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Article Open Access

CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway

  • Authors:
    • Eun‑Ok Kim
    • Shi‑Eun Kang
    • Minji Choi
    • Ki‑Jong Rhee
    • Miyong Yun
  • View Affiliations / Copyright

    Affiliations: Department of Bioindustry and Bioresource Engineering, College of Life Sciences, Sejong University, Seoul 05006, Republic of Korea, Korean Medicine Clinical Trail Center, Kyung Hee University Korean Medicine Hospital, Seoul 02453, Republic of Korea, Medical Science Research Institute, Kyung Hee University Medical Center, Seoul 02453, Republic of Korea, Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University at Wonju, Wonju, Gangwon‑do 26493, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 324-332
    |
    Published online on: December 12, 2019
       https://doi.org/10.3892/ijmm.2019.4425
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Abstract

TRAIL is an attractive candidate for anticancer therapy in a variety of tumors since it targets only tumors and not normal tissue. However, a remaining major hurdle is that the majority of tumors exhibit a resistance mechanism against the effects of TRAIL via the induction of anti‑apoptotic signaling pathways. In this study, we aimed to evaluate whether the modulation of CCR4‑NOT transcription complex subunit 2 (CNOT2) function can promote TRAIL sensitivity in non‑small‑cell lung cancer (NSCLC) cells. CNOT2 depletion partially decreased colony numbers and the proliferation of NSCLC cells. When combined with TRAIL, the suppression of CNOT2 expression markedly decreased the survival rate and increased apoptosis, as compared with TRAIL treatment alone in TRAIL‑resistant NSCLC cells. Of note, CNOT2 overexpression in TRAIL‑sensitive H460 cells enhanced the survival rate and decreased apoptosis when compared with TRAIL treatment alone. Gene expression analysis indicated that genes involved in the signal transducer and activator of transcription 3 (STAT3) signaling pathway were dominantly altered in the CNOT2‑depleted A549 cells. Under this condition, Src homology region 2 domain containing phosphatase‑1 (SHP1) was significantly upregulated and subsequently increased apoptosis. On the whole, the findings of this study demonstrate that CNOT2 participates in TRAIL sensitivity in NSCLC cells via the regulation of the STAT3 signaling pathway, and suggest that combination therapy with CNOT2 depletion and TRAIL treatment may prove to be a useful strategy for overcoming TRAIL resistance in NSCLC.
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View References

1 

World Health Organization: Cancer. https://www.who.int/news-room/fact-sheets/detail/cancer. Accessed September 12, 2018.

2 

Warth A, Muley T, Herpel E, Meister M, Herth FJ, Schirmacher P, Weichert W, Hoffmann H and Schnabel PA: Large-scale comparative analyses of immunomarkers for diagnostic subtyping of non-small-cell lung cancer biopsies. Histopathology. 61:1017–1025. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Noone AM, Howlader N, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, et al: SEER Cancer Statistics Review, 1975-2015. National Cancer Institute Bethesda; MD: 2018

4 

Schneider P, Thome M, Burns K, Bodmer JL, Hofmann K, Kataoka T, Holler N and Tschopp J: TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity. 7:831–836. 1997. View Article : Google Scholar

5 

Adams JM and Cory S: The Bcl-2 protein family: Arbiters of cell survival. Science. 281:1322–1326. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Elkholi R, Renault TT, Serasinghe MN and Chipuk JE: Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy? Cancer Metab. 2:162014. View Article : Google Scholar

7 

Russell P, Benson JD and Denis CL: Characterization of mutations in NOT2 indicates that it plays an important role in maintaining the integrity of the CCR4-NOT complex. J Mol Biol. 322:27–39. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Zwartjes CG, Jayne S, van den Berg DL and Timmers HT: Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex. J Biol Chem. 279:10848–10854. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Jayne S, Zwartjes CG, van Schaik FM and Timmers HT: Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. Biochem J. 398:461–467. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Ito K, Inoue T, Yokoyama K, Morita M, Suzuki T and Yamamoto T: CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death. Genes Cells. 16:368–379. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Sohn EJ, Jung DB, Lee H, Han I, Lee J, Lee H and Kim SH: CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells. Cancer Lett. 412:88–98. 2018. View Article : Google Scholar

12 

Kim J, Yun M, Kim EO, Jung DB, Won G, Kim B, Jung JH and Kim SH: Decursin enhances TRAIL-induced apoptosis through oxidative stress mediated- endoplasmic reticulum stress signalling in non-small cell lung cancers. Br J Pharmacol. 173:1033–1044. 2016. View Article : Google Scholar

13 

Jung JH, Kwon TR, Jeong SJ, Kim EO, Sohn EJ, Yun M and Kim SH: Apoptosis induced by tanshinone IIA and crypto-tanshinone is mediated by distinct JAK/STAT3/5 and SHP1/2 signaling in chronic myeloid leukemia K562 cells. Evid Based Complement Alternat Med. 2013:8056392013. View Article : Google Scholar

14 

Jung JH, Jung DB, Kim H, Lee H, Kang SE, Srivastava SK, Yun M and Kim SH: Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7. Oncogene. 37:3715–3728. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Jeong K, Kwon HY, Jeong MS, Sohn EJ and Kim SH: CNOT2 promotes degradation of p62/SQSTM1 as a negative regulator in ATG5 dependent autophagy. Oncotarget. 8:46034–46046. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Faraji F, Hu Y, Yang HH, Lee MP, Winkler GS, Hafner M and Hunter KW: Post-transcriptional control of tumor cell autonomous metastatic potential by CCR4-NOT deadenylase CNOT7. PLoS Genet. 12:e10058202016. View Article : Google Scholar : PubMed/NCBI

17 

Lee J, Jung JH, Hwang J, Park JE, Kim JH, Park WY, Suh JY and Kim SH: CNOT2 is critically involved in atorvastatin induced apoptotic and autophagic cell death in non-small cell lung cancers. Cancers (Basel). 11:pii: E1470. 2019. View Article : Google Scholar

18 

Vicente C, Stirparo R, Demeyer S, de Bock CE, Gielen O, Atkins M, Yan J, Halder G, Hassan BA and Cools J: The CCR4-NOT complex is a tumor suppressor in Drosophila mela-nogaster eye cancer models. J Hematol Oncol. 11:1082018. View Article : Google Scholar

19 

Grivennikov SI and Karin M: Inflammatory cytokines in cancer: Tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis. 70(Suppl 1): i104–i108. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Vicent S, Sayles LC, Vaka D, Khatri P, Gevaert O, Chen R, Zheng Y, Gillespie AK, Clarke N, Xu Y, et al: Cross-species functional analysis of cancer-associated fibroblasts identifies a critical role for CLCF1 and IL-6 in non-small cell lung cancer in vivo. Cancer Res. 72:5744–5756. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Haskins JW, Nguyen DX and Stern DF: Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration. Sci Signal. 7:ra1162014. View Article : Google Scholar : PubMed/NCBI

22 

Yu H, Yue X, Zhao Y, Li X, Wu L, Zhang C, Liu Z, Lin K, Xu-Monette ZY, Young KH, et al: LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nat Commun. 5:52182014. View Article : Google Scholar : PubMed/NCBI

23 

Meares GP, Liu Y, Rajbhandari R, Qin H, Nozell SE, Mobley JA, Corbett JA and Benveniste EN: PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation. Mol Cell Biol. 34:3911–3925. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Banerjee K, Keasey MP, Razskazovskiy V, Visavadiya NP, Jia C and Hagg T: Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells. Cell Signal. 36:154–162. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Dickens LS, Boyd RS, Jukes-Jones R, Hughes MA, Robinson GL, Fairall L, Schwabe JW, Cain K and Macfarlane M: A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death. Mol Cell. 47:291–305. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Liu H, Su D, Zhang J, Ge S, Li Y, Wang F, Gravel M, Roulston A, Song Q, Xu W, et al: Improvement of pharmacokinetic profile of TRAIL via trimertag enhances its antitumor activity in vivo. Sci Rep. 7:89532017. View Article : Google Scholar

27 

Xu W, Jing L, Wang Q, Lin CC, Chen X, Diao J, Liu Y and Sun X: Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution. Oncotarget. 6:30017–30034. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Green DR and Llambi F: Cell death signaling. Cold Spring Harb Perspect Biol. 7:2015. View Article : Google Scholar : PubMed/NCBI

29 

Yip KW and Reed JC: Bcl-2 family proteins and cancer. Oncogene. 27:6398–6406. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Zhang Y and Zhang B: TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5. Mol Cancer Res. 6:1861–1871. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Wong RS: Apoptosis in cancer: From pathogenesis to treatment. J Exp Clin Cancer Res. 30:872011. View Article : Google Scholar : PubMed/NCBI

32 

Di X, Zhang G, Zhang Y, Takeda K, Rivera Rosado LA and Zhang B: Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5. Oncotarget. 4:1349–1364. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Fernald K and Kurokawa M: Evading apoptosis in cancer. Trends Cell Biol. 23:620–633. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Stupack DG: Caspase-8 as a therapeutic target in cancer. Cancer Lett. 332:133–140. 2013. View Article : Google Scholar

35 

Khoury MP and Bourdon JC: The isoforms of the p53 protein. Cold Spring Harb Perspect Biol. 2:a0009272010. View Article : Google Scholar : PubMed/NCBI

36 

Bourdon JC, Fernandes K, Murray-Zmijewski F, Liu G, Diot A, Xirodimas DP, Saville MK and Lane DP: p53 isoforms can regulate p53 transcriptional activity. Genes Dev. 19:2122–2137. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Chung AH, Leisner TM, Dardis GJ, Bivins MM, Keller AL and Parise LV: CIB1 depletion with docetaxel or TRAIL enhances triple-negative breast cancer cell death. Cancer Cell Int. 19:262019. View Article : Google Scholar : PubMed/NCBI

38 

Fagard R, Metelev V, Souissi I and Baran-Marszak F: STAT3 inhibitors for cancer therapy: Have all roads been explored? JAKSTAT. 2:e228822013.PubMed/NCBI

39 

Xiong A, Yang Z, Shen Y, Zhou J and Shen Q: Transcription factor STAT3 as a novel molecular target for cancer prevention. Cancers (Basel). 6:926–957. 2014. View Article : Google Scholar

40 

Santoni M, Massari F, Del Re M, Ciccarese C, Piva F, Principato G, Montironi R, Santini D, Danesi R, Tortora G and Cascinu S: Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer. Expert Opin Investig Drugs. 24:809–824. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Subramaniam A, Shanmugam MK, Perumal E, Li F, Nachiyappan A, Dai X, Swamy SN, Ahn KS, Kumar AP, Tan BK, et al: Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma. Biochim Biophys Acta. 1835:46–60. 2013.

42 

Tai WT, Cheng AL, Shiau CW, Huang HP, Huang JW, Chen PJ and Chen KF: Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma. J Hepatol. 55:1041–1048. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Delibrias CC, Floettmann JE, Rowe M and Fearon DT: Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes. J Exp Med. 186:1575–1583. 1997. View Article : Google Scholar : PubMed/NCBI

44 

Wu C, Sun M, Liu L and Zhou GW: The function of the protein tyrosine phosphatase SHP-1 in cancer. Gene. 306:1–12. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Nakase K, Cheng J, Zhu Q and Marasco WA: Mechanisms of SHP-1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV-1-transformed T cells. J Leukoc Biol. 85:165–174. 2009. View Article : Google Scholar :

46 

Warner N, Burberry A, Franchi L, Kim YG, McDonald C, Sartor MA and Núñez G: A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways. Sci Signal. 6:rs32013. View Article : Google Scholar

47 

Avalle L, Camporeale A, Morciano G, Caroccia N, Ghetti E, Orecchia V, Viavattene D, Giorgi C, Pinton P and Poli V: STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses. Cell Death Differ. 26:932–942. 2019. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Kim EO, Kang SE, Choi M, Rhee KJ and Yun M: CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway. Int J Mol Med 45: 324-332, 2020.
APA
Kim, E., Kang, S., Choi, M., Rhee, K., & Yun, M. (2020). CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway. International Journal of Molecular Medicine, 45, 324-332. https://doi.org/10.3892/ijmm.2019.4425
MLA
Kim, E., Kang, S., Choi, M., Rhee, K., Yun, M."CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway". International Journal of Molecular Medicine 45.2 (2020): 324-332.
Chicago
Kim, E., Kang, S., Choi, M., Rhee, K., Yun, M."CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway". International Journal of Molecular Medicine 45, no. 2 (2020): 324-332. https://doi.org/10.3892/ijmm.2019.4425
Copy and paste a formatted citation
x
Spandidos Publications style
Kim EO, Kang SE, Choi M, Rhee KJ and Yun M: CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway. Int J Mol Med 45: 324-332, 2020.
APA
Kim, E., Kang, S., Choi, M., Rhee, K., & Yun, M. (2020). CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway. International Journal of Molecular Medicine, 45, 324-332. https://doi.org/10.3892/ijmm.2019.4425
MLA
Kim, E., Kang, S., Choi, M., Rhee, K., Yun, M."CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway". International Journal of Molecular Medicine 45.2 (2020): 324-332.
Chicago
Kim, E., Kang, S., Choi, M., Rhee, K., Yun, M."CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway". International Journal of Molecular Medicine 45, no. 2 (2020): 324-332. https://doi.org/10.3892/ijmm.2019.4425
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