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Protective effect of hydrogen sulfide on monocrotaline‑induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition

  • Authors:
    • Hui Zhang
    • Yanjun Lin
    • Yiwen Ma
    • Junfeng Zhang
    • Changqian Wang
    • Huili Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China, Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2091-2102
    |
    Published online on: October 1, 2019
       https://doi.org/10.3892/ijmm.2019.4359
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Abstract

Endothelial‑to‑mesenchymal transition (EndMT) serves an important role in the vascular remodeling of pulmonary arterial hypertension (PAH). However, little is known about the correlation between hydrogen sulfide (H2S), a protective gaseous mediator in PAH and the process of EndMT. Male Sprague‑Dawley rats (10 weeks old) received a single dose of monocrotaline (MCT; i.p., 60 mg/kg) and were randomly treated with NaHS [an H2S donor; intraperitoneal (i.p.) 1 mg/kg/day], DL‑propagylglycine (an inhibitor of H2S synthesis; PAG; i.p., 10 mg/kg/day) or saline, 7 days after MCT injection. Rats were sacrificed 21 days after MCT injection. A selection of human pulmonary artery endothelial cells (HPAECs) were pretreated with NaHS or saline and stimulated with transforming growth factor (TGF)‑β1 (10 ng/ml), and the other HPAECs were transfected with a cystathionine γ‑lyase (CSE, an H2S synthesizing enzyme) plasmid and subsequently stimulated with TGF‑β1. NaHS was indicated to inhibit EndMT and PAH progression by inhibiting the induction of the nuclear factor (NF)‑κB‑Snail pathway. In contrast, the depletion of H2S formation by PAG exacerbated EndMT and PAH by activating NF‑κB‑Snail molecules. In HPAECs, NaHS dose‑dependently inhibited TGF‑β1‑induced EndMT and the activation of the NF‑κB‑Snail pathway. Transfection with a CSE plasmid significantly repressed TGF‑β1‑induced expression of the mesenchymal marker and upregulated the expression of the endothelial marker, which was accompanied by the suppression of the NF‑κB‑Snail pathway. The inhibitory effect of CSE overexpression on TGF‑β1‑induced EndMT was significantly reversed by pretreatment with PAG. In conclusion, the current study provides novel information elucidating the beneficial effect of H2S on PAH through inhibiting the induction of the NF‑κB‑Snail pathway and the subsequent process of EndMT in pulmonary arteries.
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1 

Goumans MJ, van Zonneveld AJ and ten Dijke P: Transforming growth factor beta-induced endothelial-to-mesenchymal transition: A switch to cardiacfibrosis? Trends Cardiovasc Med. 18:293–298. 2008. View Article : Google Scholar

2 

Willis BC and Borok Z: TGF-beta-induced EMT: Mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol. 293:L525–L534. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M and Kalluri R: Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol. 19:2282–2287. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, et al: Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med. 13:952–961. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Arciniegas E, Frid MG, Douglas IS and Stenmark KR: Perspectives onendothelial-to-mesenchymal transition: Potential contribution to vascular remodeling in chronic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 293:L1–L8. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Hopper RK, Moonen JR, Diebold I, Cao A, Rhodes CJ, Tojais NF, Hennigs JK, Gu M, Wang L and Rabinovitch M: In pulmonary arterial hypertension, reduced BMPR2 promotes endothelial-to-mesenchymal transition via HMGA1 and its target slug. Circulation. 133:1783–1794. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Ranchoux B, Antigny F, Rucker-Martin C, Hautefort A, Péchoux C, Bogaard HJ, Dorfmüller P, Remy S, Lecerf F, Planté S, et al: Endothelial-to-mesenchymal transition in pulmonary hypertension. Circulation. 131:1006–1018. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Lefer DJ: A new gaseous signaling molecule emerges: Cardioprotective role of hydrogen sulfide. Proc Natl Acad Sci USA. 104:17907–17908. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Elsey DJ, Fowkes RC and Baxter GF: Regulation of cardiovascular cell function by hydrogen sulfide (H2S). Cell Biochem Funct. 28:95–106. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Tang C, Li X and Du J: Hydrogen sulfide as a new endogenous gaseous transmitter in the cardiovascular system. Curr Vasc Pharmacol. 4:17–22. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Hongfang J, Cong Bailin, Bin Zhao, Zhang Chunyu, Xinmin Liu, Weijin Zhou, Ying Shi, Tang Chaoshu and Junbao D: Effects of hydrogen sulfide on hypoxic pulmonary vascular structural remodeling. Life Sci. 78:1299–1309. 2006. View Article : Google Scholar

12 

Li X, Du J, Jin H, Tang X, Bu D and Tang C: The regulatory effect of endogenous hydrogen sulfide on pulmonary vascular structure and gasotransmitters in rats with high pulmonary blood flow. Life Sci. 81:841–849. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Li X, Du J, Jin H, Geng B and Tang C: Sodium hydrosul-fide alleviates pulmonary artery collagen remodeling in rats with high pulmonary blood flow. Heart Vessels. 23:409–419. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Luo L, Liu D, Tang C, Du J, Liu AD, Holmberg L and Jin H: Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow. Biochem Biophys Res Commun. 433:519–525. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Stenmark KR, Meyrick B, Galie N, Mooi WJ and McMurtry IF: Animal models of pulmonary arterial hypertension: The hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol. 297:L1013–L1032. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Zhang H, Guo C, Wu D, Zhang A, Gu T, Wang L and Wang C: Hydrogen sulfide inhibits the development of atherosclerosis with suppressing CX3CR1 and CX3CL1 expression. PLoS One. 7:e411472012. View Article : Google Scholar : PubMed/NCBI

17 

Lin Y, Zeng H, Gao L, Gu T, Wang C and Zhang H: Hydrogen sulfide attenuates atherosclerosis in a partially ligated carotid artery mouse model via regulating angiotensin converting enzyme 2 expression. Front Physiol. 8:7822017. View Article : Google Scholar : PubMed/NCBI

18 

Barberà MJ, Puig I, Domínguez D, Julien-Grille S, Guaita-Esteruelas S, Peiró S, Baulida J, Francí C, Dedhar S, Larue L and García de Herreros A: Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene. 23:7345–7354. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Batlle E, Sancho E, Francí C, Domínguez D, Monfar M, Baulida J, García De and Herreros A: The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumor cells. Nat Cell Biol. 2:84–89. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Julien S, Puig I, Caretti E, Bonaventure J, Nelles L, van Roy F, Dargemont C, de Herreros AG, Bellacosa A and Larue L: Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene. 26:7445–7456. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Nikitopoulou I, Orfanos SE, Kotanidou A, Maltabe V, Manitsopoulos N, Karras P, Kouklis P, Armaganidis A and Maniatis NA: Vascular endothelial-cadherin downregulation as a feature of endothelial transdifferentiation in monocrota-line-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 311:L352–L363. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Long L, Crosby A, Yang X, Southwood M, Upton PD, Kim DK and Morrell NW: Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: Potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease. Circulation. 119:566–576. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Zakrzewicz A, Kouri FM, Nejman B, Kwapiszewska G, Hecker M, Sandu R, Dony E, Seeger W, Schermuly RT, Eickelberg O and Morty RE: The transforming growth factor-beta/Smad2,3 signaling axis is impaired in experimental pulmonary hypertension. Eur Respir J. 29:1094–1104. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Reynolds AM, Holmes MD, Danilov SM and Reynolds PN: Targeted gene delivery of BMPR2 attenuates pulmonary hypertension. Eur Respir J. 39:329–343. 2012. View Article : Google Scholar

25 

Frid MG, Kale VA and Stenmark KR: Mature vascular endothelium can give rise to smooth muscle cells via endothe-lial-mesenchymal transdifferentiation: In vitro analysis. Circ Res. 90:1189–1196. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Fan HN, Wang HJ, Ren L, Ren B, Dan CR, Li YF, Hou LZ and Deng Y: Decreased expression of p38 MAPK mediates protective effects of hydrogen sulfide on hepatic fibrosis. Eur Rev Med Pharmacol Sci. 17:644–652. 2013.PubMed/NCBI

27 

Fang L, Li H, Tang C, Geng B, Qi Y and Liu X: Hydrogen sulfide attenuates the pathogenesis of pulmonary fibrosis induced by bleomycin in rats. Can J Physiol Pharmacol. 87:531–538. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Jung KJ, Jang HS, Kim JI, Han SJ, Park JW and Park KM: Involvement of hydrogen sulfide and homocysteine transsulfuration pathway in the progression of kidney fibrosis after ureteral obstruction. Biochim Biophys Acta. 1832:1989–1997. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Huang Y, Zhang Z, Huang Y, Mao Z, Yang X, Nakamura Y, Sawada N, Mitsui T, Takeda M and Yao J: Induction of inactive TGF-β1 monomer formation by hydrogen sulfide contributes to its suppressive effects on Ang II- and TGF-β1-induced EMT in renal tubular epithelial cells. Biochem Biophys Res Commun. 501:534–540. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Guo L, Peng W, Tao J, Lan Z, Hei H, Tian L, Pan W, Wang L and Zhang X: Hydrogen sulfide inhibits transforming growth factor-β1-induced EMT via Wnt/Catenin pathway. PLoS One. 11:e01470182016. View Article : Google Scholar

31 

Lv M, Li Y, Ji MH, Zhuang M and Tang JH: Inhibition of invasion and epithelial-mesenchymal transition of human breast cancer cells by hydrogen sulfide through decreased phospho-p38 expression. Mol Med Rep. 10:341–346. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Pan Y, Zhou C, Yuan D, Zhang J and Shao C: Radiation exposure promotes hepatocarcinoma cell invasion through epithelial mesenchymal transition mediated by H2S/CSE pathway. Radiat Res. 185:96–105. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Ying R, Wang XQ, Yang Y, Gu ZJ, Mai JT, Qiu Q, Chen YX and Wang JF: Hydrogen sulfide suppresses endoplasmic reticulum stress-induced endothelial-to-mesenchymal transition through Src pathway. Life Sci. 144:208–217. 2016. View Article : Google Scholar

34 

Zhang D, Du J, Tang C, Huang Y and Jin H: H2S-induced sulf-hydration: Biological function and detection methodology. Front Pharmacol. 8:6082017. View Article : Google Scholar

35 

Cheng S, Lu Y, Li Y, Gao L, Shen H and Song K: Hydrogen sulfide inhibits epithelial-mesenchymal transition in peritoneal mesothelial cells. Sci Rep. 8:58632018. View Article : Google Scholar : PubMed/NCBI

36 

Fang LP, Lin Q, Tang CS and Liu XM: Hydrogen sulfide attenuates epithelial-mesenchymal transition of human alveolar epithelial cells. Pharmacol Res. 61:298–305. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Lin Y, Ma Y, Zhang J, Wang C and Zhang H: Protective effect of hydrogen sulfide on monocrotaline‑induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition. Int J Mol Med 44: 2091-2102, 2019.
APA
Zhang, H., Lin, Y., Ma, Y., Zhang, J., Wang, C., & Zhang, H. (2019). Protective effect of hydrogen sulfide on monocrotaline‑induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition. International Journal of Molecular Medicine, 44, 2091-2102. https://doi.org/10.3892/ijmm.2019.4359
MLA
Zhang, H., Lin, Y., Ma, Y., Zhang, J., Wang, C., Zhang, H."Protective effect of hydrogen sulfide on monocrotaline‑induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition". International Journal of Molecular Medicine 44.6 (2019): 2091-2102.
Chicago
Zhang, H., Lin, Y., Ma, Y., Zhang, J., Wang, C., Zhang, H."Protective effect of hydrogen sulfide on monocrotaline‑induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition". International Journal of Molecular Medicine 44, no. 6 (2019): 2091-2102. https://doi.org/10.3892/ijmm.2019.4359
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Lin Y, Ma Y, Zhang J, Wang C and Zhang H: Protective effect of hydrogen sulfide on monocrotaline‑induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition. Int J Mol Med 44: 2091-2102, 2019.
APA
Zhang, H., Lin, Y., Ma, Y., Zhang, J., Wang, C., & Zhang, H. (2019). Protective effect of hydrogen sulfide on monocrotaline‑induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition. International Journal of Molecular Medicine, 44, 2091-2102. https://doi.org/10.3892/ijmm.2019.4359
MLA
Zhang, H., Lin, Y., Ma, Y., Zhang, J., Wang, C., Zhang, H."Protective effect of hydrogen sulfide on monocrotaline‑induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition". International Journal of Molecular Medicine 44.6 (2019): 2091-2102.
Chicago
Zhang, H., Lin, Y., Ma, Y., Zhang, J., Wang, C., Zhang, H."Protective effect of hydrogen sulfide on monocrotaline‑induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition". International Journal of Molecular Medicine 44, no. 6 (2019): 2091-2102. https://doi.org/10.3892/ijmm.2019.4359
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