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Article

Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model

  • Authors:
    • Yicheng Li
    • Wenbo Mu
    • Jiangdong Ren
    • Shalitanati Wuermanbieke
    • Tuerhongjiang Wahafu
    • Baochao Ji
    • Hairong Ma
    • Abdusami Amat
    • Keyuan Zhang
    • Li Cao
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian Xinjiang Key Laboratory of Echinococcosis, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China
  • Pages: 1541-1551
    |
    Published online on: July 26, 2019
       https://doi.org/10.3892/ijmm.2019.4290
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Abstract

Osteoarthritis (OA) is a progressive and degenerative joint disorder that is highly prevalent worldwide and for which there is currently no effective medical therapy. Artesunate (ART), a natural compound used to treat malaria, possesses diverse biological properties, including the regulation of inflammation and apoptosis in various cells; however, its role in OA remains unclear. The aim of the present study was to investigate the effects of ART on interleukin (IL)‑1β‑induced chondrocyte‑like ATDC5 cells and in an OA mouse model. The results revealed that ART dose‑dependently relieved the inhibitory effect of IL‑1β on cell viability. Moreover, ART significantly reduced the overexpression of matrix metalloproteinase (MMP)‑3, MMP‑13, a disintegrin and metalloproteinase with thrombospondin motifs‑5 and cyclooxygenase‑2 at both the gene and protein levels in chondrocyte‑like ATDC5 cells stimulated by IL‑1β. Furthermore, ART decreased the expression of pro‑apoptotic Bax, cleaved caspase‑3 and cleaved caspase‑7 in a dose‑dependent manner, and increased the expression of the anti‑apoptotic factor Bcl‑2. These changes were mediated by the inhibitory effect of ART on the nuclear factor‑κB signaling pathway, defined as repression of the phosphorylation of IκBα and p65, and improved redistribution of p65. Additionally, ART blocked the advancement of the calcified cartilage zone and the loss of proteoglycan, and lowered histological scoring of OA in a mouse model. Taken together, these results indicate that ART may be of value as a therapeutic agent for OA.
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View References

1 

Helmick CG, Felson DT, Lawrence RC, Gabriel S, Hirsch R, Kwoh CK, Liang MH, Kremers HM, Mayes MD, Merkel PA, et al: Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 58:15–25. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Chen D, Shen J, Zhao W, Wang T, Han L, Hamilton JL and Im HJ: Osteoarthritis: Toward a comprehensive understanding of pathological mechanism. Bone Res. 5:160442017. View Article : Google Scholar : PubMed/NCBI

3 

Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, Bridgett L, Williams S, Guillemin F, Hill CL, et al: The global burden of hip and knee osteoarthritis: Estimates from the global burden of disease 2010 study. Ann Rheum Dis. 73:1323–1330. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Poole AR, Kobayashi M, Yasuda T, Laverty S, Mwale F, Kojima T, Sakai T, Wahl C, El-Maadawy S, Webb G, et al: Type II collagen degradation and its regulation in articular cartilage in osteoarthritis. Ann Rheum Dis. 61(Suppl 2): ii78–ii81. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Kobayashi M, Squires GR, Mousa A, Tanzer M, Zukor DJ, Antoniou J, Feige U and Poole AR: Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum. 52:128–135. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Wang M, Shen J, Jin H, Im HJ, Sandy J and Chen D: Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis. Ann N Y Acad Sci. 1240:61–69. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Wang F, Wu L, Li L and Chen S: Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Int Immunopharmacol. 23:575–580. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Rigoglou S and Papavassiliou AG: The NF-κB signalling pathway in osteoarthritis. Int J Biochem Cell Biol. 45:2580–2584. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Pan T, Chen R, Wu D, Cai N, Shi X, Li B and Pan J: Alpha-Mangostin suppresses interleukin-1β-induced apoptosis in rat chondrocytes by inhibiting the NF-κB signaling pathway and delays the progression of osteoarthritis in a rat model. Int Immunopharmacol. 52:156–162. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Du Y, Chen G, Zhang X, Yu C, Cao Y and Cui L: Artesunate and erythropoietin synergistically improve the outcome of experimental cerebral malaria. Int Immunopharmacol. 48:219–230. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Xu H, He Y, Yang X, Liang L, Zhan Z, Ye Y, Yang X, Lian F and Sun L: Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Rheumatology (Oxford). 46:920–926. 2007. View Article : Google Scholar

12 

Lai L, Chen Y, Tian X, Li X, Zhang X, Lei J, Bi Y, Fang B and Song X: Artesunate alleviates hepatic fibrosis induced by multiple pathogenic factors and inflammation through the inhibition of LPS/TLR4/NF-κB signaling pathway in rats. Eur J Pharmacol. 765:234–241. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Guruprasad B, Chaudhary P, Choedon T and Kumar VL: Artesunate ameliorates functional limitations in Freund's complete adjuvant-induced monoarthritis in rat by maintaining oxidative homeostasis and inhibiting COX-2 expression. Inflammation. 38:1028–1035. 2015. View Article : Google Scholar

14 

Zhao C, Liu Q and Wang K: Artesunate attenuates ACLT-induced osteoarthritis by suppressing osteoclastogenesis and aberrant angiogenesis. Biomed Pharmacother. 96:410–416. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

16 

Le Graverand-Gastineau MP: Disease modifying osteoarthritis drugs: Facing development challenges and choosing molecular targets. Curr Drug Targets. 11:528–535. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Lu C, Li Y, Hu S, Cai Y, Yang Z and Peng K: Scoparone prevents IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through the PI3K/Akt/NF-κB pathway. Biomed Pharmacother. 106:1169–1174. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Liu M, Zhong S, Kong R, Shao H, Wang C, Piao H, Lv W, Chu X and Zhao Y: Paeonol alleviates interleukin-1β-induced inflammatory responses in chondrocytes during osteoarthritis. Biomed Pharmacother. 95:914–921. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Feng Z, Zheng W, Li X, Lin J, Xie C, Li H, Cheng L, Wu A and Ni W: Cryptotanshinone protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice. Int Immunopharmacol. 50:161–167. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Ho WE, Peh HY, Chan TK and Wong WS: Artemisinins: Pharmacological actions beyond anti-malarial. Pharmacol Ther. 142:126–139. 2014. View Article : Google Scholar

21 

Pereira D, Ramos E and Branco J: Osteoarthritis. Acta Med Port. 28:99–106. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Tetlow LC, Adlam DJ and Woolley DE: Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: Associations with degenerative changes. Arthritis Rheum. 44:585–594. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Verma P and Dalal K: ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis. J Cell Biochem. 112:3507–3514. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Nakao S, Ogtata Y, Shimizu E, Yamazaki M, Furuyama S and Sugiya H: Tumor necrosis factor alpha (TNF-alpha)-induced prostaglandin E2 release is mediated by the activation of cyclooxygenase-2 (COX-2) transcription via NFkappaB in human gingival fibroblasts. Mol Cell Biochem. 238:11–18. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Liu B, Goode AP, Carter TE, Utturkar GM, Huebner JL, Taylor DC, Moorman CT III, Garrett WE, Kraus VB, Guilak F, et al: Matrix metalloproteinase activity and prosta-glandin E2 are elevated in the synovial fluid of meniscus tear patients. Connect Tissue Res. 58:305–316. 2017. View Article : Google Scholar

26 

Li Y, Wang S, Wang Y, Zhou C, Chen G, Shen W, Li C, Lin W, Lin S, Huang H, et al: Inhibitory effect of the antimalarial agent artesunate on collagen-induced arthritis in rats through nuclear factor kappa B and mitogen-activated protein kinase signaling pathway. Transl Res. 161:89–98. 2013. View Article : Google Scholar

27 

He Y, Fan J, Lin H, Yang X, Ye Y, Liang L, Zhan Z, Dong X, Sun L and Xu H: The anti-malaria agent artesunate inhibits expression of vascular endothelial growth factor and hypoxia-inducible factor-1α in human rheumatoid arthritis fibroblast-like synoviocyte. Rheumatol Int. 31:53–60. 2011. View Article : Google Scholar

28 

Na JY, Kim S, Song K, Lim KH, Shin GW, Kim JH, Kim B, Kwon YB and Kwon J: Anti-apoptotic activity of Ginsenoside Rb1 in hydrogen peroxide-treated chondrocytes: Stabilization of mitochondria and the inhibition of caspase-3. J Ginseng Res. 36:242–247. 2012. View Article : Google Scholar

29 

Musumeci G, Castrogiovanni P, Mazzone V, Szychlinska MA, Castorina S and Loreto C: Histochemistry as a unique approach for investigating normal and osteoarthritic cartilage. Eur J Histochem. 58:23712014. View Article : Google Scholar : PubMed/NCBI

30 

Qin G, Wu L, Liu H, Pang Y, Zhao C, Wu S, Wang X and Chen T: Artesunate induces apoptosis via a ROS-independent and Bax-mediated intrinsic pathway in HepG2 cells. Exp Cell Res. 336:308–317. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Zhang P, Luo HS, Li M and Tan SY: Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2. Onco Targets Ther. 8:845–854. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Marcu KB, Otero M, Olivotto E, Borzi RM and Goldring MB: NF-kappaB signaling: Multiple angles to target OA. Curr Drug Targets. 11:599–613. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Pan T, Shi X, Chen H, Chen R, Wu D, Lin Z, Zhang J and Pan J: Geniposide suppresses interleukin-1β-induced inflammation and apoptosis in rat chondrocytes via the PI3K/Akt/NF-κB signaling pathway. Inflammation. 41:390–399. 2018. View Article : Google Scholar

34 

Cui Z, Crane J, Xie H, Jin X, Zhen G, Li C, Xie L, Wang L, Bian Q, Qiu T, et al: Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone. Ann Rheum Dis. 75:1714–1721. 2016. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Mu W, Ren J, Wuermanbieke S, Wahafu T, Ji B, Ma H, Amat A, Zhang K, Cao L, Cao L, et al: Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model. Int J Mol Med 44: 1541-1551, 2019.
APA
Li, Y., Mu, W., Ren, J., Wuermanbieke, S., Wahafu, T., Ji, B. ... Cao, L. (2019). Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model. International Journal of Molecular Medicine, 44, 1541-1551. https://doi.org/10.3892/ijmm.2019.4290
MLA
Li, Y., Mu, W., Ren, J., Wuermanbieke, S., Wahafu, T., Ji, B., Ma, H., Amat, A., Zhang, K., Cao, L."Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model". International Journal of Molecular Medicine 44.4 (2019): 1541-1551.
Chicago
Li, Y., Mu, W., Ren, J., Wuermanbieke, S., Wahafu, T., Ji, B., Ma, H., Amat, A., Zhang, K., Cao, L."Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model". International Journal of Molecular Medicine 44, no. 4 (2019): 1541-1551. https://doi.org/10.3892/ijmm.2019.4290
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Mu W, Ren J, Wuermanbieke S, Wahafu T, Ji B, Ma H, Amat A, Zhang K, Cao L, Cao L, et al: Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model. Int J Mol Med 44: 1541-1551, 2019.
APA
Li, Y., Mu, W., Ren, J., Wuermanbieke, S., Wahafu, T., Ji, B. ... Cao, L. (2019). Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model. International Journal of Molecular Medicine, 44, 1541-1551. https://doi.org/10.3892/ijmm.2019.4290
MLA
Li, Y., Mu, W., Ren, J., Wuermanbieke, S., Wahafu, T., Ji, B., Ma, H., Amat, A., Zhang, K., Cao, L."Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model". International Journal of Molecular Medicine 44.4 (2019): 1541-1551.
Chicago
Li, Y., Mu, W., Ren, J., Wuermanbieke, S., Wahafu, T., Ji, B., Ma, H., Amat, A., Zhang, K., Cao, L."Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model". International Journal of Molecular Medicine 44, no. 4 (2019): 1541-1551. https://doi.org/10.3892/ijmm.2019.4290
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