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Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression

  • Authors:
    • Yulian Pang
    • Mengqi Qin
    • Piaopiao Hu
    • Kaibao Ji
    • Ruihan Xiao
    • Nan Sun
    • Xinghui Pan
    • Xu Zhang
  • View Affiliations / Copyright

    Affiliations: Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Pang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1707-1720
    |
    Published online on: August 27, 2020
       https://doi.org/10.3892/ijmm.2020.4711
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Abstract

Loss of idiopathic retinal ganglion cells (RGCs) leads to irreversible vision defects and is considered the primary characteristic of glaucoma. However, effective treatment strategies in terms of RGC neuroprotection remain elusive. In the present study, the protective effects of resveratrol on RGC apoptosis, and the mechanisms underlying its effects were investigated, with a particular emphasis on the function of optic atrophy 1 (Opa1). In an ischemia/reperfusion (I/R) injury model, the notable thinning of the retina, significant apoptosis of RGCs, reduction in Opa1 expression and long Opa1 isoform to short Opa1 isoform ratios (L‑Opa1/S‑Opa1 ratio) were observed, all of which were reversed by resveratrol administration. Serum deprivation resulted in reductions in R28 cell viability, superoxide dismutase (SOD) activity, Opa1 expression and induced apoptosis, which were also partially reversed by resveratrol treatment. To conclude, results from the present study suggest that resveratrol treatment significantly reduced retinal damage and RGC apoptosis in I/R injury and serum deprivation models. In addition, resveratrol reversed the downregulated expression of Opa1 and reduced SOD activity. Mechanistically, resveratrol influenced mitochondrial dynamics by regulating the L‑Opa1/S‑Opa1 ratio. Therefore, these observations suggest that resveratrol may exhibit potential as a therapeutic agent for RGC damage in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Pang Y, Qin M, Hu P, Ji K, Xiao R, Sun N, Pan X and Zhang X: Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression. Int J Mol Med 46: 1707-1720, 2020.
APA
Pang, Y., Qin, M., Hu, P., Ji, K., Xiao, R., Sun, N. ... Zhang, X. (2020). Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression. International Journal of Molecular Medicine, 46, 1707-1720. https://doi.org/10.3892/ijmm.2020.4711
MLA
Pang, Y., Qin, M., Hu, P., Ji, K., Xiao, R., Sun, N., Pan, X., Zhang, X."Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression". International Journal of Molecular Medicine 46.5 (2020): 1707-1720.
Chicago
Pang, Y., Qin, M., Hu, P., Ji, K., Xiao, R., Sun, N., Pan, X., Zhang, X."Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression". International Journal of Molecular Medicine 46, no. 5 (2020): 1707-1720. https://doi.org/10.3892/ijmm.2020.4711
Copy and paste a formatted citation
x
Spandidos Publications style
Pang Y, Qin M, Hu P, Ji K, Xiao R, Sun N, Pan X and Zhang X: Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression. Int J Mol Med 46: 1707-1720, 2020.
APA
Pang, Y., Qin, M., Hu, P., Ji, K., Xiao, R., Sun, N. ... Zhang, X. (2020). Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression. International Journal of Molecular Medicine, 46, 1707-1720. https://doi.org/10.3892/ijmm.2020.4711
MLA
Pang, Y., Qin, M., Hu, P., Ji, K., Xiao, R., Sun, N., Pan, X., Zhang, X."Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression". International Journal of Molecular Medicine 46.5 (2020): 1707-1720.
Chicago
Pang, Y., Qin, M., Hu, P., Ji, K., Xiao, R., Sun, N., Pan, X., Zhang, X."Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression". International Journal of Molecular Medicine 46, no. 5 (2020): 1707-1720. https://doi.org/10.3892/ijmm.2020.4711
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