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International Journal of Molecular Medicine
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2019 Volume 44 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Mitochondrial electron transport chain, ROS generation and uncoupling (Review)

Ru‑Zhou Zhao, Shuai Jiang, Lin Zhang, Zhi‑Bin Yu
Pages: 3-15
Published online on: 08 May 2019

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Article Open Access

Predictive power of the Triticum root elongation test for the assessment of novel anti‑proliferative therapies

Octavian Tudorel Olaru, Anca Zanfirescu, George Mihai Nitulescu, Georgiana Nitulescu, Cristina Elena Dinu‑Pirvu, Valentina Anuta, Aristidis Tsatsakis, Demetrios A. Spandidos, Denisa Margina, Oana Cristina Seremet
Pages: 16-24
Published online on: 10 May 2019

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Article Open Access

Nur77 promotes cigarette smoke‑induced autophagic cell death by increasing the dissociation of Bcl2 from Beclin-1

Huiping Qin, Feng Gao, Yanni Wang, Bin Huang, Ling Peng, Biwen Mo, Changming Wang
Pages: 25-36
Published online on: 08 May 2019

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Article Open Access

Modulation of proliferation and differentiation of gingiva‑derived mesenchymal stem cells by concentrated growth factors: Potential implications in tissue engineering for dental regeneration and repair

Xiao Chen, Yuhe Chen, Yali Hou, Peng Song, Minyue Zhou, Minhai Nie, Xuqian Liu
Pages: 37-46
Published online on: 24 April 2019

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Article Open Access

miRNA-302e attenuates inflammation in infantile pneumonia though the RelA/BRD4/NF-κB signaling pathway

Shaoxia Li, Wenwen Cui, Qing Song, Yufei Zhou, Jingtao Li
Pages: 47-56
Published online on: 10 May 2019

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Article Open Access

The efficacy of cisplatin on nasopharyngeal carcinoma cells may be increased via the downregulation of fibroblast growth factor receptor 2

Li Pu, Lizhong Su, Xixun Kang
Pages: 57-66
Published online on: 10 May 2019

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Article Open Access

Lysophosphatidic acid induces the migration and invasion of SGC-7901 gastric cancer cells through the LPA2 and Notch signaling pathways

Zhiheng Ren, Chenli Zhang, Linna Ma, Xiao Zhang, Shuxia Shi, Deng Tang, Jinyu Xu, Yan Hu, Binsheng Wang, Fangfang Zhang, Xu Zhang, Haixue Zheng
Pages: 67-78
Published online on: 08 May 2019

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Article Open Access

EGFR monoclonal antibody panitumumab inhibits chronic proliferative cholangitis by downregulating EGFR

San‑Hu Liu, Xue‑Fang Chen, Zhi‑Bin Xie, Jie Zhou
Pages: 79-88
Published online on: 09 May 2019

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Article Open Access

Sirt1 inhibits HG-induced endothelial injury: Role of Mff-based mitochondrial fission and F‑actin homeostasis-mediated cellular migration Retraction in /10.3892/ijmm.2024.5390

Ruijie Qin, Lina Zhang, Dong Lin, Fei Xiao, Lixin Guo
Pages: 89-102
Published online on: 08 May 2019

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Article Open Access

Downregulation of CKS1B restrains the proliferation, migration, invasion and angiogenesis of retinoblastoma cells through the MEK/ERK signaling pathway Retraction in /10.3892/ijmm.2024.5382

Zhou Zeng, Zhao‑Lin Gao, Zhi‑Pei Zhang, Hai‑Bo Jiang, Chang‑Quan Yang, Jie Yang, Xiao‑Bo Xia
Pages: 103-114
Published online on: 08 May 2019

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Article Open Access

Knockdown of MSI1 inhibits the proliferation of human oral squamous cell carcinoma by inactivating STAT3 signaling

Chen‑Fei Wang, Hong‑Chuang Zhang, Xin‑Mei Feng, Xiao‑Meng Song, Yu‑Nong Wu
Pages: 115-124
Published online on: 06 May 2019

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Article Open Access

Aminosalicylic acid reduces ER stress and Schwann cell death induced by MPZ mutations

Eun Hyuk Chang, Won Min Mo, Hyun Myung Doo, Ji‑Su Lee, Hwan Tae Park, Byung‑Ok Choi, Young Bin Hong
Pages: 125-134
Published online on: 02 May 2019

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Article Open Access

Low‑intensity ultrasound enhances the chemosensitivity of hepatocellular carcinoma cells to cisplatin via altering the miR‑34a/c‑Met axis

Panpan Li, Juanjuan Zhang, Fuchun Li, Yanyan Yu, Yinghong Chen
Pages: 135-144
Published online on: 21 May 2019

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Article Open Access

Potential interaction of cadmium chloride with pancreatic mitochondria: Implications for pancreatic cancer

David R. Wallace, Demetrios A. Spandidos, Aristidis Tsatsakis, Amie Schweitzer, Vladimir Djordjevic, Aleksandra Buha Djordjevic
Pages: 145-156
Published online on: 21 May 2019

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Article Open Access

Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7 Corrigendum in /10.3892/ijmm.2024.5472

Xiaojing Fan, Kexiang Yan, Qinqin Meng, Rui Sun, Xinrong Yang, Dingfen Yuan, Fulun Li, Hui Deng
Pages: 157-171
Published online on: 24 April 2019

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Article Open Access

NLRP3 inflammasome and lipid metabolism analysis based on UPLC-Q-TOF-MS in gouty nephropathy

Yan‑Zi Zhang, Xiao‑Lu Sui, Yun‑Peng Xu, Feng‑Juan Gu, Ai‑Sha Zhang, Ji‑Hong Chen
Pages: 172-184
Published online on: 30 April 2019

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Article Open Access

MicroRNA‑199a‑5p suppresses migration and invasion in oral squamous cell carcinoma through inhibiting the EMT‑related transcription factor SOX4

Dongyi Wei, Weixin Wang, Baohong Shen, Yanjun Zhou, Xiaodong Yang, Guangjian Lu, Jianbin Yang, Yuebao Shao
Pages: 185-195
Published online on: 25 April 2019

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Article Open Access

lncRNA ZEB1-AS1 promotes migration and metastasis of bladder cancer cells by post-transcriptional activation of ZEB1

Xin Zhao, Dongwen Wang, Yongxue Ding, Jingmin Zhou, Guanghua Liu, Zhigang Ji
Pages: 196-206
Published online on: 08 May 2019

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Article Open Access

Proteomics analysis of fetal growth restriction and taurine‑treated fetal growth restriction rat brain tissue by 2D DIGE and MALDI‑TOF/TOF MS analysis

Haifeng Liu, Yan Wang, Jing Liu, Wei Fu
Pages: 207-217
Published online on: 07 May 2019

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Article Open Access

Association of nutraceutical supplements with longer telomere length

Dimitris Tsoukalas, Persefoni Fragkiadaki, Anca Oana Docea, Athanasios K. Alegakis, Evangelia Sarandi, Elena Vakonaki, Eralda Salataj, Elisavet Kouvidi, Dragana Nikitovic, Leda Kovatsi, Demetrios A. Spandidos, Aristidis Tsatsakis, Daniela Calina
Pages: 218-226
Published online on: 10 May 2019

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Article Open Access

NMDA receptor activation inhibits the protective effect of BM‑MSCs on bleomycin‑induced lung epithelial cell damage by inhibiting ERK signaling and the paracrine factor HGF

Xiangping Peng, Xiaohong Li, Chen Li, Shaojie Yue, Yanhong Huang, Pu Huang, Haipeng Cheng, Yan Zhou, Yiting Tang, Wei Liu, Dandan Feng, Ziqiang Luo
Pages: 227-239
Published online on: 13 May 2019

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Article Open Access

miR‑490‑5p regulates the proliferation, migration, invasion and epithelial‑mesenchymal transition of pharyngolaryngeal cancer cells by targeting mitogen‑activated protein kinase kinasekinase 9 Corrigendum in /10.3892/ijmm.2022.5129

Arikin Abdeyrim, Xiuqin Cheng, Meng Lian, Yuanyouan Tan
Pages: 240-252
Published online on: 13 May 2019

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Article Open Access

Glycyrrhizin protects human melanocytes from H2O2‑induced oxidative damage via the Nrf2‑dependent induction of HO‑1

Kuanhou Mou, Wenjie Pan, Dan Han, Xin Wen, Fang Cao, Yi Miao, Pan Li
Pages: 253-261
Published online on: 16 May 2019

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Article

In vitro treatment of congenital disorder of glycosylation type Ia using PLGA nanoparticles loaded with GDP‑Man

Barbara Bortot, Eleonora De Martino, Alessandra Tesser, Blendi Ura, Barbara Ruozi, Michelangelo Aloisio, Stefania Biffi, Riccardo Addobbati, Giovanni Tosi, Diego Dolcetta, Giovanni Maria Severini
Pages: 262-272
Published online on: 16 May 2019

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Article

The profibrotic effect of downregulated Na,K‑ATPase β1 subunit in alveolar epithelial cells during lung fibrosis

Biyun Li, Xiaoxi Huang, Xuefeng Xu, Wen Ning, Huaping Dai, Chen Wang
Pages: 273-280
Published online on: 16 May 2019

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Article

p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro

Guo‑Qian He, Guang‑Yu Liu, Wen‑Ming Xu, Hui‑Juan Liao, Xing‑Hui Liu, Guo‑Lin He
Pages: 281-290
Published online on: 25 April 2019

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Article

Triptolide exerts an anti-tumor effect on non‑small cell lung cancer cells by inhibiting activation of the IL‑6/STAT3 axis

Ying Huang, Zhe Chen, Yu Wang, Xin Ba, Yao Huang, Pan Shen, Hui Wang, Shenghao Tu
Pages: 291-300
Published online on: 14 May 2019

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Article

Leptin enhances glycolysis via OPA1-mediated mitochondrial fusion to promote mesenchymal stem cell survival

Fan Yang, Bing Li, Yongyao Yang, Minhua Huang, Xinghui Liu, Yang Zhang, Hui Liu, Lan Zhang, Yujia Pan, Shui Tian, Yueting Wu, Lijuan Wang, Long Yang
Pages: 301-312
Published online on: 09 May 2019

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Article

Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model

Jingfei Chen, Zhimin Long, Yanzhen Li, Min Luo, Shifang Luo, Guiqiong He
Pages: 313-323
Published online on: 15 May 2019

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Article

Total flavone of Abelmoschus manihot ameliorates Crohn's disease by regulating the NF‑κB and MAPK signaling pathways

Dan Zhang, Ping Zhu, Yue Liu, Yi Shu, Jin‑Yong Zhou, Feng Jiang, Tuo Chen, Bo‑Lin Yang, Yu‑Gen Chen
Pages: 324-334
Published online on: 06 May 2019

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Article

Ruthenium complex, TQ‑5, protects against LPS‑induced macrophage inflammation and acute liver injury in mice via downregulating NF‑κB pathways

Shaw‑Min Hou, Chih‑Hsuan Hsia, Marappan Velusamy, Thanasekaran Jayakumar, Chih‑Wei Hsia, Chao‑Chien Chang, Kuan‑Hung Lin, Yung‑Chang Lu
Pages: 335-345
Published online on: 03 May 2019

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Article

MicroRNA-625 inhibits the progression of non‑small cell lung cancer by directly targeting HOXB5 and deactivating the Wnt/β-catenin pathway Retraction in /10.3892/ijmm.2022.5134

Xiaoxia Tan, Lihua Jiang, Xia Wu, Wen Feng, Qingfang Lin
Pages: 346-356
Published online on: 20 May 2019

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Correction Open Access

[Corrigendum] Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation

Kou‑Gi Shyu, Marappan Velusamy, Chih‑Wei Hsia, Chih‑Hao Yang, Chih‑Hsuan Hsia, Duen‑Suey Chou, Thanasekaran Jayakumar, Joen‑Rong Sheu, Jiun‑Yi Li
Pages: 357-357
Published online on: 30 April 2019

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Correction Open Access

[Corrigendum] Human peripheral blood‑derived exosomes for microRNA delivery

Ji‑Young Kang, Hyewon Park, Hyoeun Kim, Dasom Mun, Hyelim Park, Nuri Yun, Boyoung Joung
Pages: 358-358
Published online on: 20 May 2019

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Review Open Access

Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Article Open Access

Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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Review Open Access

A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Review Open Access

Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Article Open Access

Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Review Open Access

Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Review Open Access

Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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Article Open Access

STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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Article Open Access

HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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Article Open Access

FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Review Open Access

Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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Review Open Access

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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