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Article

Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway

  • Authors:
    • Lijun Duan
    • Yuan Ma
    • Yonggui Wang
    • Jijun Liu
    • Zeen Tan
    • Qi Wu
    • Yonggang Wu
    • Xing Yu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Bayannaoer City Hospital, Bayannaoer, Inner Mongolia 015000, P.R. China, Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, P.R. China
  • Pages: 2260-2270
    |
    Published online on: September 25, 2020
       https://doi.org/10.3892/ijmm.2020.4739
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Abstract

The aim of the present study was to assess the activation of nuclear factor‑κB (NF‑κB) in the infrapatellar fat pads (IPFPs) of obese patients with knee osteoarthritis (KOA). For this purpose, 32 patients (22 obese patients with KOA and 10 patients with KOA with a healthy weight) treated with total knee arthroplasty (TKA) were selected. The expression levels of pro‑inflammatory cytokines and adipocytokines, and the activation of NF‑κB were detected in both the cases and controls by enzyme‑linked immunosorbent assay (ELISA), western blot analysis and immunohistochemistry where appropriate. SPSS 18.0 software was used for statistical analysis to determine the correlation between obesity and the detected cytokine levels. It was found that in patients with KOA, the expression of leptin in the synovial fluid positively correlated with body mass index (BMI; P<0.05), and the expression of interleukin (IL)‑6 in serum significantly correlated with the IL‑1β, leptin and tumor necrosis factor (TNF)‑α levels (P<0.05). Furthermore, the expression of inflammatory cytokines and adipocytokines in IPFPs differed significantly between the obese and non‑obese patients with KOA (P<0.05). By evaluating the expression of IKKβ and IκBα and the nuclear translocation ability of p‑p65, it was concluded that NF‑κB signaling was activated to a higher degree in the IPFP tissues of obese patients with KOA than in those of patients with KOA with a healthy weight. On the whole, the findings of the present study suggested that the NF‑κB signaling pathway was activated and that there were changes in the expression in levels of inflammatory cytokines and adipocytokines in the IPFP tissues of obese patients with KOA.
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1 

Oliveria SA, Felson DT, Cirillo PA, Reed JI and Walker AM: Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology. 10:161–166. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Saltiel AR and Olefsky JM: Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 127:1–4. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Eymard F and Chevalier X: Inflammation of the infrapatellar fat pad. Joint Bone Spine. 83:389–393. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Griffin T: Biomechanical and metabolic implications of obesity in OA. Osteoarthritis Cartilage. 26(Suppl): S12018. View Article : Google Scholar

5 

Francisco V, Pérez T, Pino J, López V, Franco E, Alonso A, Gonzalez-Gay MA, Mera A, Lago F, Gómez R and Gualillo O: Biomechanics, obesity, and osteoarthritis. The role of adipokines: When the levee breaks. J Orthop Res. 36:595–604. 2018.

6 

Van Beeck A, Clockaerts S, Somville J, Van Heeswijk JH, Van Glabbeek F, Bos PK and Reijman M: Does infrapatellar fat pad resection in total knee arthroplasty impair clinical outcome? A systematic review. Knee. 20:226–231. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K and Akune T: Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: A 3-year follow-up of the ROAD study. Osteoarthritis Cartilage. 20:1217–1226. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Kanneganti TD and Dixit VD: Immunological complications of obesity. Nat Immunol. 13:707–712. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Osborn O and Olefsky JM: The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 18:363–374. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Buchholz AL, Niesen MC, Gausden EB, Sterken DG, Hetzel SJ, Baum SZ, Squire MW and Kaplan LD: Metabolic activity of osteoarthritic knees correlates with BMI. Knee. 17:161–166. 2010. View Article : Google Scholar

11 

Jotanovic Z, Mihelic R, Sestan B and Dembic Z: Role of inter-leukin-1 inhibitors in osteoarthritis: An evidence-based review. Drugs Aging. 29:343–358. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Guarner V and Rubio-Ruiz ME: Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease. Interdiscip Top Gerontol. 40:99–106. 2015. View Article : Google Scholar

13 

Dalmas E, Venteclef N, Caer C, Poitou C, Cremer I, Aron-Wisnewsky J, Lacroix-Desmazes S, Bayry J, Kaveri SV, Clément K, et al: T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: Relevance to obesity and type 2 diabetes. Diabetes. 63:1966–1977. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Esser N, Legrand-Poels S, Piette J, Scheen AJ and Paquot N: Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract. 105:141–150. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Eymard F, Pigenet A, Citadelle D, Tordjman J, Foucher L, Rose C, Flouzat Lachaniette CH, Rouault C, Clément K, Berenbaum F, et al: Knee and hip intra-articular adipose tissues (IAATs) compared with autologous subcutaneous adipose tissue: A specific phenotype for a central player in osteoarthritis. Ann Rheum Dis. 76:1142–1148. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Distel E, Cadoudal T, Durant S, Poignard A, Chevalier X and Benelli C: The infrapatellar fat pad in knee osteoarthritis: An important source of interleukin-6 and its soluble receptor. Arthritis Rheum. 60:3374–3377. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Klein-Wieringa IR, Kloppenburg M, Bastiaansen-Jenniskens YM, Yusuf E, Kwekkeboom JC, El-Bannoudi H, Nelissen RG, Zuurmond A, Stojanovic-Susulic V, Van Osch GJ, et al: The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype. Ann Rheum Dis. 70:851–857. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Eymard F, Pigenet A, Citadelle D, Flouzat-Lachaniette CH, Poignard A, Benelli C, Berenbaum F, Chevalier X and Houard X: Induction of an inflammatory and prodegradative phenotype in autologous fibroblast-like synoviocytes by the infrapatellar fat pad from patients with knee osteoarthritis. Arthritis Rheumatol. 66:2165–2174. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Iwata M, Ochi H, Hara Y, Tagawa M, Koga D, Okawa A and Asou Y: Initial responses of articular tissues in a murine high-fat diet-induced osteoarthritis model: Pivotal role of the IPFP as a cytokine fountain. PLoS One. 8:e607062013. View Article : Google Scholar : PubMed/NCBI

20 

Bastiaansen-Jenniskens YM, Wei W, Feijt C, Waarsing JH, Verhaar JA, Zuurmond AM, Hanemaaijer R, Stoop R and van Osch GJ: Stimulation of fibrotic processes by the infrapatellar fat pad in cultured synoviocytes from patients with osteoarthritis: A possible role for prostaglandin f2α. Arthritis Rheum. 65:2070–2080. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Ma B and Hottiger MO: Crosstalk between Wnt/β-catenin and NF-κB signaling pathway during inflammation. Front Immunol. 7:3782016. View Article : Google Scholar

22 

Liao S, Zhou K, Li D, Xie X, Fang J and Wang J: Schisantherin A suppresses interleukin-1β-induced inflammation in human chondrocytes via inhibition of NF-κB and MAPKs activation. Eur J Pharmacol. 780:65–70. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Olivotto E, Otero M, Marcu KB and Goldring MB: Pathophysiology of osteoarthritis: Canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation. RMD Open. 1(Suppl 1): e0000612015. View Article : Google Scholar :

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

25 

Kulkarni K, Karssiens T, Kumar V and Pandit H: Obesity and osteoarthritis. Maturitas. 89:22–28. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Jiang L, Rong J, Wang Y, Hu F, Bao C, Li X and Zhao Y: The relationship between body mass index and hip osteoarthritis: A systematic review and meta-analysis. Joint Bone Spine. 78:150–155. 2011. View Article : Google Scholar

27 

Jiang L, Tian W, Wang Y, Rong J, Bao C, Liu Y, Zhao Y and Wang C: Body mass index and susceptibility to knee osteoarthritis: A systematic review and meta-analysis. Joint Bone Spine. 79:291–297. 2012. View Article : Google Scholar

28 

Wang X, Hunter D, Xu J and Ding C: Metabolic triggered inflammation in osteoarthritis. Osteoarthritis Cartilage. 23:22–30. 2015. View Article : Google Scholar

29 

Apostolopoulos V, de Courten MP, Stojanovska L, Blatch GL, Tangalakis K and de Courten B: The complex immunological and inflammatory network of adipose tissue in obesity. Mol Nutr Food Res. 60:43–57. 2016. View Article : Google Scholar

30 

Iliopoulos D, Malizos KN, Oikonomou P and Tsezou A: Integrative MicroRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS One. 3:e37402008. View Article : Google Scholar : PubMed/NCBI

31 

Gandhi R, Takahashi M, Virtanen C, Syed K, Davey JR and Mahomed NN: Microarray analysis of the infrapatellar fat pad in knee osteoarthritis: Relationship with joint inflammation. J Rheumatol. 38:1966–1972. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Lübbeke A, Finckh A, Puskas GJ, Suva D, Lädermann A, Bas S, Fritschy D, Gabay C and Hoffmeyer P: Do synovial leptin levels correlate with pain in end stage arthritis? Int Orthopaedics. 37:2071–2079. 2013. View Article : Google Scholar

33 

Francisco V, Pino J, Gonzalez-Gay MA, Mera A, Lago F, Gómez R, Mobasheri A and Gualillo O: Adipokines and inflammation: Is it a question of weight? Br J Pharmacol. 175:1569–1579. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Afif H, Benderdour M, Mfuna-Endam L, Martel-Pelletier J, Pelletier JP, Duval N and Fahmi H: Peroxisome proliferator-activated receptor gamma 1 expression is diminished in human osteoarthritis cartilage and is downregulated by interleukin-1beta in articular chondrocytes. Arthritis Res Ther. 9:R312007. View Article : Google Scholar

35 

Tu C, He J, Wu B, Wang W and Li Z: An extensive review regarding the adipokines in the pathogenesis and progression of osteoarthritis. Cytokine. 113:1–12. 2019. View Article : Google Scholar

36 

Springer BD, Carter JT, McLawhorn AS, Scharf K, Roslin M, Kallies KJ, Morton JM and Kothari SN: Obesity and the role of bariatric surgery in the surgical management of osteoarthritis of the hip and knee: A review of the literature. Surg Obes Relat Dis. 13:111–118. 2017. View Article : Google Scholar

37 

Lee WJ, Wu CS, Lin H, Lee IT, Wu CM, Tseng JJ, Chou MM and Sheu WH: Visfatin-induced expression of inflammatory mediators in human endothelial cells through the NF-kappaB pathway. Int J Obes (Lond). 33:465–472. 2009. View Article : Google Scholar

38 

Simopoulou T, Malizos K, Iliopoulos D, Stefanou N, Papatheodorou L, Ioannou M and Tsezou A: Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. Osteoarthritis Cartilage. 15:872–883. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Gross JB, Guillaume C, Gegout-Pottie P, Reboul P, Jouzeau JY, Mainard D and Presle N: The infrapatellar fat pad induces inflammatory and degradative effects in articular cells but not through leptin or adiponectin. Clin Exp Rheumatol. 35:53–60. 2017.

40 

Kontny E, Plebanczyk M, Lisowska B, Olszewska M, Maldyk P and Maslinski W: Comparison of rheumatoid articular adipose and synovial tissue reactivity to proinflammatory stimuli: Contribution to adipocytokine network. Ann Rheum Dis. 71:262–267. 2012. View Article : Google Scholar

41 

Koskinen A, Vuolteenaho K, Nieminen R, Moilanen T and Moilanen E: Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients. Clin Exp Rheumatol. 29:57–64. 2011.PubMed/NCBI

42 

Zhang Y, Wang S, Zhu J, Li C, Zhang T, Liu H, Xu Q, Ye X, Zhou L and Ye L: Effect of atmospheric PM2.5 on expression levels of NF-κB genes and inflammatory cytokines regulated by NF-κB in human macrophage. Inflammation. 41:784–794. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Li QY, Chen L, Yan MM, Shi XJ and Zhong MK: Tectorigenin regulates adipogenic differentiation and adipocytokines secretion via PPARγ and IKK/NF-κB signaling. Pharm Biol. 53:1567–1575. 2015. View Article : Google Scholar

44 

Hui W, Litherland GJ, Elias MS, Kitson GI, Cawston TE, Rowan AD and Young DA: Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Ann Rheum Dis. 71:455–462. 2012. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Duan L, Ma Y, Wang Y, Liu J, Tan Z, Wu Q, Wu Y and Yu X: Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway. Int J Mol Med 46: 2260-2270, 2020.
APA
Duan, L., Ma, Y., Wang, Y., Liu, J., Tan, Z., Wu, Q. ... Yu, X. (2020). Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway. International Journal of Molecular Medicine, 46, 2260-2270. https://doi.org/10.3892/ijmm.2020.4739
MLA
Duan, L., Ma, Y., Wang, Y., Liu, J., Tan, Z., Wu, Q., Wu, Y., Yu, X."Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway". International Journal of Molecular Medicine 46.6 (2020): 2260-2270.
Chicago
Duan, L., Ma, Y., Wang, Y., Liu, J., Tan, Z., Wu, Q., Wu, Y., Yu, X."Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway". International Journal of Molecular Medicine 46, no. 6 (2020): 2260-2270. https://doi.org/10.3892/ijmm.2020.4739
Copy and paste a formatted citation
x
Spandidos Publications style
Duan L, Ma Y, Wang Y, Liu J, Tan Z, Wu Q, Wu Y and Yu X: Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway. Int J Mol Med 46: 2260-2270, 2020.
APA
Duan, L., Ma, Y., Wang, Y., Liu, J., Tan, Z., Wu, Q. ... Yu, X. (2020). Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway. International Journal of Molecular Medicine, 46, 2260-2270. https://doi.org/10.3892/ijmm.2020.4739
MLA
Duan, L., Ma, Y., Wang, Y., Liu, J., Tan, Z., Wu, Q., Wu, Y., Yu, X."Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway". International Journal of Molecular Medicine 46.6 (2020): 2260-2270.
Chicago
Duan, L., Ma, Y., Wang, Y., Liu, J., Tan, Z., Wu, Q., Wu, Y., Yu, X."Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway". International Journal of Molecular Medicine 46, no. 6 (2020): 2260-2270. https://doi.org/10.3892/ijmm.2020.4739
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