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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April-2020 Volume 45 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Antitumor effects and mechanisms of pyropheophorbide‑α methyl ester‑mediated photodynamic therapy on the human osteosarcoma cell line MG‑63

Yanyang Chen, Hang Yin, Yong Tao, Shenxi Zhong, Haoyang Yu, Jianxiao Li, Zhibiao Bai, Yunsheng Ou
Pages: 971-982
Published online on: 10 February 2020

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Tanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen species‑dependent pathway

Shangguan Jian, Liang Chen, Lian Minxue, Che Hongmin, Tang Ronghua, Fan Xiaoxuan, Zhang Binbin, Guo Shiwen
Pages: 983-992
Published online on: 13 February 2020

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Article Open Access

Curcumin exerts protective effects against hypoxia‑reoxygenation injury via the enhancement of apurinic/apyrimidinic endonuclease 1 in SH‑SY5Y cells: Involvement of the PI3K/AKT pathway

Lei Wu, Cao Jiang, Ying Kang, Yaji Dai, Wei Fang, Peng Huang
Pages: 993-1004
Published online on: 04 February 2020

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Article Open Access

Chromomycin A3 suppresses cholangiocarcinoma growth by induction of S phase cell cycle arrest and suppression of Sp1‑related anti‑apoptotic proteins

Paksiree Saranaruk, Ryusho Kariya, Gunya Sittithumcharee, Parichart Boueroy, Thidarut Boonmars, Kanlayanee Sawanyawisuth, Chaisiri Wongkham, Sopit Wongkham, Seiji Okada, Kulthida Vaeteewoottacharn
Pages: 1005-1016
Published online on: 29 January 2020

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Article Open Access

Role of the p53‑TRPM1/miR‑211‑MMP9 axis in UVB‑induced human melanocyte migration and its potential in repigmentation

Mengyun Su, Fang Miao, Shan Jiang, Ying Shi, Longfei Luo, Xiaolei He, Jing Wan, Shizheng Xu, Tie‑Chi Lei
Pages: 1017-1026
Published online on: 27 January 2020

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Article Open Access

HIF‑1α attenuates neuronal apoptosis by upregulating EPO expression following cerebral ischemia‑reperfusion injury in a rat MCAO model

Jun Li, Tao Tao, Jian Xu, Zhi Liu, Zhehua Zou, Minglu Jin
Pages: 1027-1036
Published online on: 28 January 2020

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Article Open Access

Rab22a is a novel prognostic marker for cell progression in breast cancer Corrigendum in /10.3892/ijmm.2021.4851

Miao He, Leihua Shen, Chengwei Jiang, Ge Gao, Keren Wang, Yan Jiao, Liang Sun, Yingnan Cui, Zirui Ke, Zhaoying Yang
Pages: 1037-1046
Published online on: 05 February 2020

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Article Open Access

Unraveling the genetic causes in large pedigrees with gout by whole‑exome sequencing

Xiaoru Xia, Jing Jin, Zhen‑Ji Chen, Zhenni Zhou, Hui Chen, Chunwu Zhang, Linhua Zhang, Li Sun
Pages: 1047-1058
Published online on: 13 February 2020

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Article Open Access

Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination

Yuanzhi Li, Jundong Wang, Sen Zhong, Jun Li, Weiliang Du
Pages: 1059-1072
Published online on: 10 February 2020

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Article Open Access

SNAIL expression correlates with the translocation of syndecan‑1 intracellular domain into the nucleus in prostate cancer cell lines

Nancy Farfán, Octavio Orellana‑Serradell, Daniela Herrera, Dominique Chrzanowsky, Paulina Cubillos, Gabriel Marín, Antonio Antonio García De Herreros, Enrique A. Castellón, Héctor R. Contreras
Pages: 1073-1080
Published online on: 05 February 2020

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Article Open Access

Pirfenidone attenuates homocysteine‑induced apoptosis by regulating the connexin 43 pathway in H9C2 cells

Kai Chen, Ling Chen, Yuanshuo Ouyang, Liang Zhang, Xinzhi Li, Li Li, Junqiang Si, Li Wang, Ketao Ma
Pages: 1081-1090
Published online on: 13 February 2020

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Article Open Access

MicroRNA‑449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice

Ya‑Xin Tan, Ying Hong, Shui Jiang, Min‑Nan Lu, Shan Li, Bo Chen, Li Zhang, Tao Hu, Rui Mao, Rong Mei, Yan‑Bin Xiyang
Pages: 1091-1102
Published online on: 13 February 2020

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Article Open Access

A novel role for Livin in the response to ultraviolet B radiation and pterygium development

Shuang‑Qing Wu, Qi‑Bin Xu, Wen‑Yan Sheng, Lin‑Ya Su, Li‑Wei Zhu
Pages: 1103-1111
Published online on: 28 January 2020

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Article Open Access

Adiponectin inhibits the differentiation and maturation of osteoclasts via the mTOR pathway in multiple myeloma

Zhaoyun Liu, Hui Liu, Yanqi Li, Yangyang Wang, Rui Xing, Fu Mi, Chenhuan Xiang, Rong Fu
Pages: 1112-1120
Published online on: 24 January 2020

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Article Open Access

CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS‑induced lipid peroxidation and inflammation

Huifang Gao, Yaru Cao, Hongguang Xia, Xiangyu Zhu, Yong Jin
Pages: 1121-1129
Published online on: 28 January 2020

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Article Open Access

Lactobacillus salivarius BP121 prevents cisplatin‑induced acute kidney injury by inhibition of uremic toxins such as indoxyl sulfate and p‑cresol sulfate via alleviating dysbiosis

Tae‑Hee Lee, Dongsun Park, Yang Ji Kim, Isaac Lee, Suae Kim, Chang‑Taek Oh, Joem‑Yong Kim, Jihyun Yang, Sang‑Kyung Jo
Pages: 1130-1140
Published online on: 10 February 2020

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Article Open Access

Specific microRNAs are involved in the reno‑protective effects of sevoflurane preconditioning and ischemic preconditioning against ischemia reperfusion injury in rats

Makiko Yamamoto, Tomonori Morita, Masashi Ishikawa, Atsuhiro Sakamoto
Pages: 1141-1149
Published online on: 27 January 2020

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HDAC inhibitor sodium butyrate prevents allergic rhinitis and alters lncRNA and mRNA expression profiles in the nasal mucosa of mice

Jie Wang, Mu Cui, Fei Sun, Ke Zhou, Bei Fan, Jian‑Hua Qiu, Fu‑Quan Chen
Pages: 1150-1162
Published online on: 05 February 2020

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Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG

Yaojia Cheng, Qiuping Lu, Nannan Shi, Qiongyan Zhou, Jingjing Rong, Liyun Li, Li Wang, Chen Liu
Pages: 1163-1175
Published online on: 05 February 2020

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Exogenous carbon monoxide protects against mitochondrial DNA‑induced hippocampal pyroptosis in a model of hemorrhagic shock and resuscitation

Lan Fu, Dong‑Xue Zhang, Li‑Min Zhang, Yan‑Cheng Song, Feng‑Hai Liu, Yan Li, Xu‑Peng Wang, Wei‑Chao Zheng, Xiao‑Dong Wang, Chun‑Xiao Gui, Xiang‑Jun Kong, Li‑Qing Kang
Pages: 1176-1186
Published online on: 07 February 2020

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Article

Overexpression of IFIT2 inhibits the proliferation of chronic myeloid leukemia cells by regulating the BCR‑ABL/AKT/mTOR pathway

Zhanglin Zhang, Na Li, Shuyuan Liu, Mei Jiang, Jinghua Wan, Yonglu Zhang, Lagen Wan, Caifeng Xie, Aiping Le
Pages: 1187-1194
Published online on: 13 February 2020

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Article

Echinacoside‑induced nitric oxide production in endothelial cells: Roles of androgen receptor and the PI3K‑Akt pathway

Li Gu, Danhong Lian, Yimei Zheng, Wei Zhou, Jinlei Gu, Xin Liu
Pages: 1195-1202
Published online on: 27 January 2020

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Article

Expression and clinical significance of circular RNAs hsa_circ_0000175 and hsa_circ_0008410 in peripheral blood mononuclear cells from patients with rheumatoid arthritis

Qing Luo, Lulu Zeng, Lingbing Zeng, Jiayue Rao, Lu Zhang, Yang Guo, Zikun Huang, Junming Li
Pages: 1203-1212
Published online on: 13 February 2020

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Article Open Access

Hesperetin reverses P‑glycoprotein‑mediated cisplatin resistance in DDP‑resistant human lung cancer cells via modulation of the nuclear factor‑κB signaling pathway

Wencui Kong, Xiaoming Ling, Ying Chen, Xiaoli Wu, Zhongquan Zhao, Wenwu Wang, Shuiliang Wang, Guoxiang Lai, Zongyang Yu
Pages: 1213-1224
Published online on: 05 February 2020

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Article

Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K‑AKT‑mTOR pathway in osteoarthritic chondrocytes Corrigendum in /10.3892/ijmm.2020.4786 Corrigendum in /10.3892/ijmm.2022.5085

Yubiao Zhang, Weisong Cai, Guangtao Han, Siqi Zhou, Jianping Li, Mao Chen, Haohuan Li
Pages: 1225-1236
Published online on: 06 February 2020

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Article

Exendin‑4 inhibits lipotoxicity‑induced oxidative stress in β‑cells by inhibiting the activation of TLR4/NF‑κB signaling pathway

Ximei Shen, Liufen Luo, Meng Yang, Yuxi Lin, Jing Li, Liyong Yang
Pages: 1237-1249
Published online on: 06 February 2020

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Article

Downregulation of lncRNA MALAT1 suppresses abnormal proliferation of small intestinal epithelial stem cells through miR‑129‑5p expression in diabetic mice

Ti‑Dong Shan, Zi‑Bin Tian, Yue‑Ping Jiang
Pages: 1250-1260
Published online on: 06 February 2020

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Article

Cordyceps sinensis attenuates HBx‑induced cell apoptosis in HK‑2 cells through suppressing the PI3K/Akt pathway

Ping He, Jing Lei, Jia‑Ning Miao, Di Wu, Cheng Wang
Pages: 1261-1269
Published online on: 14 February 2020

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Retraction Open Access

[Retracted] Diagnostic and prognostic value of contrast‑enhanced ultrasound combined with diffusion‑weighted magnetic resonance imaging in different subtypes of breast cancer

Gui‑Feng Liu, Zong‑Qiang Wang, Shu‑Hua Zhang, Xue‑Feng Li, Lin Liu, Ying‑Ying Miao, Shao‑Nan Yu
Pages: 1270-1270
Published online on: 04 February 2020

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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Review Open Access

MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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Review Open Access

MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Article Open Access

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Review Open Access

Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Review Open Access

Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Review Open Access

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Review Open Access

Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)

Lu Xu, Wei Jiang, Lin Song, Jing Wang, Jiangquan Yu, Ruiqiang Zheng
Article Number: 78
Published online on: 30 January 2026

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Correction Open Access

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Published online on: 29 January 2026

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Review Open Access

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Published online on: 29 January 2026

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