Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
April-2020 Volume 45 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2020 Volume 45 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination

  • Authors:
    • Yuanzhi Li
    • Jundong Wang
    • Sen Zhong
    • Jun Li
    • Weiliang Du
  • View Affiliations / Copyright

    Affiliations: Traditional Chinese Medicine Department, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Department of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, P.R. China, Department of Infection, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1059-1072
    |
    Published online on: February 10, 2020
       https://doi.org/10.3892/ijmm.2020.4496
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Scutellarein has been identified to serve an anti‑tumor function in human colon cancer, but the underlying mechanisms remain largely unclear. The present study further investigated the effect and mechanism of scutellarein, extracted from wild chrysanthemum, in the progression of colon cancer. MTT, clone formation, flow cytometry and tumor‑bearing mice assays were used to detect cell viability, clone formation, apoptosis and tumorigenesis, respectively. Western blot and quantitative PCR assays were performed for protein and mRNA expression detection. The results revealed that, compared with the control group, scutellarein treatment significantly inhibited the viability and induced the apoptosis of colon cancer cells (P<0.05), with significant decreases in receptor for advanced glycosylation end products (RAGE) protein expression and stability and an increase in RAGE ubiquitination (P<0.05). However, the effects of scutellarein exerted in cell apoptosis and viability were rescued by RAGE overexpression, and accelerated by RAGE knockdown. Additionally, it was observed that scutellarein treatment induced a significant increase in the expression of cell division control protein 4 (CDC4) compared with the control group (P<0.05), which was then verified to interact with RAGE protein and mediate its ubiquitination. Overexpression of CDC4 inhibited colon cancer cell viability and promoted the apoptosis of SW480 and T84 cells, whereas this function was weakened when RAGE was overexpressed. Furthermore, CDC4 downregulation significantly neutralized scutellarein functions in promoting cell apoptosis and inhibiting cell viability and tumorigenesis in colon cancer cells compared with the scutellarein group (P<0.05). In conclusion, the present study revealed that scutellarein inhibited the development of colon cancer through upregulating CDC4‑mediated RAGE ubiquitination.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Labianca R, Beretta GD, Kildani B, Milesi L, Merlin F, Mosconi S, Pessi MA, Prochilo T, Quadri A, Gatta G, et al: Colon cancer. Crit Rev Oncol Hematol. 74:106–133. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Freeman HJ: Early stage colon cancer. World J Gastroenterol. 19:8468–8473. 2013. View Article : Google Scholar :

3 

Orangio GR: The economics of colon cancer. Surg Oncol Clin N Am. 27:327–347. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Zhang Y, Shi J, Huang H, Ren J, Li N and Dai M: Burden of colorectal cancer in China. Zhonghua Liu Xing Bing Xue Za Zhi. 36:709–714. 2015.In Chinese. PubMed/NCBI

5 

Sun S, Jiang P, Su W, Xiang Y, Li J, Zeng L and Yang S: Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoaging. Cytotechnology. 68:229–240. 2016. View Article : Google Scholar :

6 

Yang WS, Kim D, Yi YS, Kim JH, Jeong HY, Hwang K, Kim JH, Park J and Cho JY: AKT-targeted anti-inflammatory activity of the methanol extract of Chrysanthemum indicum var. albescens J Ethnopharmacol. 201:82–90. 2017. View Article : Google Scholar

7 

Deng Y, Jiang J, Chen S, Teng N, Song A, Guan Z, Fang W and Chen F: Combination of multiple resistance traits from wild relative species in Chrysanthemum via trigeneric hybridization. PLoS One. 7:302012. View Article : Google Scholar

8 

Hassanpouraghdam MB: Flowerhead volatile oil composition of soilless culture-grown Chrysanthemum balsamita L. Nat Prod Res. 23:672–677. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Shi X, Chen G and Liu X, Qiu Y, Yang S, Zhang Y, Fang X, Zhang C and Liu X: Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcom in vivo. Int J Mol Med. 35:31–38. 2015. View Article : Google Scholar

10 

Cheng CY, Hu CC, Yang HJ, Lee MC and Kao ES: Inhibitory effects of scutellarein on proliferation of human lung cancer A549 cells through ERK and NFκB mediated by the EGFR pathway. Chin J Physiol. 57:182–187. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Parajuli P, Joshee N, Rimando AM, Mittal S and Yadav AK: In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids. Planta Med. 75:41–48. 2009. View Article : Google Scholar

12 

Guo F, Yang F and Zhu YH: Scutellarein from Scutellaria barbata induces apoptosis of human colon cancer HCT116 cells through the ROS-mediated mitochondria-dependent pathway. Nat Prod Res. 33:2372–2375. 2019. View Article : Google Scholar

13 

Goh D, Lee YH and Ong ES: Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo. J Agric Food Chem. 53:8197–8204. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Behzad MM, Asnafi AA, Jaseb K, Jalali Far MA and Saki N: Expression of CD markers' in immune thrombocytopenic purpura: Prognostic approaches. APMIS. 125:1042–1055. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Bacher P and Scheffold A: Flow-cytometric analysis of rare antigen-specific T cells. Cytometry A. 83:692–701. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Tripathi SC, Fahrmann JF, Celiktas M, Aguilar M, Marini KD, Jolly MK, Katayama H, Wang H, Murage EN, Dennison JB, et al: MCAM mediates chemoresistance in small-cell lung cancer via the PI3K/AKT/SOX2 signaling pathway. Cancer Res. 77:4414–4425. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Wang Z and Yan X: CD146, a multi-functional molecule beyond adhesion. Cancer Lett. 330:150–162. 2013. View Article : Google Scholar

18 

Zhang H, Zhang J, Wang Z, Lu D, Feng J, Yang D, Chen X and Yan X: CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer. Oncol Lett. 5:1189–1194. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Tanida S, Mizoshita T, Mizushima T, Sasaki M, Shimura T, Kamiya T, Kataoka H and Joh T: Involvement of oxidative stress and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in inflammatory bowel disease. J Clin Biochem Nutr. 48:112–116. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Truffi M, Colombo M, Peñaranda-Avila J, Sorrentino L, Colombo F, Monieri M, Collico V, Zerbi P, Longhi E, Allevi R, et al: Nano-targeting of mucosal addressin cell adhesion molecule-1 identifies bowel inflammation foci in murine model. Nanomedicine (Lond). 12:1547–1560. 2017. View Article : Google Scholar

21 

Logsdon CD, Fuentes MK, Huang EH and Arumugam T: RAGE and RAGE ligands in cancer. Curr Mol Med. 7:777–789. 2007. View Article : Google Scholar

22 

Palanissami G and Paul SFD: RAGE and Its ligands: Molecular interplay between glycation, inflammation, and hallmarks of cancer-a review. Horm Cancer. 9:295–325. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Fuentes MK, Nigavekar SS, Arumugam T, Logsdon CD, Schmidt AM, Park JC and Huang EH: RAGE activation by S100P in colon cancer stimulates growth, migration, and cell signaling pathways. Dis Colon Rectum. 50:1230–1240. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Foot N, Henshall T and Kumar S: Ubiquitination and the regulation of membrane proteins. Physiol Rev. 97:253–281. 2017. View Article : Google Scholar

25 

Swatek KN and Komander D: Ubiquitin modifications. Cell Res. 26:399–422. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zhou MJ, Chen FZ and Chen HC: Ubiquitination involved enzymes and cancer. Med Oncol. 31:932014. View Article : Google Scholar : PubMed/NCBI

27 

Jin X, Yang C, Fan P, Xiao J, Zhang W, Zhan S, Liu T, Wang D and Wu H: CDK5/FBW7-dependent ubiquitination and degradation of EZH2 inhibits pancreatic cancer cell migration and invasion. J Biol Chem. 292:6269–6280. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Gallo LH, Ko J and Donoghue DJ: The importance of regulatory ubiquitination in cancer and metastasis. Cell Cycle. 16:634–648. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Yan C, Su H, Song X, Cao H, Kong L and Cui W: Smad ubiquitination regulatory factor 1 (Smurf1) promotes thyroid cancer cell proliferation and migration via ubiquitin-dependent degradation of kisspeptin-1. Cell Physiol Biochem. 49:2047–2059. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

31 

Xin B, He X, Wang J, Cai J, Wei W, Zhang T and Shen X: Nerve growth factor regulates CD133 function to promote tumor cell migration and invasion via activating ERK1/2 signaling in pancreatic cancer. Pancreatology. 16:1005–1014. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Huang XW, Xu Y, Sui X, Lin H, Xu JM, Han D, Ye DD, Lv GF, Liu YX, Qu XB and Duan MH: Scutellarein suppresses Aβ-induced memory impairment via inhibition of the NF-κB pathway in vivo an in vitro. Oncol Lett. 17:5581–5589. 2019.PubMed/NCBI

33 

Tian X, Chang L, Ma G, Wang T, Lv M, Wang Z, Chen L, Wang Y, Gao X and Zhu Y: Delineation of platelet activation pathway of scutellarein revealed its intracellular target as protein kinase C. Biol Pharm Bull. 39:181–191. 2016. View Article : Google Scholar

34 

Thirusangu P, Vigneshwaran V, Vijay Avin BR, Rakesh H, Vikas HM and Prabhakar BT: Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. Biochem Biophys Res Commun. 484:85–92. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Labianca R, Nordlinger B, Beretta GD, Mosconi S, Mandalà M, Cervantes A and Arnold D; ESMO Guidelines Working Group: Early colon cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 24(Suppl 6): vi64–vi72. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Bosman FT and Yan P: Molecular pathology of colon cancer. Pol J Pathol. 65(4 Suppl 1): S1–S11. 2014.In Polish.

37 

Wang F, Yang B, Zhao Y, Liao X, Gao C, Jiang R, Han B, Yang J, Liu M and Zhou R: Host-guest inclusion system of scutellarein with 2-hydroxypropyl-beta-cyclodextrin: Preparation, characterization, and anticancer activity. J Biomater Sci Polym Ed. 25:594–607. 2014. View Article : Google Scholar : PubMed/NCBI

38 

van Zoelen MA, Achouiti A and van der Poll T: RAGE during infectious diseases. Front Biosci (Schol Ed). 3:1119–1132. 2011. View Article : Google Scholar

39 

Lee TW, Kao YH, Chen YJ, Chao TF and Lee TI: Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases. Cell Mol Life Sci. 76:4103–4115. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Azizan N, Suter MA, Liu Y and Logsdon CD: RAGE maintains high levels of NFκB and oncogenic Kras activity in pancreatic cancer. Biochem Biophys Res Commun. 493:592–597. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Rahimi F, Karimi J, Goodarzi MT, Saidijam M, Khodadadi I, Razavi AN and Nankali M: Overexpression of receptor for advanced glycation end products (RAGE) in ovarian cancer. Cancer Biomark. 18:61–68. 2017. View Article : Google Scholar

42 

Tesarova P, Cabinakova M, Mikulova V, Zima T and Kalousova M: RAGE and its ligands in cancer-culprits, biomarkers, or therapeutic targets? Neoplasma. 62:353–364. 2015. View Article : Google Scholar

43 

Evankovich J, Lear T, McKelvey A, Dunn S, Londino J, Liu Y, Chen BB and Mallampalli RK: Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation. FASEB J. 31:3894–3903. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Rittinger K and Ikeda F: Linear ubiquitin chains: Enzymes, mechanisms and biology. Open Biol. 7:pii: 170026. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Ao N, Chen Q and Liu G: The small molecules targeting ubiquitin-proteasome system for cancer therapy. Comb Chem High Throughput Screen. 20:403–413. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Ding F, Xiao H, Wang M, Xie X and Hu F: The role of the ubiquitin-proteasome pathway in cancer development and treatment. Front Biosci (Landmark Ed). 19:886–895. 2014. View Article : Google Scholar

47 

Davis H and Tomlinson I: CDC4/FBXW7 and the 'just enough' model of tumourigenesis. J Pathol. 227:131–135. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Y, Wang J, Zhong S, Li J and Du W: Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination. Int J Mol Med 45: 1059-1072, 2020.
APA
Li, Y., Wang, J., Zhong, S., Li, J., & Du, W. (2020). Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination. International Journal of Molecular Medicine, 45, 1059-1072. https://doi.org/10.3892/ijmm.2020.4496
MLA
Li, Y., Wang, J., Zhong, S., Li, J., Du, W."Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination". International Journal of Molecular Medicine 45.4 (2020): 1059-1072.
Chicago
Li, Y., Wang, J., Zhong, S., Li, J., Du, W."Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination". International Journal of Molecular Medicine 45, no. 4 (2020): 1059-1072. https://doi.org/10.3892/ijmm.2020.4496
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Wang J, Zhong S, Li J and Du W: Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination. Int J Mol Med 45: 1059-1072, 2020.
APA
Li, Y., Wang, J., Zhong, S., Li, J., & Du, W. (2020). Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination. International Journal of Molecular Medicine, 45, 1059-1072. https://doi.org/10.3892/ijmm.2020.4496
MLA
Li, Y., Wang, J., Zhong, S., Li, J., Du, W."Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination". International Journal of Molecular Medicine 45.4 (2020): 1059-1072.
Chicago
Li, Y., Wang, J., Zhong, S., Li, J., Du, W."Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination". International Journal of Molecular Medicine 45, no. 4 (2020): 1059-1072. https://doi.org/10.3892/ijmm.2020.4496
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team