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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
February-2020 Volume 45 Issue 2

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Precision medicine for human cancers with Notch signaling dysregulation (Review)

Masuko Katoh, Masaru Katoh
Pages: 279-297
Published online on: 04 December 2019

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Article Open Access

Dormancy and NKG2D system in brain metastases: Analysis of immunogenicity

Charlotte Flüh, Victor Mafael, Vivian Adamski, Michael Synowitz, Janka Held‑Feindt
Pages: 298-314
Published online on: 30 December 2019

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Article Open Access

Clinically relevant GSK‑3β inhibitor 9‑ING‑41 is active as a single agent and in combination with other antitumor therapies in human renal cancer

Tsutomu Anraku, Hiroo Kuroki, Akira Kazama, Vladimir Bilim, Masaaki Tasaki, Daniel Schmitt, Andrew Mazar, Francis J. Giles, Andrey Ugolkov, Yoshihiko Tomita
Pages: 315-323
Published online on: 12 December 2019

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Article Open Access

CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway

Eun‑Ok Kim, Shi‑Eun Kang, Minji Choi, Ki‑Jong Rhee, Miyong Yun
Pages: 324-332
Published online on: 12 December 2019

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Article Open Access

Construction of a long non‑coding RNA‑mediated transcription factor and gene regulatory triplet network reveals global patterns and biomarkers for ischemic stroke

Yuze Cao, Jianjian Wang, Xiaoyu Lu, Xiaotong Kong, Chunrui Bo, Shuang  Li, Jie Li, Xuesong Sun, Na Wang, Kuo Tian, Huixue Zhang, Liying Cui
Pages: 333-342
Published online on: 09 December 2019

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Article Open Access

Andrographolide sodium bisulfate attenuates UV‑induced photo‑damage by activating the keap1/Nrf2 pathway and downregulating the NF‑κB pathway in HaCaT keratinocytes

Mei‑Ling Wang, Qing‑Yuan Zhong, Bao‑Qin Lin, Yu‑Hong Liu, Yan‑Feng Huang, Yang Chen, Jie Yuan, Zi‑Ren Su, Janis Ya‑Xian Zhan
Pages: 343-352
Published online on: 02 December 2019

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Article Open Access

A novel small molecule compound VCP979 improves ventricular remodeling in murine models of myocardial ischemia/reperfusion injury

Jing Liu, Qingshu Meng, Xiaoting Liang, Rulin Zhuang, Dongsheng Yuan, Xinyu Ge, Hao Cao, Fang Lin, Xin Gong, Huimin Fan, Binghui Wang, Xiaohui Zhou, Zhongmin Liu
Pages: 353-364
Published online on: 27 November 2019

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Article Open Access

Prenatal ethanol exposure enhances the susceptibility to depressive behavior of adult offspring rats fed a high‑fat diet by affecting BDNF‑associated pathway

Ying Yu, Dan Xu, Siyuan Cheng, Li Zhang, Zhaokun Shi, Jun Qin, Zhaohui Zhang, Hui Wang
Pages: 365-374
Published online on: 19 December 2019

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Article Open Access

Overexpression of miR‑30c‑5p reduces cellular cytotoxicity and inhibits the formation of kidney stones through ATG5

Xin Wang, Yanan Zhang, Shuai Han, Hongshen Chen, Chen Chen, Lingling Ji, Bihu Gao
Pages: 375-384
Published online on: 23 December 2019

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Article Open Access

The role of myoglobin in epithelial cancers: Insights from transcriptomics

Anne Bicker, Theresa Nauth, Daniela Gerst, Mostafa Ahmed Aboouf, Joachim Fandrey, Glen Kristiansen, Thomas Alexander Gorr, Thomas Hankeln
Pages: 385-400
Published online on: 18 December 2019

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Article Open Access

Weighted gene co‑expression network analysis to identify key modules and hub genes associated with atrial fibrillation

Wenyuan Li, Lijun Wang, Yue Wu, Zuyi Yuan, Juan Zhou
Pages: 401-416
Published online on: 03 December 2019

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Article Open Access

Humulus japonicus extract ameliorates collagen‑induced arthritis in mice through regulation of overall articular inflammation

Eun‑Jung Kang, Hyun Jong Kim, Ji Hyun Choi, Jung‑Ran Noh, Jae‑Hoon Kim, In Bok Lee, Young‑Keun Choi, Dong‑Hee Choi, Jinpyo An, Won Keun Oh, Yong‑Hoon Kim, Chul‑Ho Lee
Pages: 417-428
Published online on: 03 December 2019

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Article Open Access

Inhibition of miR‑155‑5p attenuates the valvular damage induced by rheumatic heart disease

Ang Chen, Jianlin Wen, Chuanghong Lu, Beiyou Lin, Shenglin Xian, Feng Huang, Yunjiao Wu, Zhiyu Zeng
Pages: 429-440
Published online on: 06 December 2019

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Article Open Access

miRNA‑384‑5p regulates the progression of Parkinson's disease by targeting SIRT1 in mice and SH‑SY5Y cell

Hongli Tao, Yan Liu, Yingjuan Hou
Pages: 441-450
Published online on: 12 December 2019

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Article Open Access

Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let‑7a‑5p/IGF2BP3 in cardiomyocytes

Jianting Gan, Jun Yuan, Yu Liu, Zhengde Lu, Yan Xue, Lei Shi, Huayuan Zeng
Pages: 451-460
Published online on: 23 December 2019

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Article Open Access

MicroRNA‑15a‑5p induces pulmonary artery smooth muscle cell apoptosis in a pulmonary arterial hypertension model via the VEGF/p38/MMP‑2 signaling pathway

Wenmei Zhang, Yanna Li, Xin Xi, Guangfa Zhu, Shenghao Wang, Yan Liu, Man Song
Pages: 461-474
Published online on: 18 December 2019

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Article Open Access

CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus

Qiong Wu, Miao Zhang, Xueyan Liu, Junmei Zhang, Hua Wang
Pages: 475-484
Published online on: 23 December 2019

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Article Open Access

Cancer‑related fatigue during combined treatment of androgen deprivation therapy and radiotherapy is associated with mitochondrial dysfunction Corrigendum in /10.3892/ijmm.2020.4546

Li Rebekah Feng, Brian S. Wolff, Josephine Liwang, Jeniece M. Regan, Sarah Alshawi, Sumiyya Raheem, Leorey N. Saligan
Pages: 485-496
Published online on: 18 December 2019

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Article Open Access

lncRNA CYTOR promotes tamoxifen resistance in breast cancer cells via sponging miR‑125a‑5p

Yungyong Liu, Mengdan Li, Huihui Yu, Haozhe Piao
Pages: 497-509
Published online on: 16 December 2019

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Article Open Access

miR‑195 promotes LPS‑mediated intestinal epithelial cell apoptosis via targeting SIRT1/eIF2a

Ting Yuan, Li Zhang, Shuo Yao, Shuang‑Ya Deng, Ji‑Qiang Liu
Pages: 510-518
Published online on: 18 December 2019

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Article Open Access

Combination of the ginsenosides Rb3 and Rb2 exerts protective effects against myocardial ischemia reperfusion injury in rats

Xiaomin Liu, Yichuan Jiang, Wenwen Fu, Xiaofeng Yu, Dayun Sui
Pages: 519-531
Published online on: 29 November 2019

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Article Open Access

Upregulation of miR‑423 improves autologous vein graft restenosis via targeting ADAMTS‑7

Wenjun Ren, Liwen Liang, Yongwu Li, Fei‑Yu Wei, Ninghui Mu, Libin Zhang, Wei He, Yu Cao, Da Xiong, Hongrong Li
Pages: 532-542
Published online on: 05 December 2019

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Article Open Access

miR‑146a improves hepatic lipid and glucose metabolism by targeting MED1

Kun Li, Bao Zhao, Diandian Wei, Wenrui Wang, Yixuan Cui, Lisheng Qian, Guodong Liu
Pages: 543-555
Published online on: 27 December 2019

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Article Open Access

Protective effects of human umbilical cord blood‑derived mesenchymal stem cells against dexamethasone‑induced apoptotic cell death in hair follicles

Dong Ho Bak, Esther Lee, Mi Ji Choi, Byung Chul Lee, Tae‑Rin Kwon, Jong‑Hwan Kim, Eun Su Jeon, Wonil Oh, Seog Kyun Mun, Byung Cheol Park, Jungtae Na, Beom Joon Kim
Pages: 556-568
Published online on: 27 December 2019

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Article Open Access

miR‑139‑5p affects cell proliferation, migration and adipogenesis by targeting insulin‑like growth factor 1 receptor in hemangioma stem cells

Yao Wu, Honghong Li, Juan Xie, Fan Wang, Dongsheng Cao, Yin Lou
Pages: 569-577
Published online on: 17 December 2019

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Article Open Access

lncRNA BCAR4 sponges miR‑370‑3p to promote bladder cancer progression via Wnt signaling

Rongkui Zhang, Jiping Wang, Er'na Jia, Jialiang Zhang, Nan Liu, Changliang Chi
Pages: 578-588
Published online on: 27 December 2019

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Article

Acer okamotoanum inhibits adipocyte differentiation by the regulation of adipogenesis and lipolysis in 3T3‑L1 cells

Ji Hyun Kim, Sanghyun Lee, Hyun Young Kim, Eun Ju Cho
Pages: 589-596
Published online on: 30 December 2019

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Article

MicroRNA‑432 inhibits the aggressiveness of glioblastoma multiforme by directly targeting IGF‑1R Retraction in /10.3892/ijmm.2022.5187

Xudong Chen, Xufei Zhang, Shunjin Sun, Meixiao Zhu
Pages: 597-606
Published online on: 16 December 2019

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Article

Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis

Mayumi Ukita, Kenji Matsushita, Masato Tamura, Taihiko Yamaguchi
Pages: 607-614
Published online on: 27 December 2019

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Article

NOS cofactor tetrahydrobiopterin contributes to anesthetic preconditioning induced myocardial protection in the isolated ex vivo rat heart

Chen Wang, Shigang Qiao, Lei Hong, Jie Sun, Tuanjie Che, Jianzhong An, Amadou K.S. Camara
Pages: 615-622
Published online on: 27 December 2019

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Article

Metformin alleviates endometrial hyperplasia through the UCA1/miR‑144/TGF‑β1/AKT signaling pathway

Miao Guo, Jing‑Jing Zhou, Wei Huang
Pages: 623-633
Published online on: 23 December 2019

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Article

miR‑217 and miR‑543 downregulation mitigates inflammatory response and myocardial injury in children with viral myocarditis by regulating the SIRT1/AMPK/NF‑κB signaling pathway

Kun Xia, Yong Zhang, Dongming Sun
Pages: 634-646
Published online on: 27 December 2019

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Article

Deficiency of Pdk1 contributes to primordial follicle activation via the upregulation of YAP expression and the pro‑inflammatory response

Jiayin Gao, Tiefang Song, Dehong Che, Changmin Li, Jing Jiang, Jingyao Pang, Yujuan Yang, Peiling Li
Pages: 647-657
Published online on: 20 December 2019

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Article

Anti‑platelet activity of mineral‑balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk

Gi Suk Nam, Kyu‑Shik Lee, Kyung‑Soo Nam
Pages: 658-668
Published online on: 10 December 2019

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Article

Upregulation of AGR2vH facilitates cholangiocarcinoma cell survival under endoplasmic reticulum stress via the activation of the unfolded protein response pathway

Gunticha Suwanmanee, Juthamas Yosudjai, Suchada Phimsen, Sopit Wongkham, Siwanon Jirawatnotai, Worasak Kaewkong
Pages: 669-677
Published online on: 18 December 2019

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Article

Preconditioning with repetitive electromagnetic stimulation enhances activity of bone marrow mesenchymal stem cells from elderly patients through Erk1/2 via nitric oxide

Seungwoo Nam, Suna Kim, Kangjun Yoon, Hyun Sook Hong, Youngsook Son
Pages: 678-686
Published online on: 30 December 2019

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Correction Open Access

[Corrigendum] Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non‑cyclic nucleotide‑related mechanisms

Thanasekaran Jayakumar, Kao-Chang Lin, Wan-Jung Lu, Chia-Ying Lin, Geraldine Pitchairaj, Jiun-Yi Li, Joen-Rong Sheu
Pages: 687-687
Published online on: 10 December 2019

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Correction Open Access

[Corrigendum] Structure‑activity relationship of three synthesized benzimidazole‑based oligosaccharides in human platelet activation

Yi Chang, Wen-Hsien Hsu, Wen-Bin Yang, Thanasekaran Jayakumar, Tzu-Yin Lee, Joen-Rong Sheu, Wan-Jung Lu, Jiun-Yi Li
Pages: 688-688
Published online on: 10 December 2019

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Journal Cover
August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 231
Published online on: 24 June 2026

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Review Open Access

Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

Kebing Lv, Zijie Ma, Qiuni Chen, Yang Su, Jingjing Ma, Chunling Wang, Liang Yu
Article Number: 230
Published online on: 23 June 2026

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Article Open Access

Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang
Article Number: 229
Published online on: 23 June 2026

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Review Open Access

MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review)

Hao Xie, Ling Chen, Jing Gou, Xuehong Long, Ya Yang, Hai Hu, Ping Wu, Qibing Yan, Yongkang Wu
Article Number: 228
Published online on: 22 June 2026

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Review Open Access

Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng, Huimin Li
Article Number: 227
Published online on: 22 June 2026

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Review Open Access

Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review)

Ruipu Zhang, Liang Zhang, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 226
Published online on: 22 June 2026

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Retraction Open Access

[Retracted] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer

Kiyomu Fujii, Tomonori Sasahira, Yukiko Moriwaka, Naohide Oue, Wataru Yasui, Hiroki Kuniyasu
Article Number: 225
Published online on: 22 June 2026

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Article Open Access

Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury

Jing Yao, Zeqing Huang, Songze Li, Minghui Lun, Jianing Fan
Article Number: 224
Published online on: 18 June 2026

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Article Open Access

Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang
Article Number: 223
Published online on: 18 June 2026

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Review Open Access

Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

Dimitrios A. Andreikos, Michael Aschner, Dimitrios C. Ziogas, Aristidis Tsatsakis, Demetrios A. Spandidos
Article Number: 222
Published online on: 18 June 2026

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Review Open Access

Targeting glutathione metabolism for tumor radiosensitization (Review)

Haonan Xu, Meng Du, Xiaowen Liang, Xilin Xiao, Zhiyi Chen
Article Number: 221
Published online on: 16 June 2026

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Review Open Access

Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Article Open Access

Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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Correction Open Access

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Article Open Access

Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Review Open Access

Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Review Open Access

Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Review Open Access

Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Review Open Access

Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Review Open Access

Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Review Open Access

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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September-2026 Volume 58 Issue 3

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Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response

Wan-Da Tang, Lan-Juan Zhao
Article Number: 261
Published online on: 16 July 2026

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circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching

Yujie Wang, Xiaoting Li, Meirong Wang, Nailiang Zhai, Mengqi Jiang, Bo Liu, Changjun Lv, Songzi Zhang, Xiaodong Song, Jinjin Zhang
Article Number: 260
Published online on: 15 July 2026

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Review Open Access

Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review)

Yanpeng Tian, Yu Zhang, Liling Wang, Zhongkang Li, Xiaotong Xu, Shouze Liu, Shenyu Yang, Xiangyang Ren, Menghan Xu, Xingzi Chang, Xianghua Huang, Qian Zhao, Ruixia Guo
Article Number: 259
Published online on: 15 July 2026

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Review Open Access

Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review)

Shuhong Zhang, Ge Yang
Article Number: 258
Published online on: 14 July 2026

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Review Open Access

Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 257
Published online on: 14 July 2026

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Review Open Access

Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review)

Tianhao Xie, Kang Hu, Shu Pan, Xin Tong, Haitong Huang, Hao Ding, Jun Zhao
Article Number: 256
Published online on: 13 July 2026

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Article Open Access

Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation

Mingkun Xu, Linhang Fu, Yulong Zhang, Xiuli Guo, Han Wu, Sijing Gao, Fei Xiao, Li Xu
Article Number: 255
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells

Donghong Lin, Zhaolei Cui, Lingying Kong, Feng Cheng, Jianping Xu, Fenghua Lan
Article Number: 254
Published online on: 13 July 2026

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Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

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Review Open Access

Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

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Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

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Article Open Access

Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

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Review Open Access

Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

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GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

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Review Open Access

FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

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Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

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Article Open Access

Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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Review Open Access

TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Review Open Access

Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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Article Open Access

FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Review Open Access

Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Review Open Access

Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Review Open Access

Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Review Open Access

Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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Review Open Access

ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Review Open Access

Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Review Open Access

Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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