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Article Open Access

Asiaticoside suppresses cell proliferation by inhibiting the NF‑κB signaling pathway in colorectal cancer

  • Authors:
    • Xin Zhou
    • Chunlin Ke
    • You Lv
    • Caihong Ren
    • Tiansheng Lin
    • Feng Dong
    • Yanjun Mi
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Cancer, Cancer Center, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, Fujian 361003, P.R. China, Department of Radiotherapy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China, Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China, Department of Medical Oncology, Xiamen Key Laboratory of Antitumor Drug Transformation Research, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, Fujian 361003, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1525-1537
    |
    Published online on: July 28, 2020
       https://doi.org/10.3892/ijmm.2020.4688
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Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer‑associated mortality. Asiaticoside (AC) exhibits antitumor effects; however, to the best of our knowledge, the biological function of AC in CRC cells remains unclear. Therefore, the aim of the present study was to investigate the effect of AC on CRC cells. In the present study, CCK‑8 and colony formation assays were performed to assess the effects of AV on human CRC cell lines (HCT116, SW480 and LoVo). Mitochondrial membrane potential was examined by JC‑1 staining. Cell apoptosis and cell cycle were monitored by flow cytometry, and the expression of genes was evaluated using RT‑qPCR and western blot analysis. Furthermore, the biological effect of AC in vivo was detected using a xenograft mouse model. The findings revealed that 2 µM AC suppressed the proliferation of CRC cells in a time‑ and dose‑dependent manner, but had no adverse effects on normal human intestinal FHC cells at a range of concentrations. AC decreased the mitochondrial membrane potential and increased the apoptosis of CRC cells in a dose‑dependent manner. Furthermore, AC induced cell cycle arrest at the G0/G1 phase. AC attenuated IκBα phosphorylation in a dose‑dependent manner, thereby preventing P65 from entering the nucleus, and resulting in inhibition of the NF‑κB signaling pathway. In addition, AC significantly reduced the expression of CDK4 and Cyclin D1 in a dose‑dependent manner, significantly upregulated the activation of caspase‑9 and caspase‑3, and decreased the Bcl‑2/Bax mRNA ratio. Furthermore, treatment with the NF‑κB signaling pathway inhibitor JSH‑23 significantly increased the cytotoxicity of AC in CRC cells. Findings of the xenograft mice model experiments revealed that AC significantly inhibited colorectal tumor growth in a dose‑dependent manner. Overall, AC suppressed activation of the NF‑κB signaling pathway by downregulating IκBα phosphorylation. This resulted in inhibition of CRC cell viability and an increase of cell apoptosis, which may form the basis of AC use in the treatment of patients with CRC.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Miller KD, Nogueira L, Mariotto AB, Rowland JH, Yabroff KR, Alfano CM, Jemal A, Kramer JL and Siegel RL: Cancer treatment and survivorship statistics, 2019. CA Cancer J Clin. 69:363–385. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Van der Jeught K, Xu HC, Li YJ, Lu XB and Ji G: Drug resistance and new therapies in colorectal cancer. World J Gastroenterol. 24:3834–3848. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Bahrami A, Amerizadeh F, Hassanian SM, ShahidSales S, Khazaei M, Maftouh M, Ghayour-Mobarhan M, Ferns GA and Avan A: Genetic variants as potential predictive biomarkers in advanced colorectal cancer patients treated with oxaliplatin-based chemotherapy. J Cell Physiol. 233:2193–2201. 2018. View Article : Google Scholar

5 

Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, Dańczak-Pazdrowska A and Brzezińska M: Centella asiatica in dermatology: An overview. Phytother Res. 28:1117–1124. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Chandrika UG, Prasad Kumarab and Peramune AAS: Gotu Kola (Centella asiatica): Nutritional properties and plausible health benefits. Adv Food Nutr Res. 76:125–157. 2015. View Article : Google Scholar : PubMed/NCBI

7 

da Rocha PBR, Santos Souza BD, Andrade LM, Marreto RN, Lima EM and Taveira SF: Development of a high-performance liquid chromatographic method for asiaticoside quantification in different skin layers after topical application of a Centella asiatica extract. Planta Med. 83:1431–1437. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Nowwarote N, Osathanon T, Jitjaturunt P, Manopattanasoontorn S and Pavasant P: Asiaticoside induces type I collagen synthesis and osteogenic differentiation in human periodontal ligament cells. Phytother Res. 27:457–462. 2013. View Article : Google Scholar

9 

Lee J, Jung E, Kim Y, Park J, Park J, Hong S, Kim J, Hyun C, Kim YS and Park D: Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling. Planta Med. 72:324–328. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Phaechamud T, Yodkhum K, Charoenteeraboon J and Tabata Y: Chitosan-aluminum monostearate composite sponge dressing containing asiaticoside for wound healing and angiogenesis promotion in chronic wound. Mater Sci Eng C Mater Biol Appl. 50:210–225. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Huang J, Zhou X, Shen Y, Li H, Zhou G, Zhang W, Zhang Y and Liu W: Asiaticoside loading into polylactic-co-glycolic acid electrospun nanofibers attenuates host inflammatory response and promotes M2 macrophage polarization. J Biomed Mater Res A. 108:69–80. 2020. View Article : Google Scholar

12 

Zhang CZ, Niu J, Chong YS, Huang YF, Chu Y, Xie SY, Jiang ZH and Peng LH: Porous microspheres as promising vehicles for the topical delivery of poorly soluble asiaticoside accelerate wound healing and inhibit scar formation in vitro & in vivo. Eur J Pharm Biopharm. 109:1–13. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Qi SH, Xie JL, Pan S, Xu YB, Li TZ, Tang JM, Liu XS, Shu B and Liu P: Effects of asiaticoside on the expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts. Clin Exp Dermatol. 33:171–175. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Qiu J, Yu L, Zhang X, Wu Q, Wang D, Wang X, Xia C and Feng H: Asiaticoside attenuates lipopolysaccharide-induced acute lung injury via down-regulation of NF-kB signaling pathway. Int Immunopharmacol. 26:181–187. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Luo Y, Fu C, Wang Z, Zhang Z, Wang H and Liu Y: Asiaticoside attenuates the effects of spinal cord injury through antioxidant and antiinflammatory effects, and inhibition of the p38MAPK mechanism. Mol Med Rep. 12:8294–8300. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Fitri AR, Pavasant P, Chamni S and Sumrejkanchanakij P: Asiaticoside induces osteogenic differentiation of human peri-odontal ligament cells through the Wnt pathway. J Periodontol. 89:596–605. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Al-Saeedi FJ, Bitar M and Pariyani S: Effect of asiaticoside on 99mTc-tetrofosmin and 99mTc-sestamibi uptake in MCF-7 cells. J Nucl Med Technol. 39:279–283. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Yingchun L, Huihan W, Rong Z, Guojun Z, Ying Y and Zhuogang L: Antitumor activity of asiaticoside against multiple myeloma drug-resistant cancer cells is mediated by autophagy induction, activation of effector caspases, and inhibition of cell migration, invasion, and STAT-3 signaling pathway. Med Sci Monit. 25:1355–1361. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Huang YH, Zhang SH, Zhen RX, Xu XD and Zhen YS: Asiaticoside inducing apoptosis of tumor cells and enhancing anti-tumor activity of vincristine. Ai Zheng. 23:1599–1604. 2004.In Chinese. PubMed/NCBI

20 

Al-Saeedi FJ: Study of the cytotoxicity of asiaticoside on rats and tumour cells. BMC Cancer. 14:2202014. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

22 

Perelman A, Wachtel C, Cohen M, Haupt S, Shapiro H and Tzur A: JC-1: Alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry. Cell Death Dis. 3:e4302012. View Article : Google Scholar : PubMed/NCBI

23 

Soleimani A, Rahmani F, Ferns GA, Ryzhikov M, Avan A and Hassanian SM: Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer. Gene. 726:1441322020. View Article : Google Scholar

24 

Zhang Q, Lenardo MJ and Baltimore D: 30 Years of NF-κB: A blossoming of relevance to human pathobiology. Cell. 168:37–57. 2017. View Article : Google Scholar : PubMed/NCBI

25 

de Castro Barbosa ML, da Conceicao RA, Fraga AGM, Camarinha BD, de Carvalho Silva GC, Lima AGF, Cardoso EA, de Oliveira Freitas and Lione V: NF-kappaB signaling pathway inhibitors as anticancer drug candidates. Anticancer Agents Med Chem. 17:483–490. 2017. View Article : Google Scholar

26 

Kocyigit A and Guler EM: Curcumin induce DNA damage and apoptosis through generation of reactive oxygen species and reducing mitochondrial membrane potential in melanoma cancer cells. Cell Mol Biol (Noisy-le-grand). 63:97–105. 2017. View Article : Google Scholar

27 

Yun X, Rao W, Xiao C and Huang Q: Apoptosis of leukemia K562 and Molt-4 cells induced by emamectin benzoate involving mitochondrial membrane potential loss and intracellular Ca(2+) modulation. Environ Toxicol Pharmacol. 52:280–287. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Yang Y, Zong M, Xu W, Zhang Y, Wang B, Yang M and Tao L: Natural pyrethrins induces apoptosis in human hepatocyte cells via Bax- and Bcl-2-mediated mitochondrial pathway. Chem Biol Interact. 262:38–45. 2017. View Article : Google Scholar

29 

Tang S, Hu J, Meng Q, Dong X, Wang K, Qi Y, Chu C, Zhang X and Hou L: Daidzein induced apoptosis via down-regulation of Bcl-2/Bax and triggering of the mitochondrial pathway in BGC-823 cells. Cell Biochem Biophys. 65:197–202. 2013. View Article : Google Scholar

30 

Zhu J, Chen M, Chen N, Ma A, Zhu C, Zhao R, Jiang M, Zhou J, Ye L, Fu H and Zhang X: Glycyrrhetinic acid induces G1-phase cell cycle arrest in human nonsmall cell lung cancer cells through endo-plasmic reticulum stress pathway. Int J Oncol. 46:981–988. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Bonelli M, Monica SL, Fumarola C and Alfieri R: Multiple effects of CDK4/6 inhibition in cancer: From cell cycle arrest to immunomodulation. Biochem Pharmacol. 170:1136762019. View Article : Google Scholar : PubMed/NCBI

32 

He L, Hong G, Zhou L, Zhang J, Fang J, He W, Tickner J, Han X, Zhao L and Xu J: Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kB signaling pathways. J Cell Physiol. 234:4267–4276. 2019. View Article : Google Scholar

33 

Yin Z, Yu H, Chen S, Ma C, Ma X, Xu L, Ma Z, Qu R and Ma S: Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-kB pathway. Behav Brain Res. 292:288–299. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Meshram SN, Paul D, Manne R, Choppara S, Sankaran G, Agrawal Y and Santra MK: FBXO32 activates NF-kB through IkBα degradation in inflammatory and genotoxic stress. Int J Biochem Cell Biol. 92:134–140. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Tsuchiya Y, Osaki K, Kanamoto M, Nakao Y, Takahashi E, Higuchi T and Kamata H: Distinct B subunits of PP2A regulate the NF-kB signalling pathway through dephosphorylation of IKKβ, IkBα and RelA. FEBS Lett. 591:4083–4094. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Hu J, Haseebuddin M, Young M and Colburn NH: Suppression of p65 phosphorylation coincides with inhibition of IkappaBalpha polyubiquitination and degradation. Mol Carcinog. 44:274–284. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Thoms HC, Dunlop MG and Stark LA: p38-mediated inactivation of cyclin D1/cyclin-dependent kinase 4 stimulates nucleolar translocation of RelA and apoptosis in colorectal cancer cells. Cancer Res. 67:1660–1669. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Ke C, Lv Y, Ren C, Lin T, Dong F and Mi Y: Asiaticoside suppresses cell proliferation by inhibiting the NF‑κB signaling pathway in colorectal cancer. Int J Mol Med 46: 1525-1537, 2020.
APA
Zhou, X., Ke, C., Lv, Y., Ren, C., Lin, T., Dong, F., & Mi, Y. (2020). Asiaticoside suppresses cell proliferation by inhibiting the NF‑κB signaling pathway in colorectal cancer. International Journal of Molecular Medicine, 46, 1525-1537. https://doi.org/10.3892/ijmm.2020.4688
MLA
Zhou, X., Ke, C., Lv, Y., Ren, C., Lin, T., Dong, F., Mi, Y."Asiaticoside suppresses cell proliferation by inhibiting the NF‑κB signaling pathway in colorectal cancer". International Journal of Molecular Medicine 46.4 (2020): 1525-1537.
Chicago
Zhou, X., Ke, C., Lv, Y., Ren, C., Lin, T., Dong, F., Mi, Y."Asiaticoside suppresses cell proliferation by inhibiting the NF‑κB signaling pathway in colorectal cancer". International Journal of Molecular Medicine 46, no. 4 (2020): 1525-1537. https://doi.org/10.3892/ijmm.2020.4688
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Ke C, Lv Y, Ren C, Lin T, Dong F and Mi Y: Asiaticoside suppresses cell proliferation by inhibiting the NF‑κB signaling pathway in colorectal cancer. Int J Mol Med 46: 1525-1537, 2020.
APA
Zhou, X., Ke, C., Lv, Y., Ren, C., Lin, T., Dong, F., & Mi, Y. (2020). Asiaticoside suppresses cell proliferation by inhibiting the NF‑κB signaling pathway in colorectal cancer. International Journal of Molecular Medicine, 46, 1525-1537. https://doi.org/10.3892/ijmm.2020.4688
MLA
Zhou, X., Ke, C., Lv, Y., Ren, C., Lin, T., Dong, F., Mi, Y."Asiaticoside suppresses cell proliferation by inhibiting the NF‑κB signaling pathway in colorectal cancer". International Journal of Molecular Medicine 46.4 (2020): 1525-1537.
Chicago
Zhou, X., Ke, C., Lv, Y., Ren, C., Lin, T., Dong, F., Mi, Y."Asiaticoside suppresses cell proliferation by inhibiting the NF‑κB signaling pathway in colorectal cancer". International Journal of Molecular Medicine 46, no. 4 (2020): 1525-1537. https://doi.org/10.3892/ijmm.2020.4688
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