A, Kaplan DR and Miller FD: A translational repression complex in developing mammalian neural stem cells that regulates neuronal specification. Neuron. 97:520–537 e6. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Tanaka S, Kodama T, Nonaka T, Toyoda H, Arai M, Fukazawa M, Honda Y, Honda M and Mignot E: Transcriptional regulation of the hypocretin/orexin gene by NR6A1. Biochem Biophys Res Commun. 403:178–183. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, et al: A genomic atlas of mouse hypothalamic development. Nature Neurosci. 13:767–775. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Silva JP, von Meyenn F, Howell J, Thorens B, Wolfrum C and Stoffel M: Regulation of adaptive behaviour during fasting by hypothalamic Foxa2. Nature. 462:646–650. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Dalal J, Roh JH, Maloney SE, Akuffo A, Shah S, Yuan H, Wamsley B, Jones WB, de Guzman Strong C, Gray PA, et al: Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation. Genes Dev. 27:565–578. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Honda M, Eriksson KS, Zhang S, Tanaka S, Lin L, Salehi A, Hesla PE, Maehlen J, Gaus SE, Yanagisawa M, et al: IGFBP3 colocalizes with and regulates hypocretin (orexin). PLoS One. 4:e42542009. View Article : Google Scholar : PubMed/NCBI

13 

De La Herrán-Arita AK, Zomosa-Signoret VC, Millán-Aldaco DA, Palomero-Rivero M, Guerra-Crespo M, Drucker-Colín R and Vidaltamayo R: Aspects of the narcolepsy-cataplexy syndrome in O/E3-null mutant mice. Neuroscience. 183:134–143. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Sánchez-García A, Cabral-Pacheco GA, Zomosa-Signoret VC, Ortiz-López R, Camacho A, Tabera-Tarello PM, Garnica-López JA and Vidaltamayo R: Modular organization of a hypocretin gene minimal promoter. Mol Med Rep. 17:2263–2270. 2018.

15 

Spengler D, Villalba M, Hoffmann A, Pantaloni C, Houssami S, Bockaert J and Journot L: Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J. 16:2814–2825. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Kas K, Voz ML, Hensen K, Meyen E and Van de Ven WJ: Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. J Biol Chem. 273:23026–23032. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Kamiya M, Judson H, Okazaki Y, Kusakabe M, Muramatsu M, Takada S, Takagi N, Arima T, Wake N, Kamimura K, et al: The cell cycle control gene ZAC/PLAGL1 is imprinted-a strong candidate gene for transient neonatal diabetes. Hum Mol Genet. 9:453–460. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Varrault A, Gueydan C, Delalbre A, Bellmann A, Houssami S, Aknin C, Severac D, Chotard L, Kahli M, Le Digarcher A, et al: Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth. Dev Cell. 11:711–722. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Varrault A, Dantec C, Le Digarcher A, Chotard L, Bilanges B, Parrinello H, Dubois E, Rialle S, Severac D, Bouschet T and Journot L: Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network. Nucleic Acids Res. 45:10466–10480. 2017. View Article : Google Scholar : PubMed/NCBI

20 

National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals. 8th edition. National Academies Press (US); Washington, DC: 2011

21 

Terao A, Wisor JP, Peyron C, Apte-Deshpande A, Wurts SW, Edgar DM and Kilduff TS: Gene expression in the rat brain during sleep deprivation and recovery sleep: An Affymetrix GeneChip study. Neuroscience. 137:593–605. 2006. View Article : Google Scholar

22 

Dignam JD, Lebovitz RM and Roeder RG: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489. 1983. View Article : Google Scholar : PubMed/NCBI

23 

Takizawa N, Tanaka S, Oe S, Koike T, Matsuda T and Yamada H: Hypothalamo-hypophysial system in rats with autotransplantation of the adrenal cortex. Mol Med Rep. 15:3215–3221. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

25 

Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, Bernard A, Boe AF, Boguski MS, Brockway KS, Byrnes EJ, et al: Genome-wide atlas of gene expression in the adult mouse brain. Nature. 445:168–176. 2007. View Article : Google Scholar

26 

Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D and Journot L: hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. Proc Natl Acad Sci USA. 95:8835–8840. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, et al: Orexin (hypocretin) neurons contain dynorphin. J Neurosci. 21:RC1682001. View Article : Google Scholar : PubMed/NCBI

28 

Reti IM, Reddy R, Worley PF and Baraban JM: Selective expression of Narp, a secreted neuronal pentraxin, in orexin neurons. J Neurochem. 82:1561–1565. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Tsuneki H, Wada T and Sasaoka T: Role of orexin in the central regulation of glucose and energy homeostasis. Endocr J. 59:365–374. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Nattie E and Li A: Respiration and autonomic regulation and orexin. Prog Brain Res. 198:25–46. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami Ki, Sugiyama F, Goto K, et al: Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron. 38:701–713. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Burdakov D, Jensen LT, Alexopoulos H, Williams RH, Fearon IM, O'Kelly I, Gerasimenko O, Fugger L and Verkhratsky A: Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron. 50:711–722. 2006. View Article : Google Scholar : PubMed/NCBI

33 

González JA, Jensen LT, Doyle SE, Miranda-Anaya M, Menaker M, Fugger L, Bayliss DA and Burdakov D: Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons. Eur J Neurosci. 30:57–64. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Valdivia S, Patrone A, Reynaldo M and Perello M: Acute high fat diet consumption activates the mesolimbic circuit and requires orexin signaling in a mouse model. PLoS One. 9:e874782014. View Article : Google Scholar : PubMed/NCBI

35 

Sakurai T: The neural circuit of orexin (hypocretin): Maintaining sleep and wakefulness. Nat Rev Neurosci. 8:171–181. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Fujiki N, Yoshida Y, Ripley B, Honda K, Mignot E and Nishino S: Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation. Neuroreport. 12:993–997. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Lee MG, Hassani OK and Jones BE: Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J Neurosci. 25:6716–6720. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Yoshida Y, Fujiki N, Nakajima T, Ripley B, Matsumura H, Yoneda H, Mignot E and Nishino S: Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities. Eur J Neurosci. 14:1075–1081. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Pedrazzoli M, D'Almeida V, Martins PJ, Machado RB, Ling L, Nishino S, Tufik S and Mignot E: Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation. Brain Res. 995:1–6. 2004. View Article : Google Scholar

40 

Wu MF, John J, Maidment N, Lam HA and Siegel JM: Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement. Am J Physiol Regul Integr Comp Physiol. 283:R1079–R1086. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Allard JS, Tizabi Y, Shaffery JP and Manaye K: Effects of rapid eye movement sleep deprivation on hypocretin neurons in the hypothalamus of a rat model of depression. Neuropeptides. 41:329–337. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Modirrousta M, Mainville L and Jones BE: Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors. Eur J Neurosci. 21:2807–2816. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Martins PJ, Marques MS, Tufik S and D'Almeida V: Orexin activation precedes increased NPY expression, hyperphagia, and metabolic changes in response to sleep deprivation. Am J Physiol Endocrinol Metab. 298:E726–E734. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Holmquist GP and Ashley T: Chromosome organization and chromatin modification: Influence on genome function and evolution. Cytogenet Genome Res. 114:96–125. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Sadoni N, Langer S, Fauth C, Bernardi G, Cremer T, Turner BM and Zink D: Nuclear organization of mammalian genomes. Polar chromosome territories build up functionally distinct higher order compartments. J Cell Biol. 146:1211–1226. 1999. View Article : Google Scholar : PubMed/NCBI

46 

Di Tomaso MV, Liddle P, Lafon-Hughes L, Reyes-Ábalos A and Folle G: Chromatin damage patterns shift according to Eu/Heterochromatin replication. The mechanisms of DNA replication. D S: InTech. 2013.

47 

Hayakawa K, Hirosawa M, Tabei Y, Arai D, Tanaka S, Murakami N, Yagi S and Shiota K: Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. J Biol Chem. 288:17099–17110. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Hayakawa K, Sakamoto Y, Kanie O, Ohtake A, Daikoku S, Ito Y and Shiota K: Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 12:764–778. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Hoffmann A, Ciani E, Boeckardt J, Holsboer F, Journot L and Spengler D: Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding. Mol Cell Biol. 23:988–1003. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Yuasa S, Onizuka T, Shimoji K, Ohno Y, Kageyama T, Yoon SH, Egashira T, Seki T, Hashimoto H, Nishiyama T, et al: Zac1 is an essential transcription factor for cardiac morphogenesis. Circ Res. 106:1083–1091. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Xu Y, Tamamaki N, Noda T, Kimura K, Itokazu Y, Matsumoto N, Dezawa M and Ide C: Neurogenesis in the ependymal layer of the adult rat 3rd ventricle. Exp Neurol. 192:251–264. 2005. View Article : Google Scholar : PubMed/NCBI

52 

Broberger C, De Lecea L, Sutcliffe JG and Hökfelt T: Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol. 402:460–474. 1998. View Article : Google Scholar : PubMed/NCBI

53 

Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, Kelly J, Tatro JB, Hoffman GE, Ollmann MM, Barsh GS, et al: Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol. 402:442–459. 1998. View Article : Google Scholar : PubMed/NCBI

54 

Matsuki T, Nomiyama M, Takahira H, Hirashima N, Kunita S, Takahashi S, Yagami K, Kilduff TS, Bettler B, Yanagisawa M and Sakurai T: Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci USA. 106:4459–4464. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tanaka S, Honda Y, Takaku S, Koike T, Oe S, Hirahara Y, Yoshida T, Takizawa N, Takamori Y, Kurokawa K, Kurokawa K, et al: Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription. Int J Mol Med 43: 2164-2176, 2019.
APA
Tanaka, S., Honda, Y., Takaku, S., Koike, T., Oe, S., Hirahara, Y. ... Yamada, H. (2019). Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription. International Journal of Molecular Medicine, 43, 2164-2176. https://doi.org/10.3892/ijmm.2019.4143
MLA
Tanaka, S., Honda, Y., Takaku, S., Koike, T., Oe, S., Hirahara, Y., Yoshida, T., Takizawa, N., Takamori, Y., Kurokawa, K., Kodama, T., Yamada, H."Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription". International Journal of Molecular Medicine 43.5 (2019): 2164-2176.
Chicago
Tanaka, S., Honda, Y., Takaku, S., Koike, T., Oe, S., Hirahara, Y., Yoshida, T., Takizawa, N., Takamori, Y., Kurokawa, K., Kodama, T., Yamada, H."Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription". International Journal of Molecular Medicine 43, no. 5 (2019): 2164-2176. https://doi.org/10.3892/ijmm.2019.4143
Copy and paste a formatted citation
x
Spandidos Publications style
Tanaka S, Honda Y, Takaku S, Koike T, Oe S, Hirahara Y, Yoshida T, Takizawa N, Takamori Y, Kurokawa K, Kurokawa K, et al: Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription. Int J Mol Med 43: 2164-2176, 2019.
APA
Tanaka, S., Honda, Y., Takaku, S., Koike, T., Oe, S., Hirahara, Y. ... Yamada, H. (2019). Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription. International Journal of Molecular Medicine, 43, 2164-2176. https://doi.org/10.3892/ijmm.2019.4143
MLA
Tanaka, S., Honda, Y., Takaku, S., Koike, T., Oe, S., Hirahara, Y., Yoshida, T., Takizawa, N., Takamori, Y., Kurokawa, K., Kodama, T., Yamada, H."Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription". International Journal of Molecular Medicine 43.5 (2019): 2164-2176.
Chicago
Tanaka, S., Honda, Y., Takaku, S., Koike, T., Oe, S., Hirahara, Y., Yoshida, T., Takizawa, N., Takamori, Y., Kurokawa, K., Kodama, T., Yamada, H."Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription". International Journal of Molecular Medicine 43, no. 5 (2019): 2164-2176. https://doi.org/10.3892/ijmm.2019.4143
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team