Platelet‑to‑lymphocyte ratio, neutrophil‑to‑lymphocyte ratio and monocyte‑to‑HDL cholesterol ratio as markers of peripheral artery disease in elderly patients

  • Authors:
    • Stefano Selvaggio
    • Angela Abate
    • Giuseppe Brugaletta
    • Cinzia Musso
    • Mario Di Guardo
    • Caterina Di Guardo
    • Enzo Saretto Dante Vicari
    • Marcello Romano
    • Salvatore Luca
    • Salvatore Santo Signorelli
  • View Affiliations

  • Published online on: June 16, 2020     https://doi.org/10.3892/ijmm.2020.4644
  • Pages: 1210-1216
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Abstract

Solid evidence underlines the pivotal role played by inflammation regarding atherosclerosis. Peripheral artery disease (PAD) is one of atherosclerotic cardiovascular diseases (CVDs), it is highly frequently diagnosed in older individuals. In the present study we carried out an investigation on the association between platelet‑to‑lymphocytes ratio (PLR), neutrophil‑to‑lymphocyte ratio (NLR), monocyte‑to‑HDL cholesterol ratio (MHR) with PAD as favourable markers. We identified 300 subjects aged over 70 years, without any concomitant CVDs. The PLR, NLR and MHR were assessed from peripheral venous blood routinely drawn in the ward during hospitalization. Patients were divided in groups according to ankle brachial index (ABI) value (>0.9; 0.9‑0.99; 1‑1.4; >1.4). Higher PLR (P=0.007), NLR (P=0.0001) and MHR (P=0.0001) were associated with <0.9 ABI. Patients with a >1.4 ABI showed NLR values higher compared to >0.9l ABI (P<0.01). Univariate linear regression analysis demonstrated the direct correlation between increase in PLR (P=0.0023)and MHR (P<0.0001) with the decrease in ABI value. In multivariate linear regression analysis including main cardiovascular risk factors we found that PLR, NLR and MHR were independently associated with lower ABI (P=0.0011). Results show and suggest that the elevated PLR, NLR and MHR are related to PAD evaluated with ABI measurement. PLR and MHR seem to be more reliable markers than NLR in PAD. NLR seems to be more related to incompressibility of arterial wall. It is hypothesized that these three indexes may play a role as simple and repetitive markers of PAD.

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September-2020
Volume 46 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Selvaggio S, Abate A, Brugaletta G, Musso C, Di Guardo M, Di Guardo C, Vicari ES, Romano M, Luca S, Signorelli SS, Signorelli SS, et al: Platelet‑to‑lymphocyte ratio, neutrophil‑to‑lymphocyte ratio and monocyte‑to‑HDL cholesterol ratio as markers of peripheral artery disease in elderly patients. Int J Mol Med 46: 1210-1216, 2020
APA
Selvaggio, S., Abate, A., Brugaletta, G., Musso, C., Di Guardo, M., Di Guardo, C. ... Signorelli, S.S. (2020). Platelet‑to‑lymphocyte ratio, neutrophil‑to‑lymphocyte ratio and monocyte‑to‑HDL cholesterol ratio as markers of peripheral artery disease in elderly patients. International Journal of Molecular Medicine, 46, 1210-1216. https://doi.org/10.3892/ijmm.2020.4644
MLA
Selvaggio, S., Abate, A., Brugaletta, G., Musso, C., Di Guardo, M., Di Guardo, C., Vicari, E. S., Romano, M., Luca, S., Signorelli, S. S."Platelet‑to‑lymphocyte ratio, neutrophil‑to‑lymphocyte ratio and monocyte‑to‑HDL cholesterol ratio as markers of peripheral artery disease in elderly patients". International Journal of Molecular Medicine 46.3 (2020): 1210-1216.
Chicago
Selvaggio, S., Abate, A., Brugaletta, G., Musso, C., Di Guardo, M., Di Guardo, C., Vicari, E. S., Romano, M., Luca, S., Signorelli, S. S."Platelet‑to‑lymphocyte ratio, neutrophil‑to‑lymphocyte ratio and monocyte‑to‑HDL cholesterol ratio as markers of peripheral artery disease in elderly patients". International Journal of Molecular Medicine 46, no. 3 (2020): 1210-1216. https://doi.org/10.3892/ijmm.2020.4644