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Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice

  • Authors:
    • Qing Xiao
    • Xiao‑Ya Zhao
    • Ru‑Chao Jiang
    • Xiu‑Hui Chen
    • Xiang Zhu
    • Kai‑Feng Chen
    • Sheng‑Ying Chen
    • Xiao‑Ling Zhang
    • Yuan Qin
    • Ying‑Hua Liu
    • Jian‑Dong Luo
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Molecular Target and Clinical Pharmacology, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, P.R. China, Department of Pharmacology, Guangzhou Medical University, Guangzhou, Guangdong 511436, P.R. China, Maternal and Children Hospital of Guangdong Province, Guangzhou, Guangdong 510260, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1091-1105
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    Published online on: July 16, 2019
       https://doi.org/10.3892/ijmm.2019.4277
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Abstract

Damaged endothelial progenitor cells (EPCs) are associated with poor prognosis in diabetic myocardial infarction (DMI). Our previous studies revealed that an impaired Sonic hedgehog (Shh) pathway contributes to insufficient function in diabetic EPCs; however, the roles of the Shh pathway in diabetic EPC apoptosis under basal and hypoxic/ischemic conditions remain unknown. Therefore, the present study investigated whether Shh revitalized diabetic EPCs and consequently improved the deteriorative status of DMI. For this purpose, streptozotocin injection was used in male C57/BL6 mice to induce type‑1 diabetes, and diabetic EPCs were isolated from the bone marrow. Apoptosis, cell function, and protein expression were investigated in EPCs in vitro. Mouse hearts were injected with adenovirus Shh‑modified diabetic EPCs (DM‑EPCShh) or control DM‑EPCNull immediately after coronary artery ligation in vivo. Cardiac function, capillary numbers, fibrosis, and cell apoptosis were then detected. First, the in vitro results demonstrated that the apoptosis of diabetic EPCs was reduced following treatment with Shh protein for 24 h, under normal or hypoxic conditions. BMI1 proto‑oncogene (Bmi1), an antiapoptotic protein found in several cells, was reduced in diabetic EPCs under normal or hypoxic conditions, but was upregulated after Shh protein stimulation. When Bmi1‑siRNA was administered, the antiapoptotic effect of Shh protein was significantly reversed. In addition, p53, a Bmi1‑targeted gene, was demonstrated to mediate the antiapoptotic effect of the Shh/Bmi1 pathway in diabetic EPCs. The Shh/Bmi1/p53 axis also enhanced the diabetic EPC function. In vivo, Shh‑modified diabetic EPCs exhibited increased EPC retention and decreased apoptosis at 3 days post‑DMI. At 14 days post‑DMI, these cells presented enhanced capillary density, reduced myocardial fibrosis and improved cardiac function. In conclusion, the present results demonstrated that the Shh pathway restored diabetic EPCs through the Shh/Bmi1/p53 axis, suppressed myocardial apoptosis and improved myocardial angiogenesis, thus reducing cardiac fibrosis and finally restoring myocardial repair and cardiac function in DMI. Thus, the Shh pathway may serve as a potential target for autologous cell therapy in diabetic myocardial ischemia.
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View References

1 

Patel NB and Balady GJ: Diagnostic and prognostic testing to evaluate coronary artery disease in patients with diabetes mellitus. Rev Endocr Metab Disord. 11:11–20. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Cheng R and Ma J: Angiogenesis in diabetes and obesity. Rev Endocr Metab Disord. 16:67–75. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Howangyin KY and Silvestre JS: Diabetes mellitus and ischemic diseases: Molecular mechanisms of vascular repair dysfunction. Arterioscler Thromb Vasc Biol. 34:1126–1135. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Co M, Tay E, Lee CH, Poh KK, Low A, Lim J, Lim IH, Lim YT and Tan HC: Use of endothelial progenitor cell capture stent (Genous Bio-Engineered R Stent) during primary percutaneous coronary intervention in acute myocardial infarction: Intermediate- to long-term clinical follow-up. Am Heart J. 155:128–132. 2008. View Article : Google Scholar

5 

Zhu J, Song J, Yu L, Zheng H, Zhou B, Weng S and Fu G: Safety and efficacy of autologous thymosin β4 pre-treated endothelial progenitor cell transplantation in patients with acute ST segment elevation myocardial infarction: A pilot study. Cytotherapy. 18:1037–1042. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Georgescu A, Alexandru N, Constantinescu A, Titorencu I and Popov D: The promise of EPC-based therapies on vascular dysfunction in diabetes. Eur J Pharmacol. 669:1–6. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Ling L, Shen Y, Wang K, Jiang C, Fang C, Ferro A, Kang L and Xu B: Worse clinical outcomes in acute myocardial infarction patients with type 2 diabetes mellitus: Relevance to impaired endothelial progenitor cells mobilization. PLoS One. 7:pp. e507392012, View Article : Google Scholar : PubMed/NCBI

8 

António N, Fernandes R, Ribeiro CF and Providência LA: Challenges in vascular repair by endothelial progenitor cells in diabetic patients. Cardiovasc Hematol Disord Drug Targets. 10:161–166. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Briscoe J and Thérond PP: The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol. 14:416–429. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Álvarez-Buylla A and Ihrie RA: Sonic hedgehog signaling in the postnatal brain. Semin Cell Dev Biol. 33:105–111. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Lopez-Rios J: The many lives of SHH in limb development and evolution. Semin Cell Dev Biol. 49:116–124. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Rimkus TK, Carpenter RL, Qasem S, Chan M and Lo HW: Targeting the sonic hedgehog signaling pathway: Review of smoothened and gli inhibitors. Cancers (Basel). 8. pp. E222016, View Article : Google Scholar

13 

Xiao Q, Hou N, Wang YP, He LS, He YH, Zhang GP, Yi Q, Liu SM, Chen MS and Luo JD: Impaired sonic hedgehog pathway contributes to cardiac dysfunction in type 1 diabetic mice with myocardial infarction. Cardiovasc Res. 95:507–516. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Xiao Q, Yang YA, Zhao XY, He LS, Qin Y, He YH, Zhang GP and Luo JD: Oxidative stress contributes to the impaired sonic hedgehog pathway in type 1 diabetic mice with myocardial infarction. Exp Ther Med. 10:1750–1758. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Qin Y, He YH, Hou N, Zhang GS, Cai Y, Zhang GP, Xiao Q, He LS, Li SJ, Yi Q and Luo JD: Sonic hedgehog improves ischemia-induced neovascularization by enhancing endothelial progenitor cell function in type 1 diabetes. Mol Cell Endocrinol. 423:30–39. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Liu Y, Gao M, Ma MM, Tang YB, Zhou JG, Wang GL, Du YH and Guan YY: Endophilin A2 protects H2O2-induced apoptosis by blockade of Bax translocation in rat basilar artery smooth muscle cells. J Mol Cell Cardiol. 92:122–133. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Marrotte EJ, Chen DD, Hakim JS and Chen AF: Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice. J Clin Invest. 120:4207–4219. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Krishnamurthy P, Thal M, Verma S, Hoxha E, Lambers E, Ramirez V, Qin G, Losordo D and Kishore R: IL-10 deficiency impairs bone marrow-derived endothelial progenitor cell (EPC) survival and function in ischemic myocardium. Circ Res. 109:1280–1289. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Sun YY, Bai WW, Wang B, Lu XT, Xing YF, Cheng W, Liu XQ and Zhao YX: Period 2 is essential to maintain early endothelial progenitor cell function in vitro and angiogenesis after myocardial infarction in mice. J Cell Mol Med. 18:907–918. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Zhang H, He Y, Zhang G, Li X, Yan S, Hou N, Xiao Q, Huang Y, Luo M, Zhang G, et al: HDAC2 is required by the physiological concentration of glucocorticoid to inhibit inflammation in cardiac fibroblasts. Can J Physiol Pharmacol. 95:1030–1038. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Cao L, Bombard J, Cintron K, Sheedy J, Weetall ML and Davis TW: BMI1 as a novel target for drug discovery in cancer. J Cell Biochem. 112:2729–2741. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Shahi MH, Farheen S, Mariyath MP and Castresana JS: Potential role of Shh-Gli1-BMI1 signaling pathway nexus in glioma chemoresistance. Tumour Biol. 37:15107–15114. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Wang X, Venugopal C, Manoranjan B, McFarlane N, O'Farrell E, Nolte S, Gunnarsson T, Hollenberg R, Kwiecien J, Northcott P, et al: Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells. Oncogene. 31:187–199. 2012. View Article : Google Scholar

24 

Subkhankulova T, Zhang X, Leung C and Marino S: Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors. Mol Cell Neurosci. 45:151–162. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Savvatis K, Westermann D, Schultheiss HP and Tschöpe C: Kinins in cardiac inflammation and regeneration: Insights from ischemic and diabetic cardiomyopathy. Neuropeptides. 44:119–125. 2010. View Article : Google Scholar

26 

Aragona CO, Imbalzano E, Mamone F, Cairo V, Lo Gullo A, D'Ascola A, Sardo MA, Scuruchi M, Basile G, Saitta A and Mandraffino G: Endothelial progenitor cells for diagnosis and prognosis in cardiovascular disease. Stem Cells Int. 2016:80437922016. View Article : Google Scholar : PubMed/NCBI

27 

António N, Fernandes R, Soares A, Soares F, Lopes A, Carvalheiro T, Paiva A, Pêgo GM, Providência LA, Gonçalves L and Ribeiro CF: Reduced levels of circulating endothelial progenitor cells in acute myocardial infarction patients with diabetes or pre-diabetes: Accompanying the glycemic continuum. Cardiovasc Diabetol. 13:1012014. View Article : Google Scholar : PubMed/NCBI

28 

Fu JR, Liu WL, Zhou JF, Sun HY, Xu HZ, Luo L, Zhang H and Zhou YF: Sonic hedgehog protein promotes bone marrow-derived endothelial progenitor cell proliferation, migration and VEGF production via PI 3-kinase/Akt signaling pathways. Acta Pharmacol Sin. 27:685–693. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Kanaya K, Ii M, Okazaki T, Nakamura T, Horii-Komatsu M, Alev C, Akimaru H, Kawamoto A, Akashi H, Tanaka H, et al: Sonic Hedgehog signaling regulates vascular differentiation and function in human CD34 positive cells: Vasculogenic CD34(+) cells with Sonic Hedgehog. Stem Cell Res. 14:165–176. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Kusano KF, Pola RT, Murayama T, Curry C, Kawamoto A, Iwakura A, Shintani S, Ii M, Asai J, Tkebuchava T, et al: Sonic hedgehog myocardial gene therapy: Tissue repair through transient reconstitution of embryonic signaling. Nat Med. 11:1197–1204. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Ahmed RP, Haider KH, Shujia J, Afzal MR and Ashraf M: Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway. PLoS One. 5:pp. e85762010, View Article : Google Scholar : PubMed/NCBI

32 

Xiao Q, Yang Y, Qin Y, He YH, Chen KX, Zhu JW, Zhang GP and Luo JD: AMP-activated protein kinase-dependent autophagy mediated the protective effect of sonic hedgehog pathway on oxygen glucose deprivation-induced injury of cardiomyocytes. Biochem Biophys Res Commun. 457:419–425. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Roncalli J, Renault MA, Tongers J, Misener S, Thorne T, Kamide C, Jujo K, Tanaka T, Ii M, Klyachko E and Losordo DW: Sonic hedgehog-induced functional recovery after myocardial infarction is enhanced by AMD3100-mediated progenitor-cell mobilization. J Am Coll Cardiol. 57:2444–2452. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Liu Z, Tu K, Wang Y, Yao B, Li Q, Wang L, Dou C, Liu Q and Zheng X: Hypoxia accelerates aggressiveness of hepatocellular carcinoma cells involving oxidative stress, epithelial-mesenchymal transition and non-canonical hedgehog signaling. Cell Physiol Biochem. 44:1856–1868. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Hung YH, Chang SH, Huang CT, Yin JH, Hwang CS, Yang LY and Yang DI: Inhibitor of differentiation-1 and hypoxia-inducible factor-1 mediate sonic hedgehog induction by amyloid beta-peptide in rat cortical neurons. Mol Neurobiol. 53:793–809. 2016. View Article : Google Scholar

36 

Spivak-Kroizman TR, Hostetter G, Posner R, Aziz M, Hu C, Demeure MJ, Von Hoff D, Hingorani SR, Palculict TB, Izzo J, et al: Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer. Cancer Res. 73:3235–3247. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Onishi H, Kai M, Odate S, Iwasaki H, Morifuji Y, Ogino T, Morisaki T, Nakashima Y and Katano M: Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer. Cancer Sci. 102:1144–1150. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Bijlsma MF, Groot AP, Oduro JP, Franken RJ, Schoenmakers SH, Peppelenbosch MP and Spek CA: Hypoxia induces a hedgehog response mediated by HIF-1alpha. J Cell Mol Med. 13:2053–2060. 2009. View Article : Google Scholar

39 

Marfella R, D'Amico M, Di Filippo C, Piegari E, Nappo F, Esposito K, Berrino L, Rossi F and Giugliano D: Myocardial infarction in diabetic rats: Role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1. Diabetologia. 45:1172–1181. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Ceriello A, Quagliaro L, D'Amico M, Di Filippo C, Marfella R, Nappo F, Berrino L, Rossi F and Giugliano D: Acute hyperglycemia induces nitrotyrosine formation and apoptosis in perfused heart from rat. Diabetes. 51:1076–1082. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Banerjee Mustafi S, Aznar N, Dwivedi SK, Chakraborty PK, Basak R, Mukherjee P, Ghosh P and Bhattacharya R: Mitochondrial BMI1 maintains bioenergetic homeostasis in cells. FASEB J. 30:4042–4055. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Lin X, Ojo D, Wei F, Wong N, Gu Y and Tang D: A novel aspect of tumorigenesis—BMI1 functions in regulating dna damage response. Biomolecules. 5:3396–3415. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Allegra E, Trapasso S, Pisani D and Puzzo L: The role of BMI1 as a biomarker of cancer stem cells in head and neck cancer: A review. Oncology. 86:199–205. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Ren H, Du P, Ge Z, Jin Y, Ding D, Liu X and Zou Q: TWIST1 and BMI1 in cancer metastasis and chemoresistance. J Cancer. 7:1074–1080. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Yao D, Wang Y, Xue L, Wang H, Zhang J and Zhang X: Different expression pattern and significance of p14ARF-Mdm2-p53 pathway and Bmi-1 exist between gastric cardia and distal gastric adenocarcinoma. Hum Pathol. 44:844–851. 2013. View Article : Google Scholar

46 

Xu XH, Liu Y, Li DJ, Hu J, Su J, Huang Q, Lu MQ, Yi F, Bao D and Fu YZ: Effect of shRNA-mediated gene silencing of Bmi-1 expression on chemosensitivity of CD44+ nasopharyngeal carcinoma cancer stem-like cells. Technol Cancer Res Treat. 15:NP27–NP39. 2016. View Article : Google Scholar

47 

Kundu N, Domingues CC, Chou C, Ahmadi N, Houston S, Jerry DJ and Sen S: Use of p53-silenced endothelial progenitor cells to treat ischemia in diabetic peripheral vascular disease. J Am Heart Assoc. 6:pp. e0051462017, View Article : Google Scholar : PubMed/NCBI

48 

Brownlee M: Biochemistry and molecular cell biology of diabetic complications. Nature. 414:813–820. 2001. View Article : Google Scholar : PubMed/NCBI

49 

Feldman EL: Oxidative stress and diabetic neuropathy: A new understanding of an old problem. J Clin Invest. 111:431–433. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Kim WK, Meliton V, Bourquard N, Hahn TJ and Parhami F: Hedgehog signaling and osteogenic differentiation in multipotent bone marrow stromal cells are inhibited by oxidative stress. J Cell Biochem. 111:1199–1209. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Larrick JW and Mendelsohn A: Applied healthspan engineering. Rejuvenation Res. 13:265–280. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Chen X, Gu M, Zhao X, Zheng X, Qin Y and You X: Deterioration of cardiac function after acute myocardial infarction is prevented by transplantation of modified endothelial progenitor cells over-expressing endothelial NO synthases. Cell Physiol Biochem. 31:355–365. 2013. View Article : Google Scholar

53 

Bianconi V, Sahebkar A, Kovanen P, Bagaglia F, Ricciuti B, Calabrò P, Patti G and Pirro M: Endothelial and cardiac progenitor cells for cardiovascular repair: A controversial paradigm in cell therapy. Pharmacol Ther. 181:156–168. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiao Q, Zhao XY, Jiang RC, Chen XH, Zhu X, Chen KF, Chen SY, Zhang XL, Qin Y, Liu YH, Liu YH, et al: Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice. Int J Mol Med 44: 1091-1105, 2019.
APA
Xiao, Q., Zhao, X., Jiang, R., Chen, X., Zhu, X., Chen, K. ... Luo, J. (2019). Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice. International Journal of Molecular Medicine, 44, 1091-1105. https://doi.org/10.3892/ijmm.2019.4277
MLA
Xiao, Q., Zhao, X., Jiang, R., Chen, X., Zhu, X., Chen, K., Chen, S., Zhang, X., Qin, Y., Liu, Y., Luo, J."Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice". International Journal of Molecular Medicine 44.3 (2019): 1091-1105.
Chicago
Xiao, Q., Zhao, X., Jiang, R., Chen, X., Zhu, X., Chen, K., Chen, S., Zhang, X., Qin, Y., Liu, Y., Luo, J."Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice". International Journal of Molecular Medicine 44, no. 3 (2019): 1091-1105. https://doi.org/10.3892/ijmm.2019.4277
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao Q, Zhao XY, Jiang RC, Chen XH, Zhu X, Chen KF, Chen SY, Zhang XL, Qin Y, Liu YH, Liu YH, et al: Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice. Int J Mol Med 44: 1091-1105, 2019.
APA
Xiao, Q., Zhao, X., Jiang, R., Chen, X., Zhu, X., Chen, K. ... Luo, J. (2019). Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice. International Journal of Molecular Medicine, 44, 1091-1105. https://doi.org/10.3892/ijmm.2019.4277
MLA
Xiao, Q., Zhao, X., Jiang, R., Chen, X., Zhu, X., Chen, K., Chen, S., Zhang, X., Qin, Y., Liu, Y., Luo, J."Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice". International Journal of Molecular Medicine 44.3 (2019): 1091-1105.
Chicago
Xiao, Q., Zhao, X., Jiang, R., Chen, X., Zhu, X., Chen, K., Chen, S., Zhang, X., Qin, Y., Liu, Y., Luo, J."Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice". International Journal of Molecular Medicine 44, no. 3 (2019): 1091-1105. https://doi.org/10.3892/ijmm.2019.4277
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