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Article Open Access

MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Retraction in: /10.3892/ijmm.2025.5695
  • Authors:
    • Ke Li
    • Conghu Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China, Department of Anesthesiology, The Third People's Hospital of Yancheng, Yancheng, Jiangsu 224000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1013-1028
    |
    Published online on: June 18, 2020
       https://doi.org/10.3892/ijmm.2020.4649
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Abstract

Numerous studies have identified that microRNAs (miRs) play a crucial role in the tumorigenesis of non‑small cell lung cancer (NSCLC). However, to the best of our knowledge, the physiological function of miR‑103 in NSCLC is not fully understood. Experiments in the present study revealed that miR‑103 expression was increased in NSCLC cell lines. In addition, a series of methods, including MTT, colony formation, 5‑ethynyl‑2'‑deoxyuridine, Transwell, wound healing, flow cytometric, reverse transcription‑quantitative PCR and western blot assays, were performed, which revealed that overexpression of miR‑103 enhanced cell growth, migration, invasion and epithelial‑mesenchymal transition (EMT), and suppressed apoptosis of A549 and H1299 cells. Additionally, a dual‑luciferase reporter assay indicated that miR‑103 directly targets the 3'‑untranslated region of Kruppel‑like factor 7 (KLF7), and KLF7 expression was negatively regulated by miR‑103 expression. Furthermore, the present findings demonstrated that miR‑103 promoted EMT via regulating the Wnt/β‑catenin signaling pathway in NSCLC. Collectively, the current results demonstrated that miR‑103 serves a tumorigenesis role in NSCLC development by targeting KLF7, at least partly via the Wnt/β‑catenin signaling pathway. Consequently, these findings indicated that miR‑103/KLF7/Wnt/β‑catenin may provide a novel insight into underlying biomarkers for improving the diagnosis and treatment of NSCLC.
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Duma NR, Santana-Davila and Molina JR: Non-small cell lung cancer: Epidemiology, screening, diagnosis, and treatment. Mayo Clin Proc. 94:1623–1640. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Ettinger DS, Wood DE, Akerley W, Bazhenova LA, Borghaei H, Camidge DR, Cheney RT, Chirieac LR, D'Amico TA, Demmy TL, et al: Non-small cell lung cancer, version 1.2015. J Natl Compr Canc Netw. 12:1738–1761. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Gompelmann D, Eberhardt R and Herth FJ: Advanced malignant lung disease: What the specialist can offer. Respiration. 82:111–123. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Goldstraw P, Chansky K, Crowley J, Porta RR, Asamura H, Eberhardt WE, Nicholson AG, Groome P, Mitchell A, Bolejack V, et al: The IASLC lung cancer staging project: Proposals for revision of the tnm stage groupings in the forthcoming (Eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 11:39–51. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Choi WI, Lee DY, Choi HG and Lee CW: Lung cancer development and mortality in interstitial lung disease with and without connective tissue diseases: A five-year nationwide population-based study. Respir Res. 20:1172019. View Article : Google Scholar : PubMed/NCBI

7 

Sève P, Reiman T and Dumontet C: The role of betaIII tubulin in predicting chemoresistance in non-small cell lung cancer. Lung Cancer. 67:136–143. 2010. View Article : Google Scholar

8 

Wei S, Zheng Y, Jiang Y, Li X, Geng J, Shen Y, Li Q, Wang X, Zhao C, Chen Y, et al: The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p. EBioMedicine. 44:182–193. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Raoof S, Mulford IJ, Cabanos HF, Nangia V, Timonina D, Labrot E, Hafeez N, Bilton SJ, Drier Y, Ji D, et al: Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer. Oncogene. 38:6399–6413. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Yang F, Yan Y, Yang Y, Hong X, Wang M, Yang Z, Liu B and Ye L: MiR-210 in exosomes derived from CAFs promotes non-small cell lung cancer migration and invasion through PTEN/PI3K/AKT pathway. Cell Signal. 73:109675Sep;2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

11 

Del Vescovo V, Grasso M, Barbareschi M and Denti MA: MicroRNAs as lung cancer biomarkers. World J Clin Oncol. 5:604–620. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Deng S, Calin GA, Croce CM, Coukos G and Zhang L: Mechanisms of microRNA deregulation in human cancer. Cell Cycle. 7:2643–2646. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Tüfekci KU, Meuwissen RL and Genç S: The role of microRNAs in biological processes. Methods Mol Biol. 1107:15–31. 2014. View Article : Google Scholar

14 

Qian B, Nag SA, Su Y, Voruganti S, Qin JJ, Zhang R and Cho WC: miRNAs in cancer prevention and treatment and as molecular targets for natural product anticancer agents. Curr Cancer Drug Targets. 13:519–541. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Fang C, Chen YX, Wu NY, Yin JY, Li XP, Huang HS, Zhang W, Zhou HH and Liu ZQ: MiR-488 inhibits proliferation and cisplatin sensibility in non-small-cell lung cancer (NSCLC) cells by activating the eIF3a-mediated NER signaling pathway. Sci Rep. 7:403842017. View Article : Google Scholar : PubMed/NCBI

16 

Li T, Ding ZL, Zheng YL and Wang W: MiR-484 promotes non-small-cell lung cancer (NSCLC) progression through inhibiting Apaf-1 associated with the suppression of apoptosis. Biomed Pharmacother. 96:153–164. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Fortunato O, Borzi C, Milione M, Centonze G, Conte D, Boeri M, Verri C, Moro M, Facchinetti F, Andriani F, et al: Circulating mir-320a promotes immunosuppressive macrophages M2 phenotype associated with lung cancer risk. Int J Cancer. 144:2746–2761. 2019. View Article : Google Scholar :

18 

Ni K, Wang D, Xu H, Mei F, Wu C, Liu Z and Zhou B: miR-21 promotes non-small cell lung cancer cells growth by regulating fatty acid metabolism. Cancer Cell Int. 19:2192019. View Article : Google Scholar : PubMed/NCBI

19 

Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, Enzo E, Guzzardo V, Rondina M, Spruce T, et al: A MicroRNA targeting dicer for metastasis control. Cell. 141:1195–1207. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Cai X, Liu Q, Zhang X, Ren Y, Lei X, Li S, Chen Q, Deng K, Wang P, Zhang H and Shi D: Identification and analysis of the expression of microRNA from lactating and nonlactating mammary glands of the Chinese swamp buffalo. J Dairy Sci. 100:1971–1986. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Zheng J, Liu Y, Qiao Y, Zhang L and Lu S: miR-103 promotes proliferation and metastasis by targeting KLF4 in gastric cancer. Int J Mol Sci. 18:9102017. View Article : Google Scholar :

22 

Chen HY, Lin YM, Chung HC, Lang YD, Lin CJ, Huang J, Wang WC, Lin FM, Chen Z, Huang HD, et al: miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4. Cancer Res. 72:3631–3641. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Xue D, Zhou C, Lu H, Xu R, Xu X and He X: LncRNA GAS5 inhibits proliferation and progression of prostate cancer by targeting miR-103 through AKT/mTOR signaling pathway. Tumour Biol. 14:10072016.

24 

Xia W, Ni J, Zhuang J, Qian L, Wang P and Wang J: MiR-103 regulates hepatocellular carcinoma growth by targeting AKAP12. Int J Biochem Cell Biol. 71:1–11. 2016. View Article : Google Scholar

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

26 

Poincloux R, Lizárraga F and Chavrier P: Matrix invasion by tumour cells: A focus on MT1-MMP trafficking to invadopodia. J Cell Sci. 122:3015–3024. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Yin Q, Fischer L, Noethling C and Schaefer WR: In vitro- assessment of putative antiprogestin activities of phytochemicals and synthetic UV absorbers in human endometrial ishikawa cells. Gynecol Endocrinol. 31:578–581. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Chen W, Zheng R, Zeng H, Zhang S and He J: Annual report on status of cancer in China, 2011. Chin J Cancer Res. 27:2–12. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Cortinovis D, Monica V, Pietrantonio F, Ceresoli GL, Spina CM and Wannesson L: MicroRNAs in non-small cell lung cancer: Current status and future therapeutic promises. Curr Pharm Des. 20:3982–3990. 2014. View Article : Google Scholar

30 

Boeri M, Pastorino V and Sozzi G: Role of microRNAs in lung cancer: Microrna signatures in cancer prognosis. Cancer J. 18:268–274. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Vannini I, Fanini V and Fabbri M: MicroRNAs as lung cancer biomarkers and key players in lung carcinogenesis. Clin Biochem. 46:918–925. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Tsang FH, Au SL, Wei L, Fan DN, Lee JM, Wong CC, Ng IO and Wong CM: MicroRNA-142-3p and microRNA-142-5p are down-regulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility. Front Med. 9:331–343. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, Blalock WL, Franklin RA and McCubrey JA: Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy. Leukemia. 17:590–603. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Osaki M, Oshimura M and Ito H: PI3K-Akt pathway: Its functions and alterations in human cancer. Apoptosis. 9:667–676. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Nicholson KM and Anderson NG: The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 14:381–395. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Bader AG, Kang S, Zhao L and Vogt PK: Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer. 5:921–929. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Yu QF, Liu P, Li ZY, Zhang CF, Chen SQ, Li ZH, Zhang GY and Li JC: MiR-103/107 induces tumorigenicity in bladder cancer cell by suppressing PTEN. Eur Rev Med Pharmacol Sci. 22:8616–8623. 2018.PubMed/NCBI

38 

Zheng YB, Xiao K, Xiao GC, Tong SL, Ding Y, Wang QS, Li SB and Hao ZN: MicroRNA-103 promotes tumor growth and metastasis in colorectal cancer by directly targeting LATS2. Oncol Lett. 12:2194–2200. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Zhao BS, Liu G, Wang TY, Ji YH, Qi B, Tao P, Li HC and Wu XN: Screening of microRNA in patients with esophageal cancer at same tumor node metastasis stage with different prognoses. Asian Pac J Cancer Prev. 14:139–143. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Tian Y, Xue Y, Ruan G, Cheng K, Tian J, Qiu Q, Xiao M, Li H, Yang H and Wang L: Interaction of serum microRNAs and serum folate with the susceptibility to pancreatic cancer. Pancreas. 44:23–30. 2015. View Article : Google Scholar

41 

Zhuan B, Lu Y, Chen Q, Zhao X, Li P, Yuan Q and Yang Z: Overexpression of the long noncoding RNA TRHDE-AS1 inhibits the progression of lung cancer via the miRNA-103/KLF4 axis. J Cell Biochem. 120:17616–17624. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Yang D, Wang JJ, Li JS and Xu QY: miR-103 functions as a tumor suppressor by directly targeting programmed cell death 10 in NSCLC. Oncol Res. 26:519–528. 2018. View Article : Google Scholar

43 

Zhang Z, Wu S, Muhammad S, Ren Q and Sun C: miR-103/107 promote ER stress-mediated apoptosis via targeting the Wnt3a/ β-catenin/ATF6 pathway in preadipocytes. J Lipid Res. 59:843–853. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Wang X, Lin Y, Peng L, Sun R, Gong X, Du J and Zhang X: MicroRNA-103 promotes proliferation and inhibits apoptosis in spinal osteosarcoma cells by targeting p57. Oncol Res. 26:933–940. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Fu X, Zhang W, MSu Y, Lu L, Wang D and Wang H: MicroRNA-103 suppresses tumor cell proliferation by targeting PDCD10 in prostate cancer. Prostate. 76:543–551. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Niu R, Tang Y, Xi Y and Jiang D: High expression of Krüppel-like factor 7 indicates unfavorable clinical outcomes in patients with lung adenocarcinoma. J Surg Res. 250:216–223. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Ma Y, Wu L, Liu X, Xu Y, Shi W, Liang Y, Yao L, Zheng J and Zhang J: KLF4 inhibits colorectal cancer cell proliferation dependent on NDRG2 signaling. Oncol Rep. 38:975–984. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Zhao L, Zhang Y, Liu J, Yin W, Jin D, Wang D and Zhang W: miR-185 inhibits the proliferation and invasion of non-small cell lung cancer by targeting KLF7. Oncol Res. 27:1015–1023. 2019. View Article : Google Scholar

49 

An YX, Shang YJ, Xu ZW, Zhang QC, Wang Z, Xuan WX and Zhang XJ: STAT3-induced long noncoding RNA LINC00668 promotes migration and invasion of non-small cell lung cancer via the miR-193a/KLF7 axis. Biomed Pharmacother. 116:1090232019. View Article : Google Scholar : PubMed/NCBI

50 

Roberts JT and Borchert GM: Computational prediction of MicroRNA target genes, target prediction databases, and web resources. Methods Mol Biol. 1617:109–122. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Yang X, Li L, Huang Q, Xu W, Cai X, Zhang J, Yan W, Song D, Liu T, Zhou W, et al: Wnt signaling through snail1 and zeb1 regulates bone metastasis in lung cancer. Am J Cancer Res. 5:748–755. 2015.PubMed/NCBI

52 

Zhang L, Gallup M, Zlock L, Finkbeiner W and McNamara NA: P120-catenin modulates airway epithelial cell migration induced by cigarette smoke. Biochem Biophys Res Commun. 417:49–55. 2012. View Article : Google Scholar

53 

Liu S, Ye D, Guo W, Yu W, He Y, Hu J, Wang Y, Zhang L, Liao Y, Song H, et al: G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma. Oncotarget. 6:6887–6901. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Nilsen TW: Mechanisms of microRNA-mediated gene regulation in animal cells. Trends Genet. 23:243–249. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Cullen BR: Transcription and processing of human microRNA precursors. Mol Cell. 16:861–865. 2004. View Article : Google Scholar : PubMed/NCBI

56 

Lu TX and Rothenberg ME: MicroRNA. J Allergy Clin Immunol. 141:1202–1207. 2018. View Article : Google Scholar :

57 

Yousef M, Showe L and Showe M: A study of microRNAs in silico and in vivo: Bioinformatics approaches to microRNA discovery and target identification. Febs J. 276:2150–2156. 2009. View Article : Google Scholar : PubMed/NCBI

58 

Cui J, Li D, Zhang W, Shen L and Xu X: Bioinformatics analyses combined microarray identify the deregulated microRNAs in oral cancer. Oncol Lett. 8:218–222. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Swamynathan SK: Krüppel-like factors: Three fingers in control. Hum Genomics. 4:263–270. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Dong JT and Chen C: Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases. Cell Mol Life Sci. 66:2691–2706. 2009. View Article : Google Scholar : PubMed/NCBI

61 

Sue N, Jack BH, Eaton SA, Pearson RC, Funnell AP, Turner J, Czolij R, Denyer G, Bao S, Navajas JC, et al: Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis. Mol Cell Biol. 28:3967–3978. 2008. View Article : Google Scholar : PubMed/NCBI

62 

Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB and Jain MK: Regulation of gluconeogenesis by krüppel-like factor 15. Cell Metab. 5:305–312. 2007. View Article : Google Scholar : PubMed/NCBI

63 

Huo X, Li SW, Shi T, Suo A, Ruan Z, Guo H and Yao Y: Cullin3 promotes breast cancer cells metastasis and epithelial-mesenchymal transition by targeting BRMS1 for degradation. Oncotarget. 6:41959–41975. 2015. View Article : Google Scholar : PubMed/NCBI

64 

Dellinger TH, Planutis K, Tewari KS and Holcombe RF: Role of canonical wnt signaling in endometrial carcinogenesis. Expert Rev Anticancer Ther. 12:51–62. 2012. View Article : Google Scholar

65 

Anastas JN and Moon RT: WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer. 13:11–26. 2013. View Article : Google Scholar

66 

Choi YS, Shim YM, Kim SH, Son DS, Lee HS, Kim GY, Han J and Kim J: Prognostic significance of E-cadherin and beta-catenin in resected stage I non-small cell lung cancer. Eur J Cardiothorac Surg. 24:441–449. 2003. View Article : Google Scholar : PubMed/NCBI

67 

Leung CO, Mak WN, Kai AK, Chan KS, Lee TK, Ng IO and Lo RC: Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling. Oncotarget. 7:29371–29386. 2016. View Article : Google Scholar : PubMed/NCBI

68 

Mao Y, Xu J, Li Z, Zhang N, Yin H and Liu Z: The role of nuclear β-catenin accumulation in the twist2-induced ovarian cancer EMT. PLoS One. 8:e782002013. View Article : Google Scholar

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Li K and Yuan C: MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer Retraction in /10.3892/ijmm.2025.5695. Int J Mol Med 46: 1013-1028, 2020.
APA
Li, K., & Yuan, C. (2020). MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer Retraction in /10.3892/ijmm.2025.5695. International Journal of Molecular Medicine, 46, 1013-1028. https://doi.org/10.3892/ijmm.2020.4649
MLA
Li, K., Yuan, C."MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer Retraction in /10.3892/ijmm.2025.5695". International Journal of Molecular Medicine 46.3 (2020): 1013-1028.
Chicago
Li, K., Yuan, C."MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer Retraction in /10.3892/ijmm.2025.5695". International Journal of Molecular Medicine 46, no. 3 (2020): 1013-1028. https://doi.org/10.3892/ijmm.2020.4649
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Spandidos Publications style
Li K and Yuan C: MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer Retraction in /10.3892/ijmm.2025.5695. Int J Mol Med 46: 1013-1028, 2020.
APA
Li, K., & Yuan, C. (2020). MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer Retraction in /10.3892/ijmm.2025.5695. International Journal of Molecular Medicine, 46, 1013-1028. https://doi.org/10.3892/ijmm.2020.4649
MLA
Li, K., Yuan, C."MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer Retraction in /10.3892/ijmm.2025.5695". International Journal of Molecular Medicine 46.3 (2020): 1013-1028.
Chicago
Li, K., Yuan, C."MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer Retraction in /10.3892/ijmm.2025.5695". International Journal of Molecular Medicine 46, no. 3 (2020): 1013-1028. https://doi.org/10.3892/ijmm.2020.4649
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