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CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus

  • Authors:
    • Qiong Wu
    • Miao Zhang
    • Xueyan Liu
    • Junmei Zhang
    • Hua Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Forensic Pathology, China Medical University School of Forensic Medicine, Shenyang, Liaoning 110122, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 475-484
    |
    Published online on: December 23, 2019
       https://doi.org/10.3892/ijmm.2019.4439
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Abstract

Neuronal loss and gliosis are the major pathological changes after status epilepticus (SE). The authors' previous study revealed the time‑dependent changes of cannabinoid receptor type 2 (CB2R) in hippocampal neurons of developing rats after SE, which were accompanied by a decrease in the number of neurons. Meanwhile, growing evidence indicates that CB2R stimulation exerts anti‑convulsant properties in seizure models. However, the activation of CB2R in neuronal repair in response to the damage after SE is still unclear. In this experiment, a highly‑selective CB2R agonist JWH133 and antagonist AM630 were administered to determine the activity of CB2R in neuronal autophagy and apoptosis of the post‑SE repair in developing rats. The present results revealed that activation of CB2R by JWH133, not only obviously lowered the success rate, 24‑h death rate and the Racine stage in the model, but also extended the latency period to SE. In addition, compared with the vehicle control group, CB2R activation increased neuronal autophagy and the expression of phosphorylated‑mammalian target of rapamycin (p‑mTOR)/mTOR, Beclin‑1, and LC3II/LC3I while decreasing the expression of p‑Unc‑51‑like autophagy‑activating kinase 1 (ULK‑1)/ULK1, p62, and cleaved caspase‑3. These results were dose‑dependent and were especially evident in the high‑dose group, and interestingly the opposite results were obtained in the AM630 group. Thus, CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with SE. These findings might provide an important basis for further investigation of the therapeutic role of CB2R in ameliorating epilepsy‑related neuronal damage.
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1 

Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, et al: ILAE official report: A practical clinical definition of epilepsy. Epilepsia. 55:475–482. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Engel J Jr: Mesial temporal lobe epilepsy: What have we learned? Neuroscientist. 7:340–352. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Shibley H and Smith BN: Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice. Epilepsy Res. 49:109–120. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Morimoto K, Fahnestock M and Racine RJ: Kindling and status epilepticus models of epilepsy: Rewiring the brain. Prog Neurobiol. 73:1–60. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Friedman WJ: Proneurotrophins, seizures, and neuronal apoptosis. Neuroscientist. 16:244–252. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Baram TZ, Jensen FE and Brooks-Kayal A: Does acquired epileptogenesis in the immature brain require neuronal death. Epilepsy Curr. 11:21–26. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Varvel NH, Neher JJ, Bosch A, Wang W, Ransohoff RM, Miller RJ and Dingledine R: Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus. Proc Natl Acad Sci USA. 113:E5665–E5674. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Hung SY, Huang WP, Liou HC and Fu WM: LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice. Neuropharmacology. 93:243–251. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Vieira M, Fernandes J, Carreto L, Anuncibay-Soto B, Santos M, Han J, Fernández-López A, Duarte CB, Carvalho AL and Santos AE: Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3. Neurobiol Dis. 68:26–36. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Xu M and Zhang HL: Death and survival of neuronal and astrocytic cells in ischemic brain injury: A role of autophagy. Acta Pharmacol Sin. 32:1089–1099. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Hochfeld M, Lamecker H, Thomale UW, Schulz M, Zachow S and Haberl H: Frame-based cranial reconstruction. J Neurosurg Pediatr. 13:319–323. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ and Rubinsztein DC: Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet. 36:585–595. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Hoeffer CA and Klann E: mTOR signaling: At the crossroads of plasticity, memory and disease. Trends Neurosci. 33:67–75. 2010. View Article : Google Scholar

14 

Costa-Mattioli M, Sossin WS, Klann E and Sonenberg N: Translational control of long-lasting synaptic plasticity and memory. Neuron. 61:10–26. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Laplante M and Sabatini DM: mTOR signaling in growth control and disease. Cell. 149:274–293. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M and Kim DH: ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell. 20:1992–2003. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A and Guan KL: ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol. 15:741–750. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Rubinsztein DC, Codogno P and Levine B: Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov. 11:709–730. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Harris H and Rubinsztein DC: Control of autophagy as a therapy for neurodegenerative disease. Nat Rev Neurol. 8:108–117. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G and Johansen T: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem. 282:24131–24145. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H and Mizushima N: Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 441:885–889. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Füllgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, et al: Autophagy and neurodegeneration: Pathogenic mechanisms and therapeutic opportunities. Neuron. 93:1015–1034. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Pasquali L, Longone P, Isidoro C, Ruggieri S, Paparelli A and Fornai F: Autophagy, lithium, and amyotrophic lateral sclerosis. Muscle Nerve. 40:173–194. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Fornai F, Longone P, Ferrucci M, Lenzi P, Isidoro C, Ruggieri S and Paparelli A: Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium. Autophagy. 4:527–530. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Hwang JY, Gertner M, Pontarelli F, Court-Vazquez B, Bennett MV, Ofengeim D and Zukin RS: Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die. Cell Death Differ. 24:317–329. 2017. View Article : Google Scholar :

26 

Hosseinzadeh M, Nikseresht S, Khodagholi F, Naderi N and Maghsoudi N: Cannabidiol post-treatment alleviates rat epileptic-related behaviors and activates hippocampal cell autophagy pathway along with antioxidant defense in chronic phase of pilocarpine-induced seizure. J Mol Neurosci. 58:432–440. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Soltesz I, Alger BE, Kano M, Lee SH, Lovinger DM, Ohno-Shosaku T and Watanabe M: Weeding out bad waves: Towards selective cannabinoid circuit control in epilepsy. Nat Rev Neurosci. 16:264–277. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Regehr WG, Carey MR and Best AR: Activity-dependent regulation of synapses by retrograde messengers. Neuron. 63:154–170. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Jansen EM, Haycock DA, Ward SJ and Seybold VS: Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles. Brain Res. 575:93–102. 1992. View Article : Google Scholar : PubMed/NCBI

30 

Muñoz-Luque J, Ros J, Fernández-Varo G, Tugues S, Morales-Ruiz M, Alvarez CE, Friedman SL, Arroyo V and Jiménez W: Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. J Pharmacol Exp Ther. 324:475–483. 2008. View Article : Google Scholar

31 

Galiègue S, Mary S, Marchand J, Dussossoy D, Carrière D, Carayon P, Bouaboula M, Shire D, Le Fur G and Casellas P: Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem. 232:54–61. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Li Y and Kim J: Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus. Neuroscience. 311:253–267. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Lanciego JL, Barroso-Chinea P, Rico AJ, Conte-Perales L, Callén L, Roda E, Gómez-Bautista V, López IP, Lluis C, Labandeira-García JL and Franco R: Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis. J Psychopharmacol. 25:97–104. 2011. View Article : Google Scholar

34 

Viscomi MT, Oddi S, Latini L, Pasquariello N, Florenzano F, Bernardi G, Molinari M and Maccarrone M: Selective CB2 receptor agonism protects central neurons from remote axotomy-induced apoptosis through the PI3K/Akt pathway. J Neurosci. 29:4564–4570. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Kim J and Li Y: Chronic activation of CB2 cannabinoid receptors in the hippocampus increases excitatory synaptic transmission. J Physiol. 593:871–886. 2015. View Article : Google Scholar :

36 

Stempel AV, Stumpf A, Zhang HY, Özdoğan T, Pannasch U, Theis AK, Otte DM, Wojtalla A, Rácz I, Ponomarenko A, et al: Cannabinoid type 2 receptors mediate a cell type-specific plasticity in the hippocampus. Neuron. 90:795–809. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Sugaya Y, Yamazaki M, Uchigashima M, Kobayashi K, Watanabe M, Sakimura K and Kano M: Crucial roles of the endocannabinoid 2-arachidonoylglycerol in the suppression of epileptic seizures. Cell Rep. 16:1405–1415. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Wu Q and Wang H: The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus. Epilepsy Res. 148:8–16. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Curia G, Longo D, Biagini G, Jones RS and Avoli M: The pilocarpine model of temporal lobe epilepsy. J Neurosci Methods. 172:143–157. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Racine RJ: Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol. 32:281–294. 1972. View Article : Google Scholar : PubMed/NCBI

41 

Li X, Lou X, Xu S, Wang Q, Shen M and Miao J: Knockdown of miR-372 inhibits nerve cell apoptosis induced by spinal cord ischemia/reperfusion injury via enhancing autophagy by up-regulating Beclin-1. J Mol Neurosci. 66:437–444. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H and Hiltunen M: Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. Prog Neurobiol. 106-107:33–54. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Fornai F, Longone P, Cafaro L, Kastsiuchenka O, Ferrucci M, Manca ML, Lazzeri G, Spalloni A, Bellio N, Lenzi P, et al: Lithium delays progression of amyotrophic lateral sclerosis. Proc Natl Acad Sci USA. 105:2052–2057. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Calderó J, Brunet N, Tarabal O, Piedrafita L, Hereu M, Ayala V and Esquerda JE: Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord. Neuroscience. 165:1353–1369. 2010. View Article : Google Scholar

45 

Macias M, Blazejczyk M, Kazmierska P, Caban B, Skalecka A, Tarkowski B, Rodo A, Konopacki J and Jaworski J: Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment. PLoS One. 8:e644552013. View Article : Google Scholar : PubMed/NCBI

46 

Shacka JJ, Lu J, Xie ZL, Uchiyama Y, Roth KA and Zhang J: Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neurosci Lett. 414:57–60. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Cao L, Xu J, Lin Y, Zhao X, Liu X and Chi Z: Autophagy is upregulated in rats with status epilepticus and partly inhibited by Vitamin E. Biochem Biophys Res Commun. 379:949–953. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Al Mansouri S, Ojha S, Al Maamari E, Al Ameri M, Nurulain SM and Bahi A: The cannabinoid receptor 2 agonist, β-caryophyllene, reduced voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice. Pharmacol Biochem Behav. 124:260–268. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Katsuyama S, Mizoguchi H, Kuwahata H, Komatsu T, Nagaoka K, Nakamura H, Bagetta G, Sakurada T and Sakurada S: Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception. Eur J Pain. 17:664–675. 2013. View Article : Google Scholar

50 

Choi IY, Ju C, Anthony Jalin AM, Lee DI, Prather PL and Kim WK: Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury. Am J Pathol. 182:928–939. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Cheng Y, Dong Z and Liu S: β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway. Pharmacology. 94:1–12. 2014. View Article : Google Scholar

52 

Wallace MJ, Martin BR and DeLorenzo RJ: Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity. Eur J Pharmacol. 452:295–301. 2002. View Article : Google Scholar : PubMed/NCBI

53 

Monory K, Massa F, Egertová M, Eder M, Blaudzun H, Westenbroek R, Kelsch W, Jacob W, Marsch R, Ekker M, et al: The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron. 51:455–466. 2006. View Article : Google Scholar : PubMed/NCBI

54 

Ludányi A, Eross L, Czirják S, Vajda J, Halász P, Watanabe M, Palkovits M, Maglóczky Z, Freund TF and Katona I: Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus. J Neurosci. 28:2976–2990. 2008. View Article : Google Scholar : PubMed/NCBI

55 

Carletti F, Gambino G, Rizzo V, Ferraro G and Sardo P: Cannabinoid and nitric oxide signaling interplay in the modulation of hippocampal hyperexcitability: Study on electro-physiological and behavioral models of temporal lobe epilepsy in the rat. Neuroscience. 303:149–159. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Carletti F, Gambino G, Rizzo V, Ferraro G and Sardo P: Neuronal nitric oxide synthase is involved in CB/TRPV1 signalling: Focus on control of hippocampal hyperexcitability. Epilepsy Res. 138:18–25. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Huizenga MN, Wicker E, Beck VC and Forcelli PA: Anticonvulsant effect of cannabinoid receptor agonists in models of seizures in developing rats. Epilepsia. 58:1593–1602. 2017. View Article : Google Scholar : PubMed/NCBI

58 

Rizzo V, Carletti F, Gambino G, Schiera G, Cannizzaro C, Ferraro G and Sardo P: Role of CB2 receptors and cGMP pathway on the cannabinoid-dependent antiepileptic effects in an in vivo model of partial epilepsy. Epilepsy Res. 108:1711–1718. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Tchekalarova J, da Conceição Machado K, Gomes Júnior AL, de Carvalho Melo Cavalcante AA, Momchilova A and Tzoneva R: Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice. Seizure. 57:22–26. 2018. View Article : Google Scholar : PubMed/NCBI

60 

Otabe H, Nibuya M, Shimazaki K, Toda H, Suzuki G, Nomura S and Shimizu K: Electroconvulsive seizures enhance autophagy signaling in rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 50:37–43. 2014. View Article : Google Scholar

61 

Zhang HY, Gao M, Liu QR, Bi GH, Li X, Yang HJ, Gardner EL, Wu J and Xi ZX: Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. Proc Natl Acad Sci USA. 111:E5007–E5015. 2014. View Article : Google Scholar : PubMed/NCBI

62 

Gump JM and Thorburn A: Autophagy and apoptosis: What's the connection? Trends Cell Biol. 21:387–392. 2011. View Article : Google Scholar : PubMed/NCBI

63 

Leber B and Andrews DW: Closing in on the link between apoptosis and autophagy. F1000. Biol Rep. 2:882010.

64 

Linkermann A and Green DR: Necroptosis. N Engl J Med. 370:455–465. 2014. View Article : Google Scholar : PubMed/NCBI

65 

Nikoletopoulou V, Markaki M, Palikaras K and Tavernarakis N: Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta. 1833:3448–3459. 2013. View Article : Google Scholar : PubMed/NCBI

66 

Lasarge CL and Danzer SC: Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation. Front Mol Neurosci. 7:182014. View Article : Google Scholar : PubMed/NCBI

67 

Giorgi FS, Biagioni F, Lenzi P, Frati A and Fornai F: The role of autophagy in epileptogenesis and in epilepsy-induced neuronal alterations. J Neural Transm (Vienna). 122:849–862. 2015. View Article : Google Scholar

68 

McMahon J, Huang X, Yang J, Komatsu M, Yue Z, Qian J, Zhu X and Huang Y: Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis. J Neurosci. 32:15704–15714. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu Q, Zhang M, Liu X, Zhang J and Wang H: CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus. Int J Mol Med 45: 475-484, 2020.
APA
Wu, Q., Zhang, M., Liu, X., Zhang, J., & Wang, H. (2020). CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus. International Journal of Molecular Medicine, 45, 475-484. https://doi.org/10.3892/ijmm.2019.4439
MLA
Wu, Q., Zhang, M., Liu, X., Zhang, J., Wang, H."CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus". International Journal of Molecular Medicine 45.2 (2020): 475-484.
Chicago
Wu, Q., Zhang, M., Liu, X., Zhang, J., Wang, H."CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus". International Journal of Molecular Medicine 45, no. 2 (2020): 475-484. https://doi.org/10.3892/ijmm.2019.4439
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Q, Zhang M, Liu X, Zhang J and Wang H: CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus. Int J Mol Med 45: 475-484, 2020.
APA
Wu, Q., Zhang, M., Liu, X., Zhang, J., & Wang, H. (2020). CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus. International Journal of Molecular Medicine, 45, 475-484. https://doi.org/10.3892/ijmm.2019.4439
MLA
Wu, Q., Zhang, M., Liu, X., Zhang, J., Wang, H."CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus". International Journal of Molecular Medicine 45.2 (2020): 475-484.
Chicago
Wu, Q., Zhang, M., Liu, X., Zhang, J., Wang, H."CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus". International Journal of Molecular Medicine 45, no. 2 (2020): 475-484. https://doi.org/10.3892/ijmm.2019.4439
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