Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
June-2020 Volume 45 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2020 Volume 45 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Protective effects of calbindin‑D28K on the UVB radiation‑induced apoptosis of human lens epithelial cells

  • Authors:
    • Kang Liu
    • Jianfeng Zhao
    • Liushu Yang
    • Meng Guan
    • Ling Yuan
    • Yu Geng
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The 920th Hospital of The Joint Logistic Support Force, Kunming, Yunnan 650031, P.R. China, Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1793-1802
    |
    Published online on: March 26, 2020
       https://doi.org/10.3892/ijmm.2020.4552
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Calbindin‑D28K (Calb1) may protect human lens epithelial cells (HLECs) from apoptosis, which is a process resulting in individual cell death. The protective effects of Calb1 may be attributed to buffering high concentrations of Ca2+. The present study investigated the mechanisms through which Calb1 protects SRA01/04 cells (a human lens epithelial cell line) against apoptosis induced by ultraviolet B (UVB) exposure. Cells transfected with a lentivirus overexpressing Calb1 and control cells were treated with 40 µW/cm2 irradiation for 15 min and then cultured for 24 h. The changes in intracellular Ca2+ were detected by colorimetry, and the protein expression levels of Bad, Bcl‑2 and caspase‑12 were measured by western blot analysis. The intracellular Ca2+ concentration of control HLECs increased significantly following UVB irradiation, whereas in Calb1‑overexpressing cells, the Ca2+ levels remained steady. In the control cells, the expression of Bad and caspase‑12 was upregulated, and that of Bcl‑2 was downregulated. Notably, during UVB radiation‑induced apoptosis, the overexpression of Calb1 inhibited cell death, resulting in the decreased expression of Bad and caspase‑12, and in the upregulated expression of Bcl‑2. These results suggested that Calb1 inhibited the upregulation of genes involved in apoptosis. The siRNA‑mediated knockdown of Calb1 resulted in increased rates of UVB radiation‑induced apoptosis, the increased expression of Bad and caspase‑12, and the decreased expression of Bcl‑2, further demonstrating that Calb1 may mediate UVB radiation‑mediated apoptosis by regulating Ca2+. On the whole, the findings of the present study indicate that UVB exposure can lead to an imbalance in the intracellular Ca2+ homeostasis in HLECs and that Calb1 protein exerts a negative effect on the expression of pro‑apoptotic genes in HLECs. Calb1 may thus inhibit the UVB radiation‑induced apoptosis of HLECs by regulating Ca2+.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Jia S, Shi J, Chen X and Tang L: Ultraviolet radiation-induced apoptosis in human lens epithelial cells and its effect on Bcl-2 and Bax. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 37:730–736. 2012.In Chinese. PubMed/NCBI

2 

McCarty CA and Taylor HR: A review of the epidemiologic evidence linking ultraviolet radiation and cataracts. Dev Ophthalmol. 35:21–31. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Li WC, Kuszak JR, Dunn K, Wang RR, Ma W, Wang GM, Spector A, Leib M, Cotliar AM and Weiss M: Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals. J Cell Biol. 130:169–181. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Andley UP, Walsh A, Kochevar IE and Reddan JR: Effect of ultraviolet-B radiation on protein synthesis in cultured lens epithelial cells. Curr Eye Res. 9:1099–1106. 1990. View Article : Google Scholar : PubMed/NCBI

5 

Andley UP, Malone JP and Townsend RR: Inhibition of lens photodamage by UV-absorbing contact lenses. Invest Ophthalmol Vis Sci. 52:8330–8341. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Lee DH, Cho KS, Park SG, Kim EK and Joo CK: Cellular death mediated by nuclear factor kappa B (NF-kappaB) translocation in cultured human lens epithelial cells after ultraviolet-B irradiation. J Cataract Refract Surg. 31:614–619. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Yao J, Liu Y, Wang X, Shen Y, Yuan S, Wan Y and Jiang Q: UVB radiation induces human lens epithelial cell migration via NADPH oxidase-mediated generation of reactive oxygen species and up-regulation of matrix metalloproteinases. Int J Mol Med. 24:153–159. 2009.PubMed/NCBI

8 

Miyashita H, Hatsusaka N, Shibuya E, Mita N, Yamazaki M, Shibata T, Ishida H, Ukai Y, Kubo E and Sasaki H: Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study. PLoS One. 14:e02153382019. View Article : Google Scholar : PubMed/NCBI

9 

Lofgren S: Solar ultraviolet radiation cataract. Exp Eye Res. 156:112–116. 2017. View Article : Google Scholar

10 

Galichanin K, Lofgren S and Soderberg P: Cataract after repeated daily in vivo exposure to ultraviolet radiation. Health Phys. 107:523–529. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Zhang J, Yan H, Lofgren S, Tian X and Lou MF: Ultraviolet radiation-induced cataract in mice: The effect of age and the potential biochemical mechanism. Invest Ophthalmol Vis Sci. 53:7276–7285. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Mody VC Jr, Kakar M, Elfving A, Soderberg PG and Lofgren S: Ultraviolet radiation-B-induced cataract in albino rats: Maximum tolerable dose and ascorbate consumption. Acta Ophthalmol Scand. 84:390–395. 2006. View Article : Google Scholar : PubMed/NCBI

13 

West SK, Longstreth JD, Munoz BE, Pitcher HM and Duncan DD: Model of risk of cortical cataract in the US population with exposure to increased ultraviolet radiation due to stratospheric ozone depletion. Am J Epidemiol. 162:1080–1088. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Midelfart A: Ultraviolet radiation and cataract. Acta Ophthalmol Scand. 83:642–644. 2005. View Article : Google Scholar

15 

Jing L, Kumari S, Mendelev N and Li PA: Coenzyme q10 ameliorates ultraviolet B irradiation induced cell death through inhibition of mitochondrial intrinsic cell death pathway. Int J Mol Sci. 12:8302–8315. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Shui YB, Sasaki H, Pan JH, Hata I, Kojima M, Yamada Y, Hirai KI, Takahashia N and Sasaki K: Morphological observation on cell death and phagocytosis induced by ultraviolet irradiation in a cultured human lens epithelial cell line. Exp Eye Res. 71:609–618. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Mendelev N, Witherspoon S and Li PA: Overexpression of human selenoprotein H in neuronal cells ameliorates ultraviolet irradiation-induced damage by modulating cell signaling path-ways. Exp Neurol. 220:328–334. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Ricci JE, Gottlieb RA and Green DR: Caspase-Mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biol. 160:65–75. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Celio MR: Calbindin D-28k and parvalbumin in the rat nervous system. Neuroscience. 35:375–475. 1990. View Article : Google Scholar : PubMed/NCBI

20 

Persechini A, Moncrief ND and Kretsinger RH: The EF-hand family of calcium-modulated proteins. Trends Neurosci. 12:462–467. 1989. View Article : Google Scholar : PubMed/NCBI

21 

Hemmingsen C: Regulation of renal calbindin-D28k. Pharmacol Toxicol. 87(Suppl 3): S5–S30. 2000.

22 

Duncan MJ and Franklin KM: Expression of 5-HT7 receptor mRNA in the hamster brain: Effect of aging and association with calbindin-D28K expression. Brain Res. 1143:70–77. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Iacopino AM, Rhoten WB and Christakos S: Calcium binding protein (calbindin-D28k) gene expression in the developing and aging mouse cerebellum. Brain Res Mol Brain Res. 8:283–290. 1990. View Article : Google Scholar : PubMed/NCBI

24 

Hall AK and Norman AW: Acute actions of 1,25-dihydroxyvitamin D3 upon chick pancreatic calbindin-D28K. Biochem Biophys Res Commun. 176:1057–1061. 1991. View Article : Google Scholar : PubMed/NCBI

25 

Margolis DS, Kim D, Szivek JA, Lai LW and Lien YH: Functionally improved bone in calbindin-D28k knockout mice. Bone. 39:477–484. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Faucheux C, Bareille R and Amedee J: Synthesis of calbi-ndin-D28K during mineralization in human bone marrow stromal cells. Biochemical J. 333:817–823. 1998. View Article : Google Scholar

27 

Baimbridge KG, Celio MR and Rogers JH: Calcium-Binding proteins in the nervous system. Trends Neurosci. 15:303–308. 1992. View Article : Google Scholar : PubMed/NCBI

28 

Geng Y, Lin HT, Chen W, Liu ZC, Xiang W and Chen WR: Age-Related reduction in calbindin-D28K expression in the spraguedawley rat lens. Mol Med Rep. 11:422–426. 2015. View Article : Google Scholar

29 

Ahmadian SS, Rezvanian A, Peterson M, Weintraub S, Bigio EH, Mesulam MM and Geula C: Loss of calbindin-D28K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's disease. Neurobiol Aging. 36:3163–3170. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Wang C, Jiang C, Yuan H, Xiao C and Gao D: Role of calbi-ndin-D28K in estrogen treatment for Parkinson's disease. Neural Regen Res. 8:702–707. 2013.PubMed/NCBI

31 

Ferrante RJ, Kowall NW and Richardson EP Jr: Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: A combined study using the sectiongolgi method and calbindin D28k immunocytochemistry. J Neurosci. 11:3877–3887. 1991. View Article : Google Scholar : PubMed/NCBI

32 

Kiyama H, Seto-Ohshima A and Emson PC: Calbindin D28K as a marker for the degeneration of the striatonigral pathway in Huntington's disease. Brain Res. 525:209–214. 1990. View Article : Google Scholar : PubMed/NCBI

33 

Hong SM, Chung SY, Park MS, Huh YB, Park MS and Yeo SG: Immunoreactivity of calcium-binding proteins in the central auditory nervous system of aged rats. J Korean Neurosurg Soc. 45:231–235. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Fan Y, Shi L, Gu Y, Zhao Y, Xie J, Qiao J, Yang GY, Wang Y and Lu CZ: Pretreatment with PTD-calbindin D 28k alleviates rat brain injury induced by ischemia and reperfusion. J Cereb Blood Flow Metab. 27:719–728. 2007. View Article : Google Scholar

35 

D'Orlando C, Celio MR and Schwaller B: Calretinin and calbindin D-28k, but not parvalbumin protect against glutamate-induced delayed excitotoxicity in transfected N18-RE 105 neuroblastomaretina hybrid cells. Brain Res. 945:181–190. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Meier TJ, Ho DY, Park TS and Sapolsky RM: Gene transfer of calbindin D28k cDNA via herpes simplex virus amplicon vector decreases cytoplasmic calcium ion response and enhances neuronal survival following glutamatergic challenge but not following cyanide. J Neurochem. 71:1013–1023. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Bellido T, Huening M, Raval-Pandya M, Manolagas SC and Christakos S: Calbindin-D28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity. J Biol Chem. 275:26328–26332. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Youn HY, McCanna DJ, Sivak JG and Jones LW: In vitro ultraviolet-induced damage in human corneal, lens, and retinal pigment epithelial cells. Mol Vis. 17:237–246. 2011.PubMed/NCBI

39 

Okuno T: Ultraviolet action spectrum for cell killing in a human lens epithelial cell line. Ind Health. 45:137–142. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Teng H, Huang LY, Tian F, Dong LJ and Zhang H: Effects of SMP-30 overexpression on apoptosis of human lens epithelial cells induced by ultraviolet B irradiation. Zhonghua Yan Ke Za Zhi. 53:835–841. 2017.In Chinese; Abstract available in Chinese from the publisher. PubMed/NCBI

41 

Li WC and Spector A: Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract. Free Radic Biol Med. 20:301–311. 1996. View Article : Google Scholar : PubMed/NCBI

42 

Sun X, Zou W and Zhao C: Expression of P53 during lens epithe-lial cell apoptosis induced by ultraviolet. J Tongji Med Univ. 21:263–264. 2001. View Article : Google Scholar

43 

Andley UP, Lewis RM, Reddan JR and Kochevar IE: Action spectrum for cytotoxicity in the UVA- and UVB-wavelength region in cultured lens epithelial cells. Invest Ophthalmol Vis Sci. 35:367–373. 1994.PubMed/NCBI

44 

Marian MJ, Li H, Borchman D and Paterson CA: Plasma membrane Ca2+-ATPase expression in the human lens. Exp Eye Res. 81:57–64. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Marian MJ, Mukhopadhyay P, Borchman D, Tang D and Paterson CA: Regulation of sarco/endoplasmic and plasma membrane calcium ATPase gene expression by calcium in cultured human lens epithelial cells. Cell Calcium. 41:87–95. 2007. View Article : Google Scholar

46 

Wu Q, Guo D, Bi H, Wang D and Du Y: UVB irradiation-induced dysregulation of plasma membrane calcium ATPase1 and intra-cellular calcium homeostasis in human lens epithelial cells. Mol Cell Biochem. 382:263–272. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Williams MR, Duncan G, Riach RA and Webb SF: Acetylcholine receptors are coupled to mobilization of intracellular calcium cultured human lens cells. Exp Eye Res. 57:381–384. 1993. View Article : Google Scholar : PubMed/NCBI

48 

Riach RA, Duncan G, Williams MR and Webb SF: Histamine and ATP mobilize calcium by activation of H1 and P2u receptors in human lens epithelial cells. J Physiol. 486:273–282. 1995. View Article : Google Scholar : PubMed/NCBI

49 

Masaki H, Izutsu Y, Yahagi S and Okano Y: Reactive oxygen species in HaCaT keratinocytes after UVB irradiation are triggered by intracellular Ca(2+) levels. J Investig Dermatol Symp Proc. 14:50–52. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Ding BX and Wang CB: Inhibitory effect of polypeptides from chlamys farreri on UVB-induced apoptosis and DNA damage in normal human dermal fibroblasts in vitro. Acta Pharmacol Sin. 24:1006–1010. 2003.PubMed/NCBI

51 

Wackernagel W, Ettinger K, Weitgasser U, Bakir BG, Schmut O, Goessler W and Faschinger C: Opacification of a silicone intra-ocular lens caused by calcium deposits on the optic. J Cataract Refract Surg. 30:517–520. 2004. View Article : Google Scholar : PubMed/NCBI

52 

Truscott RJ, Marcantonio JM, Tomlinson J and Duncan G: Calcium-induced opacification and proteolysis in the intact rat lens. Invest Ophthalmol Vis Sci. 31:2405–2411. 1990.PubMed/NCBI

53 

Hightower KR, Duncan G, Dawson A, Wormstone IM, Reddan J and Dziedizc D: Ultraviolet irradiation (UVB) interrupts calcium cell signaling in lens epithelial cells. Photochem Photobiol. 69:595–598. 1999.PubMed/NCBI

54 

Dolmetsch RE, Lewis RS, Goodnow CC and Healy JI: Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature. 386:855–858. 1997. View Article : Google Scholar : PubMed/NCBI

55 

Richter C and Kass GE: Oxidative stress in mitochondria: Its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation. Chem Biol Interact. 77:1–23. 1991. View Article : Google Scholar : PubMed/NCBI

56 

Martikainen P, Kyprianou N, Tucker RW and Isaacs JT: Programmed death of nonproliferating androgen-independent prostatic cancer cells. Cancer Res. 51:4693–4700. 1991.PubMed/NCBI

57 

Lynch K, Fernandez G, Pappalardo A and Peluso JJ: Basic fibroblast growth factor inhibits apoptosis of spontaneously immortalized granulosa cells by regulating intracellular free calcium levels through a protein kinase Cdelta-dependent pathway. Endocrinology. 141:4209–4217. 2000. View Article : Google Scholar : PubMed/NCBI

58 

Huang Y, Li X, Wang Y, Wang H, Huang C and Li J: Endoplasmic reticulum stress-induced hepatic stellate cell apoptosis through calcium-mediated JNK/P38 MAPK and Calpain/Caspase-12 pathways. Mol Cell Biochem. 394:1–12. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Li L, Cao Z, Jia P and Wang Z: Calcium signals and caspase-12 participated in paraoxon-induced apoptosis in EL4 cells. Toxicol In Vitro. 24:728–736. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Jiang L, Liu Y, Ma MM, Tang YB, Zhou JG and Guan YY: Mitochondria dependent pathway is involved in the protective effect of bestrophin-3 on hydrogen peroxide-induced apoptosis in basilar artery smooth muscle cells. Apoptosis. 18:556–565. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Min SK, Lee SK, Park JS, Lee J, Paeng JY, Lee SI, Lee HJ, Kim Y, Pae HO, Lee SK and Kim EC: Endoplasmic reticulum stress is involved in hydrogen peroxide induced apoptosis in immortalized and malignant human oral keratinocytes. J Oral Pathol Med. 37:490–498. 2008. View Article : Google Scholar : PubMed/NCBI

62 

Hoenderop JG, Hartog A, Stuiver M, Doucet A, Willems PH and Bindels RJ: Localization of the epithelial Ca(2+) channel in rabbit kidney and intestine. J Am Soc Nephrol. 11:1171–1178. 2000.PubMed/NCBI

63 

Sun S, Li F, Gao X, Zhu Y, Chen J, Zhu X, Yuan H and Gao D: Calbindin-D28K inhibits apoptosis in dopaminergic neurons by activation of the PI3-kinase-Akt signaling pathway. Neuroscience. 199:359–367. 2011. View Article : Google Scholar : PubMed/NCBI

64 

Verdes JM, Morana JA, Battes D, Gutiérrez F, Guerrero F, Goicoa A, Fidalgo LE, Barbeito CG, Zanuzzi CN, Portiansky EL and Gimeno EJ: Calbindin D28k expression and the absence of apoptosis in the cerebellum of solanum bonariense L-intoxicated bovines. Vet Pathol. 47:569–572. 2010. View Article : Google Scholar : PubMed/NCBI

65 

Guo Q, Christakos S, Robinson N and Mattson MP: Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: Reduced oxidative stress and preserved mitochondrial function. Proc Natl Acad Sci USA. 95:3227–3232. 1998. View Article : Google Scholar : PubMed/NCBI

66 

Turner PR, Mefford S, Christakos S and Nissenson RA: Apoptosis mediated by activation of the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein (PTHrP). Mol Endocrinol. 14:241–254. 2000. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu K, Zhao J, Yang L, Guan M, Yuan L and Geng Y: Protective effects of calbindin‑D28K on the UVB radiation‑induced apoptosis of human lens epithelial cells. Int J Mol Med 45: 1793-1802, 2020.
APA
Liu, K., Zhao, J., Yang, L., Guan, M., Yuan, L., & Geng, Y. (2020). Protective effects of calbindin‑D28K on the UVB radiation‑induced apoptosis of human lens epithelial cells. International Journal of Molecular Medicine, 45, 1793-1802. https://doi.org/10.3892/ijmm.2020.4552
MLA
Liu, K., Zhao, J., Yang, L., Guan, M., Yuan, L., Geng, Y."Protective effects of calbindin‑D28K on the UVB radiation‑induced apoptosis of human lens epithelial cells". International Journal of Molecular Medicine 45.6 (2020): 1793-1802.
Chicago
Liu, K., Zhao, J., Yang, L., Guan, M., Yuan, L., Geng, Y."Protective effects of calbindin‑D28K on the UVB radiation‑induced apoptosis of human lens epithelial cells". International Journal of Molecular Medicine 45, no. 6 (2020): 1793-1802. https://doi.org/10.3892/ijmm.2020.4552
Copy and paste a formatted citation
x
Spandidos Publications style
Liu K, Zhao J, Yang L, Guan M, Yuan L and Geng Y: Protective effects of calbindin‑D28K on the UVB radiation‑induced apoptosis of human lens epithelial cells. Int J Mol Med 45: 1793-1802, 2020.
APA
Liu, K., Zhao, J., Yang, L., Guan, M., Yuan, L., & Geng, Y. (2020). Protective effects of calbindin‑D28K on the UVB radiation‑induced apoptosis of human lens epithelial cells. International Journal of Molecular Medicine, 45, 1793-1802. https://doi.org/10.3892/ijmm.2020.4552
MLA
Liu, K., Zhao, J., Yang, L., Guan, M., Yuan, L., Geng, Y."Protective effects of calbindin‑D28K on the UVB radiation‑induced apoptosis of human lens epithelial cells". International Journal of Molecular Medicine 45.6 (2020): 1793-1802.
Chicago
Liu, K., Zhao, J., Yang, L., Guan, M., Yuan, L., Geng, Y."Protective effects of calbindin‑D28K on the UVB radiation‑induced apoptosis of human lens epithelial cells". International Journal of Molecular Medicine 45, no. 6 (2020): 1793-1802. https://doi.org/10.3892/ijmm.2020.4552
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team