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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2019 Volume 43 Issue 6

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Detection of N6‑methyladenosine modification residues (Review)

Wei Zhu, Jing‑Zi Wang, Zhiqiang Xu, Mengda Cao, Qiaoli Hu, Chen Pan, Miao Guo, Ji‑Fu Wei, Haiwei Yang
Pages: 2267-2278
Published online on: 18 April 2019

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Article Open Access

Salidroside attenuates oxidized low‑density lipoprotein‑induced endothelial cell injury via promotion of the AMPK/SIRT1 pathway

Dongming Zhao, Xinyi Sun, Shujie Lv, Miying Sun, Huatao Guo, Yujia Zhai, Zhi Wang, Peng Dai, Lina Zheng, Mingzhe Ye, Xinpeng Wang
Pages: 2279-2290
Published online on: 01 April 2019

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Article Open Access

Dual roles of IL-18 in colitis through regulation of the function and quantity of goblet cells

Zhichen Pu, Yuan Che, Weiwei Zhang, Hui Sun, Tuo Meng, Haitang Xie, Lijuan Cao, Haiping Hao
Pages: 2291-2302
Published online on: 04 April 2019

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Article Open Access

Analysis of a nanoparticle‑enriched fraction of plasma reveals miRNA candidates for Down syndrome pathogenesis Corrigendum in /10.3892/ijmm.2019.4222

Alessandro Salvi, Marika Vezzoli, Sara Busatto, Lucia Paolini, Teresa Faranda, Edoardo Abeni, Maria Caracausi, Francesca Antonaros, Allison Piovesan, Chiara Locatelli, Guido Cocchi, Gualtiero Alvisi, Giuseppina De Petro, Doris Ricotta, Paolo Bergese, Annalisa Radeghieri
Pages: 2303-2318
Published online on: 09 April 2019

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Article Open Access

Human peripheral blood‑derived exosomes for microRNA delivery Corrigendum in /10.3892/ijmm.2019.4202

Ji‑Young Kang, Hyewon Park, Hyoeun Kim, Dasom Mun, Hyelim Park, Nuri Yun, Boyoung Joung
Pages: 2319-2328
Published online on: 28 March 2019

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Article Open Access

Upregulation of interleukin-8 and activin A induces osteoclastogenesis in ameloblastoma

Xin Liu, Zhifeng Chen, Tianjun Lan, Peisheng Liang, Qian Tao
Pages: 2329-2340
Published online on: 23 April 2019

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Article Open Access

LPS‑induced upregulation of the TLR4 signaling pathway inhibits osteogenic differentiation of human periodontal ligament stem cells under inflammatory conditions

Bohan Yu, Qin Li, Min Zhou
Pages: 2341-2351
Published online on: 12 April 2019

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Article Open Access

Epigenetically altered miR‑193a‑3p promotes HER2 positive breast cancer aggressiveness by targeting GRB7

Yiyin Tang, Siyuan Yang, Maohua Wang, Dequan Liu, Yang Liu, Ying Zhang, Qian Zhang
Pages: 2352-2360
Published online on: 15 April 2019

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Article Open Access

Identification of lncRNA and mRNA expression profiles in rat spinal cords at various time‑points following cardiac ischemia/reperfusion

Qian Wang, Zhi‑Xiao Li, Yu‑Juan Li, Zhi‑Gang He, Ying‑Le Chen, Mao‑Hui Feng, Shun‑Yuan Li, Duo‑Zhi Wu, Hong‑Bing Xiang
Pages: 2361-2375
Published online on: 29 March 2019

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Article Open Access

FasL on decidual macrophages mediates trophoblast apoptosis: A potential cause of recurrent miscarriage

Jinli Ding, Tailang Yin, Nana Yan, Yanxiang Cheng, Jing Yang
Pages: 2376-2386
Published online on: 26 March 2019

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Article Open Access

MicroRNA‑576‑3p inhibits the migration and proangiogenic abilities of hypoxia‑treated glioma cells through hypoxia‑inducible factor‑1α

Qing Hu, Feng Liu, Tengfeng Yan, Miaojing Wu, Minhua Ye, Guangyao Shi, Shigang Lv, Xingen Zhu
Pages: 2387-2397
Published online on: 04 April 2019

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Article Open Access

Oxaliplatin aggravates hepatic oxidative stress, inflammation and fibrosis in a non‑alcoholic fatty liver disease mouse model

Yulei Lu, Youzhi Lin, Xiaoqing Huang, Shengming Wu, Jian Wei, Chun Yang
Pages: 2398-2408
Published online on: 01 April 2019

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Article Open Access

Development of finasteride polymer microspheres for systemic application in androgenic alopecia

Ju Hee Kim, Jungtae Na, Dong‑Ho Bak, Byung Chul Lee, Esther Lee, Mi Ji Choi, Choong Ho Ryu, Sangno Lee, Seog‑Kyun Mun, Byung Cheol Park, Beom Joon Kim, Hyun‑Shik Lee
Pages: 2409-2419
Published online on: 28 March 2019

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Article Open Access

Global brain ischemia in rats is associated with mitochondrial release and downregulation of Mfn2 in the cerebral cortex, but not the hippocampus

Katarina Klacanova, Maria Kovalska, Maria Chomova, Ivana Pilchova, Zuzana Tatarkova, Peter Kaplan, Peter Racay
Pages: 2420-2428
Published online on: 16 April 2019

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Article Open Access

Identification of key transcription factors associated with cerebral ischemia‑reperfusion injury based on gene‑set enrichment analysis

Ying‑Ying Zhang, Kai Wang, Yun‑E Liu, Wei Wang, Ao‑Fei Liu, Ji Zhou, Chen Li, Yi‑Qun Zhang, Ai‑Ping Zhang, Jin Lv, Wei‑Jian Jiang
Pages: 2429-2439
Published online on: 09 April 2019

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Article Open Access

Role of the thioredoxin interacting protein in diabetic nephropathy and the mechanism of regulating NOD‑like receptor protein 3 inflammatory corpuscle

Chunmei Gu, Shumei Liu, Hongyue Wang, Haichuan Dou
Pages: 2440-2450
Published online on: 11 April 2019

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Article Open Access

Lycopene restores the effect of ischemic postconditioning on myocardial ischemia‑reperfusion injury in hypercholesterolemic rats

Lian Duan, Changbin Liang, Xuying Li, Zijun Huang, Shuang Liu, Nan Wu, Dalin Jia
Pages: 2451-2461
Published online on: 15 April 2019

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Article

Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity

Jee Won Hwang, Yun‑Seong So, Gyu‑Un Bae, Su‑Nam Kim, Yong Kee Kim
Pages: 2462-2470
Published online on: 27 March 2019

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Article

Musashi 1-positive cells derived from mouse embryonic stem cells treated with LY294002 are prone to differentiate into intestinal epithelial-like tissues

Shao‑Yang Lan, Mei‑Ao Tan, Shu‑Hui Yang, Jia‑Zhong Cai, Bin Chen, Pei‑Wu Li, Dong‑Mei Fan, Feng‑Bin Liu, Tao Yu, Qi‑Kui Chen
Pages: 2471-2480
Published online on: 26 March 2019

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Article

Spleen tyrosine kinase‑induced JNK‑dependent NLRP3 activation is involved in diabetic cardiomyopathy

Shengyu Li, Ruiqing Liu, Meiting Xue, Yingchun Qiao, Yufeng Chen, Guangfeng Long, Xixi Tian, Yahui Hu, Pengfei Zhou, Xiaohui Dong, Zhi Qi, Yujie Cui, Yanna Shen
Pages: 2481-2490
Published online on: 27 March 2019

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Article

Brca1 is involved in tolerance to adefovir dipivoxil‑induced DNA damage

Hao Liu, Yang Wu, Fang He, Ziyuan Cheng, Zilu Zhao, Cuifang Xiang, Xiaoyu Feng, Xin Bai, Shunichi Takeda, Xiaohua Wu, Yong Qing
Pages: 2491-2498
Published online on: 11 April 2019

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Article

Protective effects of tyndallized Lactobacillus acidophilus IDCC 3302 against UVB‑induced photodamage to epidermal keratinocytes cells

A‑Rang Im, Byeonghun Lee, Dae‑Jung Kang, Sungwook Chae
Pages: 2499-2506
Published online on: 10 April 2019

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Article

Soluble receptor for advanced glycation end-products enhanced the production of IFN-γ through the NF-κB pathway in macrophages recruited by ischemia/reperfusion

Xiuling Zhang, Xianxian Cao, Mengqiu Dang, Hongxia Wang, Buxing Chen, Fenghe Du, Huihua Li, Xiangjun Zeng, Caixia Guo
Pages: 2507-2515
Published online on: 29 March 2019

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Article

Afzelin suppresses proinflammatory responses in particulate matter-exposed human keratinocytes

Ju Hee Kim, Minjeong Kim, Jae Min Kim, Mi‑Kyung Lee, Seong Jun Seo, Kui Young Park
Pages: 2516-2522
Published online on: 11 April 2019

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Article

DHA protects PC12 cells against oxidative stress and apoptotic signals through the activation of the NFE2L2/HO-1 axis

Maria Elisabetta Clementi, Giacomo Lazzarino, Beatrice Sampaolese, Anna Brancato, Giuseppe Tringali
Pages: 2523-2531
Published online on: 23 April 2019

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Correction Open Access

[Erratum] MicroRNA-101 inhibits autophagy to alleviate liver ischemia/reperfusion injury via regulating the mTOR signaling pathway

Hu Song, Chenyang Du, Xingxing Wang, Jianjun Zhang, Zhongyang Shen
Pages: 2532-2532
Published online on: 09 April 2019

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Correction Open Access

[Corrigendum] NLRP3 inflammasome is responsible for Hantavirus inducing interleukin‑1β in THP‑1 cells

Wei Ye, Yingfeng Lei, Mengmeng Yu, Yongni Xu, Mengyuan Cao, Lan Yu, Liang Zhang, Puyuan Li, Wentao Bai, Zhikai Xu, Fanglin Zhang
Pages: 2533-2533
Published online on: 01 April 2019

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Journal Cover
September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Mechanisms and therapeutic strategies of pyroptosis in sepsis‑induced acute lung injury (Review)

Wenyu Wu, Nuoran Li, Guoshu Deng, Suyi Yang, Ruifeng Zeng, Rui Chen, Jun Li
Article Number: 264
Published online on: 22 July 2026

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Review Open Access

Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review)

Fuchao Chen, Jingyue Sun, Xiao Wang
Article Number: 263
Published online on: 21 July 2026

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Expression of Concern Open Access

[Expression of Concern] Exposure to acoustic stimuli promotes the development and differentiation of neural stem cells from the cochlear nuclei through the clusterin pathway

Tao Xue, Li Wei, Ding-Jun Zha, Li Qiao, Lian-Jun Lu, Fu-Quan Chen, Jian-Hua Qiu
Article Number: 262
Published online on: 20 July 2026

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Article Open Access

Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response

Wan-Da Tang, Lan-Juan Zhao
Article Number: 261
Published online on: 16 July 2026

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Article Open Access

circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching

Yujie Wang, Xiaoting Li, Meirong Wang, Nailiang Zhai, Mengqi Jiang, Bo Liu, Changjun Lv, Songzi Zhang, Xiaodong Song, Jinjin Zhang
Article Number: 260
Published online on: 15 July 2026

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Review Open Access

Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review)

Yanpeng Tian, Yu Zhang, Liling Wang, Zhongkang Li, Xiaotong Xu, Shouze Liu, Shenyu Yang, Xiangyang Ren, Menghan Xu, Xingzi Chang, Xianghua Huang, Qian Zhao, Ruixia Guo
Article Number: 259
Published online on: 15 July 2026

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Review Open Access

Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review)

Shuhong Zhang, Ge Yang
Article Number: 258
Published online on: 14 July 2026

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Review Open Access

Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 257
Published online on: 14 July 2026

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Review Open Access

Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review)

Tianhao Xie, Kang Hu, Shu Pan, Xin Tong, Haitong Huang, Hao Ding, Jun Zhao
Article Number: 256
Published online on: 13 July 2026

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Article Open Access

Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation

Mingkun Xu, Linhang Fu, Yulong Zhang, Xiuli Guo, Han Wu, Sijing Gao, Fei Xiao, Li Xu
Article Number: 255
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells

Donghong Lin, Zhaolei Cui, Lingying Kong, Feng Cheng, Jianping Xu, Fenghua Lan
Article Number: 254
Published online on: 13 July 2026

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Article Open Access

Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

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Review Open Access

Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

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Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

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Article Open Access

Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

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Review Open Access

Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

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Review Open Access

GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

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Review Open Access

FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

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Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

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Article Open Access

Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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Review Open Access

TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Review Open Access

Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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Article Open Access

FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Review Open Access

Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Review Open Access

Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Review Open Access

Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Review Open Access

Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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Review Open Access

ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Review Open Access

Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Review Open Access

Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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October-2026 Volume 58 Issue 4

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Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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circRNA_013145‑miR‑185‑5p‑RhoA axis: A novel mechanism in the pathophysiology of diabetes‑induced erectile dysfunction

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Article Number: 267
Published online on: 24 July 2026

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Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review)

Jinyi Hou, Yaotan Li, Shijia Lin, Qingqing Liu, Huijuan Zheng, Weijing Liu, Yaoxian Wang, Liang Peng, Zhen Wang
Article Number: 266
Published online on: 23 July 2026

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Review Open Access

Effects of cuproptosis and its application in inflammatory bowel disease (Review)

Li Chen, Francis Atim Akanyibah, Jing Guan, Bing Pei, Bo Wang, Fei Mao
Article Number: 265
Published online on: 23 July 2026

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