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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November-2019 Volume 44 Issue 5

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Article

SKA1 overexpression is associated with the prognosis of esophageal squamous cell carcinoma and regulates cell proliferation and migration

  • Authors:
    • Dongxin Hu
    • Zhen Li
    • Xiao Li
    • Honghao Fu
    • Mingyan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
  • Pages: 1971-1978
    |
    Published online on: September 17, 2019
       https://doi.org/10.3892/ijmm.2019.4343
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Abstract

Spindle and kinetochore‑associated protein 1 (SKA1), a microtubule‑binding subcomplex of the outer kinetochore, is essential for complete chromosomal separation. SKA1 has been suggested as a potential biomarker for various types of cancer. However, the exact role of SKA1 in esophageal squamous cell carcinoma (ESCC) remains unclear. The present study investigated whether SKA1 affects the biological behavior of ESCC. The expression of SKA1 in ESCC tissues was measured using immunohistochemistry and reverse transcription‑quantitative polymerase chain reaction. In addition, a SKA1‑silencing lentivirus was constructed, which was transfected into TE‑1 cells to establish stable SKA1‑knockdown TE‑1 cells. Proliferation was analyzed using a Celigo image cytometer and a MTS assay. Cell cycle progression and apoptosis were analyzed by flow cytometry, while cell migration was assessed using a Transwell assay. SKA1 was significantly overexpressed in ESCC tissues, and SKA1 overexpression was significantly associated with differentiation, pathological N stage and pathological tumor‑node‑metastasis stage. SKA1 was determined to be an independent prognostic factor for ESCC. Furthermore, SKA1 was significantly overexpressed in ESCC cells, and SKA1‑silencing inhibited cell proliferation and migration, arrested the cell cycle and promoted cell apoptosis. In summary, SKA1 may serve as a potential therapeutic target and prognostic biomarker for ESCC.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Zeng H, Zhang S and He J: Annual report on status of cancer in China, 2011. Chin J Cancer Res. 27:2–12. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Arnold M, Soerjomataram I, Ferlay J and Forman D: Global incidence of oesophageal cancer by histological subtype in 2012. Gut. 64:381–387. 2015. View Article : Google Scholar

5 

Zeng H, Zheng R, Guo Y, Zhang S, Zou X, Wang N, Zhang L, Tang J, Chen J, Wei K, et al: Cancer survival in China, 2003-2005: A population-based study. Int J Cancer. 136:1921–1930. 2015. View Article : Google Scholar

6 

Yang CS, Chen X and Tu S: Etiology and prevention of esophageal cancer. Gastrointest Tumors. 3:3–16. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Abnet CC, Arnold M and Wei WQ: Epidemiology of esophageal squamous cell carcinoma. Gastroenterology. 154:360–373. 2018. View Article : Google Scholar :

8 

Wang M, Smith JS and Wei WQ: Tissue protein biomarker candidates to predict progression of esophageal squamous cell carcinoma and precancerous lesions. Ann N Y Acad Sci. 1434:59–69. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Zulfiqar M, Bluth MH and Bhalla A: Molecular diagnostics in esophageal and gastric neoplasms: 2018 update. Clin Lab Med. 38:357–365. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Welburn JP, Grishchuk EL, Backer CB, Wilson-Kubalek EM, Yates JR III and Cheeseman IM: The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Dev Cell. 16:374–385. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Schmidt JC, Arthanari H, Boeszoermenyi A, Dashkevich NM, Wilson-Kubalek EM, Monnier N, Markus M, Oberer M, Milligan RA, Bathe M, et al: The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments. Dev Cell. 23:968–980. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Dong C, Wang XL and Ma BL: Expression of spindle and kinetochore-associated protein 1 is associated with poor prognosis in papillary thyroid carcinoma. Dis Markers. 2015:6165412015. View Article : Google Scholar : PubMed/NCBI

13 

Zhao L, Jiang L, Du P, Zhang D, Liu Z, Li K and Zhang B: Expression of SKA1 and MMP-9 in primary salivary adenoid cystic carcinoma: Correlation with tumor progression and patient prognosis. Acta Otolaryngol. 136:575–579. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Wu J, Chai Y, Zhou XM, Chen QX and Yan FL: Ivor Lewis esophagectomy with two-field lymph node dissection for squamous cell carcinoma of the lower thoracic esophagus. Ai Zheng. 26:307–311. 2007.PubMed/NCBI

15 

Shi M, Wang Z, Liu XY and Chen D: Inactivation of RUNX3 predicts poor prognosis in esophageal squamous cell carcinoma after Ivor-Lewis esophagectomy. Med Oncol. 31:3092014. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

17 

Sauer G, Körner R, Hanisch A, Ries A, Nigg EA and Silljé HH: Proteome analysis of the human mitotic spindle. Mol Cell Proteomics. 4:35–43. 2005. View Article : Google Scholar

18 

Park JE, Song H, Kwon HJ and Jang CY: Ska1 cooperates with DDA3 for spindle dynamics and spindle attachment to kineto-chore. Biochem Biophys Res Commun. 470:586–592. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Thomas GE, Bandopadhyay K, Sutradhar S, Renjith MR, Singh P, Gireesh KK, Simon S, Badarudeen B, Gupta H, Banerjee M, et al: EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice. Nat Commun. 7:116652016. View Article : Google Scholar : PubMed/NCBI

20 

Abad MA, Zou J, Medina-Pritchard B, Nigg EA, Rappsilber J, Santamaria A and Jeyaprakash AA: Ska3 ensures timely mitotic progression by interacting directly with microtubules and Ska1 microtubule binding domain. Sci Rep. 6:340422016. View Article : Google Scholar : PubMed/NCBI

21 

Chen Y, Zhao J, Jiao Z, Wang W, Wang D, Yu X, Shi Z, Ge N, Pan Q, Xia J, et al: SKA1 overexpression is associated with poor prognosis in hepatocellular carcinoma. BMC Cancer. 18:12402018. View Article : Google Scholar : PubMed/NCBI

22 

Qin X, Yuan B, Xu X, Huang H and Liu Y: Effects of short interfering RNA-mediated gene silencing of SKA1 on proliferation of hepatocellular carcinoma cells. Scand J Gastroenterol. 48:1324–1332. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Tian F, Xing X, Xu F, Cheng W, Zhang Z, Gao J, Ge J and Xie H: Downregulation of SKA1 gene expression inhibits cell growth in human bladder cancer. Cancer Biother Radiopharm. 30:271–277. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Shen L, Yang M, Lin Q, Zhang Z, Miao C and Zhu B: SKA1 regulates the metastasis and cisplatin resistance of non-small cell lung cancer. Oncol Rep. 35:2561–2568. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Zhao LJ, Yang HL, Li KY, Gao YH, Dong K, Liu ZH, Wang LX and Zhang B: Knockdown of SKA1 gene inhibits cell proliferation and metastasis in human adenoid cystic carcinoma. Biomed Pharmacother. 90:8–14. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Li J, Xuan JW, Khatamianfar V, Valiyeva F, Moussa M, Sadek A, Yang BB, Dong BJ, Huang YR and Gao WQ: SKA1 over-expression promotes centriole over-duplication, centrosome amplification and prostate tumourigenesis. J Pathol. 234:178–189. 2014.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu D, Li Z, Li X, Fu H and Zhang M: SKA1 overexpression is associated with the prognosis of esophageal squamous cell carcinoma and regulates cell proliferation and migration. Int J Mol Med 44: 1971-1978, 2019.
APA
Hu, D., Li, Z., Li, X., Fu, H., & Zhang, M. (2019). SKA1 overexpression is associated with the prognosis of esophageal squamous cell carcinoma and regulates cell proliferation and migration. International Journal of Molecular Medicine, 44, 1971-1978. https://doi.org/10.3892/ijmm.2019.4343
MLA
Hu, D., Li, Z., Li, X., Fu, H., Zhang, M."SKA1 overexpression is associated with the prognosis of esophageal squamous cell carcinoma and regulates cell proliferation and migration". International Journal of Molecular Medicine 44.5 (2019): 1971-1978.
Chicago
Hu, D., Li, Z., Li, X., Fu, H., Zhang, M."SKA1 overexpression is associated with the prognosis of esophageal squamous cell carcinoma and regulates cell proliferation and migration". International Journal of Molecular Medicine 44, no. 5 (2019): 1971-1978. https://doi.org/10.3892/ijmm.2019.4343
Copy and paste a formatted citation
x
Spandidos Publications style
Hu D, Li Z, Li X, Fu H and Zhang M: SKA1 overexpression is associated with the prognosis of esophageal squamous cell carcinoma and regulates cell proliferation and migration. Int J Mol Med 44: 1971-1978, 2019.
APA
Hu, D., Li, Z., Li, X., Fu, H., & Zhang, M. (2019). SKA1 overexpression is associated with the prognosis of esophageal squamous cell carcinoma and regulates cell proliferation and migration. International Journal of Molecular Medicine, 44, 1971-1978. https://doi.org/10.3892/ijmm.2019.4343
MLA
Hu, D., Li, Z., Li, X., Fu, H., Zhang, M."SKA1 overexpression is associated with the prognosis of esophageal squamous cell carcinoma and regulates cell proliferation and migration". International Journal of Molecular Medicine 44.5 (2019): 1971-1978.
Chicago
Hu, D., Li, Z., Li, X., Fu, H., Zhang, M."SKA1 overexpression is associated with the prognosis of esophageal squamous cell carcinoma and regulates cell proliferation and migration". International Journal of Molecular Medicine 44, no. 5 (2019): 1971-1978. https://doi.org/10.3892/ijmm.2019.4343
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