Open Access

Aspirin inhibits endometrial fibrosis by suppressing the TGF‑β1‑Smad2/Smad3 pathway in intrauterine adhesions

  • Authors:
    • Zihui Zhang
    • Shuang Li
    • Jie Deng
    • Shaorong Yang
    • Ziwu Xiang
    • Hongyan Guo
    • Hongli Xi
    • Ming Sang
    • Wei Zhang
  • View Affiliations

  • Published online on: February 19, 2020     https://doi.org/10.3892/ijmm.2020.4506
  • Pages: 1351-1360
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Intrauterine adhesions (IUAs) represent one of the most common diseases in women of reproductive age. Patients with moderate‑to‑severe IUA can experience a decrease in normal menstrual patterns, amenorrhea and even infertility. At present, the first‑line treatment strategies for IUAs in the clinical practice are hysteroscopic transuterine resection of adhesion and postoperative adjuvant therapy, including oestrogen. However, a high recurrence rate of IUAs remains. In recent years, studies have demonstrated that aspirin combined with oestrogen may significantly prevent the postoperative disease recurrence rate, improve endometrial receptivity and improve the conception rate by increasing endometrial blood supply and angiogenesis more effectively. The TGF‑β1‑Smad2/Smad3 pathway is one of the important mechanisms involved in endometrial fibrosis. However, whether aspirin can inhibit endometrial fibrosis through the TGF‑β1‑Smad2/Smad3 pathway to prevent postoperative re‑adhesion remains to be elucidated. The results of the present study suggested that aspirin inhibits endometrial fibrosis by suppressing the TGF‑β1‑Smad2/Smad3 pathway, which may provide new hypotheses for the mechanism of action of aspirin in the treatment of IUAs.

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May 2020
Volume 45 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Zhang, Z., Li, S., Deng, J., Yang, S., Xiang, Z., Guo, H. ... Zhang, W. (2020). Aspirin inhibits endometrial fibrosis by suppressing the TGF‑β1‑Smad2/Smad3 pathway in intrauterine adhesions. International Journal of Molecular Medicine, 45, 1351-1360. https://doi.org/10.3892/ijmm.2020.4506
MLA
Zhang, Z., Li, S., Deng, J., Yang, S., Xiang, Z., Guo, H., Xi, H., Sang, M., Zhang, W."Aspirin inhibits endometrial fibrosis by suppressing the TGF‑β1‑Smad2/Smad3 pathway in intrauterine adhesions". International Journal of Molecular Medicine 45.5 (2020): 1351-1360.
Chicago
Zhang, Z., Li, S., Deng, J., Yang, S., Xiang, Z., Guo, H., Xi, H., Sang, M., Zhang, W."Aspirin inhibits endometrial fibrosis by suppressing the TGF‑β1‑Smad2/Smad3 pathway in intrauterine adhesions". International Journal of Molecular Medicine 45, no. 5 (2020): 1351-1360. https://doi.org/10.3892/ijmm.2020.4506