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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2020 Volume 46 Issue 6

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Transcription factor PU.1 and immune cell differentiation (Review)

Guanglan Li, Wenke Hao, Wenxue Hu
Pages: 1943-1950
Published online on: 21 October 2020

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Review

Curcuma longa aqueous extract: A potential solution for the prevention of corneal scarring as a result of pterygium surgical excision (Review)

Gianmarco Stati, Silvia Sancilio, Mariangela Basile, Antonio Angelini, Roberta Di Pietro
Pages: 1951-1957
Published online on: 25 September 2020

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Review Open Access

Role of m6A RNA methylation in cardiovascular disease (Review)

Yuhan Qin, Linqing Li, Erfei Luo, Jiantong Hou, Gaoliang Yan, Dong Wang, Yong Qiao, Chengchun Tang
Pages: 1958-1972
Published online on: 06 October 2020

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Article Open Access

Hypoxia‑induced circCCDC66 promotes the tumorigenesis of colorectal cancer via the miR‑3140/autophagy pathway

Jin Feng, Zhong Li, Ling Li, Haibin Xie, Qicheng Lu, Xiaozhou He
Pages: 1973-1982
Published online on: 07 October 2020

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Article Open Access

lncRNA KCNQ1OT1 promotes proliferation and invasion of glioma cells by targeting the miR‑375/YAP pathway Retraction in /10.3892/ijmm.2022.5170

Panfeng Ding, Bo Liang, Jixin Shou, Xinjun Wang
Pages: 1983-1992
Published online on: 19 October 2020

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Article Open Access

Hsa_circularRNA_0079201 suppresses chondrocyte proliferation and endochondral ossification by regulating the microRNA‑140‑3p/SMAD2 signaling pathway in idiopathic short stature Corrigendum in /10.3892/ijmm.2026.5760

Xijuan Liu, Chen Yan, Xueqiang Deng, Jingyu Jia
Pages: 1993-2006
Published online on: 25 September 2020

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Article Open Access

Long intergenic non‑coding RNA LINC01232 contributes to esophageal squamous cell carcinoma progression by sequestering microRNA‑654‑3p and consequently promoting hepatoma‑derived growth factor expression

Meihua Zhao, Haishan Cui, Baisui Zhao, Mei Li, Haiqing Man
Pages: 2007-2018
Published online on: 09 October 2020

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Article Open Access

Antihypertensive activity of oleanolic acid is mediated via downregulation of secretory phospholipase A2 and fatty acid synthase in spontaneously hypertensive rats

Shiming Zhang, Yuecheng Liu, Xiaoming Wang, Zhenhua Tian, Dongmei Qi, Yunlun Li, Haiqiang Jiang
Pages: 2019-2034
Published online on: 30 September 2020

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Article Open Access

Resveratrol contributes to the inhibition of liver fibrosis by inducing autophagy via the microRNA‑20a‑mediated activation of the PTEN/PI3K/AKT signaling pathway

Lili Zhu, Qiuju Mou, Yinghui Wang, Zixin Zhu, Mingliang Cheng
Pages: 2035-2046
Published online on: 09 October 2020

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Article Open Access

Knockdown of long non‑coding RNA CCAT2 suppresses the progression of thyroid cancer by inhibiting the Wnt/β‑catenin pathway

Suping Xin, Xinhua Ye
Pages: 2047-2056
Published online on: 19 October 2020

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Article Open Access

Honokiol protects against epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overproduction in rats post‑laminectomy

Daoliang Xu, Weimin Zeng, Xuyao Han, Tianchen Qian, Jingyu Sun, Fangzhou Qi, Chen Liu, Quan Wang, Haiming Jin
Pages: 2057-2068
Published online on: 22 October 2020

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Article Open Access

Hesperidin administration suppresses the proliferation of lung cancer cells by promoting apoptosis via targeting the miR‑132/ZEB2 signalling pathway

Song Tan, Lingling Dai, Pengcheng Tan, Wei Liu, Yuejun Mu, Jinguo Wang, Xiaoming Huang, Aihua Hou
Pages: 2069-2077
Published online on: 14 October 2020

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Article Open Access

MicroRNA‑202 inhibits endometrial stromal cell migration and invasion by suppressing the K‑Ras/Raf1/MEK/ERK signaling pathway Retraction in /10.3892/ijmm.2024.5375

Di Zhang, Ling Wang, Hua‑Lei Guo, Zi‑Wei Zhang, Chong Wang, Ri‑Cheng Chian, Zhi‑Fen Zhang
Pages: 2078-2088
Published online on: 09 October 2020

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Article Open Access

PTH(1‑34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway

Zhong Lv, Aikeremujiang Muheremu, Xiaochun Bai, Xuenong Zou, Tao Lin, Bailing Chen
Pages: 2089-2101
Published online on: 13 October 2020

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Article Open Access

p53 and ANXA4/NF‑κB p50 complexes regulate cell proliferation, apoptosis and tumor progression in ovarian clear cell carcinoma

Juanjuan Liu, Huimin Wang, Mingjun Zheng, Lu Deng, Xue Zhang, Bei Lin
Pages: 2102-2114
Published online on: 14 October 2020

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Article Open Access

Oral cancer cell‑derived exosomes modulate natural killer cell activity by regulating the receptors on these cells

Xueqin Zhu, Xing Qin, Xiaoning Wang, Yingnan Wang, Wei Cao, Jianjun Zhang, Wantao Chen
Pages: 2115-2125
Published online on: 24 September 2020

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Article Open Access

Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders

Xuefei Yu, Yanli Sun, Qing Cai, Xinyi Zhao, Ziyun Liu, Xindong Xue, Jianhua Fu
Pages: 2126-2136
Published online on: 22 October 2020

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Article Open Access

Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species‑mediated apoptosis by targeting the electron transport chain

Lijia Pan, Litong Nie, Sheng Yao, Aiwei Bi, Yang Ye, Yeming Wu, Zhen Tan, Zhixiang Wu
Pages: 2137-2149
Published online on: 06 October 2020

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Article Open Access

Modulation of miRNAs by vitamin C in H2O2‑exposed human umbilical vein endothelial cells

Jiandi Wu, Jingjing Liang, Meijun Li, Mingzhuo Lin, Linlin Mai, Xiaohui Huang, Jianqiu Liang, Yunzhao Hu, Yuli Huang
Pages: 2150-2160
Published online on: 13 October 2020

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Article Open Access

MicroRNA‑199a‑3p suppresses high glucose‑induced apoptosis and inflammation by regulating the IKKβ/NF‑κB signaling pathway in renal tubular epithelial cells

Ruimin Zhang, Linfang Qin, Jun Shi
Pages: 2161-2171
Published online on: 12 October 2020

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Article Open Access

Long non‑coding RNA expression profiles identify lncRNA‑XLOC_I2_006631 as a potential novel blood biomarker for Hashimoto's thyroiditis

Huiyong Peng, Si Xiong, Xiangmei Ding, Xinyi Tang, Xuehua Wang, Li Wang, Yingzhao Liu
Pages: 2172-2184
Published online on: 13 October 2020

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Article Open Access

Erythroid differentiation regulator 1 promotes wound healing by inducing the production of C‑C motif chemokine ligand 2 via the activation of MAP kinases in vitro and in vivo

Byung‑Cheol Lee, Jisun Song, Arim Lee, Daeho Cho, Tae Sung Kim
Pages: 2185-2193
Published online on: 19 October 2020

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Article Open Access

Loss of FZO1 gene results in changes of cell dynamics in fission yeast

Rongmei Yuan, Xiang Ding, Xiumei Tan, Yiling Hou
Pages: 2194-2206
Published online on: 12 October 2020

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Article Open Access

Early local neutralization of CC16 in sepsis‑induced ALI following blunt chest trauma leads to delayed mortality without benefitting overall survival

Jan Tilmann Vollrath, Philipp Stoermann, Nils Becker, Sebastian Wutzler, Frank Hildebrand, Ingo Marzi, Borna Relja
Pages: 2207-2215
Published online on: 22 October 2020

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Article Open Access

Epigallocatechin‑3‑gallate inhibits self‑renewal ability of lung cancer stem‑like cells through inhibition of CLOCK

Pan Jiang, Chuyue Xu, Pengpeng Zhang, Jianglei Ren, Fatima Mageed, Xiaoyue Wu, Lijun Chen, Falak Zeb, Qing Feng, Shanqun Li
Pages: 2216-2224
Published online on: 14 October 2020

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Article

lncRNA TUG1 promotes the brown remodeling of white adipose tissue by regulating miR‑204‑targeted SIRT1 in diabetic mice

Ying Zhang, Yuhang Ma, Mingyu Gu, Yongde Peng
Pages: 2225-2234
Published online on: 28 September 2020

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Article

YAP activity protects against endotoxemic acute lung injury by activating multiple mechanisms

Ling‑Yan Liu, Xiao‑Qiong Shan, Fu‑Kun Zhang, Xiao‑Fang Fan, Jun‑Ming Fan, Yong‑Yu Wang, Shu Fang Liu, Sun‑Zhong Mao, Yong‑Sheng Gong
Pages: 2235-2250
Published online on: 14 October 2020

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Article

Knockdown of STIP1 inhibits the invasion of CD133‑positive cancer stem‑like cells of the osteosarcoma MG63 cell line via the PI3K/Akt and ERK1/2 pathways

Jian‑Hua Wang, Chen Gong, Feng‑Jin Guo, Xiao Zhou, Ming‑Sheng Zhang, Hong Qiu, Teng‑Fei Chao, Yang Liu, Liang Qin, Hui‑Hua Xiong
Pages: 2251-2259
Published online on: 21 October 2020

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Article

Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway

Lijun Duan, Yuan Ma, Yonggui Wang, Jijun Liu, Zeen Tan, Qi Wu, Yonggang Wu, Xing Yu
Pages: 2260-2270
Published online on: 25 September 2020

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Article

Inhibition of inflammation by SP600125 in cholestatic liver injury is dependent on the administration‑based exposure profile

Xiuting Zheng, Manyun Dai, Gangming Xu, Liming Chang, Julin Yang, Aiming Liu
Pages: 2271-2279
Published online on: 29 September 2020

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Correction Open Access

[Corrigendum] Nicorandil protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis

Fengyun Zhang, Jinjin Cui, Bo Lv, Bo Yu
Pages: 2280-2281
Published online on: 28 September 2020

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Correction Open Access

[Corrigendum] Nano‑hydroxyapatite/collagen film as a favorable substrate to maintain the phenotype and promote the growth of chondrocytes cultured in vitro

Xianfang Jiang, Yanping Zhong, Li Zheng, Jinmin Zhao
Pages: 2282-2284
Published online on: 30 September 2020

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Journal Cover
October-2026 Volume 58 Issue 4

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role of adipocytes and their derived extracellular vesicles in the progression, diagnosis and treatment of liver diseases (Review)

Kangrong Li, Muhammad Zubair, Yongmin Yan, Jiahao Xu
Article Number: 293
Published online on: 20 August 2026

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Correction Open Access

[Corrigendum] EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin‑induced murine model of asthma

In Sik Shin, Mee Young Lee, Woo Young Jeon, Na Ra Shin, Chang Seob Seo, Hyekyung Ha
Article Number: 292
Published online on: 20 August 2026

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Review Open Access

Decoding fibroblast activation: Transcriptional networks in hepatic stellate cells and across fibrotic organs (Review)

Denita Charoenthanakitkul, Chaiyaboot Ariyachet
Article Number: 291
Published online on: 20 August 2026

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Review Open Access

Inflammatory bowel disease treatment: Mechanisms to clinical translation (Review)

Siqi Tang, Guoyou Gou, Youjia Liu, Fang Wang, Feihong Shu, Ya Deng, Ting Zhang, Jingyu Xu, Rui Xie
Article Number: 290
Published online on: 18 August 2026

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Review Open Access

Redox biology in PCOS: Biomarkers, mechanistic networks, and targeted interventions (Review)

Yuena Qiu, Xiaojing Guo, Jie An
Article Number: 289
Published online on: 18 August 2026

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Review Open Access

Glucose metabolism in osteoporosis: A potential therapeutic target (Review)

Shengyao Peng, Zhuo Yao, Junzhe Guo, Chi Zhang, Keda Yang, Lin Tao
Article Number: 288
Published online on: 17 August 2026

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Retraction Open Access

[Retracted] Engulfment of platelets delays endothelial cell aging via girdin and its phosphorylation

Yong Lan, Yongjun Li, Dajun Li, Peng Li, Jiyang Wang, Yongpeng Diao, Guodong Ye, Yangfang Li
Article Number: 287
Published online on: 17 August 2026

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Article Open Access

α‑Cyperone targets the PAK1‑JNK/NF‑κB axis to modulate dendritic cells maturation and Th2/Th9 differentiation in an asthma model

Hang Hu, Xing Wang, Linlin Guo, Ziling Zeng, Hongmei Tang, Yun Zhang, Jiayao Duan, Kaijin Wang
Article Number: 286
Published online on: 14 August 2026

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Article Open Access

Early high‑frequency spinal cord stimulation modulates the ROS/p38 MAPK/NF‑κB and CXCL10/CXCR3 pathways to alleviate neuropathic pain and promote spinal cord injury repair

Sitong Su, Tao Liu, Honghui Lei, Yang Yu, Caizhi Ma, Xinglang Wang, Haoyuan Chen, Zebin Huang, Meiling Cheng, Tongtong Qian, Fangyong Wang
Article Number: 285
Published online on: 13 August 2026

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Review Open Access

Shared mechanisms of musculoskeletal dysfunction in type 2 diabetes mellitus: Insights into future therapeutic directions (Review)

Zhenhong He, Hanyu Li, Yuhan Luo, Yingying Yu, Siyu Li, Tao Zhang, Dingsu Bao
Article Number: 284
Published online on: 12 August 2026

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Expression of Concern Open Access

[Expression of Concern] Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway

Xinying Zhang, Li Zhang, Zhe Chen, Siwei Li, Bingbing Che, Ningning Wang, Junting Chen, Changqing Xu, Can Wei
Article Number: 283
Published online on: 12 August 2026

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Article Open Access

G protein‑coupled receptor kinase 4 governs early kidney development via STAT3 and Nhe3a

Linh Anna Trúc Vu, Julian Gerhards, Lars D. Maerz, Martin D. Burkhalter, Melanie Philipp
Article Number: 282
Published online on: 11 August 2026

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Retraction Open Access

[Retracted] Resistant starch prevents tumorigenesis of dimethylhydrazine‑induced colon tumors via regulation of an ER stress‑mediated mitochondrial apoptosis pathway  

Qiuyu Wang, Peng Wang, Zhigang Xiao
Article Number: 281
Published online on: 10 August 2026

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Review Open Access

XBP1 signaling from tumor metabolic stress to myeloid driven immunotherapy resistance (Review)

Ziwei Chen, Jiaqi Wu, Wenxi Liu, Jie Tan, Xiaochun Peng, Yanhua Zhang, Gai Liang
Article Number: 280
Published online on: 05 August 2026

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Review Open Access

Decoding miRNA‑146a: Mechanisms of action in cardiovascular diseases and endocrine metabolic disorders (Review)

Xiu Yang, Pengcheng Li, Hao Zhao
Article Number: 279
Published online on: 05 August 2026

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Review Open Access

Contribution of p38 MAPK in liver fibrosis: An overview of mechanisms, signaling pathways, and therapeutic targets (Review)

Xueqin Yang, Huarong Li, Hao Ye, Ting Wu, Fangyun Xu, Chao Hu, Chunlei Yu, Pian Ye
Article Number: 278
Published online on: 05 August 2026

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Correction Open Access

[Corrigendum] Peroxisome proliferator‑activated receptor α regulates acesulfame‑K‑induced NAFLD via hepatic PLCβ: Foe and friend

Peng-Yao Lin, Jia-Rong Xie, Tian-Chen Qian, Shi-Song Wang, Si-Yi Yu, Wen-Bo Shi, Ying Wang, Lu-Ze Cen, Qing-Jing Zhu, Yi-Yang Zheng, Hui Gao, Rong Fang, Zhao-Xia Xia, Ai-Ming Liu, Lei Xu
Article Number: 277
Published online on: 05 August 2026

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Review Open Access

Multi‑omics insights into uveitis: From mechanisms to precision medicine (Review)

Chengzhi Liu, Qiong Wu, Mingzhen Yuan, Mingyue Liu, Xinyu Wang, Jiaqi Shen, Xusheng Cao
Article Number: 276
Published online on: 03 August 2026

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Retraction Open Access

[Retracted] Effects of miRNA‑455 on cardiac hypertrophy induced by pressure overload

Chuntao Wu, Shimin Dong, Yongjun Li
Article Number: 275
Published online on: 03 August 2026

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Article Open Access

Energy stress activates AMPK to suppress ferroptosis in neurodegenerative proteinopathies

Yuanyuan Yong, Yuxin Hu, Qian Feng, Xiaogang Zhou, Lu Yu, Dalian Qin, Jianing Mi, Jianming Wu, Jianxin Liu, Anguo Wu
Article Number: 274
Published online on: 31 July 2026

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Article Open Access

Brazilin attenuates methylglyoxal‑induced endothelial injury by enhancing eIF5A hypusination and inhibiting the AMPK/mTOR‑mediated autophagy/apoptosis axis in vitro and in vivo

Yu Liang, Jinxiang Chen, Haiyang Li, Junjing Xiong, Jingcan You, Liqun Wang, Jianbo Wu, Youkun Zheng, Mao Luo
Article Number: 273
Published online on: 30 July 2026

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Review Open Access

Post‑translational modifications in atherosclerosis: Roles, mechanisms and therapeutic potential (Review)

Xiaoxiang Xu, Fei Ma, Wei Yu
Article Number: 272
Published online on: 30 July 2026

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Review Open Access

Role of extracellular matrix in liver fibrosis regression and regeneration (Review)

Yuanzhi Zhou, Zeyuan Qiang, Yang Duan, Jiwei Huang, Haichuan Wang
Article Number: 271
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Circulating microRNA profiles and the identification of miR‑593 and miR‑511 which directly target the PROP1 gene in children with combined pituitary hormone deficiency

Yanyan Hu, Qian Wang, Zengmin Wang, Fengxue Wang, Xiaobo Guo, Guimei Li
Article Number: 270
Published online on: 29 July 2026

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Review Open Access

Unveiling the role of spatial transcriptomics in the analysis of the tumor immune microenvironment (Review)

Jialin Jiang, Xinyu Tu, Yi Cao, Qun Yan, Buqing Sai, Jian Ma
Article Number: 269
Published online on: 28 July 2026

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Expression of Concern Open Access

[Expression of Concern] Luteolin protects mice from severe acute pancreatitis by exerting HO‑1‑mediated anti‑inflammatory and antioxidant effects

Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Article Number: 268
Published online on: 27 July 2026

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Article Open Access

circRNA_013145‑miR‑185‑5p‑RhoA axis: A novel mechanism in the pathophysiology of diabetes‑induced erectile dysfunction

Wenhan Huang, Xin Lv, Jiahua Qian, Yihao Chen, Yuhe Si, Jingwei Wang, Jianxiong Ma
Article Number: 267
Published online on: 24 July 2026

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Review Open Access

Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review)

Jinyi Hou, Yaotan Li, Shijia Lin, Qingqing Liu, Huijuan Zheng, Weijing Liu, Yaoxian Wang, Liang Peng, Zhen Wang
Article Number: 266
Published online on: 23 July 2026

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Review Open Access

Effects of cuproptosis and its application in inflammatory bowel disease (Review)

Li Chen, Francis Atim Akanyibah, Jing Guan, Bing Pei, Bo Wang, Fei Mao
Article Number: 265
Published online on: 23 July 2026

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November-2026 Volume 58 Issue 5

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Correction Open Access

[Corrigendum] Tumor‑targeting novel manganese complex induces ROS‑mediated apoptotic and autophagic cancer cell death

Jia Liu, Wenjie Guo, Jing Li, Xiang Li, Ji Geng, Qiuyun Chen, Jing Gao
Article Number: 297
Published online on: 26 August 2026

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Advances in sirtuin research in lung diseases (Review)

Shuangyun Xi, Weijun Chen, Xiuli Li, Yudan Wang, Yong Ke
Article Number: 296
Published online on: 25 August 2026

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Article Open Access

lncRNA TUG1 mediates palmitic acid‑induced neuronal lipotoxic injury via the miR‑449a‑5p/caspase‑3 and Akt/GSK‑3β axes

Ya-Dong Wei, Peng-Quan Chen, Xin Zheng, Le-Qi Wu, Xin-Yi Wang, Xin-Ran Gao, Jin-Fang Ge
Article Number: 295
Published online on: 25 August 2026

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Retraction Open Access

[Retracted] Downregulation of LINC00707 promotes osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells by regulating DKK1 via targeting miR‑103a‑3p

Jun Liu, Minfei Wu, Guang Feng, Rui Li, Yang Wang, Jianhang Jiao
Article Number: 294
Published online on: 24 August 2026

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