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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October-2019 Volume 44 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Bacterial lipopolysaccharide and antimicrobial LL-37 enhance ICAM-1 expression and NF-κB p65 phosphorylation in senescent endothelial cells

Kaori Suzuki, Mari Ohkuma, Isao Nagaoka
Pages: 1187-1196
Published online on: 31 July 2019

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Article Open Access

Melatonin prevents sepsis-induced renal injury via the PINK1/Parkin1 signaling pathway

Wenling Dai, Haifeng Huang, Linjie Si, Shi Hu, Liangliang Zhou, Lingling Xu, Yijun Deng
Pages: 1197-1204
Published online on: 07 August 2019

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Article Open Access

Identification of candidate genes and miRNAs associated with neuropathic pain induced by spared nerve injury

He Li, Hong‑Quan Wan, Hai‑Jun Zhao, Shu‑Xin Luan, Chun‑Guo Zhang
Pages: 1205-1218
Published online on: 06 August 2019

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Article Open Access

MicroRNA-29a suppresses the invasion and migration of osteosarcoma cells by regulating the SOCS1/NF-κB signalling pathway through negatively targeting DNMT3B

Hao‑Li Gong, Ye Tao, Xin‑Zhan Mao, De‑Ye Song, Di You, Jiang‑Dong Ni
Pages: 1219-1232
Published online on: 24 July 2019

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Article Open Access

Radiosensitizing effects of Cyclocarya paliurus polysaccharide on hypoxic A549 and H520 human non-small cell lung carcinoma cells

Fengmin Zhang, Bin Fan, Lijun Mao
Pages: 1233-1242
Published online on: 26 July 2019

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Article Open Access

Characteristic genes in THP‑1 derived macrophages infected with Mycobacterium tuberculosis H37Rv strain identified by integrating bioinformatics methods

Yu‑Wei Zhang, Yan Lin, Hui‑Yuan Yu, Ruo‑Nan Tian, Fan Li
Pages: 1243-1254
Published online on: 30 July 2019

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Article Open Access

Neuregulin‑1 protects cardiac function in septic rats through multiple targets based on endothelial cells

Wen Kang, Yue Cheng, Fang Zhou, Long Wang, Liang Zhong, Hai Tao Li, Xi Wang, Song Dang, Xin Wang
Pages: 1255-1266
Published online on: 08 August 2019

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Article Open Access

miRNA profile obtained by next‑generation sequencing in metastatic breast cancer patients is able to predict the response to systemic treatments

Antonio Daniel Martinez‑Gutierrez, Oliver Millan Catalan, Rafael Vázquez‑Romo, Fany Iris Porras Reyes, Alberto Alvarado‑Miranda, Fernando Lara Medina, Juan E. Bargallo‑Rocha, Luz Tonatzin Orozco Moreno, David Cantú De León, Luis Alonso Herrera, César López‑Camarillo, Carlos Pérez‑Plasencia, Alma D. Campos‑Parra
Pages: 1267-1280
Published online on: 30 July 2019

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Article Open Access

Aspirin alleviates orthopedic implant‑associated infection

Yi Jiang, Sheng‑Nan Wang, Hang‑Tian Wu, Han‑Jun Qin, Ming‑Liang Ren, Jian‑Chun Lin, Bin Yu
Pages: 1281-1288
Published online on: 02 August 2019

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Article Open Access

Simvastatin promotes endothelial dysfunction by activating the Wnt/β‑catenin pathway under oxidative stress

Zhiqiang He, Xinyue Du, Yifan Wu, Lingyue Hua, Linxi Wan, Nianlong Yan
Pages: 1289-1298
Published online on: 09 August 2019

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Article Open Access

Inflammasome activity in leucocytes decreases with abdominal aortic aneurysm progression

Philipp Erhart, Sinan Cakmak, Caspar Grond‑Ginsbach, Maani Hakimi, Dittmar Böckler, Susanne Dihlmann
Pages: 1299-1308
Published online on: 07 August 2019

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Article Open Access

Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy‑mediated NLRP3 inflammasome inactivation in sepsis

Hongguang Chen, Xing Mao, Xiaoyin Meng, Yuan Li, Jingcheng Feng, Linlin Zhang, Yang Zhang, Yaoqi Wang, Yonghao Yu, Keliang Xie
Pages: 1309-1324
Published online on: 13 August 2019

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Article Open Access

Upregulation of eukaryotic translation initiation factor 4E associates with a poor prognosis in gallbladder cancer and promotes cell proliferation in vitro and in vivo

Debao Fang, Jing Peng, Guobing Wang, Dachen Zhou, Xiaoping Geng
Pages: 1325-1332
Published online on: 19 August 2019

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Article Open Access

Identification of an eight-lncRNA prognostic model for breast cancer using WGCNA network analysis and a Cox‑proportional hazards model based on L1-penalized estimation

Zhenbin Liu, Menghu Li, Qi Hua, Yanfang Li, Gang Wang
Pages: 1333-1343
Published online on: 06 August 2019

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Article Open Access

Effect of astragalosides on long non-coding RNA expression profiles in rats with adjuvant-induced arthritis

Hui Jiang, Fu‑Rong Wu, Jian Liu, Xiu‑Juan Qin, Nan‑Nan Jiang, Wei‑Ping Li
Pages: 1344-1356
Published online on: 22 July 2019

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Article Open Access

Knockdown of miR-222 inhibits inflammation and the apoptosis of LPS-stimulated human intervertebral disc nucleus pulposus cells

Yang Zhang, Jiujie Yang, Xiaoqing Zhou, Nan Wang, Zhi Li, Yubo Zhou, Jianzhou Feng, Dewei Shen, Wei Zhao
Pages: 1357-1365
Published online on: 16 August 2019

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Article Open Access

Impact of single nucleotide polymorphisms in the VEGFR2 gene on endothelial cell activation under non‑uniform shear stress

Nora M. Schacher, Dorette Raaz‑Schrauder, Francesca Pasutto, Florian M. Stumpfe, Miyuki Tauchi, Barbara Dietel, Stephan Achenbach, Katharina Urschel
Pages: 1366-1376
Published online on: 05 August 2019

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Article Open Access

Dissociation of HKII in retinal epithelial cells induces oxidative stress injury in the retina

Liqun Chu, Lin Xiao, Bing Xu, Jingmei Xu
Pages: 1377-1387
Published online on: 06 August 2019

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Article Open Access

Targeting Notch-activated M1 macrophages attenuate lung tissue damage in a rat model of ventilator induced lung injury

Danping Yin, Weiming Wang, Wei Han, Chen Fan
Pages: 1388-1398
Published online on: 16 August 2019

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Article Open Access

Differential expression of circRNAs during rat lung development

Yan‑Qing Shen, Jing‑Jing Pan, Zhong‑Yi Sun, Xiao‑Qing Chen, Xiao‑Guang Zhou, Xiao‑Yu Zhou, Rui Cheng, Yang Yang
Pages: 1399-1413
Published online on: 02 August 2019

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Article Open Access

Partial decortication ameliorates dopamine depletion‑induced striatal neuron lesions in rats

Yaofeng Zhu, Bingbing Liu, Xuefeng Zheng, Jiajia Wu, Si Chen, Zhi Chen, Tao Chen, Ziyun Huang, Wanlong Lei
Pages: 1414-1424
Published online on: 25 July 2019

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Article Open Access

Human amnion mesenchymal stem cells attenuate atherosclerosis by modulating macrophage function to reduce immune response

Xiufang Wei, Guang Sun, Xiaoxue Zhao, Qianqian Wu, Ling Chen, Yichi Xu, Xining Pang, Guoxian Qi
Pages: 1425-1435
Published online on: 23 July 2019

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Article Open Access

Next-generation sequencing predicts interaction network between miRNA and target genes in lipoteichoic acid-stimulated human neutrophils

Meng‑Chi Yen, I‑Jeng Yeh, Kuan‑Ting Liu, Shu‑Fang Jian, Chia‑Jung Lin, Ming‑Ju Tsai, Po‑Lin Kuo
Pages: 1436-1446
Published online on: 31 July 2019

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Article Open Access

Identification of differentially expressed genes and preliminary validations in cardiac pathological remodeling induced by transverse aortic constriction

Hui‑Bo Wang, Rong Huang, Kang Yang, Man Xu, Di Fan, Ming‑Xin Liu, Si‑Hui Huang, Li‑Bo Liu, Hai‑Ming Wu, Qi‑Zhu Tang
Pages: 1447-1461
Published online on: 30 July 2019

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Article Open Access

Identification of circular RNAs hsa_circ_0044235 and hsa_circ_0068367 as novel biomarkers for systemic lupus erythematosus

Qing Luo, Lu Zhang, Xue Li, Biqi Fu, Yang Guo, Zikun Huang, Junming Li
Pages: 1462-1472
Published online on: 05 August 2019

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Article Open Access

Axonal sprouting in the dorsal cochlear nucleus affects gap‑prepulse inhibition following noise exposure

Kyu‑Hee Han, Seog‑Kyun Mun, Seonyong Sohn, Xian‑Yu Piao, Ilyong Park, Munyoung Chang
Pages: 1473-1483
Published online on: 19 August 2019

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Article Open Access

Irradiation enhances the therapeutic effect of the oncolytic adenovirus XVir-N-31 in brain tumor initiating cells

Rebecca Czolk, Niklas Schwarz, Henner Koch, Sonja Schötterl, Thomas V. Wuttke, Per S. Holm, Stephan M. Huber, Ulrike Naumann
Pages: 1484-1494
Published online on: 31 July 2019

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Article

Altered expression of glucose metabolism associated genes in a tacrolimus‑induced post‑transplantation diabetes mellitus in rat model

Ling Zhang, Yunqiang He, Cunzao Wu, Minmin Wu, Xuehai Chen, Jiao Luo, Yong Cai, Peng Xia, Bicheng Chen
Pages: 1495-1504
Published online on: 16 August 2019

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Article

MicroRNA-26a targets the mdm2/p53 loop directly in response to liver regeneration

Jian Zhou, Zhuoyuan Li, Yingbin Huang, Weiqiang Ju, Dongping Wang, Xiaofeng Zhu, Xiaoshun He
Pages: 1505-1514
Published online on: 22 July 2019

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Article

L‑carnitine alleviates oxidative stress‑related damage via MAPK signaling in human lens epithelial cells exposed to H2O2

Xiaoxia Li, Fanlan Meng, Hua Li, Xia Hua, Li'an Wu, Xiaoyong Yuan
Pages: 1515-1522
Published online on: 22 July 2019

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Article

Green tea polyphenols attenuate hepatic steatosis, and reduce insulin resistance and inflammation in high-fat diet-induced rats

Hong‑Miao Xia, Jin Wang, Xiao‑Jie Xie, Li‑Juan Xu, Shi‑Qi Tang
Pages: 1523-1530
Published online on: 23 July 2019

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Article

Hydroxytyrosol promotes autophagy by regulating SIRT1 against advanced oxidation protein product‑induced NADPH oxidase and inflammatory response

Tian Sun, Qian Chen, Si‑Yuan Zhu, Qian Wu, Cong‑Rui Liao, Zheng Wang, Xiao‑Hu Wu, Hang‑Tian Wu, Jian‑Ting Chen
Pages: 1531-1540
Published online on: 05 August 2019

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Article

Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model

Yicheng Li, Wenbo Mu, Jiangdong Ren, Shalitanati Wuermanbieke, Tuerhongjiang Wahafu, Baochao Ji, Hairong Ma, Abdusami Amat, Keyuan Zhang, Li Cao
Pages: 1541-1551
Published online on: 26 July 2019

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Article

Induction of ROS‑mediated cell death and activation of the JNK pathway by a sulfonamide derivative

Rehan Ahmad, Mansoor‑Ali Vaali‑Mohammed, Mohammed Elwatidy, Omar Al‑Obeed, Khayal Al‑Khayal, Wagdy M. Eldehna, Hatem A. Abdel‑Aziz, Ahmed Alafeefy, Maha Abdulla
Pages: 1552-1562
Published online on: 23 July 2019

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Article

Icariin attenuates the severity of cerulein‑induced acute pancreatitis by inhibiting p38 activation in mice

Dong‑Uk Kim, Gi‑Sang Bae, Myoung‑Jin Kim, Ji‑Won Choi, Dong‑Gu Kim, Ho‑Joon Song, Sung‑Joo Park
Pages: 1563-1573
Published online on: 16 August 2019

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Article

Novel Notch signaling inhibitor NSI‑1 suppresses nuclear translocation of the Notch intracellular domain

Takaya Shiraishi, Masahiro Sakaitani, Satoko Otsuguro, Katsumi Maenaka, Toshiharu Suzuki, Tadashi Nakaya
Pages: 1574-1584
Published online on: 19 July 2019

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Article

KCNMB3 in spinal microglia contributes to the generation and maintenance of neuropathic pain in mice

Kazuhisa Imari, Yuka Harada, Jing Zhang, Yoshihide Mori, Yoshinori Hayashi
Pages: 1585-1593
Published online on: 19 July 2019

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Correction Open Access

[Corrigendum] MicroRNA‑497 inhibits multiple myeloma growth and increases susceptibility to bortezomib by targeting Bcl‑2

Faqing Tian, Yong Zhan, Wei Zhu, Juheng Li, Meiqin Tang, Xiaohui Chen, Jian Jiang
Pages: 1594-1594
Published online on: 02 August 2019

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Correction Open Access

[Corrigendum] Preparation and biological evaluation of a novel pH-sensitive poly (β-malic acid) conjugate for antitumor drug delivery

Youbei Qiao, Bao Liu, Yifan Peng, Erlong Ji, Hong Wu
Pages: 1595-1595
Published online on: 07 August 2019

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Journal Cover
January-2026 Volume 57 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

FK506‑binding proteins as emerging bridges linking proteostasis to multi‑system pathogenesis and therapeutic strategies (Review)

Zhi Li, Xiaolei Liu, Hesong Zeng
Article Number: 30
Published online on: 24 November 2025

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Retraction Open Access

[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Article Number: 29
Published online on: 24 November 2025

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Article Open Access

METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner

Yang Wang, Yihao Tian, Gang Yao
Article Number: 28
Published online on: 20 November 2025

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Review Open Access

Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review)

Ruihao Xu, Haoming Ren, Zhengwei Yuan, Wanqi Huang, Hui Gu
Article Number: 27
Published online on: 20 November 2025

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Article Open Access

MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang
Article Number: 26
Published online on: 18 November 2025

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Article Open Access

Synergistic effects of Akebia saponin D and Semaglutide on diabetic nephropathy and osteoporosis via the Klotho‑p53 signaling axis

Qian Zhang, Dan Wang, Hongxia Jia, Zongji Zheng, Liyan Lin, Linna Li, Ling Wang, Yaoming Xue
Article Number: 25
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Ke Li, Conghu Yuan
Article Number: 24
Published online on: 17 November 2025

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Article

Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein

Zhikui Li, Weijie Ding, Yubo Sun, Chenfeng Tian, Shuaishuai Fu, Fei Shi, Zhenchi Fang, Yuanzhe Li, Jianchang Li, Sirui Cai, Haobo Kang, Baozeng Sun, Junqi Zhang, Yuanjie Sun, Shuya Yang, Yusi Zhang, Chunmei Zhang, Yun Zhang, Xiyang Zhang, Kun Yang, Dongbo Jiang
Article Number: 23
Published online on: 14 November 2025

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Article Open Access

Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy

Boya Zhang, Defeng Kong, Siji Chen, Xuewu Sun, Hao Cheng
Article Number: 22
Published online on: 14 November 2025

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Article Open Access

Targeting p38 MAPK signaling pathway: 
Quercetin as a novel therapy for TMJ synovitis

Mosha Cheng, Yuhe Guan, Xiaotao Xin, Xin Yi, Yi Liu
Article Number: 21
Published online on: 13 November 2025

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Review Open Access

Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review)

Yuchen Wang, Boxuan Wang, Jinchao Hou, Xiaodong Huo, Chenlin Liu, Ruili Guan, Honggang Chen, Yang Zhou, Jianbin Zhang, Congcong Zhuang, Yuankang Zou
Article Number: 20
Published online on: 13 November 2025

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Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review)

Peiyu Li, Yinghui Li, Qian Meng, Jie Wang, Kun Wang, Sumin Yang
Article Number: 19
Published online on: 13 November 2025

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Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes

Xiaona Chen, Ziqi Sun, Jiabo Chen, Jinquan Zhang, Zeyu Liu, Zhengzheng Yan, Quan Li, Zhixia Chen
Article Number: 18
Published online on: 12 November 2025

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Correction Open Access

[Corrigendum]  Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

Bo Meng, Yisong Wang, Bin Li
Article Number: 17
Published online on: 10 November 2025

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Review Open Access

Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)

Jing Wang, Qin Zhao, Shuwan Zhang, Jia Liu, Xingyue Fan, Bin Han, Yaqin Hou, Xiaopeng Ai
Article Number: 16
Published online on: 05 November 2025

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Review Open Access

High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review)

Min You, Fan Wu, Feng Xiong, Xue-Fei Hu, Huan Wu, Li Zhou, Hong-Xing Zhang
Article Number: 15
Published online on: 05 November 2025

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ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model

Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang
Article Number: 14
Published online on: 05 November 2025

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Review Open Access

Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review)

Chaowei Zhang, Yuxuan Han, Weiyi Yao, Qing Hong, Na Chen
Article Number: 13
Published online on: 04 November 2025

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β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Xianyi Ding, Jiabin Wu, Lian Wang, Ke Li, Haoyang Gao, Mingyu Wu, Qiuyu Zhang, Ruonan Han, Wenhong Wang, Weihua Xiao
Article Number: 12
Published online on: 03 November 2025

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Review

Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

Xunjie Jian, Chang Cheng, Wenjie Lu, Hui Peng, Diqi Yang
Article Number: 11
Published online on: 03 November 2025

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Review Open Access

Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)

Xitong Zhao, Pengqin Wang
Article Number: 10
Published online on: 03 November 2025

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Expression of Concern Open Access

[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 9
Published online on: 29 October 2025

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Article Open Access

TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway

Linlin Xiao, Man Qu, Lulu Chen, Mingli Xiang, Qian Long, Jianguo Liu, Xiaoyan Guan, Chengcheng Liao
Article Number: 8
Published online on: 27 October 2025

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Review Open Access

Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review)

Tao Duan, Hanhai Mao, Xingyue Jiang, Ying Tian, Jidong Zhang, Jun Tan
Article Number: 7
Published online on: 27 October 2025

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Retraction Open Access

[Retracted] Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma

Guanen Qiao, Chenguang Dai, Yang He, Junjie Shi, Chunfang Xu
Article Number: 6
Published online on: 27 October 2025

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Review Open Access

Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review)

Yiming Shao, Ke Song, Ruixin Yu, He Xiao, Chengjun Li, Yuling Deng, Yuan Zhang, Yixing Ren
Article Number: 5
Published online on: 24 October 2025

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Article Open Access

Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer

Chuanxi Lai, Xiya Jia, Yiyi Chen, Kangke Chen, Fei Wang, Qiqi Zhang, Xiaonan Xiang, Zhe-Sheng Chen, Lingna Xu, Sheng Dai
Article Number: 4
Published online on: 23 October 2025

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Article Open Access

Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis

Weichao Sun, Yi Liao, Jianguo Feng, Jianhui Liang, Qifei He, Yinxing Cui, Dixi Huang, Houyin Shi, Wei You, Wei Sun, Qian Yi
Article Number: 3
Published online on: 23 October 2025

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Review

Importance of B cells (Review)

Zhiyuan Liu, Haoran Dai, Xiaoyu Cui, Yeping Liu, Zhaocheng Dong
Article Number: 2
Published online on: 22 October 2025

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Retraction Open Access

[Retracted] Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Article Number: 1
Published online on: 22 October 2025

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February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Article Open Access

Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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Review Open Access

A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Review Open Access

Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Review Open Access

Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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Article Open Access

STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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Article Open Access

HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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Article Open Access

FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Review Open Access

Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Review Open Access

Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Review Open Access

Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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