|
1
|
Trefts E, Gannon M and Wasserman DH: The
liver. Curr Biol. 27:R1147–R1151. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Targher G, Bertolini L, Padovani R,
Rodella S, Tessari R, Zenari L, Day C and Arcaro G: Prevalence of
nonalcoholic fatty liver disease and its association with
cardiovascular disease among type 2 diabetic patients. Diabetes
Care. 30:1212–1218. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Byrne CD and Targher G: NAFLD: A
multisystem disease. J Hepatol. 62(1 Suppl): S47–S64. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Cobbina E and Akhlaghi F: Non-alcoholic
fatty liver disease (NAFLD)-pathogenesis, classification, and
effect on drug metabolizing enzymes and transporters. Drug Metab
Rev. 49:197–211. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Ajith TA: Role of mitochondria and
mitochondria-targeted agents in non-alcoholic fatty liver disease.
Clin Exp Pharmacol Physiol. 45:413–421. 2018. View Article : Google Scholar
|
|
6
|
Petrosillo G, Portincasa P, Grattagliano
I, Casanova G, Matera M, Ruggiero FM, Ferri D and Paradies G:
Mitochondrial dysfunction in rat with nonalcoholic fatty liver
involvement of complex I, reactive oxygen species and cardiolipin.
Biochim Biophys Acta. 1767:1260–1267. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Wei Y, Rector RS, Thyfault JP and Ibdah
JA: Nonalcoholic fatty liver disease and mitochondrial dysfunction.
World J Gastroentero. 14:193–199. 2008. View Article : Google Scholar
|
|
8
|
Satapati S, Sunny NE, Kucejova B, Fu X, He
TT, Méndez-Lucas A, Shelton JM, Perales JC, Browning JD and Burgess
SC: Elevated TCA cycle function in the pathology of diet-induced
hepatic insulin resistance and fatty liver. J Lipid Res.
53:1080–1092. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Cortez-Pinto H, Chatham J, Chacko VP,
Arnold C, Rashid A and Diehl AM: Alterations in liver ATP
homeostasis in human nonalcoholic steatohepatitis-A pilot study.
JAMA. 282:1659–1664. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Schmid AI, Szendroedi J, Chmelik M, Krssak
M, Moser E and Roden M: Liver ATP synthesis is lower and relates to
insulin sensitivity in patients with type 2 diabetes. Diabetes
Care. 34:448–453. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Abdelmalek MF, Lazo M, Horska A, Bonekamp
S, Lipkin EW, Balasubramanyam A, Bantle JP, Johnson RJ, Diehl AM,
Clark JM, et al: Higher dietary fructose is associated with
impaired hepatic adenosine triphosphate homeostasis in obese
individuals with type 2 diabetes. Hepatology. 56:952–960. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Szendroedi J, Chmelik M, Schmid AI,
Nowotny P, Brehm A, Krssak M, Moser E and Roden M: Abnormal hepatic
energy homeostasis in type 2 diabetes. Hepatology. 50:1079–1086.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Fritsch M, Koliaki C, Livingstone R,
Phielix E, Bierwagen A, Meisinger M, Jelenik T, Strassburger K,
Zimmermann S, Brockmann K, et al: Time course of postprandial
hepatic phosphorus metabolites in lean, obese, and type 2 diabetes
patients. Am J Clin Nutr. 102:1051–1058. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Ambros V: The functions of animal
microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Hackl H, Burkard TR, Sturn A, Rubio R,
Schleiffer A, Tian S, Quackenbush J, Eisenhaber F and Trajanoski Z:
Molecular processes during fat cell development revealed by gene
expression profiling and functional annotation. Genome Biol.
6:R1082005. View Article : Google Scholar
|
|
16
|
Yuan Y, Zeng ZY, Liu XH, Gong DJ, Tao J,
Cheng HZ and Huang SD: MicroRNA-203 inhibits cell proliferation by
repressing ΔNp63 expression in human esophageal squamous cell
carcinoma. BMC Cancer. 11:572011. View Article : Google Scholar
|
|
17
|
Lima RT, Busacca S, Almeida GM, Gaudino G,
Fennell DA and Vasconcelos MH: MicroRNA regulation of core
apoptosis pathways in cancer. Eur J Cancer. 47:163–174. 2011.
View Article : Google Scholar
|
|
18
|
Liston A, Linterman M and Lu LF: MicroRNA
in the adaptive immune system, in sickness and in health. J Clin
Immunol. 30:339–346. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Esquela-Kerscher A and Slack FJ:
Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer.
6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Liang T, Liu C and Ye Z: Deep sequencing
of small RNA repertoires in mice reveals metabolic
disorders-associated hepatic miRNAs. PLoS One. 8:e807742013.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Rottiers V and Naar AM: MicroRNAs in
metabolism and metabolic disorders. Nat Rev Mol Cell Biol.
13:239–250. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Taganov KD, Boldin MP, Chang KJ and
Baltimore D: NF-kappaB-dependent induction of microRNA miR-146, an
inhibitor targeted to signaling proteins of innate immune
responses. Proc Natl Acad Sci USA. 103:12481–12486. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Cobb BS, Hertweck A, Smith J, O'Connor E,
Graf D, Cook T, Smale ST, Sakaguchi S, Livesey FJ, Fisher AG and
Merkenschlager M: A role for Dicer in immune regulation. J Exp Med.
203:2519–2527. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Liu X, Dong Y, Chen S, Zhang G, Zhang M,
Gong Y and Li X: Circulating MicroRNA-146a and MicroRNA-21 predict
left ventricular remodeling after ST-elevation myocardial
infarction. Cardiology. 132:233–241. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Xiong XD, Cho M, Cai XP, Cheng J, Jing X,
Cen JM, Liu X, Yang XL and Suh Y: A common variant in pre-miR-146
is associated with coronary artery disease risk and its mature
miRNA expression. Mutat Res. 761:15–20. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Jazdzewski K, Murray EL, Franssila K,
Jarzab B, Schoenberg DR and de la Chapelle A: Common SNP in
pre-miR-146a decreases mature miR expression and predisposes to
papillary thyroid carcinoma. Proc Natl Acad Sci USA. 105:7269–7274.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Jin X, Liu J, Chen YP, Xiang Z, Ding JX
and Li YM: Effect of miR-146 targeted HDMCP up regulation in the
pathogenesis of nonalcoholic steatohepatitis. PLoS One.
12:e01742182017. View Article : Google Scholar
|
|
28
|
Bleau AM, Redrado M, Nistal-Villan E,
Villalba M, Exposito F, Redin E, de Aberasturi AL, Larzabal L,
Freire J, Gomez-Roman J and Calvo A: miR-146a targets c-met and
abolishes colorectal cancer liver metastasis. Cancer Lett.
414:257–267. 2018. View Article : Google Scholar
|
|
29
|
Sun X, Zhang J, Hou Z, Han Q, Zhang C and
Tian Z: miR-146a is directly regulated by STAT3 in human
hepatocellular carcinoma cells and involved in anti-tumor immune
suppression. Cell Cycle. 14:243–252. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Zhang X, Ye ZH, Liang HW, Ren FH, Li P,
Dang YW and Chen G: Down-regulation of miR-146a-5p and its
potential targets in hepatocellular carcinoma validated by a TCGA-
and GEO-based study. FEBS Open Bio. 7:504–521. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Canto C, Jiang LQ, Deshmukh AS, Mataki C,
Coste A, Lagouge M, Zierath JR and Auwerx J: Interdependence of
AMPK and SIRT1 for metabolic adaptation to fasting and exercise in
skeletal muscle. Cell Metab. 11:213–219. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
33
|
Schneider L, Giordano S, Zelickson BR, S
Johnson M, A Benavides G, Ouyang X, Fineberg N, Darley-Usmar VM and
Zhang J: Differentiation of SH-SY5Y cells to a neuronal phenotype
changes cellular bioenergetics and the response to oxidative
stress. Free Radic Biol Med. 51:2007–2017. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Liu W, Cao H, Yan J, Huang R and Ying H:
'Micro-managers' of hepatic lipid metabolism and NAFLD. Wiley
Interdiscip Rev RNA. 6:581–593. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Bonawitz ND, Clayton DA and Shadel GS:
Initiation and beyond: Multiple functions of the human
mitochondrial transcription machinery. Mol Cell. 24:813–825. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Piantadosi CA, Carraway MS, Babiker A and
Suliman HB: Heme oxygenase-1 regulates cardiac mitochondrial
biogenesis via Nrf2-mediated transcriptional control of nuclear
respiratory factor-1. Circ Res. 103:1232–1240. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Scarpulla RC, Vega RB and Kelly DP:
Transcriptional integration of mitochondrial biogenesis. Trends
Endocrinol Metab. 23:459–466. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Suliman HB, Sweeney TE, Withers CM and
Piantadosi CA: Co-regulation of nuclear respiratory factor-1 by
NFkappaB and CREB links LPS-induced inflammation to mitochondrial
biogenesis. J Cell Sci. 123:2565–2575. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Campbell CT, Kolesar JE and Kaufman BA:
Mitochondrial transcription factor A regulates mitochondrial
transcription initiation, DNA packaging, and genome copy number.
Biochim Biophys Acta. 1819:921–929. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Falkenberg M, Gaspari M, Rantanen A,
Trifunovic A, Larsson NG and Gustafsson CM: Mitochondrial
transcription factors B1 and B2 activate transcription of human
mtDNA. Nat Genet. 31:289–294. 2002. View
Article : Google Scholar : PubMed/NCBI
|
|
41
|
Larsson NG, Wang J, Wilhelmsson H, Oldfors
A, Rustin P, Lewandoski M, Barsh GS and Clayton DA: Mitochondrial
transcription factor A is necessary for mtDNA maintenance and
embryogenesis in mice. Nat Genet. 18:231–236. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Dhar SS, Ongwijitwat S and Wong-Riley MT:
Nuclear respiratory factor 1 regulates all ten nuclear-encoded
Subunits of cytochrome c oxidase in neurons. J Biol Chem.
283:3120–3129. 2008. View Article : Google Scholar
|
|
43
|
Kelly DP and Scarpulla RC: Transcriptional
regulatory circuits controlling mitochondrial biogenesis and
function. Genes Dev. 18:357–368. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Scarpulla RC: Transcriptional paradigms in
mammalian mitochondrial biogenesis and function. Physiol Rev.
88:611–638. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Jia Y, Viswakarma N and Reddy JK: Med1
subunit of the mediator complex in nuclear receptor-regulated
energy metabolism, liver regeneration, and hepatocarcinogenesis.
Gene Expr. 16:63–75. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Leite NC, Salles GF, Araujo AL,
Villela-Nogueira CA and Cardoso CR: Prevalence and associated
factors of non-alcoholic fatty liver disease in patients with
type-2 diabetes mellitus. Liver Int. 29:113–119. 2009. View Article : Google Scholar
|
|
47
|
Li S, Chen X, Zhang H, Liang X, Xiang Y,
Yu C, Zen K, Li Y and Zhang CY: Differential expression of
microRNAs in mouse liver under aberrant energy metabolic status. J
Lipid Res. 50:1756–1765. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Ding J, Li M, Wan X, Jin X, Chen S, Yu C
and Li Y: Effect of miR-34a in regulating steatosis by targeting
PPARα expression in nonalcoholic fatty liver disease. Sci Rep.
5:137292015. View Article : Google Scholar
|
|
49
|
Xu Y, Zalzala M, Xu J, Li Y, Yin L and
Zhang Y: A metabolic stress-inducible miR-34a-HNF4 α pathway
regulates lipid and lipoprotein metabolism. Nat Commun. 6:74662015.
View Article : Google Scholar
|
|
50
|
Derdak Z, Villegas KA, Harb R, Wu AM,
Sousa A and Wands JR: Inhibition of p53 attenuates steatosis and
liver injury in a mouse model of non-alcoholic fatty liver disease.
J Hepatol. 58:785–791. 2013. View Article : Google Scholar :
|
|
51
|
Ahn J, Lee H, Jung CH and Ha T: Lycopene
inhibits hepatic steatosis via microRNA-21-induced downregulation
of fatty acid-binding protein 7 in mice fed a high-fat diet. Mol
Nutr Food Res. 56:1665–1674. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Sun C, Huang F, Liu X, Xiao X, Yang M, Hu
G, Liu H and Liao L: miR-21 regulates triglyceride and cholesterol
metabolism in non-alcoholic fatty liver disease by targeting HMGCR.
Int J Mol Med. 35:847–853. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
He Y, Huang C, Lin X and Li J: MicroRNA-29
family, a crucial therapeutic target for fibrosis diseases.
Biochimie. 95:1355–1359. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Pogribny IP, Starlard-Davenport A,
Tryndyak VP, Han T, Ross SA, Rusyn I and Beland FA: Difference in
expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and
miR-200b is associated with strain-specific susceptibility to
dietary nonalcoholic steatohepatitis in mice. Lab Invest.
90:1437–1446. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
He S, Guo W, Deng F, Chen K, Jiang Y, Dong
M, Peng L and Chen X: Targeted delivery of microRNA 146b mimic to
hepatocytes by lactosylated PDMAEMA nanoparticles for the treatment
of NAFLD. Artif Cells Nanomed Biotechnol. 46(Suppl 2): S217–S228.
2018. View Article : Google Scholar
|
|
56
|
Paradies G, Paradies V, Ruggiero FM and
Petrosillo G: Oxidative stress, cardiolipin and mitochondrial
dysfunction in nonalcoholic fatty liver disease. World J
Gastroentero. 20:14205–14218. 2014. View Article : Google Scholar
|
|
57
|
Azizi R, Soltani-Zangbar MS, Sheikhansari
G, Pourmoghadam Z, Mehdizadeh A, Mahdipour M, Sandoghchian S,
Danaii S, Koushaein L, Samadi Kafil H and Yousefi M: Metabolic
syndrome mediates inflammatory and oxidative stress responses in
patients with recurrent pregnancy loss. J Reprod Immunol.
133:18–26. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Ge K, Guermah M, Yuan CX, Ito M, Wallberg
AE, Spiegelman BM and Roeder RG: Transcription coactivator TRAP220
is required for PPAR gamma 2-stimulated adipogenesis. Nature.
417:563–567. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Chen W, Zhang X, Birsoy K and Roeder RG: A
muscle-specific knockout implicates nuclear receptor coactivator
MED1 in the regulation of glucose and energy metabolism. Proc Natl
Acad Sci USA. 107:10196–10201. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Yu J, Xiao Y, Liu J, Ji Y, Liu H, Xu J,
Jin X, Liu L, Guan MX and Jiang P: Loss of MED1 triggers
mitochondrial biogenesis in C2C12 cells. Mitochondrion. 14:18–25.
2014. View Article : Google Scholar
|
|
61
|
Bai L, Jia Y, Viswakarma N, Huang J,
Vluggens A, Wolins NE, Jafari N, Rao MS, Borensztajn J, Yang G and
Reddy JK: Transcription coactivator mediator subunit MED1 is
required for the development of fatty liver in the mouse.
Hepatology. 53:1164–1174. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Kornberg RD: The molecular basis of
eukaryotic transcription. Proc Natl Acad Sci USA. 104:12955–12961.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Malik S and Roeder RG: Dynamic regulation
of pol II transcription by the mammalian Mediator complex. Trends
Biochem Sci. 30:256–263. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Lieber CS, Leo MA, Mak KM, Xu Y, Cao Q,
Ren C, Ponomarenko A and DeCarli LM: Model of nonalcoholic
steatohepatitis. Am J Clin Nutr. 79:502–509. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Kim JA, Wei Y and Sowers JR: Role of
mitochondrial dysfunction in insulin resistance. Circ Res.
102:401–414. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Miele L, Grieco A, Armuzzi A, Candelli M,
Forgione A, Gasbarrini A and Gasbarrini G: Hepatic mitochondrial
beta-oxidation in patients with nonalcoholic steatohepatitis
assessed by 13C-octanoate breath test. Am J Gastroenterol.
98:2335–2336. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Iozzo P, Bucci M, Roivainen A, Någren K,
Järvisalo MJ, Kiss J, Guiducci L, Fielding B, Naum AG, Borra R, et
al: Fatty acid metabolism in the liver, measured by positron
emission tomography, is increased in obese individuals.
Gastroenterology. 139:846–856. e1–6. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Sunny NE, Parks EJ, Browning JD and
Burgess SC: Excessive hepatic mitochondrial TCA cycle and
gluconeogenesis in humans with nonalcoholic fatty liver disease.
Cell Metab. 14:804–810. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Sunny NE, Bril F and Cusi K: Mitochondrial
adaptation in nonalcoholic fatty liver disease: Novel mechanisms
and treatment strategies. Trends Endocrinol Metab. 28:250–260.
2017. View Article : Google Scholar
|
|
70
|
Rong M, He R, Dang Y and Chen G:
Expression and clinicopathological significance of miR-146a in
hepatocellular carcinoma tissues. Ups J Med Sci. 119:19–24. 2014.
View Article : Google Scholar :
|
