Open Access

Heart‑lung crosstalk in pulmonary arterial hypertension following myocardial infarction (Review)

  • Authors:
    • Wenfeng Ye
    • Haixu Guo
    • Jinrong Xu
    • Shuyun Cai
    • Yuan He
    • Xiaorong Shui
    • Shian Huang
    • Hui Luo
    • Wei Lei
  • View Affiliations

  • Published online on: June 18, 2020     https://doi.org/10.3892/ijmm.2020.4650
  • Pages: 913-924
  • Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Left heart disease is the main cause of clinical pulmonary arterial hypertension (PAH). Common types of left heart disease that result in PAH include heart failure, left ventricular systolic dysfunction, left ventricular diastolic dysfunction and valvular disease. It is currently believed that mechanical pressure caused by high pulmonary venous pressure is the main cause of myocardial infarction (MI) in individuals with ischemic cardiomyopathy and left ventricular systolic dysfunction. In the presence of decreased cardiac function, vascular remodeling of pulmonary vessels in response to long‑term stimulation by high pressure in turn leads to exacerbation of PAH. However, the underlying pathological mechanisms remain unclear. Elucidating the association between the development of MI and PAH may lead to a better understanding of potential risk factors and better disease treatment. In this article, the pathophysiological effects of multiple systems in individuals with MI and PAH were reviewed in order to provide a general perspective on various potential interactions between cardiomyocytes and pulmonary vascular cells.

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September-2020
Volume 46 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Ye W, Guo H, Xu J, Cai S, He Y, Shui X, Huang S, Luo H and Lei W: Heart‑lung crosstalk in pulmonary arterial hypertension following myocardial infarction (Review). Int J Mol Med 46: 913-924, 2020
APA
Ye, W., Guo, H., Xu, J., Cai, S., He, Y., Shui, X. ... Lei, W. (2020). Heart‑lung crosstalk in pulmonary arterial hypertension following myocardial infarction (Review). International Journal of Molecular Medicine, 46, 913-924. https://doi.org/10.3892/ijmm.2020.4650
MLA
Ye, W., Guo, H., Xu, J., Cai, S., He, Y., Shui, X., Huang, S., Luo, H., Lei, W."Heart‑lung crosstalk in pulmonary arterial hypertension following myocardial infarction (Review)". International Journal of Molecular Medicine 46.3 (2020): 913-924.
Chicago
Ye, W., Guo, H., Xu, J., Cai, S., He, Y., Shui, X., Huang, S., Luo, H., Lei, W."Heart‑lung crosstalk in pulmonary arterial hypertension following myocardial infarction (Review)". International Journal of Molecular Medicine 46, no. 3 (2020): 913-924. https://doi.org/10.3892/ijmm.2020.4650