Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
October-2020 Volume 46 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 46 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF

  • Supplementary Files
    • Supplementary Data.pdf
Article Open Access

A comprehensive analysis of RHOA mutation positive and negative angioimmunoblastic T-cell lymphomas by targeted deep sequencing, expression profiling and single cell digital image analysis

  • Authors:
    • Alexandra Butzmann
    • Kaushik Sridhar
    • Diwash Jangam
    • Jyoti Kumar
    • Malaya Kumar Sahoo
    • Nahid Shahmarvand
    • Roger Warnke
    • Elumalai Rangasamy
    • Benjamin Alan Pinsky
    • Robert Shigeo Ohgami
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Stanford University, Stanford, CA 94305, USA, Agilent Technologies, Santa Clara, CA 95051, USA
    Copyright: © Butzmann et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1466-1476
    |
    Published online on: July 28, 2020
       https://doi.org/10.3892/ijmm.2020.4686
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Angioimmunoblastic T‑cell lymphoma (AITL) is a uniquely aggressive mature T‑cell neoplasm. In recent years, recurrent genetic mutations in ras homolog family member A (RHOA), tet methylcytosine dioxygenase 2 (TET2), DNA methyltransferase 3 alpha (DNMT3A) and isocitrate dehydrogenase [NADP(+)] 2 (IDH2) have been identified as associated with AITL. However, a deep molecular study assessing both DNA mutations and RNA expression profile combined with digital image analysis is lacking. The present study aimed to evaluate the significance of molecular and morphologic features by high resolution digital image analysis in several cases of AITL. To do so, a total of 18 separate tissues from 10 patients with AITL were collected and analyzed. The results identified recurrent mutations in RHOA, TET2, DNMT3A, and IDH2, and demonstrated increased DNA mutations in coding, promoter and CCCTC binding factor (CTCF) binding sites in RHOA mutated AITLs vs. RHOA non‑mutated cases, as well as increased overall survival in RHOA mutated patients. In addition, single cell computational digital image analysis morphologically characterized RHOA mutated AITL cells as distinct from cells from RHOA mutation negative patients. Computational analysis of single cell morphological parameters revealed that RHOA mutated cells have decreased eccentricity (more circular) compared with RHOA non‑mutated AITL cells. In conclusion, the results from the present study expand our understanding of AITL and demonstrate that there are specific cell biological and morphological manifestations of RHOA mutations in cases of AITL.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Attygalle AD, Kyriakou C, Dupuis J, Grogg KL, Diss TC, Wotherspoon AC, Chuang SS, Cabeçadas J, Isaacson PG, Du MQ, et al: Histologic evolution of angioimmunoblastic T-cell lymphoma in consecutive biopsies: Clinical correlation. Am J Surg Pathol. 31:1077–1088. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Dogan A, Atygalle AD and Kyriakou C: Angioimmunoblastic T-cell lymphoma. Br J Haematol. 121:681–691. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Attygalle A, Al-Jehani R, Diss TC, Munson P, Liu H, Du MQ, Isaacson PG and Dogan A: Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10. Blood. 99:627–633. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Manso R, Sánchez-Beato M, Monsalvo S, Gómez S, Cereceda L, Llamas P, Rojo F, Mollejo M, Menárguez J, Alves J, et al: The RHOA G17V gene mutation occurs frequently in peripheral T-cell lymphoma and is associated with a characteristic molecular signature. Blood. 123:2893–2894. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Cairns RA, Iqbal J, Lemonnier F, Kucuk C, de Leval L, Jais JP, Parrens M, Martin A, Xerri L, Brousset P, et al: IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. Blood. 119:1901–1903. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N, Okuno Y, Sakata S, Kamada Y, et al: Somatic G17V Rhoa mutation specifies angioimmunoblastic T-Cell lymphoma. Blood. 122:8152013. View Article : Google Scholar

7 

Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N, Sato-Otsubo A, Okuno Y, et al: Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet. 46:171–178. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Fujisawa M, Sakata-Yanagimoto M, Nishizawa S, Komori D, Gershon P, Kiryu M, Tanzima S, Fukumoto K, Enami T, Muratani M, et al: Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma. Leukemia. 32:694–702. 2018. View Article : Google Scholar

9 

Cortes JR, Ambesi-Impiombato A, Couronné L, Quinn SA, Kim CS, da Silva Almeida AC, West Z, Belver L, Martin MS, Scourzic L, et al: RHOA G17V induces T follicular helper cell specification and promotes lymphomagenesis. Cancer Cell. 33:259–273, e7. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Ondrejka SL, Grzywacz B, Bodo J, Makishima H, Polprasert C, Said JW, Przychodzen B, Maciejewski JP and His ED: Angioimmunoblastic T-cell lymphomas with the RHOA p. Gly17Val mutation have classic clinical and pathologic features. Am J Surg Pathol. 40:335–341. 2016. View Article : Google Scholar

11 

Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD and Jaffe ES: The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 127:2375–2391. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H and Thiele J: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th edition. International Agency for Research in Cancer (IARC); Lyon: 2017

13 

Kumar J, Butzmann A, Wu S, Easly S, Zehnder JL, Warnke RA, Bangs CD, Jangam D, Cherry A, Lau J, et al: Indolent in situ B-cell neoplasms with MYC rearrangements show somatic mutations in MYC and TNFRSF14 by next-generation sequencing. Am J Surg Pathol. 43:1720–1725. 2019.PubMed/NCBI

14 

McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A, Garimella K, Altshuler D, Gabriel S, Daly M and DePristo MA: The Genome Analysis Toolkit: A MapReduceframework for analyzing next-generation DNA sequencing data. Genome Res. 20:1297–1303. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Koboldt DC, Zhang Q, Larson DE, Shen D, McLellan MD, Lin L, Miller CA, Mardis ER, Ding L and Wilson RK: VarScan2: Somatic mutation and copy number alteration discovery in cancerby exome sequencing. Genome Res. 22:568–576. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Karczewski KJ, Francioli LC, Tiao G, Cummings BB, Alföldi J, Wang Q, Collins RL, Laricchia KM, Ganna A, Birnbaum DP, et al: The mutational constraint spectrum quantified from variation in 141,456 humans. Nature. 581:434–443. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Rehm HL, Berg JS, Brooks LD, Bustamante CD, Evans JP, Landrum MJ, Ledbetter DH, Maglott DR, Martin CL, Nussbaum RL, et al: ClinGen-the clinical genome resource. N Engl J Med. 372:2235–2242. 2015. View Article : Google Scholar : PubMed/NCBI

18 

1000 Genomes Project Consortium; Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA and Abecasis GR: A global reference for human genetic variation. Nature. 526:68–74. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Exome Variant Server. http:////evs.gs.washington.edu/EVS/urisimple//evs.gs.washington.edu/EVS/Accessed February 16 2020.

20 

Kopanos C and Tsiolkas V: VarSome: The human genomic variant search engine. Bioinformatics. 35:1978–1980. 2019. View Article : Google Scholar :

21 

Blokzijl F, Janssen R, Van Boxtel R and Cuppen E: MutationalPatterns: Comprehensive genome-wide analysis of mutational processes. Genome Med. 10:332018. View Article : Google Scholar : PubMed/NCBI

22 

Chen EY, Tan CM, Kou Y, Duan Q, Wang Z, Meirelles GV, Clark NR and Ma'ayan A: Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics. 14:1282013. View Article : Google Scholar : PubMed/NCBI

23 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, et al: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 34:267–273. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Kamburov A, Stelzl U, Lehrach H and Herwig R: The ConsensusPathDB interaction database: 2013 update. Nucleic Acids Res. 41(Database Issue): D793–D800. 2013. View Article : Google Scholar :

26 

Gyarmati P, Kjellander C, Aust C, Song Y, Öhrmalm L and Giske CG: Metagenomic analysis of bloodstream infections in patients with acute leukemia and therapy-induced neutropenia. Sci Rep. 21:235322016. View Article : Google Scholar

27 

Baheti S, Tang X, O'Brien DR, Chia N, Roberts LR, Nelson H, Boughey JC, Wang L, Goetz MP, Kocher JA and Kalari KR: HGT-ID: An efficient and sensitive workflow to detect human-viral insertion sites using next-generation sequencing data. BMC Bioinformatics. 19:2712018. View Article : Google Scholar : PubMed/NCBI

28 

Kim D, Paggi JM, Park C, Bennett C and Salzberg SL: Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat Biotechnol. 37:907–915. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Anders S, Pyl PT and Huber W: HTSeq-a Python frame-work to work with high-throughoutput sequencing data. Bioinformatics. 31:166–169. 2015. View Article : Google Scholar

30 

Integrated Development for R. Version 125001. Mode: desktop. RStudio, PBC; Boston, MA: 2020, http://www.rstudio.com/. Accessed February 16 2020.

31 

Metsalu T and Vilo J: ClustVis: A web tool visualizing clustering of multivariate data using Prinicpal Component Analysis and heatmap. Nucleic Acids Res. 43(W1): W566–W570. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, Hoang CD, Diehn M and Alizadeh AA: Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 12:453–457. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Jangam D, Sridhar K, Butzmann A, Sambhagati P, Plowey ED and Ohgami RS: TBL1XR1 Mutations in primary marginal zone lymphomas of occular adnexa are associated with unique morphometric phenotypes. Curr Eye Res. Jun 19–2020.Epub ahead of print. View Article : Google Scholar

34 

Wong MA and Hartigan JA: Algorithm AS 136: A K-means clustering algorithm. J R Stat Soc Ser C. 28:100–108. 1979.

35 

Fouad S, Randell D, Galton A, Mehanna H and Landini G: Unsupervised morphological segmentation of tissue compartments in histopathological images. PLoS One. 12:e01887172017. View Article : Google Scholar : PubMed/NCBI

36 

Hart M, Lauer J, Selig M, Hanak M, Walters B and Rolauffs B: Shaping the cell and the future: Recent advancements in biophysical aspects relevant to regenerative medicine. J Funct Morphol Kinesiol. 3:22017. View Article : Google Scholar

37 

Lyons SM, Alizadeh E, Mannheimer J, Schuamberg K, Castle J, Schroder B, Turk P, Thamm D and Prasad A: Changes in cell shape are correlated with metastatic potential in murine and human osteosarcomas. Biol Open. 5:289–299. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Chiba S, Enami T, Ogawa S and Sakata-Yanagimoto M: G17V RHOA: Genetic evidence of GTP-unbound RHOA playing a role in tumorigenesis in T cells. Small GTPases. 6:100–103. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Nagao R, Kikuti YY, Carreras J, Kikuchi T, Miyaoka M, Matsushita H, Kojima M, Ando K, Sakata-Yanagimoto M, Chiba S and Nakamura N: Clinicopathologic analysis of angioimmunoblastic T-cell lymphoma with or without RHOA G17V mutation using formalin-fixed paraffin-embedded sections. Am J Surg Pathol. 40:1041–1050. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Willemsen M, Hamid MA, Winkens B and Zur Hausen A: Mutational heterogeneity of angioimmunoblastic T-cell lymphoma indicates distinct lymphomagenic pathways. Blood Cancer J. 8:62018. View Article : Google Scholar : PubMed/NCBI

41 

Yoo HY, Sung MK, Lee SH, Kim S, Lee H, Park S, Kim SC, Lee B, Rho K, Lee JE, et al: A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma. Nat Genet. 46:371–375. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Wang M, Zhang S, Chuang SS, Ashton-Key M, Ochoa E, Bolli N, Vassiliou G, Gao Z and Du MQ: Angioimmunoblastic T cell lymphoma: Novel molecular insights by mutation profiling. Oncotarget. 8:17763–17770. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Ng SY, Brown L, Stevenson K, deSouza T, Aster JC, Louissaint A Jr and Weinstock DM: RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice. Blood. 132:935–947. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Abate F, Da Silva-Almeida AC, Zairis S, Zairis S, Robles-Valero J, Couronne L, Khiabanian H, Quinn SA, Kim MY, Laginestra MA, et al: Activating mutations and trans-locations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas. Proc Natl Acad Sci USA. 114:764–769. 2017. View Article : Google Scholar

45 

Cornish AJ, Hoang PH, Dobbins SE, Law PJ, Chubb D, Orlando G and Houlston RS: Identification of recurrent non-coding mutations in B-cell lymphoma using Hi-C. Blood Adv. 3:21–32. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Zhang X, Zhang Y, Ba Z, Kyritsis N, Casellas R and Alt FW: Fundamental roles of chromatin loop extrusion in antibody class switching. Nature. 575:385–389. 2019. View Article : Google Scholar : PubMed/NCBI

47 

Weiss LM, Jaffe ES, Liu XF, Chen YY, Shibata D and Medeiros LJ: Detection and localization of Epstein-Barr viral genomes in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma. Blood. 79:1789–1795. 1992. View Article : Google Scholar : PubMed/NCBI

48 

Khan G, Norton AJ and Slavin G: Epstein-Barr virus in angioimmunoblastic T-cell lymphomas. Histopathology. 22:145–149. 1993. View Article : Google Scholar : PubMed/NCBI

49 

Zhou Y, Attygalle AD, Chuang SS, Diss T, Ye H, Liu H, Hamoudi RA, Munson P, Bacon CM, Dogan A and Du MQ: Angioimmunoblastic T-cell lymphoma: Histological progression associates with EBV and HHV6B viral load. Br J Haematol. 138:44–53. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Eladl AE, Shimada K, Suzuki Y, Takahara T, Kato S, Kohno K, Elsayed AA, Wu CC, Tokunaga T, Kinoshita T, et al: EBV status has prognostic implication among young patients with angioimmunoblastic T-cell lymphoma. Cancer Med. 9:678–688. 2020. View Article : Google Scholar

51 

Hoffmann JC, Chisholm KM, Cherry A, Chen J, Arber DA, Natkunam Y, Warnke RA and Ohgami RS: An analysis of MYC and EBV in diffuse large B-cell lymphomas associated with angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma not otherwise specified. Hum Pathol. 48:9–17. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Bal M, Gujral S, Gandhi J, Shet T, Epari S and Subramanian PG: Angioimmunoblastic T-cell lymphoma: A critical analysis of clinical, morphologic and immunophenotypic features. Indian J Pathol Microbiol. 53:640–645. 2010. View Article : Google Scholar : PubMed/NCBI

53 

De Leval L, Rickman DS, Thielen C, Reynies Ad, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, et al: The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells. Blood. 109:4952–4963. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Piccaluga PP, Agostinelli C, Califano A, Carbone A, Fantoni L, Ferrari S, Gazzola A, Gloghini A, Righi S, Rossi M, et al: Gene expression analysis of angioimmunoblastic lymphoma indicates derivation from T follicular helper cells and vascular endothelial growth factor deregulation. Cancer Res. 67:10703–10713. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Nguyen TB, Sakata-Yanagimoto M, Asabe Y, Matsubara D, Kano J, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, et al: Identification of cell-type-specific mutations in nodal T-cell lymphomas. Blood Cancer J. 7:e5162017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Butzmann A, Sridhar K, Jangam D, Kumar J, Sahoo MK, Shahmarvand N, Warnke R, Rangasamy E, Pinsky BA, Ohgami RS, Ohgami RS, et al: A comprehensive analysis of RHOA mutation positive and negative angioimmunoblastic T-cell lymphomas by targeted deep sequencing, expression profiling and single cell digital image analysis. Int J Mol Med 46: 1466-1476, 2020.
APA
Butzmann, A., Sridhar, K., Jangam, D., Kumar, J., Sahoo, M.K., Shahmarvand, N. ... Ohgami, R.S. (2020). A comprehensive analysis of RHOA mutation positive and negative angioimmunoblastic T-cell lymphomas by targeted deep sequencing, expression profiling and single cell digital image analysis. International Journal of Molecular Medicine, 46, 1466-1476. https://doi.org/10.3892/ijmm.2020.4686
MLA
Butzmann, A., Sridhar, K., Jangam, D., Kumar, J., Sahoo, M. K., Shahmarvand, N., Warnke, R., Rangasamy, E., Pinsky, B. A., Ohgami, R. S."A comprehensive analysis of RHOA mutation positive and negative angioimmunoblastic T-cell lymphomas by targeted deep sequencing, expression profiling and single cell digital image analysis". International Journal of Molecular Medicine 46.4 (2020): 1466-1476.
Chicago
Butzmann, A., Sridhar, K., Jangam, D., Kumar, J., Sahoo, M. K., Shahmarvand, N., Warnke, R., Rangasamy, E., Pinsky, B. A., Ohgami, R. S."A comprehensive analysis of RHOA mutation positive and negative angioimmunoblastic T-cell lymphomas by targeted deep sequencing, expression profiling and single cell digital image analysis". International Journal of Molecular Medicine 46, no. 4 (2020): 1466-1476. https://doi.org/10.3892/ijmm.2020.4686
Copy and paste a formatted citation
x
Spandidos Publications style
Butzmann A, Sridhar K, Jangam D, Kumar J, Sahoo MK, Shahmarvand N, Warnke R, Rangasamy E, Pinsky BA, Ohgami RS, Ohgami RS, et al: A comprehensive analysis of RHOA mutation positive and negative angioimmunoblastic T-cell lymphomas by targeted deep sequencing, expression profiling and single cell digital image analysis. Int J Mol Med 46: 1466-1476, 2020.
APA
Butzmann, A., Sridhar, K., Jangam, D., Kumar, J., Sahoo, M.K., Shahmarvand, N. ... Ohgami, R.S. (2020). A comprehensive analysis of RHOA mutation positive and negative angioimmunoblastic T-cell lymphomas by targeted deep sequencing, expression profiling and single cell digital image analysis. International Journal of Molecular Medicine, 46, 1466-1476. https://doi.org/10.3892/ijmm.2020.4686
MLA
Butzmann, A., Sridhar, K., Jangam, D., Kumar, J., Sahoo, M. K., Shahmarvand, N., Warnke, R., Rangasamy, E., Pinsky, B. A., Ohgami, R. S."A comprehensive analysis of RHOA mutation positive and negative angioimmunoblastic T-cell lymphomas by targeted deep sequencing, expression profiling and single cell digital image analysis". International Journal of Molecular Medicine 46.4 (2020): 1466-1476.
Chicago
Butzmann, A., Sridhar, K., Jangam, D., Kumar, J., Sahoo, M. K., Shahmarvand, N., Warnke, R., Rangasamy, E., Pinsky, B. A., Ohgami, R. S."A comprehensive analysis of RHOA mutation positive and negative angioimmunoblastic T-cell lymphomas by targeted deep sequencing, expression profiling and single cell digital image analysis". International Journal of Molecular Medicine 46, no. 4 (2020): 1466-1476. https://doi.org/10.3892/ijmm.2020.4686
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team