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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2019 Volume 44 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

miR‑19a promotes vascular smooth muscle cell proliferation, migration and invasion through regulation of Ras homolog family member B

Gengxin Sun, Hui Song, Suya Wu
Pages: 1991-2002
Published online on: 27 September 2019

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Article Open Access

miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation

Hu‑Nian Li, Xu Zhao, Yong‑Jiu Zha, Fang Du, Jie Liu, Liang Sun
Pages: 2003-2014
Published online on: 22 October 2019

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Article Open Access

Apoptosis induced by bruceine D in human non‑small‑cell lung cancer cells involves mitochondrial ROS‑mediated death signaling

Jian‑Hui Xie, Zheng‑Quan Lai, Xing‑Han Zheng, Yan‑Fang Xian, Qian Li, Siu‑Po Ip, You‑Liang Xie, Jian‑Nan Chen, Zi‑Ren Su, Zhi‑Xiu Lin, Xiao‑Bo Yang
Pages: 2015-2026
Published online on: 03 October 2019

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Article Open Access

Screening for differentially‑expressed microRNA biomarkers in Saudi colorectal cancer patients by small RNA deep sequencing

Yazeed A. Al‑Sheikh, Hazem K. Ghneim, Khalid K. Alharbi, Mourad A.M. Aboul‑Soud
Pages: 2027-2036
Published online on: 02 October 2019

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Article Open Access

Stop codons and the +4 nucleotide may influence the efficiency of G418 in rescuing nonsense mutations of the HERG gene

Haiyun Yu, Yanhai Meng, Shuhong Zhang, Chen Tian, Fang Wu, Ning Li, Qiuyang Li, Yulan Jin, Jielin Pu
Pages: 2037-2046
Published online on: 01 October 2019

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Article Open Access

FSH1 regulates the phenotype and pathogenicity of the pathogenic dermatophyte Microsporum canis

Furong Zhang, Can Tan, Yu Xu, Guoling Yang
Pages: 2047-2056
Published online on: 27 September 2019

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Article Open Access

The goat β‑casein/CMV chimeric promoter drives the expression of hLF in transgenic goats produced by cell transgene microinjection

Ting Zhang, Yuguo Yuan, Rui Lu, Sheng Xu, Minya Zhou, Tingting Yuan, Yaoyao Lu, Kunning Yan, Yong Cheng
Pages: 2057-2064
Published online on: 24 October 2019

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Article Open Access

Redd1 protects against post‑infarction cardiac dysfunction by targeting apoptosis and autophagy

Pianpian Huang, Jun Fu, Long Chen, Chenhui Ju, Kefei Wu, Hongxia Liu, Yun Liu, Benming Qi, Benling Qi, Lihua Liu
Pages: 2065-2076
Published online on: 04 October 2019

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Article Open Access

Upregulation of sphingosine kinase 1 contributes to ventilator-associated lung injury in a two-hit model

Yan Wang, Ting‑Ting Gao, Dun‑Feng Xu, Xiao‑Yan Zhu, Wen‑Wen Dong, Zhou Lv, Yu‑Jian Liu, Lai Jiang
Pages: 2077-2090
Published online on: 21 October 2019

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Article Open Access

Protective effect of hydrogen sulfide on monocrotaline‑induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition

Hui Zhang, Yanjun Lin, Yiwen Ma, Junfeng Zhang, Changqian Wang, Huili Zhang
Pages: 2091-2102
Published online on: 01 October 2019

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Article Open Access

Adipose‑derived stem cells overexpressing SK4 calcium‑activated potassium channel generate biological pacemakers

Mei Yang, Qingyan Zhao, Hongyi Zhao, Ankang Yang, Fengyuan Wang, Xi Wang, Yanhong Tang, Congxin Huang
Pages: 2103-2112
Published online on: 16 October 2019

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Article Open Access

TPX2 silencing exerts anti‑tumor effects on hepatocellular carcinoma by regulating the PI3K/AKT signaling pathway

Dan‑Hong Huang, Jie Jian, Shuang Li, Yan Zhang, Li‑Zhen Liu
Pages: 2113-2122
Published online on: 14 October 2019

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Article Open Access

Roles of p38α and p38β mitogen‑activated protein kinase isoforms in human malignant melanoma A375 cells

Su‑Ying Wen, Shi‑Yann Cheng, Shang‑Chuan Ng, Ritu Aneja, Chih‑Jung Chen, Chih‑Yang Huang, Wei‑Wen Kuo
Pages: 2123-2132
Published online on: 24 October 2019

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Article Open Access

Feasibility of tumor‑derived exosome enrichment in the onco‑hematology leukemic model of chronic myeloid leukemia

Simona Bernardi, Chiara Foroni, Camilla Zanaglio, Federica Re, Nicola Polverelli, Alessandro Turra, Enrico Morello, Mirko Farina, Federica Cattina, Lisa Gandolfi, Tatiana Zollner, Eugenia Accorsi Buttini, Michele Malagola, Domenico Russo
Pages: 2133-2144
Published online on: 14 October 2019

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Article Open Access

lncRNA/mRNA profiling of endometriosis rat uterine tissues during the implantation window

Han Cai, Xinxin Zhu, Zhanfei Li, Yapei Zhu, Jinghe Lang
Pages: 2145-2160
Published online on: 14 October 2019

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Article Open Access

TROP2 increases growth and metastasis of human oral squamous cell carcinoma through activation of the PI3K/Akt signaling pathway

Genxiong Tang, Qi Tang, Lizhou Jia, Yuan Chen, Liangyuan Lin, Xingwang Kuai, Aixiu Gong, Zhengqing Feng
Pages: 2161-2170
Published online on: 21 October 2019

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Article Open Access

Pistacia weinmannifolia root exerts a protective role in ovalbumin‑induced lung inflammation in a mouse allergic asthma model

Jae‑Won Lee, Jae‑Hong Min, Min‑Gu Kim, Seong‑Man Kim, Ok‑Kyoung Kwon, Tae Kyu Oh, Jae Kyoung Lee, Tae Young Kim, Sang Woo Lee, Sangho Choi, Wan‑Yi Li, Hyung Won Ryu, Kyung‑Seop Ahn, Sei‑Ryang Oh
Pages: 2171-2180
Published online on: 07 October 2019

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Article Open Access

Tacrolimus increases the expression level of the chemokine receptor CXCR2 to promote renal fibrosis progression

Dongdong Wang, Xiao Chen, Meng Fu, Hong Xu, Zhiping Li
Pages: 2181-2188
Published online on: 10 October 2019

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Article Open Access

Glutamine affects T24 bladder cancer cell proliferation by activating STAT3 through ROS and glutaminolysis

Ningchuan Sun, Ye Liang, Yuanbin Chen, Liping Wang, Dan Li, Zhijuan Liang, Lijiang Sun, Yonghua Wang, Haitao Niu
Pages: 2189-2200
Published online on: 25 October 2019

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Article Open Access

Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease

Xiu‑Mei Wang, Xiao‑Yi Wang, Yu‑Mei Huang, Xia Chen, Mu‑Han Lü, Lei Shi, Chang‑Ping Li
Pages: 2201-2212
Published online on: 18 October 2019

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Article Open Access

Dihydroartemisinin attenuates lipopolysaccharide‑induced acute lung injury in mice by suppressing NF‑κB signaling in an Nrf2‑dependent manner

Xiao‑Ting Huang, Wei Liu, Yong Zhou, Cai‑Xia Hao, Yan Zhou, Chen‑Yu Zhang, Chen‑Chen Sun, Zi‑Qiang Luo, Si‑Yuan Tang
Pages: 2213-2222
Published online on: 29 October 2019

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Article Open Access

Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington's disease therapy

Miriam Carbo, Valentina Brandi, Gianmarco Pascarella, David Sasah Staid, Gianni Colotti, Fabio Polticelli, Andrea Ilari, Veronica Morea
Pages: 2223-2233
Published online on: 15 October 2019

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Article Open Access

Biological effects of melatonin on human adipose‑derived mesenchymal stem cells

June Seok Heo, Sangshin Pyo, Ja‑Yun Lim, Dae Wui Yoon, Bo Yong Kim, Jin‑Hee Kim, Gi Jin Kim, Seung Gwan Lee, Jinkwan Kim
Pages: 2234-2244
Published online on: 27 September 2019

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Article Open Access

Tumor cell‑fibroblast heterotypic aggregates in malignant ascites of patients with ovarian cancer

Qing Han, Bangxing Huang, Zaiju Huang, Jing Cai, Lanqing Gong, Yifan Zhang, Jiahong Jiang, Weihong Dong, Zehua Wang
Pages: 2245-2255
Published online on: 02 October 2019

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Article Open Access

The A3 adenosine receptor agonist, namodenoson, ameliorates non‑alcoholic steatohepatitis in mice

Pnina Fishman, Shira Cohen, Inbal Itzhak, Johnny Amer, Ahmad Salhab, Faina Barer, Rifaat Safadi
Pages: 2256-2264
Published online on: 03 October 2019

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Article Open Access

Influence of radiation exposure pattern on the bone injury and osteoclastogenesis in a rat model

Jianglong Zhai, Feilong He, Jianping Wang, Junxiang Chen, Ling Tong, Guoying Zhu
Pages: 2265-2275
Published online on: 11 October 2019

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Article Open Access

RFC3 induces epithelial‑mesenchymal transition in lung adenocarcinoma cells through the Wnt/β‑catenin pathway and possesses prognostic value in lung adenocarcinoma

Shulei Gong, Xiaohan Qu, Shize Yang, Siyu Zhou, Peiwen Li, Qigang Zhang
Pages: 2276-2288
Published online on: 29 October 2019

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Article Open Access

Rutin promotes the formation and osteogenic differentiation of human periodontal ligament stem cell sheets in vitro

Bin Zhao, Yunpeng Zhang, Yixuan Xiong, Xin Xu
Pages: 2289-2297
Published online on: 25 October 2019

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Article

Genistein improves viability, proliferation and mitochondrial function of cardiomyoblasts cultured in physiologic and peroxidative conditions

Serena Farruggio, Giulia Raina, Grazia Cocomazzi, Carlotta Librasi, David Mary, Sergio Gentilli, Elena Grossini
Pages: 2298-2310
Published online on: 03 October 2019

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Article

Resveratrol attenuates pulmonary embolism associated cardiac injury by suppressing activation of the inflammasome via the MALAT1‑miR‑22‑3p signaling pathway

Kai Yang, Wancheng Li, Wenjuan Duan, Yi Jiang, Na Huang, Yunhui Li, Bocheng Ren, Jian Sun
Pages: 2311-2320
Published online on: 01 October 2019

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Article

Kaempferol‑3‑O‑β‑rutinoside suppresses the inflammatory responses in lipopolysaccharide‑stimulated RAW264.7 cells via the NF‑κB and MAPK pathways

Dukhyun Hwang, Min‑Jae Kang, Chang‑Won Kang, Gun‑Do Kim
Pages: 2321-2328
Published online on: 22 October 2019

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Article

Leiomyoma phosphoproteins involved in inhibition of oxidative stress and synthesis of reactive oxygen species

Blendi Ura, Lorenzo Monasta, Giorgio Arrigoni, Danilo Licastro, Giovanni Di Lorenzo, Federico Romano, Bartolomea Gaita, Federica Scrimin, Giuseppe Ricci
Pages: 2329-2335
Published online on: 21 October 2019

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Article

Osteoadherin serves roles in the regulation of apoptosis and growth in MC3T3‑E1 osteoblast cells

Eri Hamaya, Toshiaki Fujisawa, Masato Tamura
Pages: 2336-2344
Published online on: 18 October 2019

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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Review Open Access

MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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Review Open Access

MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Article Open Access

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Review Open Access

Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Review Open Access

Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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April-2026 Volume 57 Issue 4

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)

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Article Number: 78
Published online on: 30 January 2026

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[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Article Number: 77
Published online on: 29 January 2026

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Spatial metabolomics: A new tool for unravelling the metabolic disorders and heterogeneity in diabetic kidney disease (Review)

Hanfei Li, Yuxi Li, Bo Zhang, Wenhao Cheng, Guowei Ma, Jin Rong, Shiru Duan, Di Feng, Tingting Zhao
Article Number: 76
Published online on: 29 January 2026

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