Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
September-2019 Volume 44 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2019 Volume 44 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Comparison of the therapeutic effects of adipose‑derived and bone marrow mesenchymal stem cells on erectile dysfunction in diabetic rats

  • Authors:
    • Sansan Chen
    • Jianbin Zhu
    • Mingzhu Wang
    • Yanting Huang
    • Zhuolin Qiu
    • Jingjing Li
    • Xinglu Chen
    • Huiying Chen
    • Mingyu Xu
    • Jun Liu
    • Miaoqin She
    • Hongwei Li
    • Xiaorong Yang
    • Yi Wang
    • Xiangsheng Cai
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China, Technology Center, Guangdong Vitalife Bio‑Tech Co., Ltd., Foshan, Guangdong 528200, P.R. China, Reproductive Center of Obstetrics and Gynecology, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Clinical Laboratory, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China, Institute of Biotherapy, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong 510091, P.R. China, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510660, P.R. China, Central Laboratory, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1006-1014
    |
    Published online on: June 24, 2019
       https://doi.org/10.3892/ijmm.2019.4254
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to compare the effects of adipose‑derived mesenchymal stem cell (ADSC) and bone marrow mesenchymal stem cell (BMSC) transplantation into the corpora cavernosa of diabetic rats with erectile function. ADSCs and BMSCs were isolated and identified by flow cytometry. Rats with streptozocin‑induced diabetes were screened using apomorphine to obtain a rat model of diabetic erectile dysfunction, followed by transplantation of ADSCs and BMSCs into the corpora cavernosa. Two weeks later, the rats were again injected with apomorphine, the intracavernous pressure (ICP) and mean arterial pressure (MAP) of the penile tissue were measured, and the corpus cavernosum tissues were harvested. Angiogenic endothelial nitric oxide synthase (eNOS) expression was detected by western blotting and immunofluorescence analysis. The blood vessels in the corpus cavernosum were observed following hematoxylin and eosin (H&E) staining, and the expression of collagen was detected by Sirius Red staining. The cellular ultrastructure was examined by transmission electron microscopy. Intracavernous injection of ADSCs significantly increased ICP and ICP/MAP. Western blotting and immunofluorescence results revealed that ADSC treatment improved the expression of eNOS in the penile tissue of diabetic rats. The H&E staining results demonstrated that ADSC treatment promoted revascularization of the corpus cavernosum, and the results of Sirius Red staining revealed that ADSC treatment reduced penile collagen in diabetic rats. Transmission electron microscopy examination revealed that the ultrastructure of the tissues in the ADSC‑treated group was more complete compared with that in the untreated diabetic model group. In conclusion, ADSCs were found to be more effective compared with BMSCs in treating diabetes‑related erectile dysfunction.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Jangir RN and Jain GC: Diabetes mellitus induced impairment of male reproductive functions: A review. Curr Diabetes Rev. 10:147–157. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Tamás V and Kempler P: Sexual dysfunction in diabetes. Handb Clin Neurol. 126:223–232. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Sun X, Luo LH, Feng L and Li DS: Down-regulation of lncRNA MEG-3 promotes endothelial differentiation of bone marrow derived mesenchymal stem cells in repairing erectile dysfunction. Life Sci. 208:246–252. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Hu LL, Zhang KQ, Tian T, Zhang H and Fu Q: Probucol improves erectile function via Activation of Nrf2 and coordinates the HO-1 / DDAH / PPAR-γ/ eNOS pathways in streptozotocin-induced diabetic rats. Biochem Biophys Res Commun. 507:9–14. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Wu Y, Yang C, Meng F, Que F, Xiao W, Rao H, Wan Y, Taylor HS and Lu L: Nerve growth factor improves the outcome of type 2 diabetes-induced hypotestosteronemia and erectile dysfunction. Reprod Sci. 26:386–393. 2019. View Article : Google Scholar

6 

Shamloul R and Ghanem H: Erectile dysfunction. Lancet. 381:153–65. 2013. View Article : Google Scholar

7 

Xu X, Li L, Wang C, Liu Y, Chen C, Yan J, Ding H and Tang SY: The expansion of autologous adipose-derived stem cells in vitro for the functional reconstruction of nasal mucosal tissue. Cell Biosci. 5:542015. View Article : Google Scholar : PubMed/NCBI

8 

Chen S, Wang M, Chen X, Chen S, Liu L, Zhu J, Wang J, Yang X and Cai X: In vitro expression of Cytokeratin 19 in adipose-derived stem cells is induced by epidermal growth factor. Med Sci Monit. 24:4254–4261. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Liu YP, Li SZ, Yuan F, Xia J, Yu X, Liu X and Yu GR: Infrapatellar fat pad may be with tendon repairing ability and closely related with the developing process of patella Baja. Med Hypotheses. 77:620–623. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Gadelkarim M, Abushouk AI, Ghanem E, Hamaad AM, Saad AM and Abdel-Daim MM: Adipose-derived stem cells: Effectiveness and advances in delivery in diabetic wound healing. Biomed Pharmacother. 107:625–633. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Liu J, Zhu P, Song P, Xiong W, Chen H, Peng W, Wang S, Li S, Fu Z, Wang Y and Wang H: Pretreatment of adipose derived stem cells with curcumin facilitates myocardial recovery via antiapoptosis and angiogenesis. Stem Cells Int. 2015:6381532015. View Article : Google Scholar : PubMed/NCBI

12 

Burchfield JS, Paul AL, Lanka V, Tan W, Kong Y, McCallister C, Rothermel BA, Schneider JW, Gillette TG and Hill JA: Pharmacological priming of adipose-derived stem cells promotes myocardial repair. J Investig Med. 64:50–62. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Fandel TM, Albersen M, Lin G, Qiu X, Ning H, Banie L, Lue TF and Lin CS: Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury. Eur Urol. 61:201–210. 2012. View Article : Google Scholar

14 

Qiu X, Villalta J, Ferretti L, Fandel TM, Albersen M, Lin G, Dai Y, Lue TF and Lin CS: Effects of intravenous injection of adipose-derived stem cells in a rat model of radiation therapy-induced erectile dysfunction. J Sex Med. 9:1834–1841. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Garcia MM, Fandel TM, Lin G, Shindel AW, Banie L, Lin CS and Lue TF: Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells. J Sex Med. 7:89–98. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Gokce A, Abd Elmageed ZY, Lasker GF, Bouljihad M, Kim H, Trost LW, Kadowitz PJ, Abdel-Mageed AB, Sikka SC and Hellstrom WJ: Adipose tissue-derived stem cell therapy for prevention and treatment of erectile dysfunction in a rat model of Peyronie's disease. Andrology. 2:244–251. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Singh A, Lee D, Sopko N, Matsui H, Sabnekar P, Liu X, Elisseeff J, Schoenberg MP, Pienta K and Bivalacqua TJ: Biomanufacturing seamless tubular and hollow collagen scaffolds with unique design features and biomechanical properties. Adv Healthc Mater. 6:2017. View Article : Google Scholar

18 

Abdel-Latif A, Bolli R, Tleyjeh IM, Montori VM, Perin EC, Hornung CA, Zuba-Surma EK, Al-Mallah M and Dawn B: Adult bone marrow-derived cells for cardiac repair: A systematic review and meta-analysis. Arch Intern Med. 167:989–997. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Bivalacqua TJ, Deng W, Kendirci M, Usta MF, Robinson C, Taylor BK, Murthy SN, Champion HC, Hellstrom WJ and Kadowitz PJ: Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction. Am J Physiol Heart Circ Physiol. 292:H1278–H1290. 2007. View Article : Google Scholar

20 

Ryu JK, Kim DH, Song KM, Yi T, Suh JK and Song SU: Intracavernous delivery of clonal mesenchymal stem cells restores erectile function in a mouse model of cavernous nerve injury. J Sex Med. 11:411–423. 2014. View Article : Google Scholar

21 

Ryu JK, Kim DH, Song KM, Ryu DS, Kim SN, Shin DH, Yi T, Suh JK and Song SU: Intracavernous delivery of clonal mesenchymal stem cells rescues erectile function in the streptozotocin-induced diabetic mouse. Andrology. 4:172–184. 2016. View Article : Google Scholar

22 

Cai X, Li J, Wang M, She M, Tang Y, Li J, Li H and Hui H: GLP-1 treatment improves diabetic retinopathy by alleviating autophagy through GLP- 1R ERK1/2 HDAC6 signaling pathway. Int J Med Sci. 14:1203–1212. 2017. View Article : Google Scholar :

23 

Liu G, Sun X, Bian J, Wu R, Guan X, Ouyang B, Huang Y, Xiao H, Luo D, Atala A, et al: Correction of diabetic erectile dysfunction with adipose derived stem cells modified with the vascular endothelial growth factor gene in a rodent diabetic model. PLoS One. 8:pp. e727902013, View Article : Google Scholar : PubMed/NCBI

24 

Xu Y, Guan R, Lei H, Li H, Wang L, Gao Z, Song W and Xin Z: Therapeutic potential of adipose-derived stem cells-based micro-tissues in a rat model of postprostatectomy erectile dysfunction. J Sex Med. 11:2439–2448. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Decaluwé K, Pauwels B, Boydens C and Van de Voorde J: Treatment of erectile dysfunction: New targets and strategies from recent research. Pharmacol Biochem Behav. 121:146–157. 2014. View Article : Google Scholar

26 

Zhou F, Hui Y, Xin H, Xu YD, Lei HE, Yang BC, Guan RL, Li M, Hou JQ and Xin ZC: Therapeutic effects of adipose-derived stem cells-based microtissues on erectile dysfunction in streptozotocin-induced diabetic rats. Asian J Androl. 19:91–97. 2017.

27 

Hou QL, Ge MY, Zhang CD, Tian DD, Wang LK, Tian HZ, Wang WH and Zhang WD: Adipose tissue-derived stem cell therapy for erectile dysfunction in rats: A systematic review and meta-analysis. Int Urol Nephrol. 49:1127–1137. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Chen F, Zhang H, Wang Z, Ding W, Zeng Q, Liu W, Huang C, He S and Wei A: Adipose-derived stem cell-derived exosomes ameliorate erectile dysfunction in a rat model of type 2 Diabetes. J Sex Med. 14:1084–1094. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Mangır N and Türkeri L: Stem cell therapies in post-prostatectomy erectile dysfunction: A critical review. Can J Urol. 24:8609–8619. 2017.

30 

Shan HT, Zhang HB, Chen WT, Chen FZ, Wang T, Luo JT, Yue M, Lin JH and Wei AY: Combination of low-energy shock-wave therapy and bone marrow mesenchymal stem cell transplantation to improve the erectile function of diabetic rats. Asian J Androl. 19:26–33. 2017.

31 

Azadzoi KM, Goldstein I, Siroky MB, Traish AM, Krane RJ and Saenz de Tejada I: Mechanisms of ischemia-induced cavernosal smooth muscle relaxation impairment in a rabbit model of vasculogenic erectile dysfunction. J Urol. 160:2216–2222. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Burnett AL, Lowenstein CJ, Bredt DS, Chang TS and Snyder SH: Nitric oxide: A physiologic mediator of penile erection. Science. 257:401–403. 1992. View Article : Google Scholar : PubMed/NCBI

33 

Andersson KE: Erectile physiological and pathophysiological pathways involved in erectile dysfunction. J Urol. 170:S6–S13. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Procházka V, Jurčíková J, Laššák O, Vítková K, Pavliska L, Porubová L, Buszman PP, Krauze A, Fernandez C, Jalůvka F, et al: Therapeutic potential of adipose-derived therapeutic factor concentrate for treating critical limb ischemia. Cell Transplant. 25:1623–1633. 2016. View Article : Google Scholar

35 

Mazo M, Hernández S, Gavira JJ, Abizanda G, Araña M, López-Martínez T, Moreno C, Merino J, Martino-Rodríguez A, Uixeira A, et al: Treatment of reperfused ischemia with adipose-derived stem cells in a preclinical Swine model of myocardial infarction. Cell Transplant. 21:2723–2733. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Salibian AA, Widgerow AD, Abrouk M and Evans GR: Stem cells in plastic surgery: A review of current clinical and translational applications. Arch Plast Surg. 40:666–675. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Li M, Li H, Ruan Y, Wang T and Liu J: Stem cell therapy for diabetic erectile dysfunction in rats: A meta-analysis. PLoS One. 11:pp. e01543412016, View Article : Google Scholar : PubMed/NCBI

38 

Wang X, Liu C, Li S, Xu Y, Chen P, Liu Y, Ding Q, Wahafu W, Hong B and Yang M: Hypoxia precondition promotes adipose-derived mesenchymal stem cells based repair of diabetic erectile dysfunction via augmenting angiogenesis and neuroprotection. PLoS One. 10:pp. e01189512015, View Article : Google Scholar : PubMed/NCBI

39 

Liu T, Peng Y, Jia C, Fang X, Li J and Zhong W: Hepatocyte growth factor-modified adipose tissue-derived stem cells improve erectile function in streptozotocin-induced diabetic rats. Growth Factors. 33:282–289. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Albersen M, Weyne E and Bivalacqua TJ: Stem cell therapy for erectile dysfunction: Progress and future directions. Sex Med Rev. 1:50–64. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Liu Y, Yang X, Maureira P, Falanga A, Marie V, Gauchotte G, Poussier S, Groubatch F, Marie PY and Tran N: Permanently hypoxic cell culture yields rat bone marrow mesenchymal cells with higher therapeutic potential in the treatment of chronic myocardial infarction. Cell Physiol Biochem. 44:1064–1077. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Ju X, Xue D, Wang T, Ge B, Zhang Y and Li Z: Catalpol promotes the survival and VEGF secretion of bone marrow-derived stem cells and their role in myocardial repair after myocardial infarction in rats. Cardiovasc Toxicol. 18:471–481. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Wu H, Li JZ, Xie BD, Tian H, Fang SH, Jiang SL and Kang K: Lower senescence of adipose-derived stem cells than donor-matched bone marrow stem cells for surgical ventricular restoration. Stem Cells Dev. 27:612–623. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen S, Zhu J, Wang M, Huang Y, Qiu Z, Li J, Chen X, Chen H, Xu M, Liu J, Liu J, et al: Comparison of the therapeutic effects of adipose‑derived and bone marrow mesenchymal stem cells on erectile dysfunction in diabetic rats. Int J Mol Med 44: 1006-1014, 2019.
APA
Chen, S., Zhu, J., Wang, M., Huang, Y., Qiu, Z., Li, J. ... Cai, X. (2019). Comparison of the therapeutic effects of adipose‑derived and bone marrow mesenchymal stem cells on erectile dysfunction in diabetic rats. International Journal of Molecular Medicine, 44, 1006-1014. https://doi.org/10.3892/ijmm.2019.4254
MLA
Chen, S., Zhu, J., Wang, M., Huang, Y., Qiu, Z., Li, J., Chen, X., Chen, H., Xu, M., Liu, J., She, M., Li, H., Yang, X., Wang, Y., Cai, X."Comparison of the therapeutic effects of adipose‑derived and bone marrow mesenchymal stem cells on erectile dysfunction in diabetic rats". International Journal of Molecular Medicine 44.3 (2019): 1006-1014.
Chicago
Chen, S., Zhu, J., Wang, M., Huang, Y., Qiu, Z., Li, J., Chen, X., Chen, H., Xu, M., Liu, J., She, M., Li, H., Yang, X., Wang, Y., Cai, X."Comparison of the therapeutic effects of adipose‑derived and bone marrow mesenchymal stem cells on erectile dysfunction in diabetic rats". International Journal of Molecular Medicine 44, no. 3 (2019): 1006-1014. https://doi.org/10.3892/ijmm.2019.4254
Copy and paste a formatted citation
x
Spandidos Publications style
Chen S, Zhu J, Wang M, Huang Y, Qiu Z, Li J, Chen X, Chen H, Xu M, Liu J, Liu J, et al: Comparison of the therapeutic effects of adipose‑derived and bone marrow mesenchymal stem cells on erectile dysfunction in diabetic rats. Int J Mol Med 44: 1006-1014, 2019.
APA
Chen, S., Zhu, J., Wang, M., Huang, Y., Qiu, Z., Li, J. ... Cai, X. (2019). Comparison of the therapeutic effects of adipose‑derived and bone marrow mesenchymal stem cells on erectile dysfunction in diabetic rats. International Journal of Molecular Medicine, 44, 1006-1014. https://doi.org/10.3892/ijmm.2019.4254
MLA
Chen, S., Zhu, J., Wang, M., Huang, Y., Qiu, Z., Li, J., Chen, X., Chen, H., Xu, M., Liu, J., She, M., Li, H., Yang, X., Wang, Y., Cai, X."Comparison of the therapeutic effects of adipose‑derived and bone marrow mesenchymal stem cells on erectile dysfunction in diabetic rats". International Journal of Molecular Medicine 44.3 (2019): 1006-1014.
Chicago
Chen, S., Zhu, J., Wang, M., Huang, Y., Qiu, Z., Li, J., Chen, X., Chen, H., Xu, M., Liu, J., She, M., Li, H., Yang, X., Wang, Y., Cai, X."Comparison of the therapeutic effects of adipose‑derived and bone marrow mesenchymal stem cells on erectile dysfunction in diabetic rats". International Journal of Molecular Medicine 44, no. 3 (2019): 1006-1014. https://doi.org/10.3892/ijmm.2019.4254
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team