Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
February-2020 Volume 45 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2020 Volume 45 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis

  • Authors:
    • Mayumi Ukita
    • Kenji Matsushita
    • Masato Tamura
    • Taihiko Yamaguchi
  • View Affiliations / Copyright

    Affiliations: Crown and Bridge Prosthodontics, Department of Oral Functional Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Sapporo, Hokkaido 060‑8586, Japan, Department of Oral Disease Research, National Center for Geriatrics and Gerontology, Obu, Aichi 474‑8511, Japan, Biochemistry and Molecular Biology, Department of Oral Health Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Sapporo, Hokkaido 060‑8586, Japan
  • Pages: 607-614
    |
    Published online on: December 27, 2019
       https://doi.org/10.3892/ijmm.2019.4446
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The morbidity of temporomandibular joint osteoarthritis (TMJOA) increases with age. Condylar articular cartilage degradation, which causes TMJOA, is known to be involved in articular chondrocyte metabolic imbalances in the temporomandibular joint (TMJ) and in other joints of the body. Epigenetic regulation, such as the chemical modification of DNA and histones, is implicated in cartilage homeostasis. However, few studies have been conducted on the epigenetic regulation of condylar articular cartilage degradation. The present study investigated the regulation of histone H3 lysine 9 (H3K9) methylation and its effects on the pathogenesis of degenerative TMJ cartilage disorders. The histone H3K9 methylation level was decreased in degenerated condylar articular cartilage in aged mice. Treatment with chaetocin (a selective H3K9 methylation inhibitor) reduced cell viability and promoted caspase‑3/7 activity in ATDC5 mouse chondroprogenitor cells. The inhibition of H3K9 methylation increased matrix metalloproteinase (Mmp)1 and Mmp13 mRNA expression in these cells. Furthermore, the expression levels of Sox9 and collagen α1(II) (Col2a1) mRNA, which are anabolic factors for chondrogenic differentiation, were also decreased by treatment with chaetocin, which is an inhibitor of histone methyltransferases. These results indicated that histone H3K9 methylation regulates chondrocyte homeostasis in terms of cell growth, apoptosis and gene expression, and highlighted a possible future therapy option for TMJOA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet JP, List T, Svensson P, Gonzalez Y, Lobbezoo F, et al: Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: Recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group†. J Oral Facial Pain Headache. 28:6–27. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Ibi M: Inflammation and temporomandibular joint degradation. Biol Pharm Bull. 42:538–542. 2019. View Article : Google Scholar

3 

Malemud CJ: Biologic basis of osteoarthritis: State of the evidence. Curr Opin Rheumatol. 27:289–294. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Sun MM and Beier F: Chondrocyte hypertrophy in skeletal development, growth, and disease. Birth Defects Res C Embryo Today. 102:74–82. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Yang CY, Chanalaris A and Troeberg L: ADAMTS and ADAM metalloproteinases in osteoarthritis-looking beyond the 'usual suspects'. Osteoarthritis Cartilage. 25:1000–1009. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Blum R: Stepping inside the realm of epigenetic modifiers. Biomol Concepts. 6:119–136. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Black JC, Van Rechem C and Whetstine JR: Histone lysine methylation dynamics: Establishment, regulation, and biological impact. Mol Cell. 48:491–507. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Ghosh K, O'Neil K and Capell BC: Histone modifiers: Dynamic regulators of the cutaneous transcriptome. J Dermatol Sci. 89:226–232. 2018. View Article : Google Scholar :

9 

Zhang M, Egan B and Wang J: Epigenetic mechanisms underlying the aberrant catabolic and anabolic activities of osteoarthritic chondrocytes. Int J Biochem Cell Biol. 67:101–109. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Roach HI, Yamada N, Cheung KS, Tilley S, Clarke NM, Oreffo RO, Kokubun S and Bronner F: Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum. 52:3110–3124. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Ramos YF and Meulenbelt I: The role of epigenetics in osteoarthritis: Current perspective. Curr Opin Rheumatol. 29:119–129. 2017. View Article : Google Scholar

12 

Simon TC and Jeffries MA: The epigenomic landscape in osteoarthritis. Curr Rheumatol Rep. 19:302017. View Article : Google Scholar : PubMed/NCBI

13 

Furumatsu T, Tsuda M, Yoshida K, Taniguchi N, Ito T, Hashimoto M, Ito T and Asahara H: Sox9 and p300 cooperatively regulate chromatin-mediated transcription. J Biol Chem. 280:35203–35208. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Kawai S, Takagi Y, Kaneko S and Kurosawa T: Effect of three types of mixed anesthetic agents alternate to ketamine in mice. Exp Anim. 60:481–487. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Tsukamoto A, Serizawa K, Sato R, Yamazaki J and Inomata T: Vital signs monitoring during injectable and inhalant anesthesia in mice. Exp Anim. 64:57–64. 2015. View Article : Google Scholar :

16 

Xu L, Polur I, Lim C, Servais JM, Dobeck J, Li Y and Olsen BR: Early-onset osteoarthritis of mouse temporomandibular joint induced by partial discectomy. Osteoarthritis Cartilage. 17:917–922. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Atsumi T, Miwa Y, Kimata K and Ikawa Y: A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells. Cell Differ Dev. 30:109–116. 1990. View Article : Google Scholar : PubMed/NCBI

18 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Iizuka S, Oridate N, Nashimoto M, Fukuda S and Tamura M: Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing. PLoS One. 9:e1141212014. View Article : Google Scholar : PubMed/NCBI

20 

Yao Y and Wang Y: ATDC5: An excellent in vitro model cell line for skeletal development. J Cell Biochem. 114:1223–1229. 2013. View Article : Google Scholar

21 

Greiner D, Bonaldi T, Eskeland R, Roemer E and Imhof A: Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol. 1:143–145. 2005. View Article : Google Scholar

22 

Martin C and Zhang Y: The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol. 6:838–849. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Kim KI, Park YS and Im GI: Changes in the epigenetic status of the SOX-9 promoter in human osteoarthritic cartilage. J Bone Miner Res. 28:1050–1060. 2013. View Article : Google Scholar

24 

El Mansouri FE, Nebbaki SS, Kapoor M, Afif H, Martel-Pelletier J, Pelletier JP, Benderdour M and Fahmi H: Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes. Arthritis Res Ther. 16:R1132014. View Article : Google Scholar

25 

Verrier L, Vandromme M and Trouche D: Histone demethylases in chromatin cross-talks. Biol Cell. 103:381–401. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Lawson KA, Teteak CJ, Zou J, Hacquebord J, Ghatan A, Zielinska-Kwiatkowska A, Fernandes RJ, Chansky HA and Yang L: Mesenchyme-specific knockout of ESET histone methyltransferase causes ectopic hypertrophy and terminal differentiation of articular chondrocytes. J Biol Chem. 288:32119–32125. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Goldring MB and Marcu KB: Cartilage homeostasis in health and rheumatic diseases. Arthritis Res Ther. 11:2242009. View Article : Google Scholar : PubMed/NCBI

28 

Pardo A and Selman M: MMP-1: The elder of the family. Int J Biochem Cell Biol. 37:283–288. 2005. View Article : Google Scholar

29 

Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, Shah M and Thompson EW: Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum. 60:3723–3733. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Imagawa K, de Andrés MC, Hashimoto K, Itoi E, Otero M, Roach HI, Goldring MB and Oreffo RO: Association of reduced type IX collagen gene expression in human osteoarthritic chon-drocytes with epigenetic silencing by DNA hypermethylation. Arthritis Rheumatol. 66:3040–3051. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Oppenheimer H, Kumar A, Meir H, Schwartz I, Zini A, Haze A, Kandel L, Mattan Y, Liebergall M and Dvir-Ginzberg M: Set7/9 impacts COL2A1 expression through binding and repression of SirT1 histone deacetylation. J Bone Miner Res. 29:348–360. 2014. View Article : Google Scholar

32 

Eissenberg JC and Shilatifard A: Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol. 339:240–249. 2010. View Article : Google Scholar

33 

Ho L and Crabtree GR: Chromatin remodelling during development. Nature. 463:474–484. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Loeser RF: Aging and osteoarthritis: The role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthritis Cartilage. 17:971–979. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Hwang HS and Kim HA: Chondrocyte apoptosis in the pathogenesis of osteoarthritis. Int J Mol Sci. 16:26035–26054. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Wang GG, Allis CD and Chi P: Chromatin remodeling and cancer, Part I: Covalent histone modifications. Trends Mol Med. 13:363–372. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Kim TD, Shin S, Berry WL, Oh S and Janknecht R: The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells. J Cell Biochem. 113:1368–1376. 2012. View Article : Google Scholar

38 

Lu Z, Tian Y, Salwen HR, Chlenski A, Godley LA, Raj JU and Yang Q: Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells. Anticancer Drugs. 24:484–493. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Goldring MB and Marcu KB: Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis. Trends Mol Med. 18:109–118. 2012. View Article : Google Scholar :

40 

Kalladka M, Quek S, Heir G, Eliav E, Mupparapu M and Viswanath A: Temporomandibular joint osteoarthritis: Diagnosis and long-term conservative management: A topic review. J Indian Prosthodont Soc. 14:6–15. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ukita M, Matsushita K, Tamura M and Yamaguchi T: Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis. Int J Mol Med 45: 607-614, 2020.
APA
Ukita, M., Matsushita, K., Tamura, M., & Yamaguchi, T. (2020). Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis. International Journal of Molecular Medicine, 45, 607-614. https://doi.org/10.3892/ijmm.2019.4446
MLA
Ukita, M., Matsushita, K., Tamura, M., Yamaguchi, T."Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis". International Journal of Molecular Medicine 45.2 (2020): 607-614.
Chicago
Ukita, M., Matsushita, K., Tamura, M., Yamaguchi, T."Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis". International Journal of Molecular Medicine 45, no. 2 (2020): 607-614. https://doi.org/10.3892/ijmm.2019.4446
Copy and paste a formatted citation
x
Spandidos Publications style
Ukita M, Matsushita K, Tamura M and Yamaguchi T: Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis. Int J Mol Med 45: 607-614, 2020.
APA
Ukita, M., Matsushita, K., Tamura, M., & Yamaguchi, T. (2020). Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis. International Journal of Molecular Medicine, 45, 607-614. https://doi.org/10.3892/ijmm.2019.4446
MLA
Ukita, M., Matsushita, K., Tamura, M., Yamaguchi, T."Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis". International Journal of Molecular Medicine 45.2 (2020): 607-614.
Chicago
Ukita, M., Matsushita, K., Tamura, M., Yamaguchi, T."Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis". International Journal of Molecular Medicine 45, no. 2 (2020): 607-614. https://doi.org/10.3892/ijmm.2019.4446
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team