Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
September-2020 Volume 46 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 46 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review)

  • Authors:
    • Eugenio Cavalli
    • Alessia Bramanti
    • Rosella Ciurleo
    • Andrey I. Tchorbanov
    • Antonio Giordano
    • Paolo Fagone
    • Cristina Belizna
    • Placido Bramanti
    • Yehuda Shoenfeld
    • Ferdinando Nicoletti
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical and Biotechnological Sciences, University of Catania, I-95123 Catania, Italy, IRCCS Centro Neurolesi ‘Bonino‑Pulejo’, I-98124 Messina, Italy, Laboratory of Experimental Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria, Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA, Vascular and Coagulation Department, University Hospital Angers, 49000 Angers, France, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Tel‑Aviv University, Ramat Gan 5265601, Israel
    Copyright: © Cavalli et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 903-912
    |
    Published online on: June 25, 2020
       https://doi.org/10.3892/ijmm.2020.4659
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a novel β coronavirus that is the etiological agent of the pandemic coronavirus disease 2019 (COVID‑19) that at the time of writing (June 16, 2020) has infected almost 6 million people with some 450,000 deaths. These numbers are still rising daily. Most (some 80%) cases of COVID‑19 infection are asymptomatic, a substantial number of cases (15%) require hospitalization and an additional fraction of patients (5%) need recovery in intensive care units. Mortality for COVID‑19 infection appears to occur globally between 0.1 and 0.5% of infected patients although the frequency of lethality is significantly augmented in the elderly and in patients with other comorbidities. The development of acute respiratory distress syndrome and episodes of thromboembolism that may lead to disseminated intravascular coagulation (DIC) represent the primary causes of lethality during COVID‑19 infection. Increasing evidence suggests that thrombotic diathesis is due to multiple derangements of the coagulation system including marked elevation of D‑dimer that correlate negatively with survival. We propose here that the thromboembolic events and eventually the development of DIC provoked by SARS‑CoV‑2 infection may represent a secondary anti‑phospholipid antibody syndrome (APS). We will apply both Baconian inductivism and Cartesian deductivism to prove that secondary APS is likely responsible for coagulopathy during the course of COVID‑19 infection. Diagnostic and therapeutic implications of this are also discussed.
View Figures

Figure 1

Figure 2

View References

1 

Yuki K, Fujiogi M and Koutsogiannaki S: COVID-19 pathophysiology: A review. Clin Immunol. 215:1084272020. View Article : Google Scholar : PubMed/NCBI

2 

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, et al China Medical Treatment Expert Group for Covid-19: Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 382:1708–1720. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Rothan HA and Byrareddy SN: The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 109:1024332020. View Article : Google Scholar : PubMed/NCBI

4 

Li Y, Zhou W, Yang L and You R: Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor. Pharmacol Res. 157:1048332020. View Article : Google Scholar : PubMed/NCBI

5 

Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 579:270–273. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Doobay MF, Talman LS, Obr TD, Tian X, Davisson RL and Lazartigues E: Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angio-tensin system. Am J Physiol Regul Integr Comp Physiol. 292:R373–R381. 2007. View Article : Google Scholar

7 

Yan CH, Faraji F, Prajapati DP, Boone CE and DeConde AS: Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol. April 12–2020.Epub ahead of print. View Article : Google Scholar

8 

Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY, et al: Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 382:1199–1207. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Wang W, Tang J and Wei F: Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China. J Med Virol. 92:441–447. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Cascella M, Rajnik M, Cuomo A, Dulebohn SC and Di Napoli R: Features, evaluation and treatment coronavirus (COVID-19). StatPearls Publishing; Treasure Island, FL: 2020

11 

Nishiura H, Jung SM, Linton NM, Kinoshita R, Yang Y, Hayashi K, Kobayashi T, Yuan B and Akhmetzhanov AR: The extent of transmission of novel coronavirus in Wuhan, China, 2020. J Clin Med. 9:3302020. View Article : Google Scholar :

12 

Tang N, Li D, Wang X and Sun Z: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 18:844–847. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Li LQ, Huang T, Wang YQ, Wang ZP, Liang Y, Huang TB, Zhang HY, Sun W and Wang Y: COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol. 92:577–583. 2010. View Article : Google Scholar

14 

Zou Y, Guo H, Zhang Y, Zhang Z, Liu Y, Wang J, Lu H and Qian Z: Analysis of coagulation parameters in patients with COVID-19 in Shanghai, China. Biosci Trends. April 30–2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

15 

Lodigiani C, Iapichino G, Carenzo L, Cecconi M, Ferrazzi P, Sebastian T, Kucher N, Studt JD, Sacco C, Alexia B, et al: Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. 191:9–14. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Bikdeli B, Madhavan MV, Jimenez D, Chuich T, Dreyfus I, Driggin E, Nigoghossian C, Ageno W, Madjid M, Guo Y, et al Global COVID-19 Thrombosis Collaborative Group, Endorsed by the ISTH, NATF, ESVM, and the IUA, Supported by the ESC Working Group on Pulmonary Circulation and Right Ventricular Function: COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC State-of-the-Art Review. J Am Coll Cardiol. 75:2950–2973. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Tang N, Bai H, Chen X, Gong J, Li D and Sun Z: Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 18:182020.

18 

Fogarty H, Townsend L, Ni Cheallaigh C, Bergin C, Martin-Loeches I, Browne P, Bacon CL, Gaule R, Gillett A, Byrne M, et al: More on COVID-19 coagulopathy in Caucasian patients. Br J Haematol. 189:1060–1061. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Beun R, Kusadasi N, Sikma M, Westerink J and Huisman A: Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2. Int J Lab Hematol. 42(Suppl 1): 19–20. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Ye Q, Wang B and Mao J: The pathogenesis and treatment of the 'Cytokine Storm' in COVID-19. J Infect. 80:607–613. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Vaninov N: In the eye of the COVID-19 cytokine storm. Nat Rev Immunol. 20:2772020. View Article : Google Scholar : PubMed/NCBI

22 

Magro C, Mulvey JJ, Berlin D, Nuovo G, Salvatore S, Harp J, Baxter-Stoltzfus A and Laurence J: Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases. Transl Res. 220:1–13. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Risitano AM, Mastellos DC, Huber-Lang M, Yancopoulou D, Garlanda C, Ciceri F and Lambris JD: Complement as a target in COVID-19? Nat Rev Immunol. 20:343–344. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Campbell CM and Kahwash R: Will complement inhibition be the new target in treating COVID-19-related systemic thrombosis? Circulation. 141:1739–1741. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Mastaglio S, Ruggeri A, Risitano AM, Angelillo P, Yancopoulou D, Mastellos DC, Huber-Lang M, Piemontese S, Assanelli A, Garlanda C, et al: The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clin Immunol. 215:1084502020. View Article : Google Scholar : PubMed/NCBI

26 

Rodziewicz M and D'Cruz DP: An update on the management of antiphospholipid syndrome. Ther Adv Musculoskelet Dis. 12:1759720X209108552020. View Article : Google Scholar : PubMed/NCBI

27 

Million M, Bardin N, Bessis S, Nouiakh N, Douliery C, Edouard S, Angelakis E, Bosseray A, Epaulard O, Branger S, et al: Thrombosis and antiphospholipid antibody syndrome during acute Q fever: A cross-sectional study. Medicine (Baltimore). 96:e75782017. View Article : Google Scholar

28 

Mendoza-Pinto C, García-Carrasco M and Cervera R: Role of infectious diseases in the antiphospholipid syndrome (including its catastrophic variant). Curr Rheumatol Rep. 20:622018. View Article : Google Scholar : PubMed/NCBI

29 

Catoggio C, Alvarez-Uría A, Fernandez PL, Cervera R and Espinosa G: Catastrophic antiphospholipid syndrome triggered by fulminant disseminated herpes simplex infection in a patient with systemic lupus erythematosus. Lupus. 21:1359–1361. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Garcia-Carrasco M, Mendoza-Pinto C, Macias-Diaz S, Vazquez de Lara F, Etchegaray-Morales I, Galvez-Romero JL, Mendez-Martinez S and Cervera R: The role of infectious diseases in the catastrophic antiphospholipid syndrome. Autoimmun Rev. 14:1066–1071. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Gómez-Puerta JA and Cervera R: Diagnosis and classification of the antiphospholipid syndrome. J Autoimmun. 48-49:20–25. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Pengo V, Del Ross T, Ruffatti A, Bison E, Cattini MG, Pontara E, Testa S, Legnani C, Pozzi N, Peterle D, et al: Lupus anticoagulant identifies two distinct groups of patients with different antibody patterns. Thromb Res. 172:172–178. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Cervera R: Antiphospholipid syndrome. Thromb Res. 151(Suppl 1): S43–S47. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Erkan D, Espinosa G and Cervera R: Catastrophic antiphospholipid syndrome: Updated diagnostic algorithms. Autoimmun Rev. 10:74–79. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Shi W, Krilis SA, Chong BH, Gordon S and Chesterman CN: Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population. Aust N Z J Med. 20:231–236. 1990. View Article : Google Scholar : PubMed/NCBI

36 

Fields RA, Toubbeh H, Searles RP and Bankhurst AD: The prevalence of anticardiolipin antibodies in a healthy elderly population and its association with antinuclear antibodies. J Rheumatol. 16:623–625. 1989.PubMed/NCBI

37 

Arvanitakis Z, Capuano AW, Brey R, Fleischman DA, Arfanakis K, Buchman AS, Schneider JA, Levine SR and Bennett DA: Antiphospholipid Antibodies: Cognitive and Motor Decline, Neuroimaging and Neuropathology. Neuroepidemiology. 53:100–107. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Ruiz-Irastorza G, Crowther M, Branch W and Khamashta MA: Antiphospholipid syndrome. Lancet. 376:1498–1509. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Carmi O, Berla M, Shoenfeld Y and Levy Y: Diagnosis and management of catastrophic antiphospholipid syndrome. Expert Rev Hematol. 10:365–374. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Rodríguez-Pintó I, Lozano M, Cid J, Espinosa G and Cervera R: Plasma exchange in catastrophic antiphospholipid syndrome. Presse Med. 48:347–353. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Islam MA, Alam F, Wong KK, Kamal MA and Gan SH: Thrombotic management of antiphospholipid syndrome: towards novel targeted therapies. Curr Vasc Pharmacol. 15:313–326. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Quinti I, Lougaris V, Milito C, Cinetto F, Pecoraro A, Mezzaroma I, Mastroianni CM, Turriziani O, Bondioni MP, Filippini M, et al: A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia. J Allergy Clin Immunol. April 22–2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

43 

McKee DL, Sternberg A, Stange U, Laufer S and Naujokat C: Candidate drugs against SARS-CoV-2 and COVID-19. Pharmacol Res. 157:1048592020. View Article : Google Scholar : PubMed/NCBI

44 

Chighizola CB, Andreoli L, Gerosa M, Tincani A, Ruffatti A and Meroni PL: The treatment of anti-phospholipid syndrome: a comprehensive clinical approach. J Autoimmun. 90:1–27. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, Chen H, Ding X, Zhao H, Zhang H, et al: Coagulopathy and antiphos-pholipid antibodies in patients with Covid-19. N Engl J Med. 382:e382020. View Article : Google Scholar

46 

Beyrouti R, Adams ME, Benjamin L, Cohen H, Farmer SF, Goh YY, Humphries F, Jäger HR, Losseff NA, Perry RJ, et al: Characteristics of ischaemic stroke associated with COVID-19. Neurol Neurosurg Psychiatry. April 30–2020.Epub ahead of print. View Article : Google Scholar

47 

Zayet S, Klopfenstein T, Kovacs R, Stancescu S and Hagenkötter B: Acute cerebral stroke with multiple infarctions and COVID-19, France, 2020. Emerg Infect Dis. 26:262020. View Article : Google Scholar

48 

Aubignat M and Godefroy O: COVID-19 and ischemic stroke: Should we systematically look for lupus anticoagulant and antiphospholipid antibodies? Rev Neurol (Paris). 176:505–506. 2020. View Article : Google Scholar

49 

Harzallah I, Debliquis A and Drénou B: Lupus anticoagulant is frequent in patients with Covid-19. J Thromb Haemost. 2020.

50 

Bowles L, Platton S, Yartey N, Dave M, Lee K, Hart DP, MacDonald V, Green L, Sivapalaratnam S, Pasi KJ, et al: Lupus anticoagulant and abnormal coagulation tests in patients with Covid-19. N Engl J Med. May 5–2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

51 

Helms J, Tacquard C, Severac F, Leonard-Lorant I, Ohana M, Delabranche X, Merdji H, Clere-Jehl R, Schenck M, Fagot Gandet F, et al CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sepsis): High risk of thrombosis in patients with severe SARS-CoV-2 infection: A multicenter prospective cohort study. Intensive Care Med. 46:1089–1098. 2020. View Article : Google Scholar : PubMed/NCBI

52 

Pineton de Chambrun M, Frere C, Miyara M, Amoura Z, Martin-Toutain I, Mathian A, Hekimian G and Combes A: High frequency of antiphospholipid antibodies in critically-ill COVID-19 patients: a link with hypercoagulability? J Intern Med. June 12–2020.Epub ahead of print. View Article : Google Scholar

53 

Hossri S, Shadi M, Hamarsha Z, Schneider R and El-Sayegh D: Clinically significant anticardiolipin antibodies associated with COVID-19. J Crit Care. 59:32–34. 2020. View Article : Google Scholar : PubMed/NCBI

54 

Galeano-Valle F, Oblitas CM, Ferreiro-Mazón MM, Alonso-Muñoz J, Del Toro-Cervera J, di Natale M and Demelo-Rodríguez P: Antiphospholipid antibodies are not elevated in patients with severe COVID-19 pneumonia and venous thromboembolism. Thromb Res. 192:113–115. 2020. View Article : Google Scholar : PubMed/NCBI

55 

Chaudhary R, Pagali S, Garg J, Murad MH, Wysokinski WE and McBane RD 2nd: DOACs versus VKAs in older adults treated for acute venous thromboembolism: systematic review and meta-analysis. J Am Geriatr Soc. May 22–2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

56 

Marchandot B, Sattler L, Jesel L, Matsushita K, Schini-Kerth V, Grunebaum L and Morel O: COVID-19 Related coagulopathy: A distinct entity? J Clin Med. 9:92020. View Article : Google Scholar

57 

Oxley TJ, Mocco J, Majidi S, Kellner CP, Shoirah H, Singh IP, De Leacy RA, Shigematsu T, Ladner TR, Yaeger KA, et al: Large-vessel stroke as a presenting feature of Covid-19 in the young. N Engl J Med. 382:e602020. View Article : Google Scholar : PubMed/NCBI

58 

Plunk MA, Alaniz A, Olademehin OP, Ellington TL, Shuford KL and Kane RR: Design and Catalyzed Activation of Tak-242 Prodrugs for Localized Inhibition of TLR4-Induced Inflammation. ACS Med Chem Lett. 11:141–146. 2020. View Article : Google Scholar : PubMed/NCBI

59 

Stojanovic I, Cuzzocrea S, Mangano K, Mazzon E, Miljkovic D, Wang M, Donia M, Al Abed Y, Kim J, Nicoletti F, et al: In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: Modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin Immunol. 123:311–323. 2007. View Article : Google Scholar : PubMed/NCBI

60 

Nicoletti F, Fagone P, Meroni P, McCubrey J and Bendtzen K: mTOR as a multifunctional therapeutic target in HIV infection. Drug Discov Today. 16:715–721. 2011. View Article : Google Scholar : PubMed/NCBI

61 

Fagone P, Ciurleo R, Lombardo SD, Iacobello C, Palermo CI, Shoenfeld Y, Bendtzen K, Bramanti P and Nicoletti F: Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies. Autoimmun Rev. 19:1025712020. View Article : Google Scholar : PubMed/NCBI

62 

Nicoletti F, Lapenta C, Donati S, Spada M, Ranazzi A, Cacopardo B, Mangano K, Belardelli F, Perno C and Aquaro S: Inhibition of human immunodeficiency virus (HIV-1) infection in human peripheral blood leucocytes-SCID reconstituted mice by rapamycin. Clin Exp Immunol. 155:28–34. 2009. View Article : Google Scholar :

63 

Maiese K: The mechanistic target of rapamycin (mTOR): Novel considerations as an antiviral treatment and possibilities for COVID-19. Curr Neurovasc Res. April 25–2020.Epub ahead of print. View Article : Google Scholar

64 

Kolyada A, Lee CJ, De Biasio A and Beglova N: A novel dimeric inhibitor targeting Beta2GPI in Beta2GPI/antibody complexes implicated in antiphospholipid syndrome. PLoS One. 5:e153452010. View Article : Google Scholar : PubMed/NCBI

65 

Lee CJ, De Biasio A and Beglova N: Mode of interaction between β2GPI and lipoprotein receptors suggests mutually exclusive binding of β2GPI to the receptors and anionic phospholipids. Structure. 18:366–376. 2010. View Article : Google Scholar : PubMed/NCBI

66 

Lin F, Murphy R, White B, Kelly J, Feighery C, Doyle R, Pittock S, Moroney J, Smith O, Livingstone W, et al: Circulating levels of β2-glycoprotein I in thrombotic disorders and in inflammation. Lupus. 15:87–93. 2006. View Article : Google Scholar

67 

Kolyada A, Karageorgos I, Mahlawat P and Beglova N: An A1-A1 mutant with improved binding and inhibition of β2GPI/antibody complexes in antiphospholipid syndrome. FEBS J. 282:864–873. 2015. View Article : Google Scholar :

68 

Kolyada A, Porter A and Beglova N: Inhibition of thrombotic properties of persistent autoimmune anti-β2GPI antibodies in the mouse model of antiphospholipid syndrome. Blood. 123:1090–1097. 2014. View Article : Google Scholar :

69 

Agostinis C, Durigutto P, Sblattero D, Borghi MO, Grossi C, Guida F, Bulla R, Macor P, Pregnolato F, Meroni PL, et al: A non-complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome. Blood. 123:3478–3487. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cavalli E, Bramanti A, Ciurleo R, Tchorbanov AI, Giordano A, Fagone P, Belizna C, Bramanti P, Shoenfeld Y, Nicoletti F, Nicoletti F, et al: Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review). Int J Mol Med 46: 903-912, 2020.
APA
Cavalli, E., Bramanti, A., Ciurleo, R., Tchorbanov, A.I., Giordano, A., Fagone, P. ... Nicoletti, F. (2020). Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review). International Journal of Molecular Medicine, 46, 903-912. https://doi.org/10.3892/ijmm.2020.4659
MLA
Cavalli, E., Bramanti, A., Ciurleo, R., Tchorbanov, A. I., Giordano, A., Fagone, P., Belizna, C., Bramanti, P., Shoenfeld, Y., Nicoletti, F."Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review)". International Journal of Molecular Medicine 46.3 (2020): 903-912.
Chicago
Cavalli, E., Bramanti, A., Ciurleo, R., Tchorbanov, A. I., Giordano, A., Fagone, P., Belizna, C., Bramanti, P., Shoenfeld, Y., Nicoletti, F."Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review)". International Journal of Molecular Medicine 46, no. 3 (2020): 903-912. https://doi.org/10.3892/ijmm.2020.4659
Copy and paste a formatted citation
x
Spandidos Publications style
Cavalli E, Bramanti A, Ciurleo R, Tchorbanov AI, Giordano A, Fagone P, Belizna C, Bramanti P, Shoenfeld Y, Nicoletti F, Nicoletti F, et al: Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review). Int J Mol Med 46: 903-912, 2020.
APA
Cavalli, E., Bramanti, A., Ciurleo, R., Tchorbanov, A.I., Giordano, A., Fagone, P. ... Nicoletti, F. (2020). Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review). International Journal of Molecular Medicine, 46, 903-912. https://doi.org/10.3892/ijmm.2020.4659
MLA
Cavalli, E., Bramanti, A., Ciurleo, R., Tchorbanov, A. I., Giordano, A., Fagone, P., Belizna, C., Bramanti, P., Shoenfeld, Y., Nicoletti, F."Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review)". International Journal of Molecular Medicine 46.3 (2020): 903-912.
Chicago
Cavalli, E., Bramanti, A., Ciurleo, R., Tchorbanov, A. I., Giordano, A., Fagone, P., Belizna, C., Bramanti, P., Shoenfeld, Y., Nicoletti, F."Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review)". International Journal of Molecular Medicine 46, no. 3 (2020): 903-912. https://doi.org/10.3892/ijmm.2020.4659
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team