Open Access

Tanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen species‑dependent pathway

  • Authors:
    • Shangguan Jian
    • Liang Chen
    • Lian Minxue
    • Che Hongmin
    • Tang Ronghua
    • Fan Xiaoxuan
    • Zhang Binbin
    • Guo Shiwen
  • View Affiliations

  • Published online on: February 13, 2020     https://doi.org/10.3892/ijmm.2020.4499
  • Pages: 983-992
  • Copyright: © Jian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioma is the most common primary malignancy of the central nervous system and is associated with high mortality rates. Despite the available treatment options including surgery, radiotherapy and chemotherapy, the median patient survival rate is low. Therefore, the development of novel anticancer agents for the treatment of glioma is urgently required. Tanshinone I (TS I) is a tanshinone compound that is isolated from Danshen. Accumulating evidence indicates that TS I exhibits antiproliferative activity in a variety of cancer types. However, the role of TS I and its mechanism of action in human glioma remain to be elucidated. In the present study, the anticancer potential of TS I against human glioma U87 MG cells was investigated. The results indicated that TS I exerted a potential cytotoxic effect on human glioma U87 MG cells. TS I was found to induce cell proliferation, inhibition, cell cycle arrest, apoptosis and autophagy in U87 MG cells. Mechanistic experiments indicated that TS I activated endoplasmic reticulum (ER) stress and inhibited AKT signaling and apoptosis in human glioma U87 MG cells. Furthermore, the present study demonstrated that TS I induced protective autophagy in U87 MG cells. Additionally, ER stress and AKT signal‑mediated apoptosis and protective autophagy were found to be induced by TS I via intracellular reactive oxygen species accumulation. The results of the present study demonstrated that TS I may be a potential anticancer drug candidate that may be of value in the treatment of human glioma.

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April 2020
Volume 45 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Jian, S., Chen, L., Minxue, L., Hongmin, C., Ronghua, T., Xiaoxuan, F. ... Shiwen, G. (2020). Tanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen species‑dependent pathway. International Journal of Molecular Medicine, 45, 983-992. https://doi.org/10.3892/ijmm.2020.4499
MLA
Jian, S., Chen, L., Minxue, L., Hongmin, C., Ronghua, T., Xiaoxuan, F., Binbin, Z., Shiwen, G."Tanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen species‑dependent pathway". International Journal of Molecular Medicine 45.4 (2020): 983-992.
Chicago
Jian, S., Chen, L., Minxue, L., Hongmin, C., Ronghua, T., Xiaoxuan, F., Binbin, Z., Shiwen, G."Tanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen species‑dependent pathway". International Journal of Molecular Medicine 45, no. 4 (2020): 983-992. https://doi.org/10.3892/ijmm.2020.4499