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Differential expression of circRNAs during rat lung development

  • Authors:
    • Yan‑Qing Shen
    • Jing‑Jing Pan
    • Zhong‑Yi Sun
    • Xiao‑Qing Chen
    • Xiao‑Guang Zhou
    • Xiao‑Yu Zhou
    • Rui Cheng
    • Yang Yang
  • View Affiliations / Copyright

    Affiliations: Department of Neonates, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China, Department of Pediatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1399-1413
    |
    Published online on: August 2, 2019
       https://doi.org/10.3892/ijmm.2019.4299
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Abstract

At present, thousands of circular RNAs (circRNAs) have been found in cancer and various tissues from different species. However, the expression of circRNAs during rat lung development remains largely unknown. In the present study, circRNA expression profiles were screened in three mixed rat lung tissues at 3 time‑points [embryonic day (E) 19, E21 and post‑natal (P) day 3] during fetal rat development with circRNA high‑throughput sequencing. Preliminary results were verified by reverse transcription‑PCR (RT‑PCR) at 4 time‑points (E16, E19, E21 and P3). A total of 375 circRNAs were differently expressed in E19 vs. E21 (fold change ≥1.5; P<0.05). At the same time, a total of 358 circRNAs were differently expressed in E21 vs. P3 (fold change ≥1.5; P<0.05). A total of 3 circRNAs (rno_circ:chr7:24777879‑24784993, rno_circ:chr14:14620910‑14624933 and rno_circ:chr3:1988750‑​1998592) were characterized by having consistent fold changes (≥1.5) between 3 time‑points (E19, E21 and P3) and were selected for RT‑PCR at 4 time‑points (E16, E19, E21 and P3). Subsequently, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of parent genes of the differentially expressed circRNAs revealed that these circRNAs may serve important roles in lung development. The present results support that these new found circRNAs participate in lung development. Furthermore, these findings may help to clarify the physiopathological mechanism of normal rat lung development, and may further provide a physiopathological basis of lung developmental diseases.
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View References

1 

Strueby L and Thebaud B: Advances in bronchopulmonary dysplasia. Expert Rev Respir Med. 8:327–338. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Condò V, Cipriani S, Colnaghi M, Bellù R, Zanini R, Bulfoni C, Parazzini F and Mosca F: Neonatal respiratory distress syndrome: Are risk factors the same in preterm and term infants? J Matern Fetal Neonatal Med. 30:1267–1272. 2017. View Article : Google Scholar

3 

Johar D, Siragam V, Mahood TH and Keijzer R: New insights into lung development and diseases: The role of microRNAs. Biochem Cell Biol. 93:139–148. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Herriges M and Morrisey EE: Lung development: Orchestrating the generation and regeneration of a complex organ. Development. 141:502–513. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Ameis D, Khoshgoo N, Iwasiow BM, Snarr P and Keijzer R: MicroRNAs in lung development and disease. Paediatr Respir Rev. 22:38–43. 2017.PubMed/NCBI

6 

Chen LL and Yang L: Regulation of circRNA biogenesis. RNA Biol. 12:381–388. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Ebbesen KK, Hansen TB and Kjems J: Insights into circular RNA biology. RNA Biol. 14:1035–1045. 2017. View Article : Google Scholar :

8 

Zhang ZC, Guo XL and Li X: The novel roles of circular RNAs in metabolic organs. Genes Dis. 5:16–23. 2017. View Article : Google Scholar

9 

Wilusz JE: A 360° view of circular RNAs: From biogenesis to functions. Wiley Interdiscip Rev RNA. 9. pp. e14782018, View Article : Google Scholar

10 

Kulcheski FR, Christoff AP and Margis R: Circular RNAs are miRNA sponges and can be used as a new class of biomarker. J Biotechnol. 238:42–51. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Westholm JO, Miura P, Olson S, Shenker S, Joseph B, Sanfilippo P, Celniker SE, Graveley BR and Lai EC: Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation. Cell Rep. 9:1966–1980. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Venø MT, Hansen TB, Venø ST, Clausen BH, Grebing M, Finsen B, Holm IE and Kjems J: Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development. Genome Biol. 16:2452015. View Article : Google Scholar : PubMed/NCBI

13 

Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC and Salzman J: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol. 16:1262015. View Article : Google Scholar : PubMed/NCBI

14 

Mullassery D and Smith NP: Lung development. Semin Pediatr Surg. 24:152–155. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Yang Y, Kai G, Pu XD, Qing K, Guo XR and Zhou XY: Expression profile of microRNAs in fetal lung development of sprague-dawley rats. Int J Mol Med. 29:393–402. 2012.

16 

Anderson J: An introduction to routine and special staining. 2012

17 

Bolger AM, Lohse M and Usadel B: Trimmomatic: A flexible trimmer for illumina sequence data. Bioinformatics. 30:2114–2120. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Gao Y, Wang J and Zhao F: CIRI: An efficient and unbiased algorithm for de novo circular RNA identification. Genome Boil. 16:42015. View Article : Google Scholar

19 

Li H and Durbin R: Fast and accurate short read alignment with burrows-wheeler transform. Bioinformatics. 25:1754–1760. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Dang Y, Ouyang X, Zhang F, Wang K, Lin Y, Sun B, Wang Y, Wang L and Huang Q: Circular RNAs expression profiles in human gastric cancer. Sci Rep. 7:90602017. View Article : Google Scholar : PubMed/NCBI

21 

Lin Li J, Sun H, Kong Z, Yan G, Wang X, Wang Y, Wen X, Liu Y, Zheng XH, et al: High-throughput data of circular RNA profiles in human temporal cortex tissue reveals novel insights into temporal lobe epilepsy. Cell Physiol Biochem. 45:677–691. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Wang J, Zhu MC, Kalionis B, Wu JZ, Wang LL, Ge HY, Chen CC, Tang XD, Song YL, He H and Xia SJ: Characteristics of circular RNA expression in lung tissues from mice with hypoxiainduced pulmonary hypertension. Int J Mol Med. 42:1353–1366. 2018.PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

24 

Huang Li Z, Bao C, Chen C, Lin L, Wang M, Zhong X, Yu G, Hu B, Dai WL, et al: Corrigendum: Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 24:1942017. View Article : Google Scholar : PubMed/NCBI

25 

Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N and Kadener S: circRNA biogenesis competes with Pre-mRNA splicing. Mol Cell. 56:55–66. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Huang Li Z, Bao C, Chen C, Lin L, Wang M, Zhong X, Yu G, Hu B, Dai WL, et al: Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Boil. 22:256–264. 2015. View Article : Google Scholar

27 

Hsiao KY, Sun HS and Tsai SJ: Circular RNA-New member of noncoding RNA with novel functions. Exp Boil Med (Maywood). 242:1136–1141. 2017. View Article : Google Scholar

28 

Alvira CM: Nuclear factor-kappa-B signaling in lung development and disease: One pathway, numerous functions. Birth Defects Res A Clin Mol Teratol. 100:202–216. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Woik N and Kroll J: Regulation of lung development and regeneration by the vascular system. Cell Mol Life Sci. 72:2709–2718. 2018. View Article : Google Scholar

30 

Mahoney JE, Mori M, Szymaniak AD, Varelas X and Cardoso WV: The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell. 30:137–150. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Lin C, Yao E and Chuang PT: A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Dev Biol. 403:101–113. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Saito A and Nagase T: Hippo and TGF-β interplay in the lung field. Am J Physiol Lung Cell Mol Physiol. 309:L756–L767. 2015.PubMed/NCBI

33 

Goss AM, Tian Y, Tsukiyama T, Cohen ED, Zhou D, Lu MM, Yamaguchi TP and Morrisey EE: Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell. 17:290–298. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Shu W, Jiang YQ, Lu MM and Morrisey EE: Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development. 129:4831–4842. 2002.PubMed/NCBI

35 

Zhang M, Shi J, Huang Y and Lai L: Expression of canonical WNT/beta-CATENIN signaling components in the developing human lung. BMC Dev Biol. 12:212012. View Article : Google Scholar

36 

Moura RS, Carvalho-Correia E, daMota P and Correia-Pinto J: Canonical Wnt signaling activity in early stages of chick lung development. PLoS One. 9:e1123882014. View Article : Google Scholar : PubMed/NCBI

37 

Volckaert T and De Langhe SP: Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development. Dev Dyn. 244:342–366. 2015. View Article : Google Scholar

38 

Yao Y, Hua Q and Zhou Y: CircRNA has_circ_0006427 suppresses the progression of lung adenocarcinoma by regulating miR-6783-3p/DKK1 axis and inactivating Wnt/beta-catenin signaling pathway. Biochem Biophys Res Commun. 508:37–45. 2019. View Article : Google Scholar

39 

Chen D, Ma W, Ke Z and Xie F: CircRNA has_circ-100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression. Cell Cycle. 17:2080–2090. 2018. View Article : Google Scholar

40 

Han J, Zhao G, Ma X, Dong Q, Zhang H, Wang Y and Cui J: CircRNA circ-BANP-mediated miR-503/LARP1 signaling contributes to lung cancer progression. Biochem Biophys Res Commun. 503:2429–2435. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Oglesby IK, Bray IM, Chotirmall SH, Stallings RL, O'Neill SJ, McElvaney NG and Greene CM: miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression. J Immunol. 184:1702–1709. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Zhao D, Zhuang N, Ding Y, Kang Y and Shi L: MiR-221 activates the NF-κB pathway by targeting A20. Biochem Biophys Res Commun. 472:11–18. 2016. View Article : Google Scholar

43 

Mujahid S, Nielsen HC and Volpe MV: MiR-221 and miR-130a regulate lung airway and vascular development. PLoS One. 8:e559112013. View Article : Google Scholar : PubMed/NCBI

44 

Dong J, Carey WA, Abel S, Collura C, Jiang G, Tomaszek S, Sutor S, Roden AC, Asmann YW, Prakash YS and Wigle DA: MicroRNA-mRNA interactions in a murine model of hyperoxia-induced bronchopulmonary dysplasia. BMC Genomics. 13:2042012. View Article : Google Scholar : PubMed/NCBI

45 

Wu YT, Chen WJ, Hsieh WS, Tsao PN, Yu SL, Lai CY, Lee WC and Jeng SF: MicroRNA expression aberration associated with bronchopulmonary dysplasia in preterm infants: A preliminary study. Respir Care. 58:1527–1535. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Zhang XQ, Zhang P, Yang Y, Qiu J, Kan Q, Liang HL, Zhou XY and Zhou XG: Regulation of pulmonary surfactant synthesis in fetal rat type II alveolar epithelial cells by microRNA-26a. Pediatr Pulmonol. 49:863–872. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Long J, Wang Y, Wang W, Chang BH and Danesh FR: Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions. J Boil Chem. 285:23457–23465. 2010. View Article : Google Scholar

48 

Roush S and Slack FJ: The let-7 family of microRNAs. Trends Cell Biol. 18:505–516. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Büssing I, Slack FJ and Grosshans H: let-7 microRNAs in development, stem cells and cancer. Trends Mol Med. 14:400–409. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Mondol V and Pasquinelli AE: Let's make it happen: The role of let-7 microRNA in development. Curr Top Dev Biol. 99:1–30. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, et al: Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 408:86–89. 2000. View Article : Google Scholar : PubMed/NCBI

52 

Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, Wilson M, Wang X, Shelton J, Shingara J, et al: The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 67:7713–7722. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D and Slack FJ: RAS Is regulated by the let-7 MicroRNA family. Cell. 120:635–647. 2005. View Article : Google Scholar : PubMed/NCBI

54 

Shinya M, Koshida S, Sawada A, Kuroiwa A and Takeda H: Fgf signalling through MAPK cascade is required for development of the subpallial telencephalon in zebrafish embryos. Development. 128:4153–4164. 2001.PubMed/NCBI

55 

Min H, Danilenko DM, Scully SA, Bolon B, Ring BD, Tarpley JE, DeRose M and Simonet WS: Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev. 12:3156–3161. 1998. View Article : Google Scholar : PubMed/NCBI

56 

Cardoso WV and Lü J: Regulation of early lung morphogenesis: Questions, facts and controversies. Development. 133:1611–1624. 2006. View Article : Google Scholar : PubMed/NCBI

57 

Park WY, Miranda B, Lebeche D, Hashimoto G and Cardoso WV: FGF-10 is a chemotactic factor for distal epithelial buds during lung development. Dev Biol. 201:125–134. 1998. View Article : Google Scholar : PubMed/NCBI

58 

Colin AA, McEvoy C and Castile RG: Respiratory morbidity and lung function in preterm infants of 32 to 36 weeks' gestational age. Pediatrics. 126:115–128. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shen YQ, Pan JJ, Sun ZY, Chen XQ, Zhou XG, Zhou XY, Cheng R and Yang Y: Differential expression of circRNAs during rat lung development. Int J Mol Med 44: 1399-1413, 2019.
APA
Shen, Y., Pan, J., Sun, Z., Chen, X., Zhou, X., Zhou, X. ... Yang, Y. (2019). Differential expression of circRNAs during rat lung development. International Journal of Molecular Medicine, 44, 1399-1413. https://doi.org/10.3892/ijmm.2019.4299
MLA
Shen, Y., Pan, J., Sun, Z., Chen, X., Zhou, X., Zhou, X., Cheng, R., Yang, Y."Differential expression of circRNAs during rat lung development". International Journal of Molecular Medicine 44.4 (2019): 1399-1413.
Chicago
Shen, Y., Pan, J., Sun, Z., Chen, X., Zhou, X., Zhou, X., Cheng, R., Yang, Y."Differential expression of circRNAs during rat lung development". International Journal of Molecular Medicine 44, no. 4 (2019): 1399-1413. https://doi.org/10.3892/ijmm.2019.4299
Copy and paste a formatted citation
x
Spandidos Publications style
Shen YQ, Pan JJ, Sun ZY, Chen XQ, Zhou XG, Zhou XY, Cheng R and Yang Y: Differential expression of circRNAs during rat lung development. Int J Mol Med 44: 1399-1413, 2019.
APA
Shen, Y., Pan, J., Sun, Z., Chen, X., Zhou, X., Zhou, X. ... Yang, Y. (2019). Differential expression of circRNAs during rat lung development. International Journal of Molecular Medicine, 44, 1399-1413. https://doi.org/10.3892/ijmm.2019.4299
MLA
Shen, Y., Pan, J., Sun, Z., Chen, X., Zhou, X., Zhou, X., Cheng, R., Yang, Y."Differential expression of circRNAs during rat lung development". International Journal of Molecular Medicine 44.4 (2019): 1399-1413.
Chicago
Shen, Y., Pan, J., Sun, Z., Chen, X., Zhou, X., Zhou, X., Cheng, R., Yang, Y."Differential expression of circRNAs during rat lung development". International Journal of Molecular Medicine 44, no. 4 (2019): 1399-1413. https://doi.org/10.3892/ijmm.2019.4299
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