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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2020 Volume 45 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

A new threat from an old enemy: Re‑emergence of coronavirus (Review)

Anca Oana Docea, Aristidis Tsatsakis, Dana Albulescu, Oana Cristea, Ovidiu Zlatian, Marco Vinceti, Sterghios A. Moschos, Dimitris Tsoukalas, Marina Goumenou, Nikolaos Drakoulis, Josef M. Dumanov, Victor A. Tutelyan, Gennadii G. Onischenko, Michael Aschner, Demetrios A. Spandidos, Daniela Calina
Pages: 1631-1643
Published online on: 27 March 2020

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Article Open Access

Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease

Jian Li, Yufan Lu, Ning Li, Peijun Li, Jianqing Su, Zhengrong Wang, Ting Wang, Zhaoyu Yang, Yahui Yang, Haixia Chen, Lu Xiao, Hongxia Duan, Weibing Wu, Xiaodan Liu
Pages: 1644-1660
Published online on: 12 March 2020

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Article Open Access

CDK5 inhibition in vitro and in vivo induces cell death in myeloma and overcomes the obstacle of bortezomib resistance

Hailong Tang, Li Xu, Xi Cen, Li Yang, Juan Feng, Guang Li, Huafeng Zhu, Shan Gao, Yan Yu, Yaping Zhao, Zhiqiang Tian, Liping Hou, Shuchun Yu, Guangxun Gao
Pages: 1661-1672
Published online on: 26 March 2020

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Article Open Access

Resveratrol decreases cell apoptosis through inhibiting DNA damage in bronchial epithelial cells

Yun Zhang, Linlin Guo, Betty Yuen‑Kwan Law, Xiaobo Liang, Ning Ma, Guofeng Xu, Xiaoyun Wang, Xiefang Yuan, Hongmei Tang, Qi Chen, Vincent Kam‑Wai Wong, Xing Wang
Pages: 1673-1684
Published online on: 16 March 2020

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Article Open Access

Long noncoding RNA SNHG14 promotes the aggressiveness of retinoblastoma by sponging microRNA‑124 and thereby upregulating STAT3 Retraction in /10.3892/ijmm.2022.5126

Xiaowen Sun, Hui Shen, Shubin Liu, Jing Gao, Shuyan Zhang
Pages: 1685-1696
Published online on: 20 March 2020

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Article Open Access

EMT related circular RNA expression profiles identify circSCYL2 as a novel molecule in breast tumor metastasis

Chunlei Yuan, Xuliang Luo, Xiang Zhan, Huihui Zeng, Sijia Duan
Pages: 1697-1710
Published online on: 24 March 2020

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Article Open Access

Ligustrazine ameliorates lipopolysaccharide‑induced neurocognitive impairment by activating autophagy via the PI3K/AKT/mTOR pathway

Guangming Li, Sisi Liu, Huili Wang, Rui Pan, Haijie Tang, Xueqin Yan, Yanping Wang, Yongmei Fu, Fujun Jing, Jun Dong
Pages: 1711-1720
Published online on: 20 March 2020

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Article Open Access

Polyphenols from grape pomace induce osteogenic differentiation in mesenchymal stem cells

Elisa Torre, Giorgio Iviglia, Clara Cassinelli, Marco Morra, Nazario Russo
Pages: 1721-1734
Published online on: 30 March 2020

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Article Open Access

Transcriptome analysis of Klf15‑mediated inhibitory functions in a mouse deep venous thrombosis model

Jin Zhou, Xueling Zhao, Shiwei Xie, Rudan Zhou
Pages: 1735-1752
Published online on: 13 March 2020

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Article Open Access

Methylation‑associated silencing of miR‑638 promotes endometrial carcinoma progression by targeting MEF2C

Jianjiao Ni, Shanhui Liang, Boer Shan, Wenjuan Tian, Huaying Wang, Yulan Ren
Pages: 1753-1770
Published online on: 16 March 2020

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Article Open Access

miR‑539 suppresses the proliferation, migration, invasion and epithelial mesenchymal transition of pancreatic cancer cells through targeting SP1

Liang Xue, Yan Shen, Zhenglong Zhai, Shusen Zheng
Pages: 1771-1782
Published online on: 01 April 2020

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Article Open Access

CD44 inhibition attenuates EGFR signaling and enhances cisplatin sensitivity in human EGFR wild‑type non‑small‑cell lung cancer cells

Jianhua Yin, Hanyu Zhang, Xu Wu, Yuchen Zhang, Jing Li, Jing Shen, Yueshui Zhao, Zhangang Xiao, Lan Lu, Chengliang Huang, Zhuo Zhang, Fukuan Du, Yuanlin Wu, Parham Jabbarzadeh Kaboli, Chi Hin Cho, Dandan Yuan, Mingxing Li
Pages: 1783-1792
Published online on: 01 April 2020

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Article Open Access

Protective effects of calbindin‑D28K on the UVB radiation‑induced apoptosis of human lens epithelial cells

Kang Liu, Jianfeng Zhao, Liushu Yang, Meng Guan, Ling Yuan, Yu Geng
Pages: 1793-1802
Published online on: 26 March 2020

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Article Open Access

miR‑181b‑p53 negative feedback axis regulates osteosarcoma cell proliferation and invasion

Jun Wan, Feng Long, Can Zhang, Yupeng Liu
Pages: 1803-1813
Published online on: 31 March 2020

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Article Open Access

Circular RNA circ‑ACACA regulates proliferation, migration and glycolysis in non‑small‑cell lung carcinoma via miR‑1183 and PI3K/PKB pathway

Wenwen Wu, Wei Xi, Huimin Li, Mengxiang Yang, Xialei Yao
Pages: 1814-1824
Published online on: 24 March 2020

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Article Open Access

EP4 activation ameliorates liver ischemia/reperfusion injury via ERK1/2‑GSK3β‑dependent MPTP inhibition

Lin‑Lin Cai, Hai‑Tao Xu, Qi‑Long Wang, Ya‑Qing Zhang, Wei Chen, Dong‑Yu Zheng, Fang Liu, Hong‑Bin Yuan, Yong‑Hua Li, Hai‑Long Fu
Pages: 1825-1837
Published online on: 17 March 2020

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Article

Effects of cisplatin on the proliferation, invasion and apoptosis of breast cancer cells following β‑catenin silencing Retraction in /10.3892/ijmm.2024.5437

Xidan Zhu, Jia Feng, Wenguang Fu, Xiaojia Shu, Xue Wan, Jinbo Liu
Pages: 1838-1850
Published online on: 16 March 2020

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Article Open Access

Long non‑coding RNA EBLN3P promotes the recovery of the function of impaired spiral ganglion neurons by competitively binding to miR‑204‑5p and regulating TMPRSS3 expression

Wenqi Jiang, Anquan Peng, Yichao Chen, Bo Pang, Zhiwen Zhang
Pages: 1851-1863
Published online on: 17 March 2020

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Article Open Access

Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling Corrigendum in /10.3892/ijmm.2020.4663

Huashan Huang, Huizhen Yu, Liang Lin, Junming Chen, Pengli Zhu
Pages: 1864-1874
Published online on: 16 March 2020

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Article Open Access

Suberoylanilide hydroxamic acid alleviates orthotopic liver transplantation‑induced hepatic ischemia‑reperfusion injury by regulating the AKT/GSK3β/NF‑κB and AKT/mTOR pathways in rat Kupffer cells

Jingyuan Wang, Minghua Deng, Hao Wu, Menghao Wang, Jianping Gong, He Bai, Yakun Wu, Junjiang Pan, Yong Chen, Shengwei Li
Pages: 1875-1887
Published online on: 26 March 2020

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Article Open Access

Heat shock protein 90 relieves heat stress damage of myocardial cells by regulating Akt and PKM2 signaling in vivo

Xiao‑Hui Zhang, Jia‑Xin Wu, Jun‑Zhou Sha, Bo Yang, Jia‑Rui Sun, En‑Dong Bao
Pages: 1888-1908
Published online on: 31 March 2020

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Article Open Access

Altered expression of glycoprotein non‑metastatic melanoma protein B in the distal sciatic nerve following injury

Yani Zheng, Chao Huang, Xiangqun Yang, Zhiying Zhang
Pages: 1909-1917
Published online on: 31 March 2020

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Article Open Access

Tetramethylpyrazine reduces inflammation levels and the apoptosis of LPS‑stimulated human periodontal ligament cells via the downregulation of miR‑302b

Yan Duan, Wei An, Yunxia Wu, Jin Wang
Pages: 1918-1926
Published online on: 27 March 2020

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Article Open Access

Sulforaphane reduces intracellular survival of Staphylococcus aureus in macrophages through inhibition of JNK and p38 MAPK‑induced inflammation

Therese B. Deramaudt, Malika Ali, Stephane Vinit, Marcel Bonay
Pages: 1927-1941
Published online on: 01 April 2020

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Article

MicroRNA‑132 promotes oxidative stress‑induced pyroptosis by targeting sirtuin 1 in myocardial ischaemia‑reperfusion injury

Yan Zhou, Kun‑Sheng Li, Lu Liu, Shi‑Liang Li
Pages: 1942-1950
Published online on: 30 March 2020

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Article

Association between oxidative stress biomarkers and PON and GST polymorphisms as a predictor for susceptibility to the effects of pesticides

Chiara Costa, Giusi Briguglio, Federica Giambò, Rosaria Catanoso, Michele Teodoro, Daniela Caccamo, Concettina Fenga
Pages: 1951-1959
Published online on: 16 March 2020

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Correction Open Access

[Corrigendum] Cancer‑related fatigue during combined treatment of androgen deprivation therapy and radiotherapy is associated with mitochondrial dysfunction

Li Rebekah Feng, Brian S. Wolff, Josephine Liwang, Jeniece M. Regan, Sarah Alshawi, Sumiyya Raheem, Leorey N. Saligan
Pages: 1960-1960
Published online on: 17 March 2020

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

DUSP26: Unveiling a critical molecular mediator and therapeutic target in developmental dysplasia of the hip‑associated secondary osteoarthritis

Enbo Wang, Haixiang Zhang, Dechao Wu, Sadik Ali, Xianglu Ji
Article Number: 105
Published online on: 26 February 2026

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Review Open Access

mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential therapeutic targets (Review)

Rongxiu Huo, Yanting Yang, Chengcheng Wei, Yang Yang, Danli Meng, Jinying Lin, Xinxiang Huang
Article Number: 104
Published online on: 25 February 2026

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Article Open Access

Bumetanide‑blocked SLC12A2 exerts a protective effect in experimental diabetic retinopathy

Yuting Zhang, Xiuli Wang, Qinyue Xie, Yue Huang, Dongjia Huang, Ziqing Liu, Tong Xu, Man Ni, Hongwei Yang
Article Number: 103
Published online on: 25 February 2026

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Article Open Access

Peroxisome proliferator‑activated receptor α regulates acesulfame‑K‑induced NAFLD via hepatic PLCβ: Foe and friend

Peng-Yao Lin, Jia-Rong Xie, Tian-Chen Qian, Shi-Song Wang, Si-Yi Yu, Wen-Bo Shi, Ying Wang, Lu-Ze Cen, Qing-Jing Zhu, Yi-Yang Zheng, Hui Gao, Rong Fang, Zhao-Xia Xia, Ai-Ming Liu, Lei Xu
Article Number: 102
Published online on: 25 February 2026

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Retraction Open Access

[Retracted] A novel role for Livin in the response to ultraviolet B radiation and pterygium development

Shuang-Qing Wu, Qi-Bin Xu, Wen-Yan Sheng, Lin-Ya Su, Li-Wei Zhu
Article Number: 101
Published online on: 24 February 2026

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Article Open Access

Endothelial UNC5B regulates blood‑retinal barrier homeostasis

Yujia Yao, Suyu Wang, Jiajun Li, Qianzi Jin, Ziyi Chen, Qin Jiang, Keran Li
Article Number: 100
Published online on: 20 February 2026

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Review Open Access

Metabolic hubs in reproduction: The regulatory network of lipid droplets in gamete and embryo physiology (Review)

Liuzhu Pan, Zongzhuang Wen, Yi Jin
Article Number: 99
Published online on: 17 February 2026

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Review Open Access

The role and mechanism of IL‑35 in myasthenia gravis (Review)

Jing Mao, Lin-Ming Zhang, Yan-Lin Zhu, Shu-Ji Gao, Ming-Wei Liu
Article Number: 98
Published online on: 17 February 2026

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Article Open Access

miRNA‑378a‑5p attenuates the development of abdominal aortic aneurysm via ABLIM1‑MKL1 signaling pathways

Jing Wang, Yujia Zou, Yani Wang, Zheming Yang, Daoshen Liu, Xiaolin Su, Haixu Song, Kai Xu, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 97
Published online on: 16 February 2026

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Review Open Access

Dysregulated post‑translational modifications in granulosa cells drive ovarian dysfunction and potential infertility applications (Review)

Yufei Zhong, Yunfei Zou, Zhuoyuan Yang, Junjun Wang, Zezheng Pan, Jiugeng Feng
Article Number: 96
Published online on: 16 February 2026

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Review Open Access

Microglia‑mediated neuroinflammation in intracerebral hemorrhage: Pathological mechanisms and implications for therapeutic development (Review)

Xuehui Fan, Changzhi Pu, Luyi Zhong, Oucheng Wang, Binyi Zhao, Dongyi Liao, Xue Bai, Guiquan Chen, Guoqiang Yang
Article Number: 95
Published online on: 16 February 2026

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Correction Open Access

[Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs

Qing-Yong Chen, Li-Qun Xu, De-Min Jiao, Qing-Hua Yao, Yan-Yi Wang, Hui-Zhen Hu, Yu-Quan Wu, Jia Song, Jie Yan, Li-Jun Wu
Article Number: 94
Published online on: 12 February 2026

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Article Open Access

Orcinol glucoside ameliorates pulmonary fibrosis by suppressing hyaluronic acid synthesis and macrophage M2 polarization via targeting hyaluronic acid synthase 2

Caizi Li, Xinglinzi Tang, Xiaoru Luo, Xin Lai, Jing Yang, Zheng Xu, Gulizeba Muhetaer, Yizi Xie, Xiufang Huang, Hang Li
Article Number: 93
Published online on: 10 February 2026

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Review Open Access

Helicobacter pylori and hyperglycemia fuel gastric cancer glycolysis: Mechanisms and targeted intervention (Review)

Youjia Liu, Fang Wang, Ya Deng, Yanxia Hu, Feihong Shu, Jie Yu, Guoyou Gou, Min Wen, Chen Luo, Xianmin Lu, Qian Du, Jingyu Xu, Rui Xie
Article Number: 92
Published online on: 09 February 2026

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Review Open Access

Targeting the gut‑bone axis through exercise: A novel approach to osteoporosis prevention and treatment (Review)

Jingjing Wu, Siqi Zhang, Junjie Wu, Yuhang Luan, Xingchen Yao, Boyan Xu, Yiting Wang, Yingyue Sheng, Yuzheng Xue, Yilin Ren
Article Number: 91
Published online on: 09 February 2026

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Review Open Access

Chorus line in oral squamous cell carcinoma: How stromal and immune players orchestrate tumor progression (Review)

Eliano Cascardi, Mario Della Mura, Nicoletta Sgarro, Silvia Minei, Gerardo Cazzato, Eugenio Maiorano, Lorenzo Lo Muzio, Maria Eleonora Bizzoca, Fábio França Vieira E Silva, Eleonora Lo Muzio, Mario Dioguardi, Andrea Ballini
Article Number: 90
Published online on: 09 February 2026

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Correction Open Access

[Corrigendum] Hsa_circularRNA_0079201 suppresses chondrocyte proliferation and endochondral ossification by regulating the microRNA‑140‑3p/SMAD2 signaling pathway in idiopathic short stature 

Xijuan Liu, Chen Yan, Xueqiang Deng, Jingyu Jia
Article Number: 89
Published online on: 09 February 2026

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Review Open Access

Post‑translational modifications in diabetic kidney disease (Review)

Mengfei He, Zihang Wang, Zhuang Miao, Yu Zhao, Lingling Wei, Lijie Zhang, Ruili Yin, Yan Wang, Longyan Yang
Article Number: 88
Published online on: 09 February 2026

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Review Open Access

Role of vascular smooth muscle cell pathobiology in sepsis‑induced vasoplegia (Review)

Hang Ruan, Xiao-Yan Shen, Shi-Yan Liu, Shu-Sheng Li
Article Number: 87
Published online on: 06 February 2026

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Review Open Access

Signalling pathways regulated by FSTL1 in inflammation and potential therapeutic applications (Review)

Changliang Ma, Jingxin Li, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Wencui Li, Zhiqin Deng, Zhe Zhao
Article Number: 86
Published online on: 05 February 2026

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Article Open Access

Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling

Qin Deng, Zhongzhong Liu, Qifa Ye, Jia Liu, Zhihui Fu, Xingjian Zhang, Jun Luo, Zhongshan Lu, Pengpeng Yue, Jiansheng Xiao, Qi Xiao
Article Number: 85
Published online on: 05 February 2026

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Review Open Access

Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)

Wei Li, Wen-Hong Wang, Yi Song, Xu-Jiong Li, Yan Li, Xia Wang, Ting-Ting Tian, Xiao Huang, Li Zhao
Article Number: 84
Published online on: 04 February 2026

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Correction Open Access

[Corrigendum] p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro

Guo-Qian He, Guang-Yu Liu, Wen-Ming Xu, Hui-Juan Liao, Xing-Hui Liu, Guo-Lin He
Article Number: 83
Published online on: 04 February 2026

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Review Open Access

Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)

Yongchun Liang, Xinbiao Fan, Xiaofei Geng, Yunfeng Jia, Wenyu Shang, Xitong Sun, Jun Ge, Guijun Ye, Boyu Zhu, Zheng Zhang, Yuxin Kang, Xiaoyu Shan, Junping Zhang
Article Number: 82
Published online on: 03 February 2026

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IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (Review)

Hao Zhu, Hao Wang, Xia Li, Weisong Zhang, Yihao Wang, Qingze Tan, Dongxu Ying, Zhan Shi, Jianxiang Song
Article Number: 81
Published online on: 03 February 2026

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Article Open Access

Ebastine targets HER2/HER3 signaling and cancer stem cell traits to overcome trastuzumab resistance in HER2‑positive breast cancer

Eunsun Jung, Ji Young Kim, Dongmi Ko, Juyeon Seo, Sang Yoon Lee, Daeun Lee, Subeen Kim, Minsu Park, Seongjae Kim, Soeun Park, Kyoungmin Lee, Yong Koo Kang, Kee Dal Nam, Yoon-Jae Kim, Jae Hong Seo
Article Number: 80
Published online on: 02 February 2026

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Correction Open Access

[Corrigendum] Inhibition of acid‑sensing ion channel 1a attenuates acid‑induced activation of autophagy via a calcium signaling pathway in articular chondrocytes

Wen-Fan Gao, Ya-Yun Xu, Jin-Fang Ge, Fei-Hu Chen
Article Number: 79
Published online on: 02 February 2026

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Review Open Access

Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)

Lu Xu, Wei Jiang, Lin Song, Jing Wang, Jiangquan Yu, Ruiqiang Zheng
Article Number: 78
Published online on: 30 January 2026

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Correction Open Access

[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Article Number: 77
Published online on: 29 January 2026

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Review Open Access

Spatial metabolomics: A new tool for unravelling the metabolic disorders and heterogeneity in diabetic kidney disease (Review)

Hanfei Li, Yuxi Li, Bo Zhang, Wenhao Cheng, Guowei Ma, Jin Rong, Shiru Duan, Di Feng, Tingting Zhao
Article Number: 76
Published online on: 29 January 2026

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May-2026 Volume 57 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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