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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
August-2020 Volume 46 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Editorial Open Access

[Editorial] COVID‑19: Post‑lockdown guidelines

Ronald N. Kostoff, Michael B. Briggs, Alan L. Porter, Michael Aschner, Demetrios A. Spandidos, Aristidis Tsatsakis
Pages: 463-466
Published online on: 12 June 2020

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Review Open Access

Comprehensive analysis of drugs to treat SARS‑CoV‑2 infection: Mechanistic insights into current COVID‑19 therapies (Review)

George Mihai Nitulescu, Horia Paunescu, Sterghios A. Moschos, Dimitrios Petrakis, Georgiana Nitulescu, George Nicolae Daniel Ion, Demetrios A. Spandidos, Taxiarchis Konstantinos Nikolouzakis, Nikolaos Drakoulis, Aristidis Tsatsakis
Pages: 467-488
Published online on: 18 May 2020

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Review Open Access

A dissection of SARS‑CoV2 with clinical implications (Review)

Felician Stancioiu, Georgios Z. Papadakis, Stelios Kteniadakis, Boris Nikovaevich Izotov, Michael D. Coleman, Demetrios A. Spandidos, Aristidis Tsatsakis
Pages: 489-508
Published online on: 10 June 2020

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Review Open Access

Update on current views and advances on RSV infection (Review)

Ioannis N. Mammas, Simon B. Drysdale, Barbara Rath, Maria Theodoridou, Georgia Papaioannou, Alexia Papatheodoropoulou, Eirini Koutsounaki, Chryssie Koutsaftiki, Eleftheria Kozanidou, Vassilis Achtsidis, Paraskevi Korovessi, George P. Chrousos, Demetrios A. Spandidos
Pages: 509-520
Published online on: 15 June 2020

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Review Open Access

Advance genome editing technologies in the treatment of human diseases: CRISPR therapy (Review)

Meryem Alagoz, Nasim Kherad
Pages: 521-534
Published online on: 19 May 2020

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Review Open Access

Long non‑coding RNAs are novel players in oral inflammatory disorders, potentially premalignant oral epithelial lesions and oral squamous cell carcinoma (Review)

Kaiying Zhang, Wei Qiu, Buling Wu, Fuchun Fang
Pages: 535-545
Published online on: 03 June 2020

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Article Open Access

Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation

Ana Sofía Herrera-Van Oostdam, Juan Carlos Toro‑Ortíz, Jesús Adrián López, Daniel E. Noyola, David Alejandro García‑López, Noé Valentín Durán‑Figueroa, Eduardo Martínez‑Martínez, Diana P. Portales‑Pérez, Mariana Salgado‑Bustamante, Yamilé López‑Hernández
Pages: 546-560
Published online on: 03 June 2020

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Article Open Access

MicroRNA‑93 contributes to the suppression of lung inflammatory responses in LPS‑induced acute lung injury in mice via the TLR4/MyD88/NF‑κB signaling pathway

Hu Gao, Dongqiong Xiao, Linbo Gao, Xihong Li
Pages: 561-570
Published online on: 19 May 2020

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Article Open Access

LINC00473 contributes to the radioresistance of esophageal squamous cell carcinoma by regulating microRNA‑497‑5p and cell division cycle 25A

Wei‑Hua Liu, Han‑Yong Qiao, Jian Xu, Wei‑Qing Wang, Yi‑Lei Wu, Xia Wu
Pages: 571-582
Published online on: 25 May 2020

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Article Open Access

Decitabine attenuates dextran sodium sulfate‑induced ulcerative colitis through regulation of immune regulatory cells and intestinal barrier

Chang Su, Shaoqun Liu, Xiaoying Ma, Xiaotong Yang, Jianwen Liu, Peiyong Zheng, Yiou Cao
Pages: 583-594
Published online on: 18 May 2020

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Article Open Access

Fibroblast‑derived exosomal microRNA‑369 potentiates migration and invasion of lung squamous cell carcinoma cells via NF1‑mediated MAPK signaling pathway

Liping Guo, Baoli Li, Jianjun Yang, Juan Shen, Jinshan Ji, Meijing Miao
Pages: 595-608
Published online on: 22 May 2020

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Article Open Access

Exosomal microRNA‑146a derived from mesenchymal stem cells increases the sensitivity of ovarian cancer cells to docetaxel and taxane via a LAMC2‑mediated PI3K/Akt axis

Liya Qiu, Jiakun Wang, Mei Chen, Fengyun Chen, Wenluo Tu
Pages: 609-620
Published online on: 05 June 2020

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Article Open Access

Circular RNA derived from TIMP2 functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR‑185‑5p and matrix metalloproteinase 2

Wei Guo, Bin Zhang, Chao Sun, Hui‑Quan Duan, Wei‑Xiao Liu, Kun Mu, Ling Zhao, Hao‑Ran Li, Zhan‑Yin Dong, Qing Cui
Pages: 621-632
Published online on: 29 May 2020

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Article Open Access

Atorvastatin attenuates TGF‑β1‑induced fibrogenesis by inhibiting Smad3 and MAPK signaling in human ventricular fibroblasts

Yanfei Du, Haiying Xiao, Jun Wan, Xinyu Wang, Tao Li, Shuzhan Zheng, Jian Feng, Qiang Ye, Jiafu Li, Guang Li, Zhongcai Fan
Pages: 633-640
Published online on: 18 May 2020

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Article Open Access

IL‑27 suppresses airway inflammation, hyperresponsiveness and remodeling via the STAT1 and STAT3 pathways in mice with allergic asthma

Degan Lu, Jiameng Lu, Xiaoqing Ji, Yanbo Ji, Zewen Zhang, Haiying Peng, Fei Sun, Caiqing Zhang
Pages: 641-652
Published online on: 29 May 2020

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Article Open Access

Silencing of long non‑coding antisense RNA brain‑derived neurotrophic factor attenuates hypoxia/ischemia‑induced neonatal brain injury

Li‑Xing Qiao, Rui‑Bin Zhao, Ming‑Fu Wu, Li‑Hua Zhu, Zheng‑Kun Xia
Pages: 653-662
Published online on: 02 June 2020

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Article Open Access

TRAP1 attenuates H9C2 myocardial cell injury induced by extracellular acidification via the inhibition of MPTP opening

Lingxiao Zhang, Lerong Liu, Xia Li, Xing Zhang, Jiangpei Zhao, Yuanyuan Luo, Xiangyu Guo, Tongfeng Zhao
Pages: 663-674
Published online on: 04 June 2020

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Article Open Access

Paeonol exerts anti‑tumor activity against colorectal cancer cells by inducing G0/G1 phase arrest and cell apoptosis via inhibiting the Wnt/β‑catenin signaling pathway

Li‑Hua Liu, Ren‑Jie Shi, Zhi‑Cheng Chen
Pages: 675-684
Published online on: 04 June 2020

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Article Open Access

Knockdown of Tousled‑like kinase 1 inhibits survival of glioblastoma multiforme cells

Kamariah Ibrahim, Nor Azian Abdul Murad, Roslan Harun, Rahman Jamal
Pages: 685-699
Published online on: 28 May 2020

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Article Open Access

Rotenone restrains colon cancer cell viability, motility and epithelial‑mesenchymal transition and tumorigenesis in nude mice via the PI3K/AKT pathway Retraction in /10.3892/ijmm.2023.5340

Wenbo Xiao, Yongwei Liu, Maolin Dai, Yu Li, Renqun Peng, Shuangjiang Yu, Hao Liu
Pages: 700-708
Published online on: 10 June 2020

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Article Open Access

miR‑29b promotes the osteogenic differentiation of mesenchymal stem cells derived from human adipose tissue via the PTEN/AKT/β‑catenin signaling pathway

Tian Xia, Shuanghai Dong, Jiwei Tian
Pages: 709-717
Published online on: 22 May 2020

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Article Open Access

Ribonuclease T2 from Aspergillus fumigatus promotes T helper type 2 responses through M2 polarization of macrophages

Jia‑Jie Chen, Yong‑Shen He, Xiao‑Jun Zhong, Ze‑Lang Cai, Yan‑Si Lyu, Zhen‑Fu Zhao, Kunmei Ji
Pages: 718-728
Published online on: 21 May 2020

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Article Open Access

lncRNA DGCR 5/miR‑27a‑3p/BNIP3 promotes cell apoptosis in pancreatic cancer by regulating the p38 MAPK pathway

Xianjie Li, Shanxue Zhou, Tianyi Fan, Xuefeng Feng
Pages: 729-739
Published online on: 04 June 2020

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Article Open Access

MicroRNA‑16 inhibits endometrial stromal cell migration and invasion through suppression of the inhibitor of nuclear factor‑κB kinase subunit β/nuclear factor‑κB pathway

Xiaoping Wang, Rui Ren, Meili Shao, Jun Lan
Pages: 740-750
Published online on: 29 May 2020

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Article Open Access

Simvastatin inhibits the adipogenesis of bone marrow‑derived mesenchymal stem cells through the downregulation of chemerin/CMKLR1 signaling

Yao Guo, Jianzhong Huo, Dou Wu, Haihu Hao, Xinghua Ji, Enzhe Zhao, Boyuan Nie, Qiang Liu
Pages: 751-761
Published online on: 18 May 2020

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Article Open Access

Hypercapnia exacerbates the disruption of the blood‑brain barrier by inducing interleukin‑1β overproduction in the blood of hypoxemic adult rats

Hongguang Ding, Xinqiang Liu, Xusheng Li, Miaoyun Wen, Ya Li, Yongli Han, Linqiang Huang, Mengting Liu, Hongke Zeng
Pages: 762-772
Published online on: 14 May 2020

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Article Open Access

Hyperoxia reduces STX17 expression and inhibits the autophagic flux in alveolar type II epithelial cells in newborn rats

Dan Zhang, Xinyi Zhao, Dingning Zhang, Siyang Gao, Xindong Xue, Jianhua Fu
Pages: 773-781
Published online on: 27 May 2020

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Article Open Access

Upregulation of Nav1.7 by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain

Jun-Jie Tian, Chao-Yang Tan, Qin-Yi Chen, Ying Zhou, Zu-Wei Qu, Meng Zhang, Ke-Tao Ma, Wen-Yan Shi, Li Li, Jun-Qiang Si
Pages: 782-794
Published online on: 20 May 2020

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Article Open Access

Inhibition of autophagy flux by sertraline attenuates TRAIL resistance in lung cancer via death receptor 5 upregulation

Kazi Mohammad Ali Zinnah, Jae‑Won Seol, Sang‑Youel Park
Pages: 795-805
Published online on: 05 June 2020

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Article Open Access

Ursolic acid protects against cisplatin‑induced ototoxicity by inhibiting oxidative stress and TRPV1‑mediated Ca2+‑signaling Corrigendum in /10.3892/ijmm.2026.5789

Yang Di, Tao Xu, Yuan Tian, Tingting Ma, Donghao Qu, Yan Wang, Yuhan Lin, Dongyan Bao, Li Yu, Shuangyue Liu, Aimei Wang
Pages: 806-816
Published online on: 04 June 2020

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Article Open Access

Inhibitory effects of brusatol delivered using glycosaminoglycan‑placental chondroitin sulfate A‑modified nanoparticles on the proliferation, migration and invasion of cancer cells

Xin Chen, Tailang Yin, Baozhen Zhang, Beini Sun, Jie Chen, Tianxia Xiao, Baobei Wang, Mengxia Li, Jing Yang, Xiujun Fan
Pages: 817-827
Published online on: 03 June 2020

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Article Open Access

miR‑144‑3p inhibits tumor cell growth and invasion in oral squamous cell carcinoma through the downregulation of the oncogenic gene, EZH2

Longlong He, Lifan Liao, Liangzhi Du
Pages: 828-838
Published online on: 11 June 2020

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Article

CTBP1‑AS2 inhibits proliferation and induces autophagy in ox‑LDL‑stimulated vascular smooth muscle cells by regulating miR‑195‑5p/ATG14

Yang Wang, Cheng‑Xin Zhang, Sheng‑Lin Ge, Wen‑Hui Gong
Pages: 839-848
Published online on: 02 June 2020

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Article

Preliminary research on the effects and mechanisms of umbilical cord‑derived mesenchymal stem cells in streptozotocin‑induced diabetic retinopathy Corrigendum in /10.3892/ijmm.2020.4708

Ken Zhao, Jie Liu, Gang Dong, Huan Xia, Pingan Wang, Xuan Xiao, Zhen Chen
Pages: 849-858
Published online on: 01 June 2020

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Article

Long non‑coding RNA RP11‑340F14.6 promotes a shift in the Th17/Treg ratio by binding with P2X7R in juvenile idiopathic arthritis

Na Huang, Zhidan Fan, Le Ma, Huihui Ma, Hui Huang, Haiguo Yu, Xiaoyu Zhou
Pages: 859-868
Published online on: 27 May 2020

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Article

Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice

Shiguang Peng, Mei Cao, Xiaoying Sun, Yaqiong Zhou, Chu‑Yen Chen, Tian Ma, Hongjin Li, Bin Li, Bo Zhu, Xin Li
Pages: 869-879
Published online on: 21 May 2020

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Article

IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model

Jia‑Long Chen, Xue‑Li Niu, Ya‑Li Gao, Lei Ma, Xing‑Hua Gao, Hong‑Duo Chen, Rui‑Qun Qi
Pages: 880-888
Published online on: 04 June 2020

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Article

Sevoflurane preconditioning inhibits cardiomyocyte injury induced by oxygen‑glucose deprivation by modulating TXNIP

Meina Ma, Rui Li, Wenbo Sun, Qi Wang, Hong Yu, Hongmei Yu
Pages: 889-897
Published online on: 11 June 2020

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Journal Cover
July-2026 Volume 58 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Sex differences in cardiovascular‑kidney‑metabolic syndrome: From pathogenesis to treatment response (Review)

Yanqin Fan, Hongtu Hu, Jing Cheng
Article Number: 202
Published online on: 27 May 2026

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Retraction Open Access

[Retracted] BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury

Yin Yang, Chunyang Guo, Bo Liao, Junjun Cao, Chen Liang, Xijing He
Article Number: 201
Published online on: 25 May 2026

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Article Open Access

Integrative transcriptomic analysis unveils FXR as a key regulator of intestinal stemness and inflammation in ulcerative colitis

Hao Lin, Xinran Cheng, Yangyang Ren, Yongmei Zhang, Weixu Chen, Qingyan Lu, Yiqing Tian
Article Number: 200
Published online on: 22 May 2026

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Article Open Access

Ginsenoside Rg3 potentiates cisplatin antitumor activity while mitigating nephrotoxicity through SIRT1‑mediated suppression of the NLRP3 inflammasome

Jinghui Zhai, Yueming Zhang, Jiawei Gong, Li Fu, Sixi Zhang
Article Number: 199
Published online on: 22 May 2026

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Article Open Access

Identification of diagnostic markers for diabetic kidney disease by weighted gene co‑expression network analysis and machine learning

Qiming Xu, Chunjing Xu, Ziyang Liu, Jianrao Lu, Jing Hu, Lin Liao
Article Number: 198
Published online on: 21 May 2026

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Article Open Access

CTRP3 alleviates neuropathic pain by improving mitochondrial biogenesis and mitochondrial unfolded protein response via spinal SIRT1 in rats

Tianzhu Liu, Longqing Zhang, Wei Mei
Article Number: 197
Published online on: 21 May 2026

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Correction Open Access

[Corrigendum] Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis

Zhaorui Sun, Cong Wang, Chaowen Shi, Fangfang Sun, Xiaomeng Xu, Weiping Qian, Shinan Nie, Xiaodong Han
Article Number: 196
Published online on: 20 May 2026

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Article Open Access

Ganoderma lucidum polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice

Xin Jin, Xuan Liu, Yun-Juan Wang, Zi-Li Lei, Yan-Hong Yang
Article Number: 195
Published online on: 20 May 2026

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Article Open Access

Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment

Shi-Na Song, Jun-Ying Wu, Mao-Mei Song, Xiao-Feng Li, Jian-Ming Wang, Wen-Hui Jia, Chang-Xin Li, Sui-Yi Xu
Article Number: 194
Published online on: 19 May 2026

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Review Open Access

Bone‑origin repair in diabetic foot ulcers: Mechanisms of callus formation and endocrine effects in healing (Review)

Sen Chen, Xiaofei Cui
Article Number: 193
Published online on: 19 May 2026

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Review Open Access

Unraveling the molecular landscape of chronic radiation injury: From oxidative stress signaling to translational modeling (Review)

Zhenjun Xi, Xiaodong Li, Chunhui Yang, Li Wang, Jingxin Mao, Qianqian Liu, Chang Liu, Qian Li, Yuanfang Hou, Jie Wan, Chengzhuo Yang, Feiji Sun, Chao Yu, Miao Wang, Baocheng Yuan, Yongsheng Liu, Qing Hu, Li Zhang, Xuemei Li, Xiaobing Li
Article Number: 192
Published online on: 19 May 2026

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Retraction Open Access

[Retracted] Cocktail therapy with a combination of interferon, ribavirin and angiotensin‑II type 1 receptor blocker attenuates murine liver fibrosis development

Hitoshi Yoshiji, Ryuichi Noguchi, Yasuhide Ikenaka, Kosuke Kaji, Yosuke Aihara, Yusaku Shirai, Junichi Yoshii, Koji Yanase, Hiroshi Fukui
Article Number: 191
Published online on: 18 May 2026

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Review Open Access

Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review)

Chenglin Lu, Xiangyu Qi, Yuting Tong, Peng Lu, Dandan Luo, Qingbo Guan, Chunxiao Yu
Article Number: 190
Published online on: 14 May 2026

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Review Open Access

Primary cilia dysfunction: A critical driver of metabolic diseases (Review)

Xiaojing Wang, Yi Jin, Kejia Xie, Pengfei Yao, Liguo Song, Hongdan Liu, Yanjie Tan
Article Number: 189
Published online on: 14 May 2026

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Review Open Access

Gut‑brain axis in anesthesia and critical illness: Molecular crosstalk and its impact on delirium and outcome (Review)

Xigang Ma, Yongsen Zhao
Article Number: 188
Published online on: 14 May 2026

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Article Open Access

Betulinic acid alleviates the inflammatory injury of osteoblasts in osteoporosis by augmenting autophagy via the AMPK-mTOR signaling pathway

Yiwei Zhao, Zechao Qu, Lin Liu, Yong Zhang, Xiaohao Wang, Bo Zhang, Yining Gong, Liang Yan
Article Number: 187
Published online on: 13 May 2026

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Correction Open Access

[Corrigendum] Induction of cardiomyocyte‑like cells from hair follicle cells in mice

Yong-Hee Kim, Bang-Jin Kim, Seok-Man Kim, Sun-Uk Kim, Buom-Yong Ryu
Article Number: 186
Published online on: 13 May 2026

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Review Open Access

Spatial hepatology: Decoding liver zonation for metabolic and regenerative therapeutics (Review)

Guiqing Chen, Hongyan Jia, Kai Zhao, Chang Gao, Yue Liu, Hong Zhu, Dakai Yang, Yun Cai
Article Number: 185
Published online on: 13 May 2026

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Article Open Access

Hepatic p38γ exacerbates acetaminophen‑induced acute liver injury via PI3K/Akt‑dependent mechanisms

Hui Fang, Min Shu, Jiaju Wang, Heng Tian, Jianguo Zhang, Ying Hu, He Li, Huan Zhou, Kangsheng Gu, Zhenhua Ren
Article Number: 184
Published online on: 12 May 2026

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Pharmacological activity, molecular mechanisms and therapeutic potential of erianin (Review)

Chengyi Ming, Ni Zhu, You Yu, Hong Zhou, Meichun Hu
Article Number: 183
Published online on: 12 May 2026

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Review Open Access

Rab27: Molecular switch of tumor exosome secretion (Review)

Mengtian Tang, Zhongjian Zhu, Huaxin Duan, Shiming Tan, Mengzhou Shen, Xianjie Jiang, Qiu Peng, Linda Oyang, Zongyao Ren, Yujuan Zhou, Qianjin Liao
Article Number: 182
Published online on: 12 May 2026

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IL‑17A+ γδT cell activation via the HMGB1‑TLR2/4‑NF‑κB signaling pathways in biliary atresia

Meng-Xin Zhang, Jing-Feng Tang, Mei Hong, Ying Yang, Yun Zhou, Shui-Qing Chi, Li-Ying Rong, Guo-Qing Cao, Xi Zhang, Jin-Xiang Zhang, Shao-Tao Tang
Article Number: 181
Published online on: 11 May 2026

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CircRAD18 promotes glioblastoma proliferation, migration and invasion via the miR‑1231/LUC7L2 axis

Lumeng Song, Ping Xiong, Amu Jike, Xiaochao Xia, Lifang Mao, Zihao Wang, Yinchuan Cheng, Shumin Wang, Shizheng Tan, Dongnan Yu, Zheng Li, Xiaoping Tang, Shun Li
Article Number: 180
Published online on: 11 May 2026

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Correction Open Access

[Corrigendum] Expression of FKBP52 in the ovaries of PCOS rats

Shiyan Song, Yong Tan
Article Number: 179
Published online on: 11 May 2026

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Article Open Access

miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis

Xiaoyu Wang, Lin Song, Jiafeng Wang, Qianqian Xie, Yan Wang, Chunyan Li, Tianqi Wang, Yifeng Du
Article Number: 178
Published online on: 08 May 2026

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Radiotherapy and cytokines: A systems view of immunotherapy and toxicity (Review)

Siyuan Zhou, Yurong Jiang, Jixu Fan, Minjie Guo, Yi Wen, Chunhua Dai
Article Number: 177
Published online on: 08 May 2026

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Advances in understanding the NLRP3 inflammasome‑mediated mechanisms and therapeutic targets in diabetic nephropathy (Review)

Xiwei Wang, Shuang Li, Xiaotian Ge, Tao Xie, Sainan Li, Ruiqi Yuan, Tianxi Li, Hui Yuan
Article Number: 176
Published online on: 06 May 2026

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Expression of Concern Open Access

[Expression of Concern] ISL1 promotes cancer progression and inhibits cisplatin sensitivity in triple‑negative breast cancer cells

Yang Zhang, Lu Wang, Peng Gao, Zhiguo Sun, Ning Li, Yanqin Lu, Jianglun Shen, Jian Sun, Yiming Yang, Hao Dai, Haifeng Cai
Article Number: 175
Published online on: 06 May 2026

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Phosphorylation beyond the plasma membrane: How secretory pathway kinases sculpt the cellular dialogue in cancer (Review)

Ziang Geng, Shu Guan, Shaoqi Du, Shuo Zhang, Jiaxin Hao, Siyuan Tian, Chen Zhu, Shaonan Du
Article Number: 174
Published online on: 06 May 2026

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Ferroptosis in musculoskeletal disorders: Emerging mechanisms and therapeutic opportunities (Review)

Wenhui Gu, Haifeng Zhang, Lisha Ye, Fangming Liu, Ting Xu, Yinxian Yu, Guohua Wang
Article Number: 173
Published online on: 05 May 2026

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Retraction Open Access

[Retracted] Regulation of p38 MAPK phosphorylation inhibits chondrocyte apoptosis in response to heat stress or mechanical stress

Ken Takebe, Takayuki Nishiyama, Shinya Hayashi, Shingo Hashimoto, Takaaki Fujishiro, Noriyuki Kanzaki, Kohei Kawakita, Kenjiro Iwasa, Ryosuke Kuroda, Masahiro Kurosaka
Article Number: 172
Published online on: 04 May 2026

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Dapagliflozin attenuates ferroptosis in diabetic nephropathy through activation of the Nrf2/HO‑1 signaling pathway

Hanshuang Liu, Xiaoxiao Zhang, Yubing Cui, Shengxi Xiong, Linjuan Huang, Min Li, Chen Shao, Xiaolei Hu
Article Number: 171
Published online on: 30 April 2026

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Ligustroflavone protects against acute kidney injury by inhibiting ferroptosis via acting on GSK3β/NRF2 signaling

Jiayu Song, Long Wang, Yaru Wang, Jie Meng, Jingyi Sheng, Yongfeng Zhao, San Yan Xu, Juan Lei, Fangfang Cai, Yunwen Yang
Article Number: 170
Published online on: 30 April 2026

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Correction Open Access

[Corrigendum] Differential regulation of the biosynthesis of glucose transporters by the PI3‑K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla

Yoen Kyung Lee, Ji Eun Kim, So Hee Nam, Jun Seo Goo, Sun Il Cho, Young Hwan Choi, Chang Jun Bae, Ong Min Woo, Jung Sik Cho, Dae Youn Hwang
Article Number: 169
Published online on: 28 April 2026

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August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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