Open Access

Towards effective COVID‑19 vaccines: Updates, perspectives and challenges (Review)

  • Authors:
    • Daniela Calina
    • Anca Oana Docea
    • Demetrios Petrakis
    • Alex M. Egorov
    • Aydar A. Ishmukhametov
    • Alexsandr G. Gabibov
    • Michael I. Shtilman
    • Ronald Kostoff
    • Félix Carvalho
    • Marco Vinceti
    • Demetrios A. Spandidos
    • Aristidis Tsatsakis
  • View Affiliations

  • Published online on: May 6, 2020     https://doi.org/10.3892/ijmm.2020.4596
  • Pages: 3-16
  • Copyright: © Calina et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the current context of the pandemic triggered by SARS-COV-2, the immunization of the population through vaccination is recognized as a public health priority. In the case of SARS‑COV‑2, the genetic sequencing was done quickly, in one month. Since then, worldwide research has focused on obtaining a vaccine. This has a major economic impact because new technological platforms and advanced genetic engineering procedures are required to obtain a COVID‑19 vaccine. The most difficult scientific challenge for this future vaccine obtained in the laboratory is the proof of clinical safety and efficacy. The biggest challenge of manufacturing is the construction and validation of production platforms capable of making the vaccine on a large scale.
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July 2020
Volume 46 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Calina, D., Docea, A.O., Petrakis, D., Egorov, A.M., Ishmukhametov, A.A., Gabibov, A.G. ... Tsatsakis, A. (2020). Towards effective COVID‑19 vaccines: Updates, perspectives and challenges (Review). International Journal of Molecular Medicine, 46, 3-16. https://doi.org/10.3892/ijmm.2020.4596
MLA
Calina, D., Docea, A. O., Petrakis, D., Egorov, A. M., Ishmukhametov, A. A., Gabibov, A. G., Shtilman, M. I., Kostoff, R., Carvalho, F., Vinceti, M., Spandidos, D. A., Tsatsakis, A."Towards effective COVID‑19 vaccines: Updates, perspectives and challenges (Review)". International Journal of Molecular Medicine 46.1 (2020): 3-16.
Chicago
Calina, D., Docea, A. O., Petrakis, D., Egorov, A. M., Ishmukhametov, A. A., Gabibov, A. G., Shtilman, M. I., Kostoff, R., Carvalho, F., Vinceti, M., Spandidos, D. A., Tsatsakis, A."Towards effective COVID‑19 vaccines: Updates, perspectives and challenges (Review)". International Journal of Molecular Medicine 46, no. 1 (2020): 3-16. https://doi.org/10.3892/ijmm.2020.4596