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Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway

  • Authors:
    • Xiong Wu
    • Shuanglong Chen
    • Chuanhui Lu
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    Affiliations: Three Departments of General Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, P.R. China, Department of Breast Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361001, P.R. China, Department of Gastrointestinal Surgery, Cancer Hospital, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, Fujian 361001, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 162-174
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    Published online on: November 13, 2019
       https://doi.org/10.3892/ijmm.2019.4404
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Abstract

To verify whether amyloid precursor protein (APP) affects the migration and invasion of breast cancer cell lines, and to understand its underlying mechanisms, epithelial‑mesenchymal transition (EMT), the mitogen‑activated protein kinase (MAPK) signaling pathway and the matrix metalloproteinase (MMP) family were investigated in MDA‑MB‑231, MCF‑7 and BT474 human breast cancer cells. Breast cancer cell lines were transfected with plasmids containing APP coding sequences (pEGFP‑n1‑APP) and APP short hairpin RNA (pENTR APP shRNA). APP overexpression efficiency, knockout efficiency and the expression levels of related genes were tested using reverse transcription‑quantitative PCR (RT‑qPCR) and western blot analyses. The effects of APP and mitogen‑activated protein kinase kinase (MEK) inhibitor on cell migration and invasion were examined using Transwell assays. The results demonstrated that APP was significantly upregulated in the pEGFP‑n1‑APP group (P<0.05), and significantly downregulated in the pENTR APP shRNA group (P<0.05), compared with the control group. APP overexpression increased the migratory and invasive ability of human breast cancer cells (P<0.05), whereas APP silencing significantly inhibited cell migration and invasion (P<0.05). RT‑qPCR and western blot analysis results suggested that APP overexpression significantly increased the expression of MMP‑9, MMP‑2, MMP‑3, N‑cadherin and vimentin (P<0.05). In addition, the enhanced expression of APP markedly affected the phosphorylation of mitogen‑activated protein kinase kinase kinase 11 (MLK3), mitogen‑activated protein kinase kinase 4 (MEK4) and mitogen‑activated protein kinase 10 (JNK3; P<0.05). Additionally, APP overexpression had no effect on the total expression levels of MLK3, MEK4, and JNK3; however, APP overexpression significantly decreased the expression levels of E‑cadherin and cytokeratin (P<0.05). Conversely, APP silencing had the opposite effects. When cells were treated with the MEK inhibitor PD0325901, the expression of APP was not altered, nor was the expression levels of MEK and its upstream signaling molecules. Taken together, the present findings suggested that APP could affect the migration and invasion of human breast cancer cells by mediating the activation of the MAPK signaling pathway, thereby promoting the EMT process.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Antoni MH and Dhabhar FS: The impact of psychosocial stress and stress management on immune responses in patients with cancer. Cancer. 125:1417–1431. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Cedolini C, Bertozzi S, Londero AP, Bernardi S, Seriau L, Concina S, Cattin F and Risaliti A: Type of breast cancer diagnosis, screening, and survival. Clin Breast Cancer. 14:235–240. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Criscitiello C, Viale G and Curigliano G: Peptide vaccines in early breast cancer. Breast. 44:128–134. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Feng C, Zhang H, Chen J, Wang S, Xin Y, Qu Y, Zhang Q, Ji W, Yamashita F, Rui M and Xu X: Ratiometric co-encapsulation and co-delivery of doxorubicin and paclitaxel by tumor-targeted lipo-disks for combination therapy of breast cancer. Int J Pharm. 560:191–204. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Balazy KE, Benitez CM, Gutkin PM, Jacobson CE, von Eyben R and Horst KC: Association between primary language, a lack of mammographic screening, and later stage breast cancer presentation. Cancer. 125:2057–2065. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Peart O: Breast intervention and breast cancer treatment options. Radiol Technol. 86:535M–558M; quiz 559-562. 2015.PubMed/NCBI

8 

Castaneda SA and Strasser J: Updates in the treatment of breast cancer with radiotherapy. Surg Oncol Clin N Am. 26:371–382. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Klein CA: Parallel progression of primary tumours and metastases. Nat Rev Cancer. 9:302–312. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Yousefi M, Nosrati R, Salmaninejad A, Dehghani S, Shahryari A and Saberi A: Organ-specific metastasis of breast cancer: Molecular and cellular mechanisms underlying lung metastasis. Cell Oncol (Dordr). 41:123–140. 2018. View Article : Google Scholar

11 

Sharma R, Sharma R, Khaket TP, Dutta C, Chakraborty B and Mukherjee TK: Breast cancer metastasis: Putative therapeutic role of vascular cell adhesion molecule-1. Cell Oncol (Dordr). 40:199–208. 2017. View Article : Google Scholar

12 

Uemura MI, French JT, Hess KR, Liu D, Raghav K, Hortobagyi GN, Arun BK, Valero V, Ueno NT, Alvarez RH, et al: Development of CNS metastases and survival in patients with inflammatory breast cancer. Cancer. 124:2299–2305. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Szarszewska M, Markowska A, Jach R, Marszałek A, Filas V, Bednarek W, Olejek A, Tomczak P, Sajdak S, Nowak-Markwitz E, et al: Significance of BRCA1 expression in breast and ovarian cancer patients with brain metastasis-A multicentre study. Adv Med Sci. 64:235–240. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Fu B, Zhang A, Li M, Pan L, Tang W, An M, Liu W and Zhang J: Circular RNA profile of breast cancer brain metastasis: Identification of potential biomarkers and therapeutic targets. Epigenomics. 10:1619–1630. 2018. View Article : Google Scholar

15 

Rice SL and Friedman KP: Clinical PET-MR imaging in breast cancer and lung cancer. PET Clin. 11:387–402. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Liu H, Li Z, Deng M, Liu Q, Zhang T, Guo W, Li P and Qiao W: Prognostic and clinicopathological value of CXCL12/SDF1 expression in breast cancer: A meta-analysis. Clin Chim Acta. 484:72–80. 2018. View Article : Google Scholar : PubMed/NCBI

17 

BacalbaȘa N, Balescu I, Dima S and Popescu I: Long-term survivors after liver resection for breast cancer liver metastases. Anticancer Res. 35:6913–6917. 2015.

18 

Ma R, Feng Y, Lin S, Chen J, Lin H, Liang X, Zheng H and Cai X: Mechanisms involved in breast cancer liver metastasis. J Transl Med. 13:642015. View Article : Google Scholar : PubMed/NCBI

19 

Holen I, Lefley DV, Francis SE, Rennicks S, Bradbury S, Coleman RE and Ottewell P: IL-1 drives breast cancer growth and bone metastasis in vivo. Oncotarget. 7:75571–75584. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Neelakantan D, Zhou H, Oliphant MUJ, Zhang X, Simon LM, Henke DM, Shaw CA, Wu MF, Hilsenbeck SG, White LD, et al: EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells. Nat Commun. 8:157732017. View Article : Google Scholar : PubMed/NCBI

21 

Chaffer CL, San Juan BP, Lim E and Weinberg RA: EMT, cell plasticity and metastasis. Cancer Metastasis Rev. 35:645–654. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Xu M, Wang S, Wang Y, Wu H, Frank JA, Zhang Z and Luo J: Role of p38γ MAPK in regulation of EMT and cancer stem cells. Biochim Biophys Acta Mol Basis Dis. 1864:3605–3617. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Tian M and Schiemann WP: TGF-β stimulation of EMT programs elicits non-genomic ER-α activity and anti-estrogen resistance in breast cancer cells. J Cancer Metastasis Treat. 3:150–160. 2017. View Article : Google Scholar :

24 

Mutlu M, Saatci Ö, Ansari SA, Yurdusev E, Shehwana H, Konu Ö, Raza U and Şahin Ö: miR-564 acts as a dual inhibitor of PI3K and MAPK signaling networks and inhibits proliferation and invasion in breast cancer. Sci Rep. 6:325412016. View Article : Google Scholar : PubMed/NCBI

25 

Wang X, Zhou X, Li G, Zhang Y, Wu Y and Song W: Modifications and trafficking of APP in the pathogenesis of Alzheimer's disease. Front Mol Neurosci. 10:2942017. View Article : Google Scholar : PubMed/NCBI

26 

Hefter D and Draguhn A: APP as a protective factor in acute neuronal insults. Front Mol Neurosci. 10:222017. View Article : Google Scholar : PubMed/NCBI

27 

Hatami A, Monjazeb S, Milton S and Glabe CG: Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid-β peptide. J Biol Chem. 292:3172–3185. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Wilkins HM and Swerdlow RH: Amyloid precursor protein processing and bioenergetics. Brain Res Bull. 133:71–79. 2017. View Article : Google Scholar :

29 

Habib A, Sawmiller D and Tan J: Restoring soluble amyloid precursor protein α functions as a potential treatment for Alzheimer's disease. J Neurosci Res. 95:973–991. 2017. View Article : Google Scholar

30 

Strilic B, Yang L, Albarrán-Juárez J, Wachsmuth L, Han K, Müller UC, Pasparakis M and Offermanns S: Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 536:215–218. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Lei H, Zhang Y, Huang L, Xu S, Li J, Yang L, Wang L, Xing C, Wang X and Peng Y: L-3-n-Butylphthalide regulates proliferation, migration, and differentiation of neural stem cell in vitro and promotes neurogenesis in APP/PS1 mouse model by regulating BDNF/TrkB/CREB/Akt pathway. Neurotox Res. 34:477–488. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Harder H, Holroyd P, Burkinshaw L, Watten P, Zammit C, Harris PR, Good A and Jenkins V: A user-centred approach to developing bWell, a mobile app for arm and shoulder exercises after breast cancer treatment. J Cancer Surviv. 11:732–742. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Di Stadio CS, Altieri F, Minopoli G, Miselli G, Rippa E and Arcari P: Role of human GKN1 on APP processing in gastric cancer. Biochimie. 135:149–153. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Tsang JYS, Lee MA, Ni YB, Chan SK, Cheung SY, Chan WW, Lau KF and Tse GMK: Amyloid precursor protein is associated with aggressive behavior in nonluminal breast cancers. Oncologist. 23:1273–1281. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Takagi K, Ito S, Miyazaki T, Miki Y, Shibahara Y, Ishida T, Watanabe M, Inoue S, Sasano H and Suzuki T: Amyloid precursor protein in human breast cancer: An androgen-induced gene associated with cell proliferation. Cancer Sci. 104:1532–1538. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Mao Y, Zhang Y, Fan S, Chen L, Tang L, Chen X and Lyu J: GALNT6 promotes tumorigenicity and metastasis of breast cancer cell via β-catenin/MUC1-C signaling pathway. Int J Biol Sci. 15:169–182. 2019. View Article : Google Scholar :

37 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

38 

Schwartz RS and Erban JK: Timing of metastasis in breast cancer. N Engl J Med. 376:2486–2488. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Peart O: Metastatic breast cancer. Radiol Technol. 88:519M–539M. 2017.PubMed/NCBI

40 

Pandey P, Sliker B, Peters HL, Tuli A, Herskovitz J, Smits K, Purohit A, Singh RK, Dong J, Batra SK, et al: Amyloid precursor protein and amyloid precursor-like protein 2 in cancer. Oncotarget. 7:19430–19444. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Golde TE, Cai XD, Shoji M and Younkin SG: Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease. Ann N Y Acad Sci. 695:103–108. 1993. View Article : Google Scholar : PubMed/NCBI

42 

Zhao L, He D, Jiao M, Kong L, Shao C, Chen J, Fang Z, Ma X, Chen H, Li L, et al: Overexpression of histone deacetylase and amyloid precursor protein in hepatocellular carcinoma. Technol Cancer Res Treat. 16:586–594. 2017. View Article : Google Scholar :

43 

Sobol A, Galluzzo P, Liang S, Rambo B, Skucha S, Weber MJ, Alani S and Bocchetta M: Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells. J Cell Physiol. 230:1064–1074. 2015. View Article : Google Scholar :

44 

Miyazaki T, Ikeda K, Horie-Inoue K and Inoue S: Amyloid precursor protein regulates migration and metalloproteinase gene expression in prostate cancer cells. Biochem Biophys Res Commun. 452:828–833. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Yu Y, Lv F, Liang D, Yang Q, Zhang B, Lin H, Wang X, Qian G, Xu J and You W: HOTAIR may regulate proliferation, apoptosis, migration and invasion of MCF-7 cells through regulating the P53/Akt/JNK signaling pathway. Biomed Pharmacother. 90:555–561. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Zhou J, Zhang WW, Peng F, Sun JY, He ZY and Wu SG: Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3. Cancer Manag Res. 10:535–544. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Shi C, Zhu X, Wang J and Long D: Estrogen receptor α promotes non-amyloidogenic processing of platelet amyloid precursor protein via the MAPK/ERK pathway. J Steroid Biochem Mol Biol. 144(Pt B): 280–285. 2014. View Article : Google Scholar

48 

Zhao XW, Zhou JP, Bi YL, Wang JY, Yu R, Deng C, Wang WK, Li XZ, Huang R, Zhang J and Tao DT: The role of MAPK signaling pathway in formation of EMT in oral squamous carcinoma cells induced by TNF-α. Mol Biol Rep. 46:3149–3156. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Kumar K, Chow CR, Ebine K, Arslan AD, Kwok B, Bentrem DJ, Eckerdt FD, Platanias LC and Munshi HG: Differential regulation of ZEB1 and EMT by MAPK-interacting protein kinases (MNK) and eIF4E in pancreatic cancer. Mol Cancer Res. 14:216–227. 2016. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wu X, Chen S and Lu C: Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway. Int J Mol Med 45: 162-174, 2020.
APA
Wu, X., Chen, S., & Lu, C. (2020). Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway. International Journal of Molecular Medicine, 45, 162-174. https://doi.org/10.3892/ijmm.2019.4404
MLA
Wu, X., Chen, S., Lu, C."Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway". International Journal of Molecular Medicine 45.1 (2020): 162-174.
Chicago
Wu, X., Chen, S., Lu, C."Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway". International Journal of Molecular Medicine 45, no. 1 (2020): 162-174. https://doi.org/10.3892/ijmm.2019.4404
Copy and paste a formatted citation
x
Spandidos Publications style
Wu X, Chen S and Lu C: Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway. Int J Mol Med 45: 162-174, 2020.
APA
Wu, X., Chen, S., & Lu, C. (2020). Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway. International Journal of Molecular Medicine, 45, 162-174. https://doi.org/10.3892/ijmm.2019.4404
MLA
Wu, X., Chen, S., Lu, C."Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway". International Journal of Molecular Medicine 45.1 (2020): 162-174.
Chicago
Wu, X., Chen, S., Lu, C."Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway". International Journal of Molecular Medicine 45, no. 1 (2020): 162-174. https://doi.org/10.3892/ijmm.2019.4404
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