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miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation

  • Authors:
    • Hu‑Nian Li
    • Xu Zhao
    • Yong‑Jiu Zha
    • Fang Du
    • Jie Liu
    • Liang Sun
  • View Affiliations / Copyright

    Affiliations: Emergency and Critical Care Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2003-2014
    |
    Published online on: October 22, 2019
       https://doi.org/10.3892/ijmm.2019.4380
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Abstract

In the present study, we examined the function of microRNA (miR)‑146a‑5p in patients with refractory Mycoplasma pneumoniae pneumonia. In brief, the expression of miR‑146a‑5p was reduced in patients with refractory Mycoplasma pneumoniae pneumonia. Downregulation of miR‑146a‑5p reduced inflammation in an in vitro model of refractory Mycoplasma pneumoniae pneumonia, whilst overexpression of miR‑146a‑5p promoted inflammation. Downregulation of miR‑146a‑5p induced the protein expression of ATP‑binding cassette subfamily G member 1 (ABCG1) and interleukin 1 receptor‑associated kinase 1 (IRAK‑1), while suppressed expression was observed of the aforementioned proteins following overexpression of miR‑146a‑5p in an in vitro model of refractory Mycoplasma pneumoniae pneumonia. The administration of small interfering RNA against RXR or IRAK‑1 attenuated the effects of miR‑146a‑5p on inflammation in an in vitro model of refractory Mycoplasma pneumoniae pneumonia. Collectively, these results suggested that miR‑146a‑5p reduced ABCG1 expression in refractory Mycoplasma pneumoniae pneumonia via downregulation of IRAK‑1.
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Copy and paste a formatted citation
Spandidos Publications style
Li HN, Zhao X, Zha YJ, Du F, Liu J and Sun L: miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation. Int J Mol Med 44: 2003-2014, 2019.
APA
Li, H., Zhao, X., Zha, Y., Du, F., Liu, J., & Sun, L. (2019). miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation. International Journal of Molecular Medicine, 44, 2003-2014. https://doi.org/10.3892/ijmm.2019.4380
MLA
Li, H., Zhao, X., Zha, Y., Du, F., Liu, J., Sun, L."miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation". International Journal of Molecular Medicine 44.6 (2019): 2003-2014.
Chicago
Li, H., Zhao, X., Zha, Y., Du, F., Liu, J., Sun, L."miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation". International Journal of Molecular Medicine 44, no. 6 (2019): 2003-2014. https://doi.org/10.3892/ijmm.2019.4380
Copy and paste a formatted citation
x
Spandidos Publications style
Li HN, Zhao X, Zha YJ, Du F, Liu J and Sun L: miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation. Int J Mol Med 44: 2003-2014, 2019.
APA
Li, H., Zhao, X., Zha, Y., Du, F., Liu, J., & Sun, L. (2019). miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation. International Journal of Molecular Medicine, 44, 2003-2014. https://doi.org/10.3892/ijmm.2019.4380
MLA
Li, H., Zhao, X., Zha, Y., Du, F., Liu, J., Sun, L."miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation". International Journal of Molecular Medicine 44.6 (2019): 2003-2014.
Chicago
Li, H., Zhao, X., Zha, Y., Du, F., Liu, J., Sun, L."miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation". International Journal of Molecular Medicine 44, no. 6 (2019): 2003-2014. https://doi.org/10.3892/ijmm.2019.4380
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