Open Access

miR‑144‑3p inhibits tumor cell growth and invasion in oral squamous cell carcinoma through the downregulation of the oncogenic gene, EZH2

  • Authors:
    • Longlong He
    • Lifan Liao
    • Liangzhi Du
  • View Affiliations

  • Published online on: June 11, 2020     https://doi.org/10.3892/ijmm.2020.4638
  • Pages: 828-838
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Accumulating evidence demonstrates that microRNAs (miRNAs or miRs) play important roles in the development and progression of human malignancies, including oral squamous cell carcinoma (OSCC); however, the unique roles of miRNAs are not yet fully understood in OSCC. The present study aimed to identify novel miRNAs associated with OSCC and to elucidate their functions. Based on a microarray analysis, miR‑144‑3p was found to be one of the most significantly downregulated miRNAs in OSCC tissues. Its low expression was closely associated with tumor size, differentiation and lymph node metastasis. Functionally, miR‑144‑3p overexpression suppressed proliferation, promoted apoptosis, and suppressed the invasion and migration of OSCC cells. In addition, enhancer of zeste homolog 2 (EZH2), a well‑known oncogene, was proven to be a direct target of miR‑144‑3p, and its protein expression was negatively regulated by miR‑144‑3p. Moreover, EZH2 expression was increased, and inversely correlated with the miR‑144‑3p level in OSCC tissues. Notably, EZH2 knockdown inhibited cell proliferation, promoted cell apoptosis, and suppressed the invasion and migration of OSCC cells, whereas EZH2 overexpression partially reversed the anticancer effects mediated by miR‑144‑3p overexpression. On the whole, the findings of the present study suggest that miR‑144‑3p functions as a tumor suppressor by targeting the EZH2 oncogene, and may thus be considered as a potential diagnostic and therapeutic target for OSCC.
View Figures
View References

Related Articles

Journal Cover

August-2020
Volume 46 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos
He L, Liao L and Du L: miR‑144‑3p inhibits tumor cell growth and invasion in oral squamous cell carcinoma through the downregulation of the oncogenic gene, EZH2. Int J Mol Med 46: 828-838, 2020
APA
He, L., Liao, L., & Du, L. (2020). miR‑144‑3p inhibits tumor cell growth and invasion in oral squamous cell carcinoma through the downregulation of the oncogenic gene, EZH2. International Journal of Molecular Medicine, 46, 828-838. https://doi.org/10.3892/ijmm.2020.4638
MLA
He, L., Liao, L., Du, L."miR‑144‑3p inhibits tumor cell growth and invasion in oral squamous cell carcinoma through the downregulation of the oncogenic gene, EZH2". International Journal of Molecular Medicine 46.2 (2020): 828-838.
Chicago
He, L., Liao, L., Du, L."miR‑144‑3p inhibits tumor cell growth and invasion in oral squamous cell carcinoma through the downregulation of the oncogenic gene, EZH2". International Journal of Molecular Medicine 46, no. 2 (2020): 828-838. https://doi.org/10.3892/ijmm.2020.4638