Open Access

A dissection of SARS‑CoV2 with clinical implications (Review)

  • Authors:
    • Felician Stancioiu
    • Georgios Z. Papadakis
    • Stelios Kteniadakis
    • Boris Nikovaevich Izotov
    • Michael D. Coleman
    • Demetrios A. Spandidos
    • Aristidis Tsatsakis
  • View Affiliations

  • Published online on: June 10, 2020     https://doi.org/10.3892/ijmm.2020.4636
  • Pages: 489-508
  • Copyright: © Stancioiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

We are being confronted with the most consequential pandemic since the Spanish flu of 1918‑1920 to the extent that never before have 4 billion people quarantined simultaneously; to address this global challenge we bring to the forefront the options for medical treatment and summarize SARS‑CoV2 structure and functions, immune responses and known treatments. Based on literature and our own experience we propose new interventions, including the use of amiodarone, simvastatin, pioglitazone and curcumin. In mild infections (sore throat, cough) we advocate prompt local treatment for the naso‑pharynx (inhalations; aerosols; nebulizers); for moderate to severe infections we propose a tried‑and‑true treatment: the combination of arginine and ascorbate, administered orally or intravenously. The material is organized in three sections: i) Clinical aspects of COVID‑19; acute respiratory distress syndrome (ARDS); known treatments; ii) Structure and functions of SARS‑CoV2 and proposed antiviral drugs; iii) The combination of arginine‑ascorbate.
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August-2020
Volume 46 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos
Stancioiu F, Papadakis GZ, Kteniadakis S, Izotov BN, Coleman MD, Spandidos DA and Tsatsakis A: A dissection of SARS‑CoV2 with clinical implications (Review). Int J Mol Med 46: 489-508, 2020
APA
Stancioiu, F., Papadakis, G.Z., Kteniadakis, S., Izotov, B.N., Coleman, M.D., Spandidos, D.A., & Tsatsakis, A. (2020). A dissection of SARS‑CoV2 with clinical implications (Review). International Journal of Molecular Medicine, 46, 489-508. https://doi.org/10.3892/ijmm.2020.4636
MLA
Stancioiu, F., Papadakis, G. Z., Kteniadakis, S., Izotov, B. N., Coleman, M. D., Spandidos, D. A., Tsatsakis, A."A dissection of SARS‑CoV2 with clinical implications (Review)". International Journal of Molecular Medicine 46.2 (2020): 489-508.
Chicago
Stancioiu, F., Papadakis, G. Z., Kteniadakis, S., Izotov, B. N., Coleman, M. D., Spandidos, D. A., Tsatsakis, A."A dissection of SARS‑CoV2 with clinical implications (Review)". International Journal of Molecular Medicine 46, no. 2 (2020): 489-508. https://doi.org/10.3892/ijmm.2020.4636