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Article

The profibrotic effect of downregulated Na,K‑ATPase β1 subunit in alveolar epithelial cells during lung fibrosis

  • Authors:
    • Biyun Li
    • Xiaoxi Huang
    • Xuefeng Xu
    • Wen Ning
    • Huaping Dai
    • Chen Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary and Critical Care Medicine, China‑Japan Friendship School of Clinical Medicine, Peking University, Beijing 100029, P.R. China, Department of Medical Research, Beijing Chao‑Yang Hospital, Beijing 100020, P.R. China, Department of Surgical Intensive Care Unit, Beijing An‑Zhen Hospital, Capital Medical University, Beijing 100029, P.R. China, Department of Genetics and Cellular Biology, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China
  • Pages: 273-280
    |
    Published online on: May 16, 2019
       https://doi.org/10.3892/ijmm.2019.4201
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Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by progressive lung scarring and excessive extracellular matrix depositon. When stimulated, alveolar epithelial cells (AECs) are aberrantly activated, the expression of profibrotic molecules is enhanced, and lung fibrosis is promoted, but the mechanism for this is unclear. It has been reported that a downregulation of the Na,K‑ATPase β1 subunit in renal epithelial cells is involved in renal fibrosis development, but the role of this protein in lung fibrosis remains unknown. In the present study, the expression of the Na,K‑ATPase β1 subunit was revealed to be markedly decreased in AECs of patients with IPF and a bleomycin‑induced pulmonary fibrosis mouse model. Treatment with transforming growth factor β‑1 led to significantly downregulation of the Na,K‑ATPase β1 subunit in lung adenocarcioma A549 cells. Furthermore, the knockdown of the Na,K‑ATPase β1 subunit in A549 cells resulted in the upregulation of profibrotic molecules, activation of the neurogenic locus notch homolog protein 1 and extracellular signal‑regulated kinase 1/2 signaling pathways and induction of endoplasmic reticulum stress. These findings reveal that the downregulation of the Na,K‑ATPase β1 subunit enhances the expression of profibrotic molecules in AECs and may contribute to IPF pathogenesis.
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View References

1 

Coultas DB, Zumwalt RE, Black WC and Sobonya RE: The epidemiology of interstitial lung diseases. Am J Respir Crit Care Med. 150:967–972. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Mannino DM, Etzel RA and Parrish RG: Pulmonary fibrosis deaths in the United States, 1979-1991. An analysis of multiple-cause mortality data. Am J Respir Crit Care Med. 153:1548–1552. 1996. View Article : Google Scholar : PubMed/NCBI

3 

Noble PW: Idiopathic pulmonary fibrosis: Natural history and prognosis. Clin Chest Med. 27(1 Suppl 1): S11–S16. v2006. View Article : Google Scholar : PubMed/NCBI

4 

Raghu G, Weycker D, Edelsberg J, Bradford WZ and Oster G: Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 174:810–816. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, et al: An official ATS/ERS/JRS/ALAT statement: Idiopathic pulmonary fibrosis: Evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 183:788–824. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Cai M, Zhu M, Ban C, Su J, Ye Q, Liu Y, Zhao W, Wang C and Dai H: Clinical features and outcomes of 210 patients with idiopathic pulmonary fibrosis. Chin Med J (Engl). 127:1868–1873. 2014.

7 

Selman M, King TE and Pardo A; American Thoracic Society; European Respiratory Society; American College of Chest Physicians: Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med. 134:136–151. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Thannickal VJ, Toews GB, White ES, Lynch JP III and Martinez FJ: Mechanisms of pulmonary fibrosis. Annu Rev Med. 55:395–417. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Zoz DF, Lawson WE and Blackwell TS: Idiopathic pulmonary fibrosis: A disorder of epithelial cell dysfunction. Am J Med Sci. 341:435–438. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Selman M and Pardo A: Role of epithelial cells in idiopathic pulmonary fibrosis: From innocent targets to serial killers. Proc Am Thorac Soc. 3:364–372. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Baumgartner KB, Samet JM, Stidley CA, Colby TV and Waldron JA: Cigarette smoking: A risk factor for idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 155:242–248. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Taskar VS and Coultas DB: Is idiopathic pulmonary fibrosis an environmental disease? Proc Am Thorac Soc. 3:293–298. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Raghu G, Freudenberger TD, Yang S, Curtis JR, Spada C, Hayes J, Sillery JK, Pope CE II and Pellegrini CA: High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis. Eur Respir J. 27:136–142. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Hubbard R, Lewis S, Richards K, Johnston I and Britton J: Occupational exposure to metal or wood dust and aetiology of cryptogenic fibrosing alveolitis. Lancet. 347:284–289. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Kelly BG, Lok SS, Hasleton PS, Egan JJ and Stewart JP: A rearranged form of Epstein-Barr virus DNA is associated with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 166:510–513. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, et al: Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 301:L71–L78. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Rock JR, Barkauskas CE, Cronce MJ, Xue Y, Harris JR, Liang J, Noble PW and Hogan BL: Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci USA. 108:E1475–E1483. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D and Chapman HA: Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci USA. 103:13180–13185. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Jiang C, Liu G, Luckhardt T, Antony V, Zhou Y, Carter AB, Thannickal VJ and Liu RM: Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease. Aging Cell. 16:1114–1124. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Korfei M, Ruppert C, Mahavadi P, Henneke I, Markart P, Koch M, Lang G, Fink L, Bohle RM, Seeger W, et al: Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 178:838–846. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Im J, Kim K, Hergert P and Nho RS: Idiopathic pulmonary fibrosis fibroblasts become resistant to Fas ligand-dependent apoptosis via the alteration of decoy receptor 3. J Pathol. 240:25–37. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Araya J, Kojima J, Takasaka N, Ito S, Fujii S, Hara H, Yanagisawa H, Kobayashi K, Tsurushige C, Kawaishi M, et al: Insufficient autophagy in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 304:L56–L69. 2013. View Article : Google Scholar

23 

Geng J, Huang X, Li Y, Xu X, Li S, Jiang D, Liang J, Wang C and Dai H: Down-regulation of USP13 mediates phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis. Respir Res. 16:1242015. View Article : Google Scholar : PubMed/NCBI

24 

Nie Y, Sun L, Wu Y, Yang Y, Wang J, He H, Hu Y, Chang Y, Liang Q, Zhu J, et al: AKT2 regulates pulmonary inflammation and fibrosis via modulating macrophage activation. J Immunol. 198:4470–4480. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Peljto AL, Zhang Y, Fingerlin TE, Ma SF, Garcia JG, Richards TJ, Silveira LJ, Lindell KO, Steele MP, Loyd JE, et al: Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis. JAMA. 309:2232–2239. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Rajasekaran SA, Huynh TP, Wolle DG, Espineda CE, Inge LJ, Skay A, Lassman C, Nicholas SB, Harper JF, Reeves AE, et al: Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis. Mol Cancer Ther. 9:1515–1524. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Mony S, Lee SJ, Harper JF, Barwe SP and Langhans SA: Regulation of Na,K-ATPase beta1-subunit in TGF-β2-mediated epithelial-to-mesenchymal transition in human retinal pigmented epithelial cells. Exp Eye Res. 115:113–122. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Pierre SV and Xie Z: The Na,K-ATPase receptor complex: Its organization and membership. Cell Biochem Biophys. 46:303–316. 2006. View Article : Google Scholar

29 

Xie Z and Askari A: Na(+)/K(+)-ATPase as a signal transducer. Eur J Biochem. 269:2434–2439. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Barwe SP, Anilkumar G, Moon SY, Zheng Y, Whitelegge JP, Rajasekaran SA and Rajasekaran AK: Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility. Mol Biol Cell. 16:1082–1094. 2005. View Article : Google Scholar :

31 

Dong Y, Geng Y, Li L, Li X, Yan X, Fang Y, Zheng X, Dong S, Liu X, Yang X, et al: Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice. J Exp Med. 212:235–252. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Yogo Y, Fujishima S, Inoue T, Saito F, Shiomi T, Yamaguchi K and Ishizaka A: Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis. Respir Res. 10:802009. View Article : Google Scholar : PubMed/NCBI

33 

Wang YC, Liu JS, Tang HK, Nie J, Zhu JX, Wen LL and Guo QL: miR-221 targets HMGA2 to inhibit bleomycin-induced pulmonary fibrosis by regulating TGFβ1/Smad3-induced EMT. Int J Mol Med. 38:1208–1216. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Zheng Q, Tong M, Ou B, Liu C, Hu C and Yang Y: Isorhamnetin protects against bleomycin-induced pulmonary fibrosis by inhibiting endoplasmic reticulum stress and epithelial-mesenchymal transition. Int J Mol Med. 43:117–126. 2019.

35 

Xu X, Wan X, Geng J, Li F, Yang T and Dai H: Rapamycin regulates connective tissue growth factor expression of lung epithelial cells via phosphoinositide 3-kinase. Exp Biol Med (Maywood). 238:1082–1094. 2013. View Article : Google Scholar

36 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

37 

Tokhtaeva E, Sachs G and Vagin O: Assembly with the Na, K-ATPase alpha(1) subunit is required for export of beta(1) and beta(2) subunits from the endoplasmic reticulum. Biochemistry. 48:11421–11431. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Lemas MV, Hamrick M, Takeyasu K and Fambrough DM: 26 amino acids of an extracellular domain of the Na,K-ATPase alpha-subunit are sufficient for assembly with the Na,K-ATPase beta-subunit. J Biol Chem. 269:8255–8259. 1994.PubMed/NCBI

39 

Zatyka M, Ricketts C, da Silva Xavier G, Minton J, Fenton S, Hofmann-Thiel S, Rutter GA and Barrett TG: Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress. Hum Mol Genet. 17:190–200. 2008. View Article : Google Scholar

40 

Lawson WE, Crossno PF, Polosukhin VV, Roldan J, Cheng DS, Lane KB, Blackwell TR, Xu C, Markin C, Ware LB, et al: Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: Association with altered surfactant protein processing and herpesvirus infection. Am J Physiol Lung Cell Mol Physiol. 294:L1119–L1126. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Mulugeta S, Nguyen V, Russo SJ, Muniswamy M and Beers MF: A surfactant protein C precursor protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase 3 activation. Am J Respir Cell Mol Biol. 32:521–530. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Maguire JA, Mulugeta S and Beers MF: Endoplasmic reticulum stress induced by surfactant protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells. Am J Respir Cell Mol Biol. 44:404–414. 2011. View Article : Google Scholar :

43 

Ulianich L, Garbi C, Treglia AS, Punzi D, Miele C, Raciti GA, Beguinot F, Consiglio E and Di Jeso B: ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells. J Cell Sci. 121:477–486. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Morbini P, Inghilleri S, Campo I, Oggionni T, Zorzetto M and Luisetti M: Incomplete expression of epithelial-mesenchymal transition markers in idiopathic pulmonary fibrosis. Pathol Res Pract. 207:559–567. 2011. View Article : Google Scholar : PubMed/NCBI

45 

La J, Reed E, Chan L, Smolyaninova LV, Akomova OA, Mutlu GM, Orlov SN and Dulin NO: Downregulation of TGF-β Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase. PLoS One. 11:e01683632016. View Article : Google Scholar

46 

Li B, Huang X, Liu Z, Xu X, Xiao H, Zhang X, Dai H and Wang C: Ouabain ameliorates bleomycin induced pulmonary fibrosis by inhibiting proliferation and promoting apoptosis of lung fibroblasts. Am J Transl Res. 10:2967–2974. 2018.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li B, Huang X, Xu X, Ning W, Dai H and Wang C: The profibrotic effect of downregulated Na,K‑ATPase β1 subunit in alveolar epithelial cells during lung fibrosis. Int J Mol Med 44: 273-280, 2019.
APA
Li, B., Huang, X., Xu, X., Ning, W., Dai, H., & Wang, C. (2019). The profibrotic effect of downregulated Na,K‑ATPase β1 subunit in alveolar epithelial cells during lung fibrosis. International Journal of Molecular Medicine, 44, 273-280. https://doi.org/10.3892/ijmm.2019.4201
MLA
Li, B., Huang, X., Xu, X., Ning, W., Dai, H., Wang, C."The profibrotic effect of downregulated Na,K‑ATPase β1 subunit in alveolar epithelial cells during lung fibrosis". International Journal of Molecular Medicine 44.1 (2019): 273-280.
Chicago
Li, B., Huang, X., Xu, X., Ning, W., Dai, H., Wang, C."The profibrotic effect of downregulated Na,K‑ATPase β1 subunit in alveolar epithelial cells during lung fibrosis". International Journal of Molecular Medicine 44, no. 1 (2019): 273-280. https://doi.org/10.3892/ijmm.2019.4201
Copy and paste a formatted citation
x
Spandidos Publications style
Li B, Huang X, Xu X, Ning W, Dai H and Wang C: The profibrotic effect of downregulated Na,K‑ATPase β1 subunit in alveolar epithelial cells during lung fibrosis. Int J Mol Med 44: 273-280, 2019.
APA
Li, B., Huang, X., Xu, X., Ning, W., Dai, H., & Wang, C. (2019). The profibrotic effect of downregulated Na,K‑ATPase β1 subunit in alveolar epithelial cells during lung fibrosis. International Journal of Molecular Medicine, 44, 273-280. https://doi.org/10.3892/ijmm.2019.4201
MLA
Li, B., Huang, X., Xu, X., Ning, W., Dai, H., Wang, C."The profibrotic effect of downregulated Na,K‑ATPase β1 subunit in alveolar epithelial cells during lung fibrosis". International Journal of Molecular Medicine 44.1 (2019): 273-280.
Chicago
Li, B., Huang, X., Xu, X., Ning, W., Dai, H., Wang, C."The profibrotic effect of downregulated Na,K‑ATPase β1 subunit in alveolar epithelial cells during lung fibrosis". International Journal of Molecular Medicine 44, no. 1 (2019): 273-280. https://doi.org/10.3892/ijmm.2019.4201
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