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Article

Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity

  • Authors:
    • Jee Won Hwang
    • Yun‑Seong So
    • Gyu‑Un Bae
    • Su‑Nam Kim
    • Yong Kee Kim
  • View Affiliations / Copyright

    Affiliations: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women's University, Seoul 140‑742, Republic of Korea, Natural Products Research Center, Korea Institute of Science and Technology Gangneung Institute, Gangneung 210‑340, Republic of Korea
  • Pages: 2462-2470
    |
    Published online on: March 27, 2019
       https://doi.org/10.3892/ijmm.2019.4147
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Abstract

The present study demonstrated that protein arginine methyltransferase 6 (PRMT6) negatively regulates the activity of peroxisome proliferator‑activated receptor γ (PPARγ). The results indicated that the overexpression of PRMT6 inhibited the transactivity of PPARγ and subsequently decreased the expression levels of PPARγ target genes. Contrarily, the depletion or inhibition of PRMT6 increased PPARγ reporter activity and the expression of its target genes. It was also confirmed that PRMT6 was involved in the process of adipocyte differentiation. In addition, PRMT6 interacted with, but did not methylate, PPARγ. PRMT6 bound to the PPAR‑responsive regulatory element of the adipocyte Protein 2 (aP2) promoter in conjunction with PPARγ and generated the repressive epigenetic mark arginine 2 on histone H3 asymmetric di‑methylation, which suppressed aP2 gene expression. Therefore, PRMT6 may serve as an important regulator of PPARγ activity in adipogenic differentiation and may be an attractive therapeutic target for human metabolic diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Hwang JW, So YS, Bae GU, Kim SN and Kim YK: Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity. Int J Mol Med 43: 2462-2470, 2019.
APA
Hwang, J.W., So, Y., Bae, G., Kim, S., & Kim, Y.K. (2019). Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity. International Journal of Molecular Medicine, 43, 2462-2470. https://doi.org/10.3892/ijmm.2019.4147
MLA
Hwang, J. W., So, Y., Bae, G., Kim, S., Kim, Y. K."Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity". International Journal of Molecular Medicine 43.6 (2019): 2462-2470.
Chicago
Hwang, J. W., So, Y., Bae, G., Kim, S., Kim, Y. K."Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity". International Journal of Molecular Medicine 43, no. 6 (2019): 2462-2470. https://doi.org/10.3892/ijmm.2019.4147
Copy and paste a formatted citation
x
Spandidos Publications style
Hwang JW, So YS, Bae GU, Kim SN and Kim YK: Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity. Int J Mol Med 43: 2462-2470, 2019.
APA
Hwang, J.W., So, Y., Bae, G., Kim, S., & Kim, Y.K. (2019). Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity. International Journal of Molecular Medicine, 43, 2462-2470. https://doi.org/10.3892/ijmm.2019.4147
MLA
Hwang, J. W., So, Y., Bae, G., Kim, S., Kim, Y. K."Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity". International Journal of Molecular Medicine 43.6 (2019): 2462-2470.
Chicago
Hwang, J. W., So, Y., Bae, G., Kim, S., Kim, Y. K."Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity". International Journal of Molecular Medicine 43, no. 6 (2019): 2462-2470. https://doi.org/10.3892/ijmm.2019.4147
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